ADENOCARD SUMMARY
ADENOCARD® IV
(adenosine injection)
FOR RAPID BOLUS INTRAVENOUS USE
Adenosine is an endogenous nucleoside occurring in all cells of the body.
Intravenous Adenocard (adenosine injection) is indicated for the following.
Conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome). When clinically advisable, appropriate vagal maneuvers (e.g., Valsalva maneuver), should be attempted prior to Adenocard administration.
It is important to be sure the Adenocard solution actually reaches the systemic circulation (see DOSAGE AND ADMINISTRATION).
Adenocard does not convert atrial flutter, atrial fibrillation, or ventricular tachycardia to normal sinus rhythm. In the presence of atrial flutter or atrial fibrillation, a transient modest slowing of ventricular response may occur immediately following Adenocard administration.
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NEWS HIGHLIGHTSMedia Articles Related to Adenocard (Adenosine)
Adenosine
Source: MedicineNet Varicose Veins Specialty [2009.01.27]
Title: Adenosine
Category: Vitamins and Supplements
Created: 1/27/2009 4:00:00 PM
Last Editorial Review: 1/27/2009 4:00:07 PM
That '4 Hour Erection': New Discovery May Help Prevent A Complication Of Priapism
Source: Sexual Health / STDs News From Medical News Today [2009.10.28]
For men coping with painful erections lasting for long periods of time, or priapism, new research published online in The FASEB Journal offers hope. That's because researchers from the United States and China show that the enzyme adenosine deaminase may prevent priapism from progressing to penile fibrosis, a condition associated with the build up of scar tissue and eventual impotence.
Published Studies Related to Adenocard (Adenosine)
Preconditioning effects of adenosine in patients with severe coronary artery disease but preserved coronary flow reserve. [2009.08]
BACKGROUND: Adenosine plays a key role in different protective and adaptive responses to ischemia and has been suggested to induce ischemic preconditioning. AIM: To investigate whether a low-dose adenosine infusion reduces the ischemic burden induced by pharmacological stress without affecting the coronary flow reserve (CFR)... CONCLUSION: Low-dose adenosine infusion improves regional LV systolic function in the ischemic walls, without any effect on CFR, suggesting that the observed improvement may be because of ischemic preconditioning.
Effect of adenosine 5'-triphosphate infusions on the nutritional status and survival of preterminal cancer patients. [2009.08]
The aim of the study was to investigate the effect of intravenous infusions of adenosine 5'-triphosphate (ATP) on nutritional status and survival in preterminal cancer patients. Ninety-nine preterminal cancer patients (estimated life expectancy 1-6 months) with mixed tumor types were randomly allocated to receive either intravenous ATP weekly (8-10 h/week, maximum 50 microg/kg/min) for 8 weeks, or no ATP (control group)...
Adenosine modulates oesophageal sensorimotor function in humans. [2009.08]
BACKGROUND AND AIMS: Adenosine mediates somatic and visceral pain, but its effects on gut visceral nociception are unknown. The aim of the present study was to test the hypothesis that adenosine alters oesophageal sensorimotor function... CONCLUSIONS: Adenosine can induce visceral hyperalgesia and decrease oesophageal distensibility in humans. These evoked sensorimotor changes are similar to those described in patients with functional oesophageal (non-cardiac) chest pain. Thus, adenosine modulates oesophageal sensorimotor function and may play a role in the pathogenesis of functional chest pain.
Randomized evaluation of intracoronary nitroprusside vs. adenosine after thrombus aspiration during primary percutaneous coronary intervention for the prevention of no-reflow in acute myocardial infarction: the REOPEN-AMI study protocol. [2009.07]
CONCLUSIONS: REOPEN-AMI will provide important data on the efficacy and safety of intracoronary nitroprusside and adenosine as an adjunctive treatment to percutaneous coronary intervention after thrombus aspiration for patients with acute myocardial infarction.
Application of a shortened inhaled adenosine-5'-monophosphate challenge in young children using the forced oscillation technique. [2009.07]
BACKGROUND: Adenosine-5'-monophosphate (AMP) is an indirect challenge agent thought to reflect allergic airway inflammation. The forced oscillation technique (FOT) is ideal for use in young children and is suitable for inhaled challenge studies in patients who are in this age group. We assessed the agreement between a shortened and a standard AMP challenge and the repeatability of the shortened AMP challenge using FOT as a primary outcome variable... CONCLUSIONS: We demonstrated that a shortened AMP challenge that can be applied to young children is comparable to the standard AMP challenge and is highly repeatable. Further studies in young children to assess the clinical role of a shortened AMP challenge using FOT are required.
Clinical Trials Related to Adenocard (Adenosine)
ADVANCE MPI 2: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI) [Completed]
Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to
thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately.
The investigational drug, regadenoson (CVT-3146) is a selective A2A adenosine receptor
agonist, the receptor responsible for coronary vasodilation, and is being studied for
potential use as a pharmacologic stress agent in myocardial perfusion imaging (MPI) studies.
This study will compare the safety and efficacy of regadenoson to that of Adenoscan in
detecting reversible myocardial perfusion defects.
ADVANCE MPI 1: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI) [Completed]
Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to
thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately.
The investigational drug, regadenoson (CVT-3146) is a selective A2A adenosine receptor
agonist, the receptor responsible for coronary vasodilation, and is being studied for
potential use as a pharmacologic stress agent in myocardial perfusion imaging (MPI) studies.
This study will compare the safety and efficacy of regadenoson to that of Adenoscan in
detecting reversible myocardial perfusion defects.
AMP as a Better Delivery System of Adenosine [Suspended]
Adenosine and AMP are substances normally present in the body. Adenosine is also given for
the treatment of some heart rhythm problems and may be used to reduce heart damage during
heart attacks. The problem in using adenosine is that it is taken up by cells and,
therefore, very little of the adenosine we give by vein or in the artery actually reaches the
tissue. We propose to use AMP as a way to improve delivery of adenosine. AMP is inactive by
itself, but is converted to adenosine in tissue. We hope that by giving AMP we will increase
levels of adenosine in tissue. To see if this is true, we will give either adenosine or AMP
into the forearm artery while we measure how much adenosine reaches the forearm tissue.
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia [Completed]
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral
effects by stimulation of specific adenosine receptors. taken together these effects protect
against ischaemia-reperfusion injury of (myocardial)muscles and agsinst the development of
atherosclerosis. Genetic variations in genes encoding for adenosine receptors or for enzymes
involved in the formation or breakdown of adenosine could potentially modulate these effects.
In this study, we aim to determine the functional effects of two frequent genetic
polymorphisms in the adenosine receptor and AMPdeaminase (involved in the formation of
adenosine) on the vascular effects of adenosine.
Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans? [Suspended]
We are studying the affect of caffeine on the sensitivity of detecting coronary artery
disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is
a drug used routinely in patients to relax heart blood vessels in order to assess for the
presence of coronary artery disease. Often, if patients have had caffeine, the adenosine
scan is not used because of the belief that caffeine may reduce the ability to detect
coronary artery disease. We would like to test whether caffeine affects our ability to
detect coronary artery disease with adenosine tracer scanning. We will perform an imaging
study of the heart with adenosine after you have received caffeine.
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