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Adipex-P (Phentermine Hydrochloride) - Summary



ADIPEX-P® (Phentermine Hydrochloride USP, 37.5 mg) CIV

ADIPEX-P®, an anorectic agent for oral administration, is available as a capsule or tablet containing 37.5 mg of phentermine hydrochloride (equivalent to 30 mg ofphentermine base).

ADIPEX-P® (phentermine hydrochloride) is indicated as a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index >/=30 kg/m2, or >/=27 kg/m2 in the presence of other risk factors (e.g., hypertension, diabetes, hyperlipidemia).

Below is a chart of Body Mass Index (BMI) based on various heights and weights.

BMI is calculated by taking the patient's weight, in kilograms (kg), divided by the patient's height, in meters (m), squared. Metric conversions are as follows: pounds ÷ 2.2 = kg; inches × 0.0254 = meters.

The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use.

See all Adipex-P indications & dosage >>


Media Articles Related to Adipex-P (Phentermine)

ACC: Weight Loss Might Also Shed Afib
Source: MedPage Today Endocrinology [2015.03.17]
(MedPage Today) -- Freedom from arrhythmia linked to substantial, sustained weight loss.

LEGACY: Long-term Weight Loss Decreases AF Symptoms
Source: theheart.org | Medscape Cardiology Headlines [2015.03.16]
Steady, sustained weight-loss trumps yo-yo, loss-gain fluctuations in reducing AF burden and symptom severity in overweight and obese adults, suggests a new study from Australian researchers.
Heartwire from Medscape

Gut bacteria may decrease weight loss from bariatric surgery
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2015.03.10]
The benefits of weight loss surgery, along with a treatment plan that includes exercise and dietary changes, are well documented.

Both low intensity and high intensity workouts effective for weight loss
Source: Sports Medicine / Fitness News From Medical News Today [2015.03.03]
Patients at risk for diabetes or heart disease may want to choose their workout intensity based on health goals, according to an article being published in Annals of Internal Medicine.

Weight Loss
Source: MedicineNet Anorexia Nervosa Specialty [2015.02.18]
Title: Weight Loss
Category: Health and Living
Created: 8/27/2001 12:00:00 AM
Last Editorial Review: 2/18/2015 12:00:00 AM

more news >>

Published Studies Related to Adipex-P (Phentermine)

Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP). [2011.11.03]
A 56-week randomized controlled trial was conducted to evaluate safety and efficacy of a controlled-release combination of phentermine and topiramate (PHEN/TPM CR) for weight loss (WL) and metabolic improvements. Men and women with class II and III obesity (BMI >/= 35 kg/m(2)) were randomized to placebo, PHEN/TPM CR 3.75/23 mg, or PHEN/TPM CR 15/92 mg, added to a reduced-energy diet...

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. [2011.04.16]
BACKGROUND: Obesity is associated with a reduction in life expectancy and an increase in mortality from cardiovascular diseases, cancer, and other causes. We therefore assessed the efficacy and safety of two doses of phentermine plus topiramate controlled-release combination as an adjunct to diet and lifestyle modification for weight loss and metabolic risk reduction in individuals who were overweight and obese, with two or more risk factors... INTERPRETATION: The combination of phentermine and topiramate, with office-based lifestyle interventions, might be a valuable treatment for obesity that can be provided by family doctors. FUNDING: Vivus. Copyright (c) 2011 Elsevier Ltd. All rights reserved.

Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension. [2010.12]
This study compared the effects of intravenous infusions of phenylephrine and mephentermine on the prevention of maternal hypotension and neonatal outcome in patients receiving spinal anaesthesia for caesarean section. Sixty ASA 1-2 patients with term, uncomplicated singleton pregnancy undergoing caesarean section under spinal anaesthesia were randomly divided into two groups of 30 each, to receive a prophylactic intravenous infusion of either phenylephrine or mephentermine...

Randomized controlled trial to investigate the effects of a newly developed formulation of phentermine diffuse-controlled release for obesity. [2010.10]
AIM: To evaluate the efficacy and safety of a newly developed formulation of phentermine diffuse-controlled release (DCR) in patients with obesity... CONCLUSIONS: Short-term phentermine DCR treatment resulted in significant reduction in weight and improvement of metabolic parameters, including waist circumference and some lipid profiles, without clinically severe adverse events. Further study is needed to show long-term efficacy and safety of phentermine DCR in Korean patients with obesity. (c) 2010 Blackwell Publishing Ltd.

Enhanced weight loss following coadministration of pramlintide with sibutramine or phentermine in a multicenter trial. [2010.09]
Preclinical evidence suggests that pharmacotherapy for obesity using combinations of agents targeted at distinct regulatory pathways may produce robust additive or synergistic effects on weight loss. This randomized placebo-controlled trial examined the safety and efficacy of the amylin analogue pramlintide alone or in combination with either phentermine or sibutramine...

more studies >>

Clinical Trials Related to Adipex-P (Phentermine)

Topiramate-Phentermine Combinations for Cocaine Dependence [Recruiting]
This study will determine the influence of topiramate (Topamax) and phentermine (Adipex), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine.

Studying the Effects of Phentermine on Eating Behavior [Recruiting]
The goal of this study is to determine whether one week of phentermine compared to placebo administration results in changes in food intake during a laboratory meal.

A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects [Completed]
This study will examine the safety, tolerability, and body weight effect of subcutaneous pramlintide alone and in various combinations with the oral antiobesity agents sibutramine or phentermine in overweight and obese subjects.

more trials >>


Based on a total of 32 ratings/reviews, Adipex-P has an overall score of 7.66. The effectiveness score is 8 and the side effect score is 6.75. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Adipex-P review by 36 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   weight loss
Dosage & duration:   37.5mg. taken 1 day for the period of 5 years
Other conditions:   none
Other drugs taken:   prozac
Reported Results
Benefits:   lost weight very fast then mantained it for 4 years.
Side effects:   dry mouth, restless,no appitite
Comments:   I was given this drug to help lose weight, it worked perfect other than it was very costly and very few doctors prescibe it.


Adipex-P review by 30 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   Weightloss
Dosage & duration:   37.5 (dosage frequency: 1 a day) for the period of 2weeks
Other conditions:   n/a
Other drugs taken:   n./a
Reported Results
Benefits:   This is my second wee taking the meds and i weighed myself the other day i have lost 14lbs already and i still have a few more weeks to go before the month is up..
Side effects:   Jitters, energized, not as tired as i use to be
Comments:   I wanted to lose the weight within a month time to prepare for a wddings.. i was in a size 12 and have noticed the change already


Adipex-P review by 34 year old female patient

Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   weightloss
Dosage & duration:   1 (dosage frequency: 3x day) for the period of 6weeks
Other conditions:   n/a
Other drugs taken:   n/a
Reported Results
Benefits:   It did help control my appetite in the beginning. After 2 weeks I tended to get very hungry late after it wore off. I lost 5 lbs the 1st week, I feel that was just water weight and not much after that. It did give me lots of energy.
Side effects:   It made me very jittery and shaky.

See all Adipex-P reviews / ratings >>

Page last updated: 2015-03-17

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