ALBUTEROL SUMMARY
Albuterol tablets contain albuterol sulfate, USP, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator.
Albuterol tablets are indicated for the relief of bronchospasm in adults and children 6 years of age and older with reversible obstructive airway disease.
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NEWS HIGHLIGHTS
Published Studies Related to Albuterol
Active albuterol or placebo, sham acupuncture, or no intervention in asthma. [2011.07.14] BACKGROUND: In prospective experimental studies in patients with asthma, it is difficult to determine whether responses to placebo differ from the natural course of physiological changes that occur without any intervention. We compared the effects of a bronchodilator, two placebo interventions, and no intervention on outcomes in patients with asthma... CONCLUSIONS: Although albuterol, but not the two placebo interventions, improved FEV(1) in these patients with asthma, albuterol provided no incremental benefit with respect to the self-reported outcomes. Placebo effects can be clinically meaningful and can rival the effects of active medication in patients with asthma. However, from a clinical-management and research-design perspective, patient self-reports can be unreliable. An assessment of untreated responses in asthma may be essential in evaluating patient-reported outcomes. (Funded by the National Center for Complementary and Alternative Medicine.).
Comparative efficacy of inhaled albuterol between two hand-held delivery devices in horses with recurrent airway obstruction. [2011.07] REASONS FOR PERFORMING STUDY: Studies investigating the clinical efficacy of albuterol administered with the same propellant and commercially available delivery devices in horses with recurrent airway obstruction (RAO) are not currently available. OBJECTIVES: To determine the efficacy of aerosolised albuterol administered to horses with RAO by means of 2 commercially available, hand-held delivery devices... CONCLUSIONS: Aerosolised albuterol is an effective bronchodilator in horses with recurrent airway obstruction. There is no statistically significant difference between the 2 commercially available aerosol delivery devices in terms of efficacy. POTENTIAL RELEVANCE: Aerosolised albuterol is effectively delivered using currently available devices leading to maximal bronchodilation in horses with RAO at an average dose of 540 microg. (c) 2011 EVJ Ltd.
Efficacy of racemic albuterol versus levalbuterol used as a continuous nebulization for the treatment of acute asthma exacerbations: a randomized, double-blind, clinical trial. [2011.03] OBJECTIVE: To compare racemic albuterol (RAC) with levalbuterol (LEV) in continuous form for the treatment of acute pediatric asthma exacerbations in the emergency department... CONCLUSIONS: At the doses used, RAC appears to be superior to LEV with respect to changes in FEV1 and asthma score. There was no significant difference between the drugs with respect to admission rates or side-effect profile.
Active albuterol or placebo, sham acupuncture, or no intervention in asthma. [2011] on outcomes in patients with asthma... CONCLUSIONS: Although albuterol, but not the two placebo interventions, improved
Efficacy of racemic albuterol versus levalbuterol used as a continuous
nebulization for the treatment of acute asthma exacerbations: a randomized,
double-blind, clinical trial. [2011] emergency department... CONCLUSIONS: At the doses used, RAC appears to be superior to LEV with respect to
Clinical Trials Related to Albuterol
Testing Potential Synergistic Effects of Albuterol and Caffeine on Metabolic Rate [Completed]
Preterm Infant Inhaled Albuterol Dosing [Recruiting]
The purpose of this study is to help determine the best dose of albuterol in premature
babies at risk of developing bronchopulmonary dysplasia (BPD). BPD is the chronic lung
disease of prematurity and is associated with increased morbidity and mortality, longer
hospital stays, and increased healthcare utilization. Albuterol is an inhaled medication
frequently used in premature infants with chronic lung disease and in people with asthma. It
is believed to be safe, but the optimal dose for infants is not clear. The investigators
hypothesize that albuterol may help a subset of premature infants with lung disease, but
they need to determine the best dose prior to doing research about how effective it is for
chronic lung disease/BPD. Response to each of three doses of albuterol will be measure using
pulmonary function tests.
Efficacy and Safety Comparison of Albuterol Spiromax® and ProAir® Hydrofluoroalkane (HFA) in Pediatric Patients [Completed]
This is a multicenter, randomized, double-blind, double-dummy, placebo-controlled,
single-dose, 5-treatment, 5-period, 5-way crossover study in pediatric patients with
persistent asthma. The primary purpose of this study is to compare the efficacy and safety
of Albuterol Spiromax with that of ProAir HFA in pediatric asthma patients at 2 delivered
dose levels equivalent to 90 mcg and 180 mcg of albuterol base.
