NEWS HIGHLIGHTS
Published Studies Related to Alphagan P (Brimonidine Ophthalmic)
Brimonidine tartrate 0.15%, dorzolamide hydrochloride 2%, and brinzolamide 1% compared as adjunctive therapy to prostaglandin analogs. [2009.09]
OBJECTIVE: To compare the efficacy of brimonidine, dorzolamide, and brinzolamide in reducing intraocular pressure (IOP) when used as adjunctive therapy to a prostaglandin analog (PGA)... CONCLUSIONS: The addition of brimonidine to a PGA provided greater IOP lowering than the addition of either dorzolamide or brinzolamide. Further studies are needed to evaluate the relative long-term efficacy and tolerability of these medications as adjunctive therapy to a PGA. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
Meta-analysis of randomized controlled trials comparing timolol with brimonidine in the treatment of glaucoma. [2008.04]
This paper aims to compare the efficacy and tolerability of timolol versus brimonidine in the treatment of glaucoma. Comprehensive searches were performed using Medline, Embase and the Cochrane Controlled Trials Register for randomized controlled trials comparing timolol and brimonidine... Brimonidine is associated with a higher rate of allergy.
Effect of brimonidine tartrate 0.15% on scotopic pupil: controlled trial. [2007.10]
PURPOSE: The aim of this study was to evaluate the duration of the effect of one single dose of brimonidine tartrate 0.15% on pupil diameter, under scotopic conditions, when applied topically in 1 eye of normal subjects... CONCLUSIONS: Miotic response of brimonidine tartrate 0.15% lasted for at least 8 h and has a significant effect on the nontreated eye.
Effect of Brimonidine Tartrate 0.15% on Scotopic Pupil-Controlled Trial. [2007.09.27]
Purpose: The aim of this study was to evaluate the duration of the effect of one single dose of brimonidine tartrate 0.15% on pupil diameter, under scotopic conditions, when applied topically in 1 eye of normal subjects. Methods: The eyes of 19 normal volunteers were randomized so that 1 eye had 1 drop of brimonidine tartrate 0.15% and the other received no medication...
Effect of prophylactic brimonidine instillation on bleeding during strabismus surgery in adults. [2007.09]
PURPOSE: To investigate the effects of preoperative brimonidine-purite 0.15% instillation on intraoperative bleeding and postoperative subconjunctival hemorrhage during strabismus surgery in adult patients. DESIGN: Randomized comparative interventional case series... CONCLUSIONS: Topical brimonidine administration before strabismus surgery may reduce intraoperative bleeding and postoperative subconjunctival hemorrhage in adult patients.
Clinical Trials Related to Alphagan P (Brimonidine Ophthalmic)
Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension [Completed]
This study evaluates the safety and efficacy of brimonidine 0. 2%/timolol 0. 5% fixed
combination ophthalmic solution compared with concurrent brimonidine 0. 2% and timolol
ophthalmic solutions
Comparison of Brimonidine Purite, Dorzolamide, and Brinzolamide as Adjunctive Therapy to Prostaglandin Analogs [Completed]
The purpose of this study is to compare the efficacy of brimonidine Purite, dorzolamide, and
brinzolamide in reducing intraocular pressure when added to prostaglandin analog therapy
(bimatoprost, latanoprost, or travoprost) in patients with glaucoma or ocular hypertension.
Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan [Completed]
Systemic Bioavailability Study Of Col-118 Administered Topically as a 0.18 % Facial Gel And Brimonidine Ophthalmic Solution 0.2% [Recruiting]
Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma [Completed]
Low-pressure (normal tension) glaucoma is a type of open-angle glaucoma resulting in damage
to the optic nerve and abnormalities of the visual field. Eye (intraocular) pressure in this
type of glaucoma is not higher than that usually considered to be normal (less than 21 mmHg)
for the eye. The present treatment of low-pressure glaucoma is also directed to lowering the
“normal” eye pressure. Both medications in this study, brimonidine and timolol, lower eye
pressure.
Laboratory research over the past decade indicates the potential to treat glaucoma not only
by lowering eye pressure, but with treatments aimed at the damage occurring at the optic
nerve. One group of drugs, selective alpha2-adrenergic agonists, have been shown in
laboratory animals to protect against the effects of nerve damage following local stroke.
Brimonidine, one of the medications in the current study, is a selective alpha2-adrenergic
agonist which protects against damage to optic nerve in animal models of glaucoma..
The hypothesis of the present study is that brimonidine eye drops provide protection to the
damaged optic nerve independent of lowering eye pressure in patients with low-pressure
glaucoma. This will be determined by (1) measuring eye pressure, (2) performing visual field
examinations, and (3) examination of the optic nerve.
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