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Alphagan P (Brimonidine Tartrate Ophthalmic) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

Antihypertensives/Cardiac Glycosides

Because ALPHAGAN ® P may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with ALPHAGAN ® P is advised.

CNS Depressants

Although specific drug interaction studies have not been conducted with ALPHAGAN ® P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered.

Tricyclic Antidepressants

Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine. It is not known whether the concurrent use of these agents with ALPHAGAN ® P in humans can lead to resulting interference with the IOP lowering effect. Caution is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines.

Monoamine Oxidase Inhibitors

Monoamine oxidase (MAO) inhibitors may theoretically interfere with the metabolism of brimonidine and potentially result in an increased systemic side-effect such as hypotension. Caution is advised in patients taking MAO inhibitors which can affect the metabolism and uptake of circulating amines.

OVERDOSAGE

Very limited information exists on accidental ingestion of brimonidine in adults; the only adverse reaction reported to date has been hypotension. Symptoms of brimonidine overdose have been reported in neonates, infants, and children receiving ALPHAGAN ® P as part of medical treatment of congenital glaucoma or by accidental oral ingestion (see USE IN SPECIFIC POPULATIONS, 8.4). Treatment of an oral overdose includes supportive and symptomatic therapy; a patent airway should be maintained.

CONTRAINDICATIONS

Neonates and Infants (under the age of 2 years)

ALPHAGAN ® P is contraindicated in neonates and infants (under the age of 2 years).

Hypersensitivity Reactions

ALPHAGAN ® P is contraindicated in patients who have exhibited a hypersensitivity reaction to any component of this medication in the past.

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