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Adenosine (Adenosine) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The following reactions were reported with intravenous adenosine used in controlled U.S. clinical trials.The placebo group had less than 1% rate of all of these reactions.

Cardiovascular Facial flushing (18%), headache (2%), sweating, palpitations, chest pain, hypotension (less than 1%).

Respiratory Shortness of breath/dyspnea (12%), chest pressure (7%), hyperventilation, head pressure (less than 1%).

Central Nervous System Lightheadedness (2%), dizziness, tingling in arms, numbness (1%), apprehension, blurred vision, burning sensation, heaviness in arms, neck and back pain (less than 1%).

Gastrointestinal Nausea (3%), metallic taste, tightness in throat, pressure in groin (less than 1%).

Post Marketing Experience

(see WARNINGS)

The following adverse events have been reported from marketing experience with adenosine. Because these events are reported voluntarily from a population of uncertain size, are associated with concomitant diseases and multiple drug therapies and surgical procedures, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Decisions to include these events in labeling are typically based on one or more of the following factors: (1) seriousness of the event, (2) frequency of the reporting, (3) strength of causal connection to the drug, or a combination of these factors.

Cardiovascular
Prolonged asystole, ventricular tachycardia, ventricular fibrillation, transient increase in blood pressure, bradycardia, atrial fibrillation, and Torsade de Pointes

Respiratory
Bronchospasm

Central Nervous System
Seizure activity, including tonic clonic (grand mal) seizures, and loss of consciousness.



REPORTS OF SUSPECTED ADENOSINE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Adenosine. The information is not vetted and should not be considered as verified clinical evidence.

Possible Adenosine side effects / adverse reactions in 61 year old female

Reported by a physician from Japan on 2011-11-14

Patient: 61 year old female weighing 52.6 kg (115.7 pounds)

Reactions: Basal Cell Carcinoma

Adverse event resulted in: hospitalization

Suspect drug(s):
Methotrexate Sodium
    Dosage: 15 mg, weekly
    Administration route: Oral
    Start date: 2009-03-09
    End date: 2009-12-15

Cephadol
    Dosage: unk, as needed
    Administration route: Oral
    Indication: Meniere's Disease
    Start date: 2008-01-01

Methycobal
    Dosage: unk, as needed
    Administration route: Oral
    Indication: Meniere's Disease
    Start date: 2008-01-01

Norvasc
    Dosage: 5 mg, 1x/day
    Administration route: Oral
    Start date: 2009-10-24

Omeprazole
    Dosage: 10 mg, 1x/day
    Administration route: Oral
    Indication: Gastritis Prophylaxis
    Start date: 2007-06-29

Adenosine
    Dosage: unk, as needed
    Administration route: Oral
    Indication: Meniere's Disease
    Start date: 2008-01-01

Blinded CP-690,550
    Dosage: unk
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2010-02-15
    End date: 2010-06-30

Methotrexate Sodium
    Dosage: 10 mg, weekly
    Administration route: Oral
    Start date: 2009-12-21
    End date: 2010-06-28

Levofloxacin
    Dosage: unk, 3x/day
    Indication: Conjunctivitis Allergic
    Start date: 2009-01-01

Fluorometholone
    Dosage: unk, 3x/day
    Indication: Conjunctivitis Allergic
    Start date: 2009-01-01

Blinded NO Subject Drug
    Dosage: unk
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2010-02-15
    End date: 2010-06-30

Micardis
    Dosage: 40 mg, 1x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2008-06-20
    End date: 2010-09-06

Blinded Placebo
    Dosage: unk
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2010-02-15
    End date: 2010-06-30

Alfarol
    Dosage: 0.25 ug, 1x/day
    Administration route: Oral
    Indication: Osteoporosis
    Start date: 2004-10-28

Methotrexate Sodium
    Dosage: 12.5 mg, weekly
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2007-07-30
    End date: 2009-03-03

Folic Acid
    Dosage: 5 mg, weekly
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2009-08-26
    End date: 2010-06-29

Hyalein
    Dosage: unk, 4x/day
    Indication: DRY Eye
    Start date: 2009-01-01



Possible Adenosine side effects / adverse reactions in 41 year old female

Reported by a physician from Qatar on 2012-01-09

Patient: 41 year old female

Reactions: Electrocardiogram ST Segment Depression, Dyspnoea, Supraventricular Tachycardia, Arteriospasm Coronary, Troponin T Increased, Electrocardiogram ST Segment Elevation

Adverse event resulted in: hospitalization

Suspect drug(s):
Adenosine



Possible Adenosine side effects / adverse reactions in 63 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-23

Patient: 63 year old female

Reactions: Angioedema

Adverse event resulted in: hospitalization

Suspect drug(s):
Cardiolite
    Dosage: (30 millicuries), intravenous
    Indication: Cardiac Stress Test
    Start date: 2002-07-23
    End date: 2002-07-25

Adenosine
    Dosage: 140 ug/kg/min, intravenous
    Indication: Cardiac Stress Test
    Start date: 2002-07-23

Other drugs received by patient: Vitamin B12; Atarax; Glyburide; Aspirin; Actose (Pioglitazone Hydrochloride); Folate Sodium (Folate Sodium); Glipizide; Magnesium (Magnesium); Glucophage; Toprol-XL; Calcium Carbonate; Miacalcin; Vasotec; Lasix; Potassium Chloride; Vitamin E



See index of all Adenosine side effect reports >>

Drug label data at the top of this Page last updated: 2008-11-17

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