ADVERSE REACTIONS
The following reactions were reported with intravenous adenosine used in controlled U.S. clinical trials.The placebo group had less than 1% rate of all of these reactions.
Cardiovascular Facial flushing (18%), headache (2%), sweating, palpitations, chest pain, hypotension (less than 1%).
Respiratory Shortness of breath/dyspnea (12%), chest pressure (7%), hyperventilation, head pressure (less than 1%).
Central Nervous System Lightheadedness (2%), dizziness, tingling in arms, numbness (1%), apprehension, blurred vision, burning sensation, heaviness in arms, neck and back pain (less than 1%).
Gastrointestinal Nausea (3%), metallic taste, tightness in throat, pressure in groin (less than 1%).
Post Marketing Experience
(see WARNINGS)
The following adverse events have been reported from marketing experience with adenosine. Because these events are reported voluntarily from a population of uncertain size, are associated with concomitant diseases and multiple drug therapies and surgical procedures, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Decisions to include these events in labeling are typically based on one or more of the following factors: (1) seriousness of the event, (2) frequency of the reporting, (3) strength of causal connection to the drug, or a combination of these factors.
Cardiovascular
Prolonged asystole, ventricular tachycardia, ventricular fibrillation, transient increase in blood pressure, bradycardia, atrial fibrillation, and Torsade de Pointes
Respiratory
Bronchospasm
Central Nervous System
Seizure activity, including tonic clonic (grand mal) seizures, and loss of consciousness.
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO ADENOSINE
Below is a sample of reports where side effects / adverse reactions may be related to Adenosine. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Adenosine side effects / adverse reactions in 66 year old male
Reported by a individual with unspecified qualification from United Kingdom on 2007-02-28
Patient: 66 year old male
Reactions: Chest Pain, Arteriospasm Coronary, Hyperhidrosis, Electrocardiogram ST Segment Elevation
Suspect drug(s):
Adenosine
Possible Adenosine side effects / adverse reactions in 71 year old male
Reported by a pharmacist from United States on 2007-03-05
Patient: 71 year old male weighing 89.8 kg (197.6 pounds)
Reactions: Procedural Complication, Bronchospasm
Suspect drug(s):
Adenosine
Possible Adenosine side effects / adverse reactions in 52 year old male
Reported by a pharmacist from United States on 2007-03-05
Patient: 52 year old male weighing 115.7 kg (254.5 pounds)
Reactions: Bronchospasm
Suspect drug(s):
Adenosine
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