NEWS HIGHLIGHTSMedia Articles Related to Acyclovir
valacyclovir - oral, Valtrex
Source: MedicineNet Genital Herpes In Women Specialty [2011.09.21]
Title: valacyclovir - oral, Valtrex
Category: Medications Second Source
Created: 3/2/2005 12:00:00 AM
Last Editorial Review: 9/21/2011 12:00:00 AM
Acyclovir
Source: MedicineNet acyclovir Specialty [2011.04.27]
Title: Acyclovir
Category: Medical Dictionary
Created: 7/31/2004 12:00:00 AM
Last Editorial Review: 4/27/2011 5:27:15 PM
Published Studies Related to Acyclovir
Oral acyclovir suppression and neurodevelopment after neonatal herpes. [2011.10.06]
BACKGROUND: Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors of neonatal herpes simplex virus (HSV) disease... CONCLUSIONS: Infants surviving neonatal HSV disease with CNS involvement had improved neurodevelopmental outcomes when they received suppressive therapy with oral acyclovir for 6 months. (Funded by the National Institute of Allergy and Infectious Diseases; CASG 103 and CASG 104 ClinicalTrials.gov numbers, NCT00031460 and NCT00031447, respectively.).
The effects of daily distress and personality on genital HSV shedding and lesions in a randomized, double-blind, placebo-controlled, crossover trial of acyclovir in HSV-2 seropositive women. [2011.10]
Herpes simplex virus (HSV) infections are ubiquitous in humans, but the determinants of clinical and virologic severity are not completely understood.
Patterns of herpes simplex virus shedding over 1 month and the impact of acyclovir and HIV in HSV-2-seropositive women in Tanzania. [2011.08]
OBJECTIVES: Few studies have examined the frequency and duration of genital herpes simplex virus (HSV) shedding in sub-Saharan Africa. This study describes HSV shedding patterns among a sample of HSV-2-seropositive women enrolled in a placebo-controlled trial of HSV suppressive therapy (acyclovir 400 mg twice a day) in Tanzania... CONCLUSIONS: HSV shedding was common, varying greatly by individual. Shedding rates were similar to studies in African and non-African settings. Among HIV-negative women, shedding rates were lower in the acyclovir arm; however, acyclovir did not substantially impact on HSV shedding in HIV-positive women.
Lack of a pharmacokinetic interaction between steady-state tipranavir/ritonavir and single-dose valacyclovir in healthy volunteers. [2011.03]
OBJECTIVE: This study assessed the single-dose pharmacokinetics of the herpes antiviral acyclovir (administered as the pro-drug valacyclovir) alone and in combination with twice-daily 200 mg ritonavir-boosted tipranavir (500 mg) at steady state... CONCLUSIONS: When administered as a single dose of valacyclovir with steady-state tipranavir/ritonavir, there were no clinically important changes in acyclovir pharmacokinetics. This result indicates that valacyclovir can be co-administered safely with no dose adjustments.
A randomized, double-blind, placebo-controlled trial of valacyclovir prophylaxis to prevent zoster recurrence from months 4 to 24 after BMT. [2011.02]
Reactivation of latent VZV remains a significant cause of morbidity after SCT. Twenty-five percent or more of patients undergoing SCT will experience zoster within the first year after transplant... Adverse events resulting in discontinuation were more frequent in the placebo group (5 of 26 vs 3 of 27 for placebo and study drug, respectively).
Clinical Trials Related to Acyclovir
Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS) [Completed]
To evaluate the safety of topically applied SP-303 gel and to compare the efficacy of SP-303
gel in combination with acyclovir, relative to acyclovir alone, for the treatment of
recurrent Herpes Simplex Virus (HSV) 1 and 2 infections, affecting the genital, perianal and
neighboring areas, in patients with AIDS.
A Study to Describe the Pharmacokinetics of Acyclovir in Premature Infants (PTN_Acyclo) [Recruiting]
Acyclovir is a drug used to treat herpes simplex virus (HSV) infections in babies.
Appropriate dosing of acyclovir is known for adults and children but acyclovir has not been
adequately studied in full-term or premature neonates. HSV is a very serious infection in
babies <6 months of age and often results in death or profound mental retardation. HSV
leads to profound mental retardation in young infants because the virus attacks the central
nervous system.
