ADIPEX-P SUMMARY
ADIPEX-P® (Phentermine Hydrochloride USP, 37.5 mg) CIV
ADIPEX-P®, an anorectic agent for oral administration, is available as a capsule or tablet containing 37.5 mg of phentermine hydrochloride (equivalent to 30 mg ofphentermine base).
ADIPEX-P® (phentermine hydrochloride) is indicated as a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index >/=30 kg/m2, or >/=27 kg/m2 in the presence of other risk factors (e.g., hypertension, diabetes, hyperlipidemia).
Below is a chart of Body Mass Index (BMI) based on various heights and weights.
BMI is calculated by taking the patient's weight, in kilograms (kg), divided by the patient's height, in meters (m), squared. Metric conversions are as follows: pounds ÷ 2.2 = kg; inches × 0.0254 = meters.
The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use.
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NEWS HIGHLIGHTSMedia Articles Related to Adipex-P (Phentermine)
Low-Carb Diet May Lead To Similar Benefits As Weight Loss Medication Combined With A Low-Fat Diet
Source: Nutrition / Diet News From Medical News Today [2010.02.04]
A low-carbohydrate diet appears to be associated with substantial weight loss similar to that produced by a combination of the weight-loss drug orlistat and a low-fat diet, but may be more effective in reducing blood pressure. William S. Yancy Jr., M.D., M.H.S., and colleagues at the Department of Veterans Affairs Medical Center and Duke University Medical Center, Durham, N.C...
High Altitudes May Aid Weight Loss
Source: MedicineNet Obesity (Weight Loss) Specialty [2010.02.04]
Title: High Altitudes May Aid Weight Loss
Category: Health News
Created: 2/4/2010 10:03:00 AM
Last Editorial Review: 2/4/2010 10:03:09 AM
Obese Women Undergoing Infertility Treatment Advised Not To Attempt Rapid Weight Loss
Source: Fertility News From Medical News Today [2010.02.03]
Obese women who undergo rapid weight loss to get pregnant may harm rather than improve their chances of having a healthy baby, a leading researcher suggested this week. Professor Richard Legro of the Department of Obstetrics and Gynecology at Penn State University College of Medicine, Hershey, Pennsylvania, USA, said the subject was under-researched and outcomes unknown...
Low Carb Diet Lowered Blood Pressure More Effectively Than Weight Loss Pill
Source: Hypertension News From Medical News Today [2010.01.26]
A new study from the US showed that two popular weight loss methods, one using the obesity treatment weight-loss pill orlistat plus a low-fat diet and another just based on a low carb diet were equally effective at helping people lose significant amounts of weight, but in a surprising twist found that that the low carb diet was much better at helping them lower blood pressure...
Leptin Therapy Could Hold Key To Long-Term Weight Loss
Source: Endocrinology News From Medical News Today [2010.01.19]
Hormone Helps to Regulate Energy Homeostasis, Neuroendocrine Function, and Metabolism Leptin is a hormone that plays a central role in fat metabolism. Patients with genetic leptin deficiency are obese, and treatment with leptin leads to dramatic weight loss through decreased food intake and possible increased energy expenditure...
Published Studies Related to Adipex-P (Phentermine)
Comparison of potency of ephedrine and mephentermine for prevention of post-spinal hypotension in caesarean section. [2008.05]
The dosages and potency of intravenous mephentermine for prevention of post-spinal hypotension are not available in English literature. This study was designed to determine the minimum effective dose (ED50) of mephentermine and to compare its potency with that of ephedrine for prevention of post-spinal hypotension in parturients undergoing caesarean section...
Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section. [2005.01]
This study compared the effects of intravenous infusions of ephedrine and mephentermine for maintenance of maternal arterial pressure and neonatal outcome in pregnant women receiving subarachnoid block for lower segment Caesarean section. Sixty patients who developed hypotension following subarachnoid block for Caesarean section were randomly divided into two groups of 30 each to receive an intravenous infusion of ephedrine or mephentermine...
Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. [2003.08]
Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation. We administered placebo, tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine 37.5 mg and D-amphetamine 20 mg at 15.30 h following overnight sleep deprivation and compare their effects on cognitive and motor performance in healthy young men...
A comparison of tyrosine against placebo, phentermine, caffeine, and D-amphetamine during sleep deprivation. [2003.08]
Sleep deprivation can impair alertness and cognitive and motor performance... Tyrosine (when compared to placebo) had no effect on any sleep related measure, but it did stimulate prolactin release.
Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin. [2000.04.01]
As expected on the basis of published research in both humans and animals, treatment with phentermine/fenfluramine lowers plasma 5-hydroxytryptamine [corrected], whereas treatment with phentermine had no significant effect. In light of these findings, future research should focus on mechanisms other than increased plasma 5-hydroxytryptamine [corrected] to explain how fenfluramine increases the risk of primary pulmonary hypertension and valvular heart disease..
Clinical Trials Related to Adipex-P (Phentermine)
A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects [Completed]
This study will examine the safety, tolerability, and body weight effect of subcutaneous
pramlintide alone and in various combinations with the oral antiobesity agents sibutramine or
phentermine in overweight and obese subjects.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 26 ratings/reviews, Adipex-P has an overall score of 7.65. The effectiveness score is 7.85 and the side effect score is 6.62. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Adipex-P review by 36 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | weight loss |
| Dosage & duration: | | 37.5mg. taken 1 day for the period of 5 years |
| Other conditions: | | none |
| Other drugs taken: | | prozac | | |
Reported Results |
| Benefits: | | lost weight very fast then mantained it for 4 years. |
| Side effects: | | dry mouth, restless,no appitite |
| Comments: | | I was given this drug to help lose weight, it worked perfect other than it was very costly and very few doctors prescibe it. |
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| | Adipex-P review by 30 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | Weightloss |
| Dosage & duration: | | 37.5 (dosage frequency: 1 a day) for the period of 2weeks |
| Other conditions: | | n/a |
| Other drugs taken: | | n./a | | |
Reported Results |
| Benefits: | | This is my second wee taking the meds and i weighed myself the other day i have lost 14lbs already and i still have a few more weeks to go before the month is up.. |
| Side effects: | | Jitters, energized, not as tired as i use to be |
| Comments: | | I wanted to lose the weight within a month time to prepare for a wddings.. i was in a size 12 and have noticed the change already |
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| | Adipex-P review by 34 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | weightloss |
| Dosage & duration: | | 1 (dosage frequency: 3x day) for the period of 6weeks |
| Other conditions: | | n/a |
| Other drugs taken: | | n/a | | |
Reported Results |
| Benefits: | | It did help control my appetite in the beginning. After 2 weeks I tended to get very hungry late after it wore off. I lost 5 lbs the 1st week, I feel that was just water weight and not much after that. It did give me lots of energy. |
| Side effects: | | It made me very jittery and shaky. |
| Comments: | | |
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Page last updated: 2010-02-04
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