ALFENTANIL SUMMARY
ALFENTANIL
INJECTION, USP
Alfentanil Injection, USP is an opioid analgesic chemically designated as N-[1-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide monohydrochloride (1:1) with a molecular weight of 452.
Alfentanil Injection is indicated:
as an analgesic adjunct given in incremental doses in the maintenance of anesthesia with barbiturate/nitrous oxide/oxygen.
as an analgesic administered by continuous infusion with nitrous oxide/oxygen in the maintenance of general anesthesia.
as a primary anesthetic agent for the induction of anesthesia in patients undergoing general surgery in which endotracheal intubation and mechanical ventilation are required.
as the analgesic component for monitored anesthesia care (MAC).
SEE DOSAGE CHART FOR MORE COMPLETE INFORMATION ON THE USE OF ALFENTANIL INJECTION.
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NEWS HIGHLIGHTSMedia Articles Related to Alfentanil
Abdominal Surgery Without General Anesthesia
Source: Clinical Trials / Drug Trials News From Medical News Today [2009.11.04]
A recent review in Faculty of 1000 Medicine Reports, a publication in which clinicians highlight advances in medical practice, suggests regional pain relief could be used during abdominal surgery. In this review, Michael Schaefer recommends a new approach that can be performed without the need for general anaesthetics.
Anesthesia, Exertional Heat Deaths May Be Linked
Source: MedicineNet Hyperthermia Specialty [2009.10.26]
Title: Anesthesia, Exertional Heat Deaths May Be Linked
Category: Health News
Created: 10/23/2009 4:10:00 PM
Last Editorial Review: 10/26/2009
Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Source: MedicineNet Hernia Specialty [2009.03.25]
Title: Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Category: Health News
Created: 3/25/2009 2:00:00 AM
Last Editorial Review: 3/25/2009
New Technique For Injectable Facial Fillers Improves Comfort, Recovery
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.10.29]
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect. These and other benefits of a new injection technique that UT Southwestern Medical Center plastic surgeons are helping pioneer are outlined in the October issue of Plastic and Reconstructive Surgery.
New Technique For Injectable Facial Fillers Improves Comfort And Recovery
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.10.29]
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect. These and other benefits of a new injection technique that UT Southwestern Medical Center plastic surgeons are helping pioneer are outlined in the October issue of Plastic and Reconstructive Surgery.
Published Studies Related to Alfentanil
Prevention of propofol-induced pain in children: combination of alfentanil and lidocaine vs alfentanil or lidocaine alone. [2009.09]
BACKGROUND: Pain from a propofol injection is a common side-effect in paediatric patients. This prospective, randomized, double-blind study evaluated the efficacy of a combined pretreatment of alfentanil with lidocaine on the incidence and severity of propofol injection pain in children... CONCLUSIONS: Our study demonstrated that the combination treatment of two different analgesic modalities, alfentanil and lidocaine, could prevent the moderate and severe pain on propofol injection, and reduce the incidence of mild pain compared with each drug alone.
Nefopam and alfentanil additively reduce the shivering threshold in humans whereas nefopam and clonidine do not. [2009.07]
BACKGROUND: Induction of therapeutic hypothermia is often complicated by shivering. Nefopam reduces the shivering threshold with minimal side effects. Consequently, nefopam is an attractive component for induction of therapeutic hypothermia. However, nefopam alone is insufficient; it will thus need to be combined with another drug. Clonidine and alfentanil each reduce the shivering threshold. This study, therefore, tested the hypothesis that nefopam, combined either with clonidine or alfentanil, synergistically reduces the shivering threshold... CONCLUSIONS: Nefopam and alfentanil additively reduce the shivering threshold, but nefopam and clonidine do not.
Nurse-administered propofol-alfentanil sedation using a patient-controlled analgesia pump compared with opioid-benzodiazepine sedation for outpatient colonoscopy. [2009.06]
BACKGROUND AND STUDY AIM: Nurse-administered propofol sedation (NAPS) and patient-controlled sedation using patient-controlled analgesia (PCA) pumps are gaining increasing popularity for gastrointestinal endoscopy. We compared the safety and efficacy of NAPS using PCA pumps with diazemuls-pethidine sedation (DPS) for outpatient colonoscopy... CONCLUSION: Despite higher costs, nurse-administered propofol-alfentanil sedation using a PCA pump can provide deeper conscious sedation, comparable satisfaction, and similar complication risks compared with conventional opioid-benzodiazepine sedation.
Post-induction alfentanil reduces sevoflurane-associated emergence agitation in children undergoing an adenotonsillectomy. [2009.05]
BACKGROUND: Emergence agitation is a common problem in paediatric anaesthesia, especially after volatile induction and maintenance anaesthesia (VIMA) with sevoflurane. The purpose of this study was to investigate the effect of alfentanil to prevent emergence agitation without delayed recovery after VIMA with sevoflurane in children undergoing an adenotonsillectomy... CONCLUSION: The administration of alfentanil 10 microg/kg after induction of anaesthesia for children undergoing an adenotonsillectomy under VIMA reduced the incidence of emergence agitation without delaying the recovery time or causing significant hypotension.
Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal laryngeal mask airway insertion conditions and haemodynamic changes in children. [2009.03]
This study was designed to compare the effects of ketamine and alfentanil administered prior to induction of anaesthesia with propofol, on the haemodynamic changes and ProSeal laryngeal mask airway (PLMA) insertion conditions in children. Eighty children, aged between 3-132 months, were randomly allocated to receive either alfentanil 20 microg.kg(-1) (alfentanil group) or ketamine 0.5 mg.kg(-1) (ketamine group) before induction of anaesthesia...
Clinical Trials Related to Alfentanil
Stress During Deep Sedation With Propofol With and Without Alfentanil [Recruiting]
This is a randomized clinical trial of deep procedural sedation with propofol with and
without supplemental alfentanil. Patients will be assessed for total and fractionated serum
catecholamines before and after the procedure in addition to usual procedural sedation
outcomes parameters to assess the adrenergic effect of propofol sedation without
supplemental opioid.
Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation [Recruiting]
Genetic Determinants of Opioids Analgesia [Completed]
The response to opioids varies greatly among individuals. Some of these variability is
accounted for by genetic factors.
The present study was designed to evaluate the possibility that genetic polymorphism in the
gene encoding for mu opioid receptor may explain variability in the response to alfentanil
during lithotripsy.
Pilot Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil [Recruiting]
The purpose of this study is to follow a person's response to experimental pain after
multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can
tolerate the pain more, less, or the same at the end of the study.
Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols [Recruiting]
Giving infiltration analgesia around the neck of the womb (= paracervical block, PCB) is
frequently experienced as a painful procedure by women undergoing follicle aspiration. Two
sedation protocols, where in the one protocol a low dose of alfentanil hydrochloride is
already administered before the PCB, will be compared with each other and pain relief
measured using the 'Visual Analogue Scale' and the 'Short-Form McGill Questionnaire'
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