The investigators hypothesize that the currently recommended dose of acyclovir is inadequate
to produce adequate blood levels to combat herpes simplex infection. The investigators
propose to study acyclovir levels in the blood of babies who are placed on acyclovir to
treat a suspected HSV infection. This will allow them to determine the appropriate dose in
premature infants. This is an unmet public health need because it is likely that the drug
behaves differently in premature infants than it does in term infants and older children.
Premature babies have more body water and less body tissue. Their kidneys are more immature
and do not function as well as full term infants. Premature neonates are also at the
greatest risk from herpes infection because they have poorly functioning immature immune
systems. Early and appropriate treatment with acyclovir has resulted in improved outcome in
term infants.
A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand [Completed]
Herpes infection is an important co-factor in HIV transmission. A recent meta-analysis
demonstrated that HSV infection contributed to a 2-fold increased risk of HIV transmission.
Suppressive therapy with acyclovir has been a method proposed to reduce HIV transmission. We
are conducting a randomized controlled cross-over trial to evaluate the effect of acyclovir
suppressive therapy on HIV genital shedding in women co-infected with HIV-1 and Herpes
Simplex Virus Type-2 (HSV-2) in Thailand.
Effectiveness of Acyclovir in Suppressing HIV Viral Load in Women Coinfected With HIV and Herpes Simplex Virus Type 2 (HSV-2) [Recruiting]
The purpose of this study is to determine whether acyclovir is effective in suppressing HIV
viral load in women infected with both HIV-1 and herpes simplex virus type 2 (HSV-2) who are
starting HIV treatment for the first time.
Iontophoretic Application of Acyclovir Cream to Treat Recurrent Herpes Labialis [Completed]
Currently approved drugs for the treatment of herpes labialis (cold sores) exhibit low levels
of efficacy due to the limited ability of the drugs to penetrate the skin to the site where
the herpes virus is replicating. Iontophoresis uses electric current to enhance the delivery
of drugs through the skin. This trial is testing a new iontophoretic device for the delivery
of acyclovir cream to treat cold sores.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 12 ratings/reviews, Acyclovir has an overall score of 9. The effectiveness score is 9.17 and the side effect score is 9. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Acyclovir review by 26 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | cold sores |
| Dosage & duration: | | 400 mg taken twice a day for the period of 1 year |
| Other conditions: | | NA |
| Other drugs taken: | | NA | | |
Reported Results |
| Benefits: | | My whole lip used to swell up and I would get over a dozen little pockets of fluid that would merge into one giant blister. Now, cold sores appear 1/2 as often as before - down to every other month at most. One or two little pockets of fluid usually appear without the unsightly swelling. The cold sore is dried up within 24 hrs. They became unnoticeable to everyone. |
| Side effects: | | I had to take it with food or I would get a little upset stomach. |
| Comments: | | I have been taking Acyclovir daily for 1 year so far and will continue as long as my doctor allows me to. |
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| | Acyclovir review by 31 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Cold sore |
| Dosage & duration: | | 5% (dosage frequency: 6 times a day) for the period of 3 days |
| Other conditions: | | none |
| Other drugs taken: | | Abreva, Campho-phenique | | |
Reported Results |
| Benefits: | | I was 6 days into having my very first cold sore which had since turned into TWO on the left and right sides of my bottom lip and I had already tried abreva and campho-phenique with absolutely no benefit. I thought I was going to suffer for weeks. It was so painful and kept scabbing then the scabs would fall off after drinking or taking a shower. Then I saw my dr who prescribed Zovirax ointment. I swear, the NEXT day, both cold sores were half the size and no longer "weeping". It is just about healed. This stuff works and now that I know I get cold sores, I will never be without Zovirax. Ever. |
| Side effects: | | None |
| Comments: | | Blotted lips to dry and allow the ointment stay on lips. Wash hands well before and after application. Apply a thin layer to lips 6 x per day and especially right before bed. |
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| | Acyclovir review by 43 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | herpes |
| Dosage & duration: | | don't know (dosage frequency: daily) for the period of probably a year |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | This drug did not completely eliminate outbreaks. While it may have diminished length and extent of outbreak, still had more than expected. Decided not to take any longer and had better results taking Olive Leaf extract daily |
| Side effects: | | none |
| Comments: | | prescribed as a daily preventive for herpes outbreak. |
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