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Alfentanil (Alfentanil Hydrochloride) - Summary




Alfentanil Injection, USP is an opioid analgesic chemically designated as N-[1-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide monohydrochloride (1:1) with a molecular weight of 452.

Alfentanil Injection is indicated:

as an analgesic adjunct given in incremental doses in the maintenance of anesthesia with barbiturate/nitrous oxide/oxygen.

as an analgesic administered by continuous infusion with nitrous oxide/oxygen in the maintenance of general anesthesia.

as a primary anesthetic agent for the induction of anesthesia in patients undergoing general surgery in which endotracheal intubation and mechanical ventilation are required.

as the analgesic component for monitored anesthesia care (MAC).


See all Alfentanil indications & dosage >>


Media Articles Related to Alfentanil

Wayne State research team issued patent for new anesthesia monitoring technology
Source: Pain / Anesthetics News From Medical News Today [2015.06.17]
A team of researchers from Wayne State University was recently issued a U.S.

General anesthesia in young children linked to poorer intelligence, language development
Source: Pain / Anesthetics News From Medical News Today [2015.06.08]
Children who undergo surgical anesthesia under the age of 4 may have poorer language development and a lower IQ, according to new research from Cincinnati Children's Hospital.

More Evidence That General Anesthesia May Affect Young Brains
Source: MedicineNet MRI Scan Specialty [2015.06.08]
Title: More Evidence That General Anesthesia May Affect Young Brains
Category: Health News
Created: 6/8/2015 12:00:00 AM
Last Editorial Review: 6/8/2015 12:00:00 AM

Surgery Patients Might Not Need Sedative Before Anesthesia
Source: MedicineNet lorazepam Specialty [2015.03.04]
Title: Surgery Patients Might Not Need Sedative Before Anesthesia
Category: Health News
Created: 3/3/2015 12:00:00 AM
Last Editorial Review: 3/4/2015 12:00:00 AM

For children with autism, trips to the dentist just got easier
Source: Dentistry News From Medical News Today [2015.05.14]
Adjusting the environment to be more soothing could eliminate the need for general anesthesia to cope with routine cleaningsGoing to the dentist might have just gotten a little less scary for the...

more news >>

Published Studies Related to Alfentanil

A double-blinded randomized evaluation of alfentanil and morphine vs fentanyl: analgesia and sleep trial (DREAMFAST). [2013]
interference... CONCLUSIONS: Despite better early postoperative analgesia, pain-related sleep

Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. [2011.04]
Alfentanil (ALF) is a validated probe for hepatic, first-pass, and intestinal cytochrome P450 (CYP) 3A activity, using plasma clearances, single-point concentrations, and noninvasive pupil diameter change (miosis).

Comparison of propofol and the combination of propofol and alfentanil during bronchoscopy: a randomized study. [2011.01]
BACKGROUND: propofol is an excellent sedative agent for use in patients undergoing bronchoscopy. The addition of an opioid to propofol can be advantageous because of the antitussive effect of the opioid and the possible improvement in sedation quality. However, it may increase the risk of hypoxaemia. To investigate the effect of the addition of alfentanil to propofol, we performed a prospective study to compare propofol-only sedation with propofol-alfentanil combination sedation in patients undergoing bronchoscopy... CONCLUSIONS: the combination of propofol and alfentanil resulted in a greater respiratory depression than propofol alone; furthermore, the addition of an opioid did not improve the quality of sedation. In conclusion, we do not recommend sedation with propofol and alfentanil during bronchoscopy. 2010 The Acta Anaesthesiologica Scandinavica Foundation.

Comparison of alfentanil and remifentanil infusions in combination with propofol for the outpatient extra-corporeal shock wave lithotripsy. [2011]
PURPOSE: The aim of this study is to compare the efficiency of propofol+remifentanil to propofol+alfentanil in reducing pain in patients with urinary system stones undergoing outpatient Extracorporeal Shock Wave Lithotripsy (ESWL)... CONCLUSION: We concluded that both methods may be successfully used for patients undergoing ESWL (Tab. 6, Rief. 29).

Optimal bolus dose of alfentanil for successful tracheal intubation during sevoflurane induction with and without nitrous oxide in children. [2010.05]
BACKGROUND: The goals of this study were to determine the effective bolus dose of alfentanil required for successful tracheal intubation during inhalation induction using sevoflurane 5% without neuromuscular block in children, and whether nitrous oxide reduces these doses... CONCLUSIONS: The effective bolus dose of alfentanil for successful tracheal intubation was 11.5 microg kg(-1) in 50% of children during inhalation induction using sevoflurane 5% without neuromuscular blocking agent. Addition of nitrous oxide 60% in oxygen reduced the effective alfentanil dose by 25%.

more studies >>

Clinical Trials Related to Alfentanil

Stress During Deep Sedation With Propofol With and Without Alfentanil [Recruiting]
This is a randomized clinical trial of deep procedural sedation with propofol with and without supplemental alfentanil. Patients will be assessed for total and fractionated serum catecholamines before and after the procedure in addition to usual procedural sedation outcomes parameters to assess the adrenergic effect of propofol sedation without supplemental opioid.

Alfentanil Versus Sufentanil for Pain in Children During for Tracheal Suction [Recruiting]

Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With Frenectomy [Recruiting]
Several methods have been demonstrated to improve intubating conditions during sevoflurane induction in children. These include opioids, propofol, and addition of neuromuscular blocking agents in pediatric patients. But the study about the comparison of these agents has been uncommon. Frenectomy is common procedure to treat ankyloglossia. It is a short procedure performed under general anesthesia. The investigators aimed to compare intubating conditions among children with propofol, alfentanil or rocuronium after sevoflurane induction.

Evaluation of Propranolol's Effect on Pain and Inflammation. [Recruiting]
Previous studies have shown that the beta-adrenergic system plays a role in processing pain and the expression of hyperalgesia. Recent studies have investigated the analgesic effects,

and potential anti-hyperalgesic effects (using a model of OIH - opioid induced hyperalgesia)

of propranolol, a beta antagonist. We plan to further investigate the analgesic effects, and the potential anti inflammatory effects, of propranolol and compare those effects to Alfentanil, an opioid of known effect, and placebo

Alfentanil: Simultaneous Testing Pilot [Recruiting]
To evaluate two paradigms for simultaneous assessment of hepatic and intestinal CYP3A activity.

more trials >>

Reports of Suspected Alfentanil Side Effects

Anaphylactic Shock (7)Respiratory Depression (4)Fatigue (4)Maternal Exposure During Pregnancy (2)Toxic Epidermal Necrolysis (2)Maternal Drugs Affecting Foetus (1)Caesarean Section (1)Upper Airway Obstruction (1)Hepatitis Acute (1)

Page last updated: 2015-06-17

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