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Aerospan (Flunisolide Hemihydrate Inhalation) - Summary

 
 



AEROSPAN SUMMARY

AEROSPAN™
(flunisolide HFA, 80 mcg)
Inhalation Aerosol

Flunisolide hemihydrate, the active component of AEROSPANTM (flunisolide HFA, 80 mcg) Inhalation Aerosol, is a corticosteroid.

AEROSPAN Inhalation Aerosol is indicated for the maintenance treatment of asthma as prophylactic therapy in adult and pediatric patients 6 years of age and older. AEROSPAN Inhalation Aerosol is also indicated for asthma patients requiring oral corticosteroid therapy, where adding AEROSPAN Inhalation Aerosol may reduce or eliminate the need for oral corticosteroids.

AEROSPAN Inhalation Aerosol is NOT indicated for the relief of acute bronchospasm.


See all Aerospan indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Aerospan (Flunisolide Inhalation)

How Twitter can help predict asthma-related emergency room visits
Source: Respiratory / Asthma News From Medical News Today [2015.04.18]
Researchers created a model that was able to predict with 75 percent accuracy how many asthma-related emergency room visits a hospital could expect on a given dayTwitter users who post information...

Asthma rates among black youth are similarly high in urban, rural communities
Source: Respiratory / Asthma News From Medical News Today [2015.04.10]
Asthma rates among black youth living in urban Detroit and rural Georgia are essentially the same, researchers report, a finding that conflicts with the widely held theory that city life is a risk...

Asthma Rates Similar Among Black Children in Urban, Rural Areas: Study
Source: MedicineNet Allergy Specialty [2015.04.10]
Title: Asthma Rates Similar Among Black Children in Urban, Rural Areas: Study
Category: Health News
Created: 4/9/2015 12:00:00 AM
Last Editorial Review: 4/10/2015 12:00:00 AM

NIH-funded scientists identify receptor for asthma-associated virus
Source: Respiratory / Asthma News From Medical News Today [2015.04.09]
Receptor gene variant may increase risk of childhood illnesses, asthmaScientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of...

Witnessing drug problems or domestic violence causes greater asthma incidence
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2015.04.07]
Children exposed to dysfunction in home had 28 percent higher chance of developing asthmaNo home is perfect, but dysfunction in the home is now revealed to be especially dangerous for children at...

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Published Studies Related to Aerospan (Flunisolide Inhalation)

Linear growth and bone maturation are unaffected by 1 year of therapy with inhaled flunisolide hydrofluoroalkane in prepubescent children with mild persistent asthma: a randomized, double-blind, placebo-controlled trial. [2011.10]
BACKGROUND: Inhaled corticosteroids (ICS) are the preferred long-term therapy for subjects with persistent asthma. However, concerns remain about potential effects of long-term ICS use on growth in children. OBJECTIVE: To determine the effect of 1 year of inhalation therapy with flunisolide hydrofluoroalkane (HFA) on growth velocity and bone maturation in children with mild persistent asthma... CONCLUSIONS: In this study, flunisolide HFA did not suppress growth or bone maturation at the highest approved dose for children with persistent asthma. Copyright (c) 2011 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Intranasal flunisolide treatment in patients with non-allergic rhinitis. [2011.04]
Non-allergic rhinitis (NAR) is a heterogeneous disease, characterized by nasal hyperreactivity and inflammation...

High-dose inhaled flunisolide versus budesonide in the treatment of acute asthma exacerbations in preschool-age children. [2009.04]
The role of inhaled corticosteroids in asthma exacerbation is debated. We compared high doses of nebulized budesonide versus high doses of nebulized flunisolide, in association with a short-acting beta-2-agonist, in the treatment of moderate asthma exacerbation in preschool children... High doses of inhaled flunisolide and budesonide are both effective in the management of moderate asthma exacerbations in pre-school-age children, but the flunisolide therapeutic effect was faster than budesonide.

Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects. [2007.07]
OBJECTIVE: To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects... CONCLUSION: Inhalation of flunisolide by normal subjects for 1 month does not cause any acute or clinically perceived effect in the peripheral or respiratory muscles.

Inhaled flunisolide suppresses the hypothalamic-pituitary-adrenocortical axis, but has minimal systemic immune effects in healthy cats. [2006.01]
Feline bronchial disease is commonly treated with oral glucocorticoids (OGC), which might be contraindicated in cats with certain infectious, endocrine, renal, or cardiac diseases...

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Clinical Trials Related to Aerospan (Flunisolide Inhalation)

Validation Of Preference Module Of Experience With Allergic Rhinitis Nasal Sprays Questionnaire (EARNS-Q) [Completed]
The objective of this cross-over study is to validate the Preference Module of the EARNS-Q in adult subjects (>=18 years of age) with Seasonal Allergic Rhinitis (SAR) taking beclomethasone dipropionate and beclomethasone dipropionate and flunisolide.

Mentored Patient-Oriented Research Career Development Award [Recruiting]
Asthmatics have inflammation in the large airways (tubes through which air travels in and out of the lungs). The large airways are located in the central lung. New research shows that asthmatics also have inflammation in the small airways. The small airways are located in the peripheral lung (the parts of the lung away from the central lung). Until now, most of the inhaled medications available have been made up of big particles that never reach the peripheral lung. The purpose of this study is to try to measure the level of inflammation in the peripheral lung in asthmatics and see if this inflammation can be decreased with different types of inhaled corticosteroids. The investigators will check airway inflammation before and after use of an inhaled corticosteroid that has a large particle size and should only reach the large airways (Flunisolide-CFC), and before and after use of an inhaled, small particle corticosteroid that should reach both the large and small airways (Flunisolide-HFA). Subjects will make 6 study visits over two phases of the study. In the first phase, the investigators will collect baseline information about subjects while they are using placebo (inactive substance). In the second phase, subjects will take either the large or small particle corticosteroid. Visits will involve questionnaires and various tests measuring lung function (such as spirometry, forced oscillation, and methacholine challenge). Exhaled nitric oxide will be measured as an indication of inflammation. Subjects will also measure and make note of lung function at home twice daily using a peak expiratory flow meter. Two of the visits will involve fiberoptic bronchoscopy so that the investigators may collect cells and tissue samples without surgery. Another two of the visits will involve the use of high resolution computed tomography (HRCT) scans to indirectly evaluate disease in distant parts of the lungs.

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Page last updated: 2015-04-18

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