Media Articles Related to Alfentanil
Anesthesia and Cognitive Decline: No Link?
Source: Medscape Psychiatry & Mental Health Headlines [2016.01.26]
There is no significant link between anesthesia and mild cognitive impairment, according to a large, population-based study.
Medscape Medical News
Study finds no link between surgical anesthesia and MCI
Source: Pain / Anesthetics News From Medical News Today [2016.01.20]
A Mayo Clinic study of people who received anesthesia for surgery after age 40 found no association between the anesthesia and development of mild cognitive impairment later in life.
Anesthesia After 40 Not Linked to Mental Decline Later, Study Finds
Source: MedicineNet Dementia Specialty [2016.01.20]
Title: Anesthesia After 40 Not Linked to Mental Decline Later, Study Finds
Category: Health News
Created: 1/20/2016 12:00:00 AM
Last Editorial Review: 1/20/2016 12:00:00 AM
More pain before root canal, less to gain from anesthesia
Source: Dentistry News From Medical News Today [2015.12.11]
Before starting any root canal procedure, dental surgeons reach for a local anesthetic.
How the brain wakes you up
Source: Sleep / Sleep Disorders / Insomnia News From Medical News Today [2015.12.21]
Scientists from Bern have discovered a mechanism which is responsible for the rapid arousal from sleep and anesthesia in the brain.
Published Studies Related to Alfentanil
A double-blinded randomized evaluation of alfentanil and morphine vs fentanyl:
analgesia and sleep trial (DREAMFAST). 
interference... CONCLUSIONS: Despite better early postoperative analgesia, pain-related sleep
Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. [2011.04]
Alfentanil (ALF) is a validated probe for hepatic, first-pass, and intestinal cytochrome P450 (CYP) 3A activity, using plasma clearances, single-point concentrations, and noninvasive pupil diameter change (miosis).
Comparison of propofol and the combination of propofol and alfentanil during bronchoscopy: a randomized study. [2011.01]
BACKGROUND: propofol is an excellent sedative agent for use in patients undergoing bronchoscopy. The addition of an opioid to propofol can be advantageous because of the antitussive effect of the opioid and the possible improvement in sedation quality. However, it may increase the risk of hypoxaemia. To investigate the effect of the addition of alfentanil to propofol, we performed a prospective study to compare propofol-only sedation with propofol-alfentanil combination sedation in patients undergoing bronchoscopy... CONCLUSIONS: the combination of propofol and alfentanil resulted in a greater respiratory depression than propofol alone; furthermore, the addition of an opioid did not improve the quality of sedation. In conclusion, we do not recommend sedation with propofol and alfentanil during bronchoscopy. 2010 The Acta Anaesthesiologica Scandinavica Foundation.
Comparison of alfentanil and remifentanil infusions in combination with propofol for the outpatient extra-corporeal shock wave lithotripsy. 
PURPOSE: The aim of this study is to compare the efficiency of propofol+remifentanil to propofol+alfentanil in reducing pain in patients with urinary system stones undergoing outpatient Extracorporeal Shock Wave Lithotripsy (ESWL)... CONCLUSION: We concluded that both methods may be successfully used for patients undergoing ESWL (Tab. 6, Rief. 29).
Optimal bolus dose of alfentanil for successful tracheal intubation during sevoflurane induction with and without nitrous oxide in children. [2010.05]
BACKGROUND: The goals of this study were to determine the effective bolus dose of alfentanil required for successful tracheal intubation during inhalation induction using sevoflurane 5% without neuromuscular block in children, and whether nitrous oxide reduces these doses... CONCLUSIONS: The effective bolus dose of alfentanil for successful tracheal intubation was 11.5 microg kg(-1) in 50% of children during inhalation induction using sevoflurane 5% without neuromuscular blocking agent. Addition of nitrous oxide 60% in oxygen reduced the effective alfentanil dose by 25%.
Clinical Trials Related to Alfentanil
Optimal Dose of Alfentanil for Removal of Supreme Laryngeal Mask Airway During Emergence From Desflurane Anaesthesia [Recruiting]
This study aims to determine the optimal dose of alfentanil in suppressing the airway
reflexes during supreme LMA removal in anaesthetized adult.
Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP) [Completed]
Self-administration of propofol and opioid mixture by the patient him- or herself
(patient-controlled sedation, PCS) could be successful alternative to the
anesthesiologists-managed deep sedation during endoscopic retrograde
cholangiopancreatography (ERCP). However, it is not known which opioid would be the most
suitable for PCS. The aim of this double-blind study was to compare remifentanil and
alfentanil in PCS during ERCP.
Sedation During Bronchoscopy:Dexmedetomidine vs Alfentanil [Completed]
The purpose of this study is to find the best sedation necessary for patients undergoing
bronchoscopy. Patients are randomized to three different regimes of sedation during
bronchoscopy were studied:
1. - Group standard/control: local anesthesia only(C)
2. - Group alfentanil + local anesthesia(A)
3. - Group dexmedetomidine + local anesthesia(D) The primary endpoint is the bronchoscopy
score. Secondary endpoints are: Level of sedation and tolerance bronchoscopy
examination. Measured parameters on the safety of examination are: the lowest
saturation, needs to supplemental oxygen, amnesia , choking sensation or chest pain and
if the patient is ready or not to undertake bronchoscopy second time in his life if
necessary. Endtidal CO2, Respiratory rate, Blood pressure, Heart rate, level of oxygen
are collected every 5 minutes before, during and after the bronchoscopy.
Comparison of Propofol/Alfentanil With Propofol/Ketamine [Not yet recruiting]
A prospective, randomized, patient-blinded comparison of the safety and efficacy of
conscious sedation by propofol/alfentanil with propofol/ketamine in patients undergoing
flexible fiberoptic bronchoscopy.
Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation [Recruiting]
Reports of Suspected Alfentanil Side Effects
Anaphylactic Shock (7),
Respiratory Depression (4),
Maternal Exposure During Pregnancy (2),
Toxic Epidermal Necrolysis (2),
Maternal Drugs Affecting Foetus (1),
Caesarean Section (1),
Upper Airway Obstruction (1),
Hepatitis Acute (1)