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Alkeran Injection (Melphalan) - Summary

 

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WARNING

Melphalan should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Severe bone marrow suppression with resulting infection or bleeding may occur. Controlled trials comparing intravenous (IV) to oral melphalan have shown more myelosuppression with the IV formulation. Hypersensitivity reactions, including anaphylaxis, have occurred in approximately 2% of patients who received the IV formulation. Melphalan is leukemogenic in humans. Melphalan produceschromosomal aberrations in vitro and in vivo and, therefore, should be considered potentially mutagenic in humans.

 

SUMMARY

ALKERAN®
(melphalan hydrochloride)
for Injection

ALKERAN (melphalan), also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent which is active against selective human neoplastic diseases.

ALKERAN for Injection is indicated for the palliative treatment of patients with multiple myeloma for whom oral therapy is not appropriate.

NEWS HIGHLIGHTS RELATED TO ALKERAN INJECTION

Media Articles Related to Alkeran Injection (Melphalan)

melphalan-oral, Alkeran
Source: MedicineNet Amyloidosis Specialty [2005.03.02]

Bortezomib (Velcade) in Combo Scores For Initial Myeloma Treatment
Source: MedPageToday.com - Latest medical news and health news plus CME for physicians and healthcare professionals [2008.08.27]

MMRC Partners With Celgene Corporation On Phase I/II Trial Of Pomalidomide In Relapsed And Refractory Multiple Myeloma Patients
Source: Blood / Hematology News From Medical News Today [2008.08.26]

Bristol-Myers Squibb And PDL BioPharma Enter Global Alliance To Develop Novel Treatment For Multiple Myeloma
Source: Blood / Hematology News From Medical News Today [2008.08.21]

The Multiple Myeloma Research Consortium Announces Initiation Of First Four-Drug Combination Study To Treat Newly Diagnosed Multiple Myeloma Patients
Source: Blood / Hematology News From Medical News Today [2008.08.18]

more>>

Published Studies Related to Alkeran Injection (Melphalan)

Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized, controlled trial. [2008.05.27]

Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial. [2007.10.06]

High-dose melphalan versus melphalan plus dexamethasone for AL amyloidosis. [2007.09.13]

A randomised comparison of melphalan with prednisone or dexamethasone as induction therapy and dexamethasone or observation as maintenance therapy in multiple myeloma: NCIC CTG MY.7. [2007.01]

Pegfilgrastim compared with filgrastim after high-dose melphalan and autologous hematopoietic peripheral blood stem cell transplantation in multiple myeloma patients. [2006.11]

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Clinical Trials Related to Alkeran Injection (Melphalan)

Comparison of Melphalan-Prednisone (MP) to MP Plus Thalidomide in the Treatment of Newly Diagnosed Very Elderly Patients (> 75 Years) With Multiple Myeloma [Terminated]

Arsenic Trioxide With Ascorbic Acid and Melphalan for Myeloma Patients [Completed]

Phase II Trial of a Chemotherapy Alone Regimen of IV Busulfan (Busulfex), Melphalan and Fludarabine as Myeloablative Regimen Followed by an Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplant From an HLA-Identical, or HLA-Non Identical Related or Unrelated Donor [Active, not recruiting]

Velcade®-Melphalan Association in Autologous Stem-Cell Transplantation (ASCT) [Active, not recruiting]

Velcade-Melphalan-Prednisone in Older Untreated Multiple Myeloma Patients. [Active, not recruiting]

more>>

Page last updated: 2008-08-27

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