Albuterol HFA (Albuterol Sulfate) - Summary

ALBUTEROL HFA SUMMARY

Albuterol Sulfate HFA
INHALATION AEROSOL
For Oral Inhalation Only
PRESCRIBING INFORMATION

The active ingredient of Albuterol Sulfate HFA Inhalation Aerosol is albuterol sulfate, a racemic salt, which is a relatively selective beta₂-adrenergic bronchodilator.

Albuterol Sulfate HFA Inhalation Aerosol is indicated in adults and children 12 years of age and older for the treatment or prevention of bronchospasm with reversible obstructive airway disease.

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NEWS HIGHLIGHTS

Published Studies Related to Albuterol HFA (Albuterol)

Bronchodilator effects of exercise hyperpnea and albuterol in mild-to-moderate asthma. [2009.08]
In asthmatic patients, either bronchodilatation or bronchoconstriction may develop during exercise. In 18 patients with mild-to-moderate asthma, we conducted two studies with the aims to 1) quantify the bronchodilator effect of hyperpnea induced by incremental-load maximum exercise compared with effects of inhaled albuterol (study 1, n=10) and 2) determine the time course of changes in airway caliber during prolonged constant-load exercise (study 2, n=8)...

High-dose continuous nebulized levalbuterol for pediatric status asthmaticus: a randomized trial. [2009.08]
OBJECTIVE: To assess the use of high-dose continuous levalbuterol (LEV), the single active (R)-enantiomer of racemic albuterol (RAC), in the treatment of status asthmaticus... CONCLUSIONS: Substituting high-dose continuous LEV for RAC did not reduce the time on continuous therapy and had similar adverse effects in children who had failed initial treatment with RAC.

Safety of daily albuterol in infants with a history of bronchospasm: a multi-center placebo controlled trial. [2009.07.16]
INTRODUCTION: Inhaled short-acting bronchodilators are recommended for the quick relief of bronchospasm symptoms in children including those less than five years of age. However, limited safety data is available in this young population... CONCLUSION: This study provides additional albuterol HFA safety information for the treatment of children aged birth </=24 months with a history of bronchospasm.

Home use of albuterol for asthma exacerbations. [2009.06]
BACKGROUND: To reduce symptoms and emergency department (ED) visits, the National Asthma Education and Prevention Program (NAEPP) guidelines recommend early treatment of acute asthma symptoms with albuterol and oral corticosteroids. Yet, ED visits for asthma are frequent and often occur several days after onset of increased symptoms, particularly for children from low-income, urban neighborhoods. OBJECTIVES: To describe home use of albuterol and identify factors associated with appropriate albuterol use... CONCLUSIONS: Caregivers reported that they would use albuterol to treat their child's worsening asthma symptoms, but many described inappropriate use. Detailed evaluation of proper albuterol use at home may provide insight into how health care professionals can better educate and support parents in their management of acute exacerbations and more effective use of AAPs.

The effects of nebulized albuterol on esophageal function in asthmatic patients. [2008.10]
CONCLUSIONS: Nebulized albuterol induces a dose-dependent reduction in LES basal pressure in asthmatic patients. These effects raise the possibility that gastroesophageal reflux may occur after bronchodilator therapy.

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Clinical Trials Related to Albuterol HFA (Albuterol)

Safety and Tolerability Study of Levalbuterol HFA and Racemic Albuterol HFA in Pediatrics Subjects With Asthma [Completed]
The purpose of this study is to compare the safety and tolerability of levalbuterol HFA metered dose inhaler (MDI) versus racemic albuterol HFA MDI in pediatric subjects 4-11 years of age with asthma

Chronic-Dose Safety and Efficacy Study of Albuterol-HFA-MDI In Pediatric Asthmatics [Active, not recruiting]

Controlled, 12-Week Study of Albuterol HFA Versus the Active Control, Proventil(R)-HFA in Asthmatic Patients [Active, not recruiting]
This 12-week clinical study evaluates the safety and efficacy of Albuterol Sulfate HFA Inhalation Aerosol (Albuterol-HFA, or: A004), Armstrong's proposed HFA formulation of metered dose inhaler (MDI) of Albuterol (Treatment T), in comparison with:

1. Placebo control: (HFA propellant only, Treatment P); and

2. Active control: 3M/Key's Proventil-HFA (Treatment R).

The treatments will be given as self-administered oral inhalations in adult and adolescent patients with mild-to-moderate asthma, for 12-weeks. Dosing regimen throughout the 12-week study is two actuations four times daily (QID).

Safety and Tolerability Study of Levalbuterol HFA Compared to Racemic Albuterol HFA in Subjects With Asthma [Completed]

Study of Levalbuterol and Racemic Albuterol in Pediatric Subjects With Reactive Airways Disease (RAD) [Completed]
The purpose of this study is to compare the efficacy of two dose levels of levalbuterol compared with one dose level of racemic albuterol in pediatric subjects aged birth to 48 months old.

more trials >>

PATIENT REVIEWS / RATINGS / COMMENTS

Albuterol HFA review by 47 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		copd
Dosage & duration:		17grams (dosage frequency: every 2 to 4 hours) for the period of till they took it off market
Other conditions:		none
Other drugs taken:		advair
		Reported Results
Benefits:		copd
Side effects:		this was given to me for copd and chronic bronchitus there were no side effects
Comments:		i used the albuterol in haler as a life saver every 2 to 4 hours. i use the adair 250/50 i think twice a day. these medications help me breathe. since they have discontinued the albuterol i have been using a product call proventic. because of the global warning they have taken somethinng out of these products that help it push into lungs, they say the other is the sme does and it may be but it doesn't seem to work as well and i have to use more of it.

Albuterol HFA review by 47 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		copd
Dosage & duration:		17grams (dosage frequency: every 2 to 4 hours) for the period of till they took it off market
Other conditions:		none
Other drugs taken:		advair
		Reported Results
Benefits:		copd
Side effects:		this was given to me for copd and chronic bronchitus there were no side effects
Comments:		i used the albuterol in haler as a life saver every 2 to 4 hours. i use the adair 250/50 i think twice a day. these medications help me breathe. since they have discontinued the albuterol i have been using a product call proventic. because of the global warning they have taken somethinng out of these products that help it push into lungs, they say the other is the sme does and it may be but it doesn't seem to work as well and i have to use more of it.

Albuterol HFA review by 47 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		copd
Dosage & duration:		17grams (dosage frequency: every 2 to 4 hours) for the period of till they took it off market
Other conditions:		none
Other drugs taken:		advair
		Reported Results
Benefits:		copd
Side effects:		this was given to me for copd and chronic bronchitus there were no side effects
Comments:		i used the albuterol in haler as a life saver every 2 to 4 hours. i use the adair 250/50 i think twice a day. these medications help me breathe. since they have discontinued the albuterol i have been using a product call proventic. because of the global warning they have taken somethinng out of these products that help it push into lungs, they say the other is the sme does and it may be but it doesn't seem to work as well and i have to use more of it.