® Gel, 5%, contains dapsone, a sulfone, in an aqueous gel base for topical dermatologic use. ACZONE
® Gel, 5% is a gritty translucent material with visible drug substance particles.
® Gel, 5%, is indicated for the topical treatment of acne vulgaris.
Media Articles Related to Aczone (Dapsone Topical)
What's New in Acne and Rosacea
Source: Medscape Dermatology Headlines [2016.04.29]
Dr Hillary Baldwin summarizes the latest acne and rosacea news from the 2016 American Academy of Dermatology meeting.
Pregnancy Prevention Program in Acne Drug Users Ineffective
Source: Medscape Dermatology Headlines [2016.04.26]
Results suggest one or two children are born each year with birth defects related to isotretinoin and subpar contraceptive use.
Medscape Medical News
Contraception Safety Program for Acne Drug Failing in Canada
Source: MedicineNet Acne Specialty [2016.04.26]
Title: Contraception Safety Program for Acne Drug Failing in Canada
Category: Health News
Created: 4/25/2016 12:00:00 AM
Last Editorial Review: 4/26/2016 12:00:00 AM
Pregnancy guidelines for harmful acne drug not adhered to by many women
Source: Pregnancy / Obstetrics News From Medical News Today [2016.04.25]
A new study suggests around 30-50 percent of women who use the acne drug isotretinoin do not adhere to current pregnancy prevention guidelines.
Acne Drug: FDA Advisors Recommend OTC Adapalene
Source: MedPage Today Dermatology [2016.04.15]
(MedPage Today) -- Panel votes 16-0 that the drug is safe for use without a prescription.
Published Studies Related to Aczone (Dapsone Topical)
Erosive pustular dermatosis of the scalp: A review with a focus on dapsone therapy. [2011.11.08]
CONCLUSION: Our observations demonstrate topical dapsone 5% gel to be a novel, safe, and efficacious therapeutic alternative for mild to moderate EPDS. Copyright (c) 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Hematologic safety of dapsone gel, 5%, for topical treatment of acne vulgaris. [2008.12]
OBJECTIVE: To evaluate the risk of hemolysis in subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency who were treated for acne vulgaris with either dapsone gel, 5% (dapsone gel), or vehicle gel... CONCLUSIONS: After treatment with dapsone gel, 5%, no clinical or laboratory evidence of drug-induced hemolytic anemia was noted in G6PD-deficient subjects with acne vulgaris. Trial Registration clinicaltrials.gov Identifier: NCT00243542.
Efficacy and safety of dapsone gel 5% for the treatment of acne vulgaris in adolescents. [2008.02]
Two 12-week, randomized, vehicle-controlled... Results from the large number of adolescent participants in these 3 studies show that dapsone gel is an effective and safe topical therapy for the treatment of acne vulgaris in adolescents aged 12 to 15 years for up to 12 months.
Dapsone gel 5% for the treatment of acne vulgaris: safety and efficacy of long-term (1 year) treatment. [2007.10]
Dapsone gel 5%, a topical formulation of dapsone, was shown to deliver clinically effective doses of dapsone with minimal systemic absorption in 2 randomized, vehicle-controlled, 12-week studies of patients with acne vulgaris... These results show that dapsone gel 5% is safe and effective for long-term treatment of acne vulgaris and has a rapid onset of action.
Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. [2007.03]
BACKGROUND: A new aqueous gel formulation of dapsone has been developed that allows clinically-effective doses of dapsone to be administered topically with minimal systemic absorption. OBJECTIVES: The goal of these studies was to evaluate the efficacy and safety of dapsone gel, 5% in the treatment of acne... CONCLUSIONS: Dapsone gel, 5% appears to be an effective, safe, and well-tolerated treatment for acne vulgaris, with a rapid onset of action.
Clinical Trials Related to Aczone (Dapsone Topical)
A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4% [Completed]
The purpose of this study is to compare the safety and efficacy of 5% Dapsone Topical Gel,
(DTG) twice daily in combination with once daily vehicle control, adapalene gel 0. 1% or
benzoyl peroxide gel 4%. The second objective of the study is to determine dapsone exposure
after co-administration of DTG 5% with vehicle control, adapalene or benzoyl peroxide gel.
Dapsone Gel 5% and Tretinoin Gel 0.025% Versus Tretinoin Gel 0.025% Monotherapy for Facial Acne Vulgaris [Completed]
A 12-week evaluation of the safety and efficacy of dapsone gel 5% when used with tretinoin
gel 0. 025% compared with tretinoin gel 0. 025% monotherapy in treating moderate to severe
facial acne vulgaris
Dapsone Gel 5% and Tazarotene Cream 0.1% Versus Tazarotene Cream 0.1% Monotherapy for Facial Acne Vulgaris [Completed]
A 12-week evaluation of the safety and efficacy of dapsone gel 5% when used with tazarotene
cream 0. 1% compared with tazarotene cream 0. 1% monotherapy in treating moderate to severe
facial acne vulgaris
Reports of Suspected Aczone (Dapsone Topical) Side Effects
Drug Ineffective (17),
Completed Suicide (4),
LIP Swelling (2),
Expired Drug Administered (2),
Hypoaesthesia Oral (2),
Oedema Peripheral (2),
Swelling Face (2), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Aczone has an overall score of 8. The effectiveness score is 8 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
Aczone review by 48 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Considerably Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || acne|
|Dosage & duration:|| || 5% (dosage frequency: twice a day) for the period of three months so far|
|Other conditions:|| || possible mild rosacea|
|Other drugs taken:|| || none|
|Benefits:|| || improve cystic acne on chin -- I still get a few bumps but not as many or as violent as before the treatment.|
|Side effects:|| || perhaps a little dryness but I cannot say that this was a problem at all.|
|Comments:|| || I have tried many prescription and nonprescription medications for adult acne. This one worked as well as any of them with less irritation. While I was using the medication to treat cystic acne I also saw a significant improvement is white heads and black heads. White heads on my forehead virtually disappeared. |
Page last updated: 2016-04-29