NEWS HIGHLIGHTS
Published Studies Related to AK-Fluor (Fluorescein)
Evaluation of the side effects and image quality during fluorescein angiography comparing 2 mL and 5 mL sodium fluorescein. [2008.10]
BACKGROUND: Although intravenous fluorescein angiography (IVFA) is a relatively safe procedure, side effects have been shown to occur. The designed purpose of this study was to demonstrate a reduction in the frequency and severity of side effects during digital IVFA using 2 mL compared with 5 mL of 10% sodium fluorescein (NaFl). The secondary hypothesis was to show that no loss of image quality occurred with a reduction in the NaFl dose utilizing digital fluorescein angiography... INTERPRETATION: Two millilitres of NaFl for IVFA produces inferior quality digital images compared with 5 mL of NaFl. The potential reduction in adverse events associated with 2 mL of NaFl becomes unimportant in light of this significant finding regarding image quality.
The effect of topical diclofenac on choroidal blood flow in early postoperative pseudophakias with regard to cystoid macular edema formation. [2007.12]
PURPOSE: To study the chronological change in choroidal blood flow (ChBFlow), disruption of the blood-aqueous barrier, and incidence of cystoid macular edema (CME) in early postoperative pseudophakic eyes, as well as the effect of nonsteroidal anti-inflammatory drug (NSAID) eye drops on these phenomena... CONCLUSIONS: Reduction of ChBFlow, disruption of the blood-aqueous barrier, and incidence of CME in early postsurgical pseudophakic eyes were more effectively prevented chronologically in eyes treated with diclofenac than in those treated with fluorometholone.
Preoperative topical indomethacin to prevent pseudophakic cystoid macular edema. [2007.05]
PURPOSE: To evaluate the effectiveness of a nonsteroidal antiinflammatory drug (NSAID) on pseudophakic cystoid macular edema (CME) and determine the efficacy when used preoperatively and after uneventful phacoemulsification surgery. SETTING: Department of Ophthalmology, Kocatepe University, School of Medicine, Afyonkarahisar, Turkey... CONCLUSION: Nonsteroidal antiinflammatory drugs decreased the incidence of CME, and their efficacy increased when begun preoperatively.
Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography. [2007.01]
PURPOSES: To determine the efficacy of bromopride in the prophylaxis of nausea during fluorescein angiography, when compared with a placebo... CONCLUSION: Bromopride did not prevent the occurrence of nausea in fluorescein angiography, when compared with a placebo.
Long-term results of intravitreal bevacizumab injection for choroidal neovascularization secondary to angioid streaks. [2009.10]
PURPOSE: To investigate the long-term efficacy of intravitreal injections of bevacizumab (Avastin; Genentech Inc, South San Francisco, California, USA) for choroidal neovascularization (CNV) secondary to angioid streaks. DESIGN: Observational case series... CONCLUSIONS: An intravitreal injection of bevacizumab seems to maintain visual acuity. However, CNV frequently recurred or new CNV developed during the long follow-up.
Clinical Trials Related to AK-Fluor (Fluorescein)
Flourescein for Lymphatic Mapping and Sentinel Lymph Node Biopsy in Patients With Stage I and II Malignant Melanoma [Recruiting]
The purpose of this research study is to use two different drugs to find where melanoma
might spread and to remove these tissues. We believe that tumor cells from the melanoma
first move through the lymphatic system (a system of clear fluid that moves around the body
and carries white blood cells, much like the blood system) to a lymph node in an orderly
way. If we can identify the first lymph nodes to receive a tumor cell, this can be removed
and examined. We currently use one drug, called "technetium-99m sulfur colloid" which can
detect about 90% of the first lymph nodes that the tumor cells would move to.
Technetium-99m is a radioactive compound and can be detected through the skin by a special
instrument that reads radioactivity. As part of this research, we would like to use a
second drug called "fluorescein" (Fluorescite®) to see if it will identify the same lymph
nodes or additional ones and examine these. This drug is fluorescent and can be detected
even through the skin using a blue light. This drug is approved by the Federal Drug
Administration (FDA) to for injection in the vein as a diagnostic aid and has been safely
used in people for many years. In this study, we will be injecting it under the skin, which
is a different use from how it is currently approved by the FDA. In the past another drug
has been used, called "isosulfan blue" (Lymphazurin®), but availability of this drug is
currently limited, and it has higher risks associated with it.
This study is being conducted by Dr. Robert Andtbacka, Dr. Dirk Noyes, Dr. James McGreevy
and at University of Utah. This study is a Phase I/II and is done to find out if the drug
can be used safely when given under the skin and if it will work for this purpose.
Corneal Topographer Fluorescein Patterns [Recruiting]
The objective of this study is to determine if corneal topography can be used to predict the
fluorescein pattern of keratoconus lenses on the eye. A corneal topography image will be
taken and the computer selected lens will be placed on the eye. After placement of the lens
color photographs will be taken of the eye's fluorescein pattern and compared to the
computer predicted pattern.
Keratometric and Fluorescein Tear Breakup Time [Recruiting]
The purpose of the research is to determine if putting fluorescein onto the eye (most common
test done for dry eye syndrome) is an accurate way to measure dry eye symptoms. The
investigators can avoid placing any foreign substance into the eye by using a manual
keratometer. Therefore, the investigators want to compare the measurements of tear break up
time using fluorescein with using a manual keratometer and then compare these measurements
to a validated dry eye symptoms questionnaire.
Measuring tear break up time using a manual keratometer is a better way to estimate dry eye
symptoms than using fluorescein to measure tear break up time.
Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy [Recruiting]
The retinal vasculature changes dramatically in patients with diabetic retinopathy
especially between non-proliferative and proliferative disease. The retinal vasculature can
be imaged and quantified using special dyes. This study will test whether the pattern of the
retinal vasculature changes in patients with different levels of diabetic retinopathy can be
quantified using computerized image analysis. In addition, the study will evaluate whether
new drugs to treat diabetic retinopathy will be able to reverse these vascular changes.
Clinical Trial of Intravitreal Microplasmin in Infants and Children Scheduled for Vitrectomy [Not yet recruiting]
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