Media Articles Related to AK-Fluor (Fluorescein)
Fluorescein Angiography Details Vasculature in ROP
Source: Medscape Ophthalmology Headlines [2014.04.08]
The imaging procedure demonstrates subtle changes in vasculature in bevacizumab-treated eyes with retinopathy of prematurity (ROP), but must be performed by a skilled photographer for optimal results.
Medscape Medical News
Published Studies Related to AK-Fluor (Fluorescein)
Minimized cardiopulmonary bypass reduces retinal microembolization: a randomized clinical study using fluorescein angiography. [2011.01]
BACKGROUND: The use of minimized cardiopulmonary bypass (MCPB) circuits has recently increased in an attempt to reduce the adverse effects of CPB. This prospective randomized study aimed to determine the effects of MCPB on retinal microembolization and related inflammatory, coagulation, and endothelial markers compared with conventional extracorporeal circulation (CCPB) among patients undergoing coronary artery bypass graft surgery... CONCLUSIONS: Retinal microembolization was found to be decreased after the use of minimized CPB compared with CCPB, suggesting a decreased embolic load to the brain after MCPB. Copyright (c) 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Association of fluorescein angiographic features with visual acuity and with optical coherence tomographic and stereoscopic color fundus photographic features of diabetic macular edema in a randomized clinical trial. [2010.11]
BACKGROUND: Fluorescein angiography (FA) has been performed as part of the management of diabetic macular edema for many years. Its current role relative to the role of optical coherence tomography (OCT) is not well defined. PURPOSE: To evaluate the associations of FA features with visual acuity (VA) and with OCT and fundus photographic characteristics in eyes with diabetic macular edema... CONCLUSION: Fluorescein leakage is associated with VA and some OCT and color photographic variables. We did not identify any unique FA variables that had a stronger association with VA than OCT measures of retinal thickness. These data may be useful to investigators planning future diabetic macular edema clinical trials.
Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study system for evaluation of stereoscopic color fundus photographs and fluorescein angiograms: SCORE Study Report 9. [2010.09]
OBJECTIVE: To describe the procedures and reproducibility for grading stereoscopic color fundus photographs and fluorescein angiograms of participants in the SCORE Study... CONCLUSIONS: The fundus photography and fluorescein angiography grading procedures for the SCORE Study are reproducible and can be used for multicenter longitudinal studies of RVO. A systematic temporal drift occurred in evaluating area of retinal thickening.
Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1. [2010.05]
PURPOSE: The purpose of this study was to assess macular perfusion with fundus fluorescein angiography at the 4-month time point in a prospective randomized, single-center 2-year trial comparing intravitreal bevacizumab and laser therapy in patients with diabetic macular edema... CONCLUSION: At 4 months, there was no evidence of worsening macular ischemia in either group.
NSAIDs in combination therapy for the treatment of chronic pseudophakic cystoid macular edema. [2010.02]
PURPOSE: The purpose of this study was to evaluate the addition of topical nonsteroidal antiinflammatory drugs (NSAIDs) to intravitreal corticosteroid and antivascular endothelial growth factor injections for the treatment of chronic cystoid macular edema... CONCLUSION: Although NSAID therapy seems to potentiate the improvements produced by corticosteroids and antivascular endothelial growth factor therapy for chronic pseudophakic cystoid macular edema, only nepafenac- and bromfenac-treated eyes showed reduced retinal thickness at 12 weeks and 16 weeks. Furthermore, nepafenac produced a sustained improvement in visual acuity.
Clinical Trials Related to AK-Fluor (Fluorescein)
Flourescein for Lymphatic Mapping and Sentinel Lymph Node Biopsy in Patients With Stage I and II Malignant Melanoma [Recruiting]
The purpose of this research study is to use two different drugs to find where melanoma
might spread and to remove these tissues. We believe that tumor cells from the melanoma
first move through the lymphatic system (a system of clear fluid that moves around the body
and carries white blood cells, much like the blood system) to a lymph node in an orderly
way. If we can identify the first lymph nodes to receive a tumor cell, this can be removed
and examined. We currently use one drug, called "technetium-99m sulfur colloid" which can
detect about 90% of the first lymph nodes that the tumor cells would move to.
Technetium-99m is a radioactive compound and can be detected through the skin by a special
instrument that reads radioactivity. As part of this research, we would like to use a
second drug called "fluorescein" (Fluorescite┬«) to see if it will identify the same lymph
nodes or additional ones and examine these. This drug is fluorescent and can be detected
even through the skin using a blue light. This drug is approved by the Federal Drug
Administration (FDA) to for injection in the vein as a diagnostic aid and has been safely
used in people for many years. In this study, we will be injecting it under the skin, which
is a different use from how it is currently approved by the FDA. In the past another drug
has been used, called "isosulfan blue" (Lymphazurin┬«), but availability of this drug is
currently limited, and it has higher risks associated with it.
This study is being conducted by Dr. Robert Andtbacka, Dr. Dirk Noyes, Dr. James McGreevy
and at University of Utah. This study is a Phase I/II and is done to find out if the drug
can be used safely when given under the skin and if it will work for this purpose.
Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging [Recruiting]
The purpose of this study is to determine whether phase variance optical coherence
tomography (PV-OCT), a software-based optical coherence tomography(OCT) image processing
technology, can be used to generate angiographic images of the retinochoroidal vasculature
that are comparable to those produced by fluorescein angiography (FA), the current gold
standard diagnostic test.
Corneal Topographer Fluorescein Patterns [Recruiting]
The objective of this study is to determine if corneal topography can be used to predict the
fluorescein pattern of keratoconus lenses on the eye. A corneal topography image will be
taken and the computer selected lens will be placed on the eye. After placement of the lens
color photographs will be taken of the eye's fluorescein pattern and compared to the
computer predicted pattern.
Keratometric and Fluorescein Tear Breakup Time [Recruiting]
The purpose of the research is to determine if putting fluorescein onto the eye (most common
test done for dry eye syndrome) is an accurate way to measure dry eye symptoms. The
investigators can avoid placing any foreign substance into the eye by using a manual
keratometer. Therefore, the investigators want to compare the measurements of tear break up
time using fluorescein with using a manual keratometer and then compare these measurements
to a validated dry eye symptoms questionnaire.
Measuring tear break up time using a manual keratometer is a better way to estimate dry eye
symptoms than using fluorescein to measure tear break up time.
Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Subjects With Dry Eye - Effects on Central Cornea [Recruiting]
The purpose of this study is to evaluate the safety and efficacy of 2% rebamipide compared
to placebo in clearing of fluorescein staining of the central cornea in subjects with dry