Single-Dose Cross-Over Study of the Effects of Albuterol-HFA in Exercise Induced Bronchoconstriction [Terminated]
This clinical study will evaluate and establish the protective effects of Amphastar's
Albuterol Sulfate HFA Inhalation Aerosol (Albuterol-HFA), in preventing exercise-induced
bronchoconstriction (EIB) in adolescent and adult asthmatic patients, in comparison with (1)
Proventil®-HFA (Reference drug and Active Control ), and (2) Placebo-HFA control (HFA
propellant only). Safety of the test drug, Albuterol-HFA, will also be evaluated in
comparison to the Active and Placebo Controls. Analyses will be performed to determine if
the Armstrong's Albuterol-HFA has resulted in a significant bronchoprotective effect, with
attenuated Max % Fall in FEV1, in comparison to the Placebo-HFA control.
Efficacy of Inhaled Albuterol Spiromax® in Subjects With Persistent Asthma With Steady State Pharmacokinetics [Completed]
The primary objective of this study is to evaluate the efficacy of Albuterol Spiromax®
versus placebo in subjects with persistent asthma.
Reports of Suspected Albuterol Side Effects
Hallucination (57),
Dyspnoea (54),
Drug Ineffective (33),
Asthma (24),
Malaise (23),
Pneumonia (22),
Maternal Exposure During Pregnancy (16),
Memory Impairment (16),
Headache (14),
Loss of Consciousness (14), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 10 ratings/reviews, Albuterol has an overall score of 7.10. The effectiveness score is 8.20 and the side effect score is 8.20. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| Albuterol review by 25 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | asthma |
Dosage & duration: | | 2 puffs pid (dosage frequency: when necessary and before exercise) for the period of years and years |
Other conditions: | | environmental allergies |
Other drugs taken: | | allegra | | Reported Results |
Benefits: | | I could breathe, and if I took it before exercise, I wouldn't need it during. |
Side effects: | | none noticed |
Comments: | | I have been taking albuterol for years. I take it when I feel tight in my chest as well as before exercising. I rarely use it, whereas I used to nee dit almost every day. Now... once every month or two, unless I'm exercising. |
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| Albuterol review by 42 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | Mild Side Effects | | Treatment Info |
Condition / reason: | | asthma |
Dosage & duration: | | one inhalation (dosage frequency: as needed) for the period of over 20 years |
Other conditions: | | allergies |
Other drugs taken: | | none | | Reported Results |
Benefits: | | Having had asthma since I was a child, I have been using various medications for a long time. Thankfully I do not need to use albuterol daily, as I know some people do, but I use it as needed when I am experiencing an asthma attach. This happens on average once a month, less in warmer months, more during the winder.
As far as being effective albuterol, and the name brand inhaler is the best, and to my knowledge, still the only small inhaler that really works. I'm sure it has saved lives. With one inhalation I am able to breath again within minutes, this is even if I am having a bad attack, and am really strugling. So it is very effective |
Side effects: | | But, when I use albuterol I experience mild chest pains afterward. Not immediately, but typically later that day or the next. They don't last long, just a sharp pain or two, but it does occur fairly often. In my case, since I don't use albuterol regularly, it's well worth it. |
Comments: | | Inhalation, pump spray |
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| Albuterol review by 47 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Ineffective |
Side effects: | | Extremely Severe Side Effects | | Treatment Info |
Condition / reason: | | Astham |
Dosage & duration: | | 1 Puff (dosage frequency: once a day) for the period of over several days |
Other conditions: | | None |
Other drugs taken: | | None | | Reported Results |
Benefits: | | There were no treatment benefits, only side effects.Albuterol HFA made it so difficult for me to breathe, I had to use the discontunued albuterol (in the light blue dispenser)to recover. I'm very worried I won't survive the change. |
Side effects: | | Albuterol HFA made it so difficult for me to breathe, I had to use the discontunued albuterol (in the light blue dispenser)to recover. I'm very worried I won't survive the change. |
Comments: | | Prescribed as needed up to for times a day. |
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Page last updated: 2013-02-10
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