NEWS HIGHLIGHTSMedia Articles Related to Adcirca (Tadalafil)
Adcirca Approved for Lung Disorder
Source: MedicineNet tadalafil Specialty [2009.05.27]
Title: Adcirca Approved for Lung Disorder
Category: Health News
Created: 5/27/2009 7:00:00 AM
Last Editorial Review: 5/27/2009
Effects Of Once-Daily Tadalafil On Erectile Function In Men With Erectile Dysfunction And Signs And Symptoms Of Benign Prostatic Hyperplasia
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2009.07.12]
UroToday.com - Men with benign prostatic hyperplasia (BPH) often suffer from lower urinary tract symptoms (LUTS; BPH-LUTS) such as urinary frequency, urgency, intermittency, nocturia, straining, incomplete emptying, or weak urinary stream. BPH-LUTS and erectile dysfunction (ED), both highly prevalent conditions in aging men, are frequently associated in the same men, may have common pathophysiological mechanisms, and contribute negatively to quality of life.
Tadalafil (Cialis) In The Treatment Of Erectile Dysfunction
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2009.05.30]
UroToday.com - This updated review of tadalafil (Cialis), one of the three available phosphodiesterase type 5 (PDE5) inhibitors that revolutionized the treatment of erectile dysfunction (ED), analyzes its latest clinical studies. Tadalafil's most unique and identifying characteristic is its long half-life of 17.5 hours, compared with 4 hours for sildenafil (Viagra) and vardenafil (Levitra).
Study Reported Tadalafil Taken Once Daily Improved Erectile Function In Men With ED And Sexual Quality Of Life In Couples
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2009.05.07]
Eli Lilly and Company (NYSE: LLY) announced results from a double-blind, placebo-controlled study which showed that tadalafil 5 mg dose taken once daily was generally well-tolerated, improved erectile function for men with erectile dysfunction (ED) and reported improvement in the sexual quality of life scores for men and their female partners.
Published Studies Related to Adcirca (Tadalafil)
Randomized Placebo-Controlled Crossover Trial of Tadalafil in Raynaud's Phenomenon Secondary to Systemic Sclerosis. [2009.10]
OBJECTIVE: Raynaud's phenomenon (RP) is an important clinical feature of systemic sclerosis (SSc) for which consistently effective therapies are lacking. The study was designed to assess the safety, tolerability, and efficacy of tadalafil, a selective, long acting type V cyclic GMP phosphodiesterase (PDE-5) inhibitor, in this clinical syndrome... CONCLUSION: Tadalafil appears to be safe and well tolerated but lacks efficacy in comparison to placebo as a treatment for RP secondary to SSc.
[Chronic PDE-5 inhibition in patients with erectile dysfunction : New treatment approach using once daily Tadalafil.] [2009.09.09]
Erectile dysfunction (ED) is often associated with increased cardiovascular risk. There is increasing evidence suggesting that dysfunction of the vascular endothelium with reduced bioavailability of nitric oxide (NO) may be the pathogenetic link between ED and cardiovascular disease... Interestingly in a pilot study of on-demand versus chronic administration of Tadalafil for 4 weeks, only regular dosing improved several markers of endothelial function.
Dexamethasone but not tadalafil improves exercise capacity in adults prone to high-altitude pulmonary edema. [2009.08.15]
RATIONALE: Whether pulmonary hypertension at high altitude limits exercise capacity remains uncertain. OBJECTIVES: To gain further insight into the pathophysiology of hypoxia induced pulmonary hypertension and the resulting reduction in exercise capacity, we investigated if the reduction in hypoxic pulmonary vasoconstrictive response with corticosteroids or phosphodiesterase-5 inhibition improves exercise capacity... CONCLUSIONS: Corticosteroids, but not phosphodiesterase-5 inhibition, partially prevented the limitation of exercise capacity in subjects with intense hypoxic pulmonary vasoconstriction at high altitude.
Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily. [2009.07]
An efficacy study of tadalafil (5 mg once daily) for treating erectile dysfunction included sexual satisfaction and psychosocial outcome measures such as Treatment satisfaction (THX) domain of Sexual Life Quality Questionnaire, Self-Esteem And Relationship (SEAR) questionnaire, Sexual Encounter Profile questions 4 (SEP4; hardness satisfaction) and 5 (SEP5; overall satisfaction), intercourse satisfaction (IS) and overall satisfaction (OS) domains of International Index of Erectile Function (IIEF), and partner SEP question 3 (pSEP3)...
Impact on erectile function and sexual quality of life of couples: a double-blind, randomized, placebo-controlled trial of tadalafil taken once daily. [2009.05]
CONCLUSIONS: Tadalafil 5 mg once daily significantly improved EF and sexual quality of life for men with ED. In addition, the sexual quality of life of the female partners of the men treated with tadalafil was significantly improved.
Clinical Trials Related to Adcirca (Tadalafil)
Effect of Tadalafil Once a Day in Men With Erectile Dysfunction [Recruiting]
The primary aim of this study is to assess the efficacy and safety of tadalafil 5 mg
administered once a day in subjects with erectile dysfunction (ED) who are naïve to PDE5
(phosphodiesterase type 5) inhibitors. Patients may be dose reduced to 2. 5mg based on
tolerability
A Trial of Tadalafil in Patients With Squamous Cell Carcinoma of the Upper Aero Digestive Tract [Recruiting]
The purpose of this trial is to determine whether or not Cialis (tadalafil) administered to
head and neck squamous cell cancer patients augments immune response.
Tadalafil in Treating Patients Undergoing Surgery for Cancer of the Oral Cavity or Oropharynx [Recruiting]
RATIONALE: Biological therapies, such as tadalafil, may stimulate the immune system in
different ways and stop tumor cells from growing.
PURPOSE: This randomized clinical trial is studying how well tadalafil works in treating
patients who are undergoing surgery for cancer of the oral cavity or oropharynx.
Tadalafil for the Treatment of Raynaud's [Recruiting]
The investigators propose that tadalafil will increase digital blood flow and improve the
symptoms and signs of secondary Raynaud's phenomenon.
Multinational Study to Evaluate Tadalafil in Asian Men With of Benign Prostatic Hyperplasia [Recruiting]
This study is a Randomized, Double Blind, Placebo and Tamsulosin Controlled, Parallel
Design, Multinational Study to Evaluate the Efficacy and Safety of Tadalafil Once a day
Dosing for 12 weeks in Asian Men With Signs and Symptoms of Benign Prostatic Hyperplasia
(BPH)
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