ADIPEX-P SUMMARY
ADIPEX-P® (Phentermine Hydrochloride USP, 37.5 mg) CIV
ADIPEX-P®, an anorectic agent for oral administration, is available as a capsule or tablet containing 37.5 mg of phentermine hydrochloride (equivalent to 30 mg ofphentermine base).
ADIPEX-P® (phentermine hydrochloride) is indicated as a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index >/=30 kg/m2, or >/=27 kg/m2 in the presence of other risk factors (e.g., hypertension, diabetes, hyperlipidemia).
Below is a chart of Body Mass Index (BMI) based on various heights and weights.
BMI is calculated by taking the patient's weight, in kilograms (kg), divided by the patient's height, in meters (m), squared. Metric conversions are as follows: pounds ÷ 2.2 = kg; inches × 0.0254 = meters.
The limited usefulness of agents of this class (see CLINICAL PHARMACOLOGY) should be measured against possible risk factors inherent in their use.
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ADIPEX-P NEWS HIGHLIGHTS Media Articles Related to Adipex-P (Phentermine)
Study Indicates Support Group Attendance Improves Post-Surgical Weight Loss
Source: Diabetes News From Medical News Today [2009.07.02]
Major scientific contributors within the bariatric and psychiatric industries publicized the results of a recent study demonstrating that LAP-BAND(R) patients who regularly attend support groups experience considerably higher rates of post-surgical weight loss. Authors Dr. Kathryn A. Kaiser, Dr. Susan Franks and Dr. Adam Smith discussed their findings at the 26th Annual American Society for Metabolic & Bariatric Surgery (ASMBS) Meeting.
Novel Non-Surgical Therapy Dramatically Increases Weight Loss In Obese Patients; Results From Pilot Clinical Study Presented At ASMBS
Source: Obesity / Weight Loss / Fitness News From Medical News Today [2009.06.29]
GI Dynamics, a leader in non-surgical treatments for type 2 diabetes and obesity, today announced results from a pilot clinical study which demonstrated the substantially enhanced weight loss effects of combining the company's EndoBarrier Gastrointestinal Liner with a new EndoBarrier Flow Restrictor.
Weight Loss Surgery May Defeat Diabetes
Source: MedicineNet glucose Specialty [2009.06.25]
Title: Weight Loss Surgery May Defeat Diabetes
Category: Health News
Created: 6/25/2009
Last Editorial Review: 6/25/2009
ENDO: Drug Combo Boosts Weight Loss and Quality of Life (CME/CE)
Source: MedPage Today Endocrinology [2009.06.19]
WASHINGTON (MedPage Today) -- Obese patients lost almost 10% of their body weight when treated with a fixed-dose combination of two generic drugs and intensive behavior modification, a randomized trial showed.
Diabetes Drug Byetta May Aid Weight Loss in Obese Patients
Source: MedicineNet Diarrhea Specialty [2009.06.12]
Title: Diabetes Drug Byetta May Aid Weight Loss in Obese Patients
Category: Health News
Created: 6/12/2009 7:00:00 AM
Last Editorial Review: 6/12/2009
Published Studies Related to Adipex-P (Phentermine)
Comparison of potency of ephedrine and mephentermine for prevention of post-spinal hypotension in caesarean section. [2008.05]
The dosages and potency of intravenous mephentermine [generic for Adipex-P] for prevention of post-spinal hypotension are not available in English literature. This study was designed to determine the minimum effective dose (ED50) of mephentermine and to compare its potency with that of ephedrine for prevention of post-spinal hypotension in parturients undergoing caesarean section...
Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section. [2005.01]
This study compared the effects of intravenous infusions of ephedrine and mephentermine [generic for Adipex-P] for maintenance of maternal arterial pressure and neonatal outcome in pregnant women receiving subarachnoid block for lower segment Caesarean section. Sixty patients who developed hypotension following subarachnoid block for Caesarean section were randomly divided into two groups of 30 each to receive an intravenous infusion of ephedrine or mephentermine...
Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. [2003.08]
Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation. We administered placebo, tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine [generic for Adipex-P] 37.5 mg and D-amphetamine 20 mg at 15.30 h following overnight sleep deprivation and compare their effects on cognitive and motor performance in healthy young men...
A comparison of tyrosine against placebo, phentermine, caffeine, and D-amphetamine during sleep deprivation. [2003.08]
Sleep deprivation can impair alertness and cognitive and motor performance... Tyrosine (when compared to placebo) had no effect on any sleep related measure, but it did stimulate prolactin release.
Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin. [2000.04.01]
As expected on the basis of published research in both humans and animals, treatment with phentermine [generic for Adipex-P]/fenfluramine lowers plasma 5-hydroxytryptamine [corrected], whereas treatment with phentermine had no significant effect. In light of these findings, future research should focus on mechanisms other than increased plasma 5-hydroxytryptamine [corrected] to explain how fenfluramine increases the risk of primary pulmonary hypertension and valvular heart disease..
Clinical Trials Related to Adipex-P (Phentermine)
A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects [Completed]
This study will examine the safety, tolerability, and body weight effect of subcutaneous
pramlintide alone and in various combinations with the oral antiobesity agents sibutramine or
phentermine in overweight and obese subjects.
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ADIPEX-P PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 19 ratings/reviews, Adipex-P has an overall score of 7.42. The effectiveness score is 7.58 and the side effect score is 6.21. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Adipex-P review by 21 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | weightloss |
| Dosage & duration: | | 37.5mg taken 1 day for the period of 2 years off and on |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | I lost 40lbs the first time I took it in only 2 months and kept it off for 1 year. I gained 20lbs back after that. I'm taking it again now and loose back down to my normal weight, stop taking it and gain all the weight back plus some. I've done this three times now even with an extensive workout routine and very healthy eating habits. |
| Side effects: | | Major mood swings, dry mouth, insomnia, facial twitching and jitters. The first time I took it I had thoughts of suicide that I had never experienced before but I was taking more than prescribed...not recomended. |
| Comments: | | Very satisfied with the results while taking the pill, considerable weightloss. I've found it difficult to keep the weight off though. |
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| | Adipex-P review by 31 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | obesity |
| Dosage & duration: | | one 37.5 tab taken daily for the period of one year |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | It was able to supress my hunger enough to "get through" the tough times and not be so grumpy about it :) Simply, I was not STARVING all the time, and it made the weight loss bearable. It was not EASY, but it gave me the drive to keep going because I wasn't so miserable while doing it. I ate a 1200 calorie a day or less diet and exercised many times a week...so I would have lost weight anyway, but it just made it easier. |
| Side effects: | | Dry mouth, constipation at times, sometimes felt a bit like my heart raced under stress after taking it for a long time. |
| Comments: | | One tablet a day for about a year to help aid in weight loss. I have been able to keep it off give or take a few pounds, almost a year later. |
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| | Adipex-P review by 34 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | weightloss |
| Dosage & duration: | | 1 (dosage frequency: 3x day) for the period of 6weeks |
| Other conditions: | | n/a |
| Other drugs taken: | | n/a | | |
Reported Results |
| Benefits: | | It did help control my appetite in the beginning. After 2 weeks I tended to get very hungry late after it wore off. I lost 5 lbs the 1st week, I feel that was just water weight and not much after that. It did give me lots of energy. |
| Side effects: | | It made me very jittery and shaky. |
| Comments: | | |
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Page last updated: 2009-07-02
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