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Adrucil (Fluorouracil) - Side Effects and Adverse Reactions



Stomatitis and esophagopharyngitis (which may lead to sloughing and ulceration), diarrhea, anorexia, nausea and emesis are commonly seen during therapy.

Leukopenia usually follows every course of adequate therapy with fluorouracil. The lowest white blood cell counts are commonly observed between the 9th and 14th days after the first course of treatment, although uncommonly the maximal depression may be delayed for as long as 20 days. By the 30th day the count has usually returned to the normal range.

Alopecia and dermatitis may be seen in a substantial number of cases. The dermatitis most often seen is a pruritic maculopapular rash usually appearing on the extremities and less frequently on the trunk. It is generally reversible and usually responsive to symptomatic treatment.

Other adverse reactions are:

  •   Hematologic: pancytopenia, thrombocytopenia, agranulocytosis, anemia.
  •   Cardiovascular: myocardial ischemia, angina.
  •   Gastrointestinal: gastrointestinal ulceration and bleeding.
  •   Allergic Reactions: anaphylaxis and generalized allergic reactions.
  •   Neurologic: acute cerebellar syndrome (which may persist following discontinuance of treatment), nystagmus, headache.
  •   Dermatologic: dry skin; fissuring; photosensitivity, as manifested by erythema or increased pigmentation of the skin; vein pigmentation; palmar-planter erythrodysesthesia syndrome, as manifested by tingling of the hands and feet followed by pain, erythema and swelling.
  •   Ophthalmic: lacrimal duct stenosis, visual changes, lacrimation, photophobia.
  •   Psychiatric: disorientation, confusion, euphoria.
  •   Miscellaneous: thrombophlebitis, epistaxis, nail changes (including loss of nails).
Drug label data at the top of this Page last updated: 2012-08-14

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