Acetazolamide (Acetazolamide) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse reactions, occurring most often early in therapy, include paresthesias, particularly a "tingling" feeling in the extremities, hearing dysfunction or tinnitus, loss of appetite, taste alteration and gastrointestinal disturbances, such as nausea, vomiting and diarrhea; polyuria, and occasional instances of drowsiness and confusion.

Metabolic acidosis and electrolyte imbalance may occur.

Transient myopia has been reported. This condition invariably subsides upon diminution or discontinuance of the medication.

Other occasional adverse reactions include urticaria, melena, hematuria, glycosuria, hepatic insufficiency, flaccid paralysis, photosensitivity and convulsions. Also see PRECAUTIONS: Information for Patients for possible reactions common to sulfonamide derivatives. Fatalities have occurred although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia and other blood dyscrasias (see WARNINGS).

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO ACETAZOLAMIDE

Possible Acetazolamide side effects / adverse reactions in 64 year old female

Reported by a individual with unspecified qualification from France on 2007-01-24

Patient: 64 year old female weighing 71.0 kg (156.2 pounds)

Reactions: Abdominal Pain, Hypovolaemic Shock, Hyperkalaemia, Cholestasis, Lactic Acidosis, Somnolence, Haemodynamic Instability, Laboratory Test Abnormal, Intracardiac Thrombus, Renal Failure Acute, Nausea, Atrial Flutter, Hyponatraemia, Cell Death, Cardiogenic Shock, NO Therapeutic Response, Dehydration, Acute Hepatic Failure, Bradycardia

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Isoptin
    Dosage: 120 mg once po
    Administration route: Oral
    Indication: Atrial Tachycardia
    Start date: 2006-08-29
    End date: 2006-08-30

Acetazolamide
    Dosage: df po
    Administration route: Oral
    Indication: Diuretic Therapy

Furosemide
    Dosage: df po
    Administration route: Oral
    Indication: Diuretic Therapy
    End date: 2006-08-01

Furosemide
    Dosage: 40 mg qday po
    Administration route: Oral
    Indication: Diuretic Therapy
    Start date: 2006-08-01

Furosemide
    Dosage: df po
    Administration route: Oral
    Indication: Diuretic Therapy
    Start date: 2006-01-01

Other drugs received by patient: Fluindione; Phloroglucinol; Prednisolone; Spironolactone; Trimethylphloroglucinol; Aspirin; Potassium Chloride; Aerosol

Possible Acetazolamide side effects / adverse reactions in 65 year old female

Reported by a individual with unspecified qualification on 2007-03-01

Patient: 65 year old female

Reactions: Retinopathy, Retinal Haemorrhage, Miosis, Visual Acuity Reduced

Adverse event resulted in: hospitalization

Suspect drug(s):
Dexamethasone
    Administration route: Topical
    Indication: Angle Closure Glaucoma

Pilocarpine
    Administration route: Topical
    Indication: Angle Closure Glaucoma

Acetazolamide
    Indication: Angle Closure Glaucoma

Iopidine
    Administration route: Topical
    Indication: Angle Closure Glaucoma

Possible Acetazolamide side effects / adverse reactions in 65 year old female

Reported by a individual with unspecified qualification from United Kingdom on 2007-03-08

Patient: 65 year old female

Reactions: Retinopathy, Intraocular Pressure Decreased, Retinal Haemorrhage, Miosis, Visual Acuity Reduced

Adverse event resulted in: hospitalization