Akineton (Biperiden Hydrochloride) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Atropine-like side effects such as dry mouth; blurred vision; drowsiness; euphoria or disorientation; urinary retention; postural hypotension; constipation; agitation; disturbed behavior may been seen. A case of generalized choreic movements has been reported in a Parkinson's disease patient when biperiden was added to carbidopa/levodopa. A reduction in rapid eye movement (REM) sleep, characterized by increased REM latency and decreased percentage of REM sleep, has been reported. There usually are no significant changes in blood pressure or heart rate in patients who have been given the parenteral form of AKINETON. Mild transient postural hypotension and bradycardia may occur. These side effects can be minimized or avoided by slow intravenous administration. No local tissue reactions have been reported following intramuscular injection. If gastric irritation occurs following oral administration, it can be avoided by administering the drug during or after meals.

The central anticholinergic syndrome can occur as an adverse reaction to properly prescribed anticholinergic medication. See OVERDOSAGE section for signs and symptoms of the central anticholinergic syndrome, and for treatment.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO AKINETON

Possible Akineton side effects / adverse reactions in 65 year old female

Reported by a physician from Japan on 2007-01-30

Patient: 65 year old female

Reactions: Delirium

Suspect drug(s):
Paxil
    Administration route: Oral
    Indication: Depression
    Start date: 2006-07-06
    End date: 2006-09-29

Haloperidol
    Administration route: Oral

Akineton
    Administration route: Oral

Other drugs received by patient: Nitrazepam

Possible Akineton side effects / adverse reactions in 41 year old male

Reported by a individual with unspecified qualification from Germany on 2007-02-06

Patient: 41 year old male

Reactions: Confusional State, Blood Alkaline Phosphatase Decreased, Urinary Incontinence, Disorientation, Tremor, Haemoglobin Decreased, Haematocrit Decreased, Gamma-Glutamyltransferase Increased, Sedation, Coordination Abnormal

Adverse event resulted in: hospitalization

Suspect drug(s):
Tegretol
    Dosage: 200 mg/day
    Indication: Aggression
    Start date: 2003-08-04
    End date: 2003-08-18

Tegretol
    Dosage: 800 mg/day
    Administration route: Oral
    Start date: 2003-08-16
    End date: 2003-08-16

Seropram
    Dosage: 20 mg/day
    Administration route: Oral
    Indication: Aggression
    Start date: 2003-08-04
    End date: 2003-08-18

Lithium Carbonate
    Dosage: 660 mg/day
    Administration route: Oral
    Indication: Aggression
    Start date: 2003-08-04
    End date: 2003-08-13

Lithium Carbonate
    Dosage: 1320 mg/day
    Administration route: Oral
    Start date: 2003-08-14
    End date: 2003-08-19

Clopixol
    Dosage: 60 mg/day
    Administration route: Oral

Temesta
    Dosage: 7.5 mg/day

Akineton
    Dosage: 4 mg/day
    Administration route: Oral

Pantozol
    Dosage: 40 mg/day
    Administration route: Oral

Other drugs received by patient: Ferrum Hausmann

Possible Akineton side effects / adverse reactions in 41 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2007-02-06

Patient: 41 year old male

Reactions: Confusional State, Urinary Incontinence, Disorientation, Loss of Consciousness, Tremor, Sedation, Mental Disorder, Gait Disturbance

Adverse event resulted in: hospitalization

Suspect drug(s):
Pantozol
    Administration route: Oral

Seropram
    Administration route: Oral
    Start date: 2003-08-04
    End date: 2003-08-18

Lithium Carbonate
    Administration route: Oral
    Start date: 2003-08-04
    End date: 2003-08-13

Lithium Carbonate
    Administration route: Oral
    Start date: 2003-08-14
    End date: 2003-08-19

Carbamazepine
    Administration route: Oral
    Start date: 2003-08-04
    End date: 2003-08-18

Carbamazepine
    Administration route: Oral
    Start date: 2003-08-16
    End date: 2003-08-16

Temesta

Clopixol
    Administration route: Oral

Akineton
    Administration route: Oral

Other drugs received by patient: Ferrum Hausmann