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Adipex-P (Phentermine Hydrochloride) - Summary



Phentermine hydrochloride USP is a sympathomimetic amine anorectic. It has the chemical name of α,α,-Dimethylphenethylamine hydrochloride.

ADIPEX-P® is indicated as a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index ≥ 30 kg/m2, or ≥ 27 kg/m2 in the presence of other risk factors (e.g., controlled hypertension, diabetes, hyperlipidemia).

Below is a chart of body mass index (BMI) based on various heights and weights.

BMI is calculated by taking the patient’s weight, in kilograms (kg), divided by the patient’s height, in meters (m), squared. Metric conversions are as follows: pounds ÷ 2.2 = kg; inches x 0.0254 = meters.

The limited usefulness of agents of this class, including ADIPEX-P®, [ see Clinical Pharmacology (12.1, 12.2) ] should be measured against possible risk factors inherent in their use such as those described below.

See all Adipex-P indications & dosage >>


Media Articles Related to Adipex-P (Phentermine)

High-protein diet curbs metabolic benefits of weight loss
Source: Diabetes News From Medical News Today [2016.10.12]
Dieters sometimes consume extra protein to stave off hunger and prevent loss of muscle tissue that often comes with weight loss.

'Obesity gene' does not hinder weight loss
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2016.09.21]
The belief that so-called obesity genes can hinder weight loss is called into question by a new study review. Genetics may not be so vital after all.

Use of wearable device does not improve weight loss
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2016.09.21]
Among overweight or obese young adults, the addition of a wearable technology device (that provided feedback on physical activity) to a standard behavioral intervention resulted in less weight loss...

Online intervention helps sustain weight loss
Source: IT / Internet / E-mail News From Medical News Today [2016.07.27]
New research, led by the University of Southampton, has found that an online behavioural counselling tool is effective at helping people lose weight.

Bad' Foods That Are Good for Weight Loss in Pictures
Source: MedicineNet phentermine Specialty [2016.06.07]
Title: Bad' Foods That Are Good for Weight Loss in Pictures
Category: Slideshows
Created: 12/23/2008 12:00:00 AM
Last Editorial Review: 6/7/2016 12:00:00 AM

more news >>

Published Studies Related to Adipex-P (Phentermine)

Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP). [2011.11.03]
A 56-week randomized controlled trial was conducted to evaluate safety and efficacy of a controlled-release combination of phentermine and topiramate (PHEN/TPM CR) for weight loss (WL) and metabolic improvements. Men and women with class II and III obesity (BMI >/= 35 kg/m(2)) were randomized to placebo, PHEN/TPM CR 3.75/23 mg, or PHEN/TPM CR 15/92 mg, added to a reduced-energy diet...

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. [2011.04.16]
BACKGROUND: Obesity is associated with a reduction in life expectancy and an increase in mortality from cardiovascular diseases, cancer, and other causes. We therefore assessed the efficacy and safety of two doses of phentermine plus topiramate controlled-release combination as an adjunct to diet and lifestyle modification for weight loss and metabolic risk reduction in individuals who were overweight and obese, with two or more risk factors... INTERPRETATION: The combination of phentermine and topiramate, with office-based lifestyle interventions, might be a valuable treatment for obesity that can be provided by family doctors. FUNDING: Vivus. Copyright (c) 2011 Elsevier Ltd. All rights reserved.

Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension. [2010.12]
This study compared the effects of intravenous infusions of phenylephrine and mephentermine on the prevention of maternal hypotension and neonatal outcome in patients receiving spinal anaesthesia for caesarean section. Sixty ASA 1-2 patients with term, uncomplicated singleton pregnancy undergoing caesarean section under spinal anaesthesia were randomly divided into two groups of 30 each, to receive a prophylactic intravenous infusion of either phenylephrine or mephentermine...

Randomized controlled trial to investigate the effects of a newly developed formulation of phentermine diffuse-controlled release for obesity. [2010.10]
AIM: To evaluate the efficacy and safety of a newly developed formulation of phentermine diffuse-controlled release (DCR) in patients with obesity... CONCLUSIONS: Short-term phentermine DCR treatment resulted in significant reduction in weight and improvement of metabolic parameters, including waist circumference and some lipid profiles, without clinically severe adverse events. Further study is needed to show long-term efficacy and safety of phentermine DCR in Korean patients with obesity. (c) 2010 Blackwell Publishing Ltd.

Enhanced weight loss following coadministration of pramlintide with sibutramine or phentermine in a multicenter trial. [2010.09]
Preclinical evidence suggests that pharmacotherapy for obesity using combinations of agents targeted at distinct regulatory pathways may produce robust additive or synergistic effects on weight loss. This randomized placebo-controlled trial examined the safety and efficacy of the amylin analogue pramlintide alone or in combination with either phentermine or sibutramine...

more studies >>

Clinical Trials Related to Adipex-P (Phentermine)

Topiramate-Phentermine Combinations for Cocaine Dependence [Recruiting]
This study will determine the influence of topiramate (Topamax) and phentermine (Adipex), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine.

Studying the Effects of Phentermine on Eating Behavior [Recruiting]
The goal of this study is to determine whether one week of phentermine compared to placebo administration results in changes in food intake during a laboratory meal.

The Effect of Phentermine and B12 on Weight Loss Among Obese Patients [Completed]
This is a pilot study designed to test the hypothesis that the combination of phentermine and B12 will result in significantly greater weight loss among obese patients compared to phentermine alone.

Phentermine/Gastric Band Weight Loss Study [Withdrawn]
This is a prospective, randomized, double-blind controlled trial. The goal is to show whether the administration of daily oral Phentermine will augment patient weight loss and resolve obesity associated comorbidities following gastric band operation.

A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects [Completed]
This study will examine the safety, tolerability, and body weight effect of subcutaneous pramlintide alone and in various combinations with the oral antiobesity agents sibutramine or phentermine in overweight and obese subjects.

more trials >>


Based on a total of 32 ratings/reviews, Adipex-P has an overall score of 7.66. The effectiveness score is 8 and the side effect score is 6.75. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Adipex-P review by 36 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   weight loss
Dosage & duration:   37.5mg. taken 1 day for the period of 5 years
Other conditions:   none
Other drugs taken:   prozac
Reported Results
Benefits:   lost weight very fast then mantained it for 4 years.
Side effects:   dry mouth, restless,no appitite
Comments:   I was given this drug to help lose weight, it worked perfect other than it was very costly and very few doctors prescibe it.


Adipex-P review by 30 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   Weightloss
Dosage & duration:   37.5 (dosage frequency: 1 a day) for the period of 2weeks
Other conditions:   n/a
Other drugs taken:   n./a
Reported Results
Benefits:   This is my second wee taking the meds and i weighed myself the other day i have lost 14lbs already and i still have a few more weeks to go before the month is up..
Side effects:   Jitters, energized, not as tired as i use to be
Comments:   I wanted to lose the weight within a month time to prepare for a wddings.. i was in a size 12 and have noticed the change already


Adipex-P review by 34 year old female patient

Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   weightloss
Dosage & duration:   1 (dosage frequency: 3x day) for the period of 6weeks
Other conditions:   n/a
Other drugs taken:   n/a
Reported Results
Benefits:   It did help control my appetite in the beginning. After 2 weeks I tended to get very hungry late after it wore off. I lost 5 lbs the 1st week, I feel that was just water weight and not much after that. It did give me lots of energy.
Side effects:   It made me very jittery and shaky.

See all Adipex-P reviews / ratings >>

Page last updated: 2016-10-12

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