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Aldactazide (Spironolactone / Hydrochlorothiazide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The following adverse reactions have been reported and, within each category (body system), are listed in order of decreasing severity.

Hydrochlorothiazide

Body as a whole: Weakness.

Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).

Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialoadenitis, cramping, constipation, gastric irritation, nausea, anorexia.

Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.

Hypersensitivity: Anaphylactic reactions, necrotizing angitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.

Metabolic: Electrolyte imbalance (see Precautions ), hyperglycemia, glycosuria, hyperuricemia.

Musculoskeletal: Muscle spasm.

Nervous system/psychiatric: Vertigo, paresthesias, dizziness, headache, restlessness.

Renal: Renal failure, renal dysfunction, interstitial nephritis (see Warnings ).

Skin: Erythema multiforme, pruritus.

Special senses: Transient blurred vision, xanthopsia.

Spironolactone

Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting.

Endocrine: Gynecomastia (see Precautions ), inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding. Carcinoma of the breast has been reported in patients taking spironolactone but a cause and effect relationship has not been established.

Hematologic: Agranulocytosis.

Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis.

Nervous system/psychiatric: Mental confusion, ataxia, headache, drowsiness, lethargy.

Liver/biliary: A very few cases of mixed cholestatic/hepatocellular toxicity, with one reported fatality, have been reported with spironolactone administration.

Renal: Renal dysfunction (including renal failure).



REPORTS OF SUSPECTED ALDACTAZIDE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Aldactazide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Aldactazide side effects / adverse reactions in 78 year old female

Reported by a pharmacist from United States on 2011-10-06

Patient: 78 year old female weighing 47.6 kg (104.8 pounds)

Reactions: Hyperkalaemia, Pain, Muscular Weakness

Adverse event resulted in: hospitalization

Suspect drug(s):
Enalapril Maleate
    Dosage: 20mg bid po chronic
    Administration route: Oral
    Indication: Hypertension

Aldactazide
    Dosage: 25/25 x 2 bid po chronic
    Administration route: Oral
    Indication: Hypertension

Other drugs received by patient: Metoprolol Tartrate; Lipitor; Sotalol HCL; Glyburide; Coumadin; Aspirin



Possible Aldactazide side effects / adverse reactions in 87 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-22

Patient: 87 year old female

Reactions: Agranulocytosis, Pyrexia

Adverse event resulted in: hospitalization

Suspect drug(s):
Diltiazem HCL
    Dosage: df
    Indication: Product Used FOR Unknown Indication
    End date: 2011-05-04

Pantoprazole
    Dosage: df
    Indication: Product Used FOR Unknown Indication
    End date: 2011-05-04

Bactrim
    Dosage: df
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-04-20
    End date: 2011-04-25

Molsidomine (Molsidomine)
    Dosage: df
    Indication: Product Used FOR Unknown Indication
    End date: 2011-05-04

Flagyl
    Dosage: df, 5 times per month, oral
    Administration route: Oral
    Indication: Infection Prophylaxis
    Start date: 2010-08-01
    End date: 2011-04-05

Aldactazide
    Dosage: df
    Indication: Product Used FOR Unknown Indication
    End date: 2011-05-04



Possible Aldactazide side effects / adverse reactions in 64 year old male

Reported by a individual with unspecified qualification from France on 2012-04-30

Patient: 64 year old male

Reactions: Renal Impairment, Vascular Purpura

Adverse event resulted in: hospitalization

Suspect drug(s):
Influvac (Influenza Virus Vaccine Polyvalet) (Influenza Virus Surface
    Dosage: 0.0027 df (1 df, 1 in 1 in 1 y), intramuscular
    Indication: Influenza Immunisation
    Start date: 2011-11-01

Renitec (Enalapril) (20 MG, Oral Lyophilisate) (Enalapril)
    Dosage: 1 df (1 df, 1 in 1 d), oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2008-10-01

Diamicron (Gliclazide) (30 MG, Modified-Release Tablet) (Gliclazide)
    Dosage: 4 df (4 df, morning), oral
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2008-10-01

Sinrom (Acenociymarol) (4 MG, Tablet) (Acenocoumarol)
    Dosage: 1.25 df and 1df alternately, oral
    Administration route: Oral
    Indication: Atrial Fibrillation
    Start date: 2008-10-01

Glucophage
    Dosage: oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-10-01

Allopurinol
    Dosage: 1 df (1 df, 1 in 1 d), oral
    Administration route: Oral
    Indication: Gout
    Start date: 2008-10-01
    End date: 2012-03-23

Lercan (Lercanidioube Hydrochloride) (10 MG, Film-Coated Talbet) (Lerc
    Dosage: 1 df (1 df, 1 in 1 d), oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2008-10-01

Aldactazide
    Dosage: 1 df (1 df, 1 in 1 d),oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2008-10-01

Omeprazole
    Dosage: 1 df (1 df, 1 in 1d), oral
    Administration route: Oral
    Indication: Gastritis
    Start date: 2008-10-01

Trandate
    Dosage: 3 df (1 df, 3 in 1 d), oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2008-10-01

Levothyroxine Sodium
    Dosage: 1 df (1 df, 1 in 1d),oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-10-01

Furosemide
    Dosage: from 1 df to several df depending on respiratory conditions, oral
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2010-10-01

Digoxin
    Dosage: oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-10-01



See index of all Aldactazide side effect reports >>

Drug label data at the top of this Page last updated: 2006-05-31

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