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Adrucil (Fluorouracil) - Drug Interactions, Contraindications, Overdosage, etc



Drug Interactions

Leucovorin calcium may enhance the toxicity of fluorouracil.

Also see WARNINGS section.


The possibility of overdosage with fluorouracil is unlikely in view of the mode of administration. Nevertheless, the anticipated manifestations would be nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis). No specific antidotal therapy exists. Patients who have been exposed to an overdose of fluorouracil should be monitored hematologically for at least four weeks. Should abnormalities appear, appropriate therapy should be utilized.

The acute intravenous toxicity of fluorouracil is as follows:

Species LD50
(mg/kg ±S.E.)
Mouse 340 ± 17
Rat 165 ± 26
Rabbit 27 ± 5.1
Dog 31.5 ± 3.8


ADRUCIL Injection therapy is contraindicated for patients in a poor nutritional state, those with depressed bone marrow function, those with potentially serious infections or those with a known hypersensitivity to ADRUCIL.


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Manufactured by:
Teva Parenteral Medicines, Inc.
Irvine, CA 92618
Issued: July 2007

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