Adagen (Pegademase Bovine) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

There are no known drug interactions with ADAGEN ^® (pegademase bovine) Injection. However, Vidarabine is a substrate for ADA and 2'-deoxycoformycin is a potent inhibitor of ADA. Thus, the activities of these drugs and ADAGEN ^® (pegademase bovine) Injection could be substantially altered if they are used in combination with one another.

OVERDOSAGE

There is no documented experience with ADAGEN ^® (pegademase bovine) Injection overdosage. An intraperitoneal dose of 50,000 U/kg of ADAGEN ^® (pegademase bovine) Injection in mice resulted in weight loss up to 9%.

CONTRAINDICATIONS

There is no evidence to support the safety and efficacy of ADAGEN ^® (pegademase bovine) Injection as preparatory or support therapy for bone marrow transplantation. Since ADAGEN ^® (pegademase bovine) Injection is administered by intramuscular injection, it should be used with caution in patients with thrombocytopenia and should not be used if thrombocytopenia is severe.