Aldoclor (Methyldopa / Chlorothiazide) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

ALDOCLOR drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

Acute overdosage may produce acute hypotension with other responses attributable to brain and gastrointestinal malfunction (excessive sedation, weakness, bradycardia, dizziness, lightheadedness, constipation, distention, flatus, diarrhea, nausea, vomiting).

In the event of overdosage, symptomatic and supportive measures should be employed. When ingestion is recent, gastric lavage or emesis may reduce absorption. Otherwise, management includes special attention to cardiac rate and output, blood volume, electrolyte imbalance, paralytic ileus, urinary function and cerebral activity.

Sympathomimetic drugs [e.g., levarterenol, epinephrine, ARAMINE * (Metaraminol Bitartrate)] may be indicated. Methyldopa is dialyzable. The degree to which chlorothiazide is removed by hemodialysis has not been established.

The oral LD₅₀ of methyldopa is greater than 1.5 g/kg in both the mouse and the rat. The oral LD₅₀ of chlorothiazide is 8.5 g/kg, greater than 10 g/kg, and greater than 1 g/kg in the mouse, rat, and dog respectively.

*Registered trademark of MERCK & CO., INC.

CONTRAINDICATIONS

ALDOCLOR is contraindicated in patients:

• with active hepatic disease, such as acute hepatitis and active cirrhosis
• with liver disorders previously associated with methyldopa therapy (see WARNINGS)
• with anuria
• with hypersensitivity to methyldopa, or to chlorothiazide or other sulfonamide-derived drugs
• on therapy with monoamine oxidase (MAO) inhibitors.