Media Articles Related to Afinitor (Everolimus)
FDA OKs New Kids' Dose of Cancer Drug
Source: MedPage Today Product Alert [2012.08.30]
WASHINGTON -- The FDA has approved a pediatric dosage of the cancer drug everolimus (Afinitor Disperz) for the treatment of a rare brain tumor.
Published Studies Related to Afinitor (Everolimus)
Everolimus for subependymal giant cell astrocytoma in patients with tuberous
sclerosis complex: 2-year open-label extension of the randomised EXIST-1 study. 
continuing 4-year extension phase of EXIST-1... INTERPRETATION: These results support the longer-term use of everolimus in
A randomized phase II study of everolimus for advanced pancreatic neuroendocrine
tumors in Chinese patients. 
Everolimus, an oral inhibitor of mammalian target of mTOR, has been recently
shown to have antitumor effect in a phase III, double-blind, randomized trial
(RADIANT-3) of 410 patients with advanced pancreatic neuroendocrine tumors
(PNETs). The purpose of this study was to investigate the specific efficacy and
safety of everolimus in the Chinese patient with PNETs...
Efficacy and safety of everolimus for subependymal giant cell astrocytomas
associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised,
placebo-controlled phase 3 trial. 
subependymal giant cell astrocytomas associated with tuberous sclerosis complex... INTERPRETATION: These results support the use of everolimus for subependymal
Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer:
BOLERO-2 final progression-free survival analysis. 
this patient population... CONCLUSION: The addition of everolimus to exemestane markedly prolonged PFS in
Everolimus for previously treated advanced gastric cancer: results of the
randomized, double-blind, phase III GRANITE-1 study. 
gastric cancer... CONCLUSION: Compared with BSC, everolimus did not significantly improve overall
Clinical Trials Related to Afinitor (Everolimus)
Everolimus (RAD001) in Metastatic Transitional Cell Carcinoma of the Urothelium [Recruiting]
The purpose of this study is to learn what effects, good and/or bad, Everolimus has on
advanced urothelial cancer.
The goal of this clinical research study is to learn if the study drug Everolimus can shrink
or slow the growth of urothelial cancer. The safety of this drug will also be studied. The
patients physical state, changes in the size of the tumor, and laboratory findings taken
while on-study will help us decide if Everolimus is safe and effective.
RAD001 (Everolimus) + Docetaxel + Cisplatin as Induction Chemotherapy in Patients With Local-Regional Advanced Head and Neck Cancer [Recruiting]
The purpose of this study is to test the safety of RAD001 (everolimus) tablets at different
dose levels, when added to docetaxel and cisplatin. We want to find out what effects, good
and/or bad, that everolimus has when added to docetaxel and cisplatin as treatment for head
and neck cancer.
Everolimus (RAD001) in Primary Therapy of Waldenstrom's Macroglobulinemia [Recruiting]
The purpose of this research study is to determine the safety of RAD001(Everolimus) and the
highest dose of this drug that can be given to people safely. RAD001(Everolimus) is a drug
that works by preventing cells in the body from growing and dividing. Information from basic
and Phase I clinical research studies suggests that RAD001 also may help to prevent tumor
growth in people with relapsed or refractory lymphoma.
Radiation Therapy (IMRT) + RAD001 (Everolimus) + Cisplatin for Patients With Head and Neck Cancer [Recruiting]
The purpose of this study is to determine the best doses of RAD001 (everolimus) tablets and
cisplatin to give to patients who are receiving radiation therapy for head and neck cancer.
Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma With Merlin/NF2 Loss as a Biomarker to Predict Sensitivity [Recruiting]
For patients with malignant pleural mesothelioma that has grown despite treatment with
standard chemotherapy, no treatment has yet proven beneficial. The purpose of this study is
to find out what effects, both good and bad, that everolimus has on the cancer. Everolimus
works by blocking a protein that helps the cancer grow. The goal of this clinical research
study is to learn if the study drug everolimus can shrink or slow the growth of
mesothelioma. The safety of this drug will also be studied. The patients' physical state,
changes in the size of the tumor, and laboratory findings taken during the study will help
us decide if everolimus is safe and effective.
Reports of Suspected Afinitor (Everolimus) Side Effects
Neoplasm Malignant (362),
Neoplasm Progression (337),
Anaemia (113), more >>