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Advicor (Lovastatin) - Summary

 

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ADVICOR SUMMARY

ADVICOR contains niacin extended-release and lovastatin in combination. Niacin, a B-complex vitamin, and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, are both lipid-altering agents.

ADVICOR is a fixed-dose combination product and is not indicated for initial therapy (see DOSAGE AND ADMINISTRATION). Therapy with lipid-altering agents should be only one component of multiple risk-factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Initial medical therapy is indicated with a single agent as an adjunct to diet when the response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has been inadequate (see also Table 7 and the NCEP treatment guidelines1).

ADVICOR is indicated for the treatment of primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Frederickson Types IIa and IIb; Table 6) in:

  • Patients treated with lovastatin who require further TG-lowering or HDL-raising who may benefit from having niacin added to their regimen
  • Patients treated with niacin who require further LDL-lowering who may benefit from having lovastatin added to their regimen

ADVICOR NEWS HIGHLIGHTS

Media Articles Related to Advicor (Lovastatin)

Cholesterol Drug Plays Role In Melanoma Remission
Source: Cholesterol News From Medical News Today [2008.08.13]

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Published Studies Related to Advicor (Lovastatin)

The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet. [2007.09]

Moderate alcohol consumption and safety of lovastatin and warfarin among men: the post-coronary artery bypass graft trial. [2006.05]

Plasma clearance of lovastatin versus chinese red yeast rice in healthy volunteers. [2005.12]

Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine. [2005.11]

Efficacy and safety of lovastatin therapy in adolescent girls with heterozygous familial hypercholesterolemia. [2005.09]

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Clinical Trials Related to Advicor (Lovastatin)

The Dose Response of Niacin ER/Lovastatin on Peak Walking Time (PWT) in Patients With Intermittent Claudication - TROPIC [Completed]

Effect of Niacin ER/Lovastatin on Peak Walking Time & Claudication Onset Time in Patients With Intermittent Claudication [Completed]

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Page last updated: 2008-08-13

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