Published Studies Related to Adalat CC (Nifedipine)
Effect of nifedipine on choroidal blood flow regulation during isometric
healthy subjects... CONCLUSIONS: In conclusion, the data of the present study suggest that nifedipine
Comparison of the efficacy of nifedipine and hydralazine in hypertensive crisis in pregnancy. [2011.11]
Intravenous hydralazine is a commonly administered arteriolar vasodilator that is effective for hypertensive emergencies associated with pregnancy...
Adjuvant Tamsulosin or Nifedipine After Extracorporeal Shock Wave Lithotripsy for Renal Stones: A Double Blind, Randomized, Placebo-controlled Trial. [2011.11]
OBJECTIVE: To evaluate the effects of the adjuvant use of tamsulosin or nifedipine after extracorporeal shock wave lithotripsy for nonlower pole kidney stones 5-20 mm in size... CONCLUSION: The stone-free rates after extracorporeal shock wave lithotripsy with adjuvant tamsulosin or nifedipine were significantly increased only for nonlower pole renal stones 10-20 mm in size compared with placebo. Nifedipine was associated with more adverse effects than placebo. Copyright A(c) 2011 Elsevier Inc. All rights reserved.
Effect of nifedipine on anorectal sensorimotor functions in health and fecal incontinence. [2011.07]
The mechanisms of increased rectal stiffness in women with fecal incontinence (FI) and rectal urgency are not understood. Our hypothesis was that distention-induced activation of mechanosensitive L-type calcium channels in smooth muscle contributes to increased rectal stiffness in FI...
A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic. [2011.07]
OBJECTIVE: * To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic... CONCLUSIONS: * Administration of tamsulosin and nifedipine in MET was determined to be safe and effective for distal ureteric stones with renal colic. * Tamsulosin was significantly better than nifedipine in relieving renal colic and facilitating ureteric stone expulsion. (c) 2010 THE AUTHORS. BJU INTERNATIONAL (c) 2010 BJU INTERNATIONAL.
Clinical Trials Related to Adalat CC (Nifedipine)
Effects of Adalat LA and Coracten on Drug Levels, Blood Pressure, and Heart Rate in Fed Patients With Hypertension [Completed]
This study compares the effect of Adalat LA to Coracten on drug levels as well as changes in
blood pressure and heart rate in fed hypertensive subjects. Subjects are dosed with either
Adalat or Coracten for first 2 weeks, followed by the other drug for 2 weeks, and then
switched back to the original drug for one day. Blood samples, blood pressure, and heart
rate are taken before and after each treatment period.
The Pharmacokinetics of Nifedipine Controlled Release Tablets in Hypertensive Patients on Hemodialysis [Not yet recruiting]
This is a prospective, open, non-randomized, non-controlled study. 20 patients with
hypertension on chronic maintenance hemodialysis will be enrolled in the study. All patients
had mild to moderate hypertension and are receiving antihypertensive agents.
This study was designed to investigate effects of Adalat GITS on hemodialytic blood
pressures in patients with chronic hemodialysis by using ABPM and measuring the drug plasma
concentrations. For the purpose of investigating the influence of hemodialysis on the drug
plasma concentration as well as its efficacy, it should be necessary to assign the subjects
with the Adalat monotherapy. Since most patients in the hemodialysis center will be those
who need and already receive combination therapy, it would be practical to start Adalat
60mg/day monotherapy to remain similar antihypertensive effect when discontinuing the
previous treatment in this study population to be screened and enrolled. And taking into
the consideration of clinical practice, few patients undergoing hemodialysis could be well
controlled by low dose Adalat 30mg/day alone. So this study will evaluate the effect and
safety of Adalat GITS 60mg/day alone and thereafter the influence of hemodialysis on the
drug plasma concentration without any other possible drug interaction. The agents are given
orally once a day at 08: 00h and patients are followed for at least 4 weeks. After that,the
patients whose blood pressure are well controlled by Adalat GITS 60mg/day by office blood
pressure would be enrolled for further ABPM assessment and plasma concentration evaluation.
Low-dose Nifedipine-Valsartan Combination Compared to Up-titrated Valsartan Monotherapy in Essential Hypertension [Recruiting]
This will be a multi-center, prospective, randomized, open-label, parallel design, two arm
comparator trial. In the proposed study, the investigators will compare low-dose combination
therapy of Nifedipine GITS/OROS plus Valsartan with up-titrated monotherapy of Valsartan
with respect to their blood pressure-decreasing effects in patients with essential
hypertension. The study consists of a screening visit, followed by randomization and
administration of either Nifedipine GITS/OROS 30 mg in combination with Valsartan 80 mg or
Valsartan 160 mg for 12 weeks of treatment. The primary efficacy parameters will be mean SBP
and DBP on office BP monitoring at 12 weeks of treatment compared to baseline.
An Open Label Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing in Human Subjects [Recruiting]
This is an open label study. The study will consist of 1 treatment group: coated Nifedipine
suppository containing 12 mg of Nifedipine, administered BID to subjects with chronic anal
Study of Nifedipine GITS and Candesartan Combination Compared to Monotherapy in Patients With Essential Hypertension [Recruiting]
The purpose of this study is to determine the blood pressure lowering responses of various
dose combinations of nifedipine GITS and candesartan as compared to treatment with each
component on their own (monotherapy) and placebo (a look-alike tablet without active
ingredient). The drugs - nifedipine GITS and candesartan - which are being investigated are
currently approved for use in patients with essential hypertension alone or together with
other antihypertensive drugs (combination therapy), but the optimal dose of nifedipine GITS
and candesartan used together in the treatment of essential hypertension has not been
established yet. In this study patients will be treated with various doses of nifedipine
GITS and/or candesartan or placebo. These different regimes will be administered once a day
and will be assessed based on their blood pressure lowering effects (mean sitting diastolic
blood pressure) in subjects with mild to moderate essential hypertension.
Reports of Suspected Adalat CC (Nifedipine) Side Effects
White Blood Cell Count Decreased (4),
Fluid Retention (3),
Altered State of Consciousness (3),
Drug Ineffective (2),
Cardiac Disorder (2),
Feeling Hot (2),
Malabsorption (2), more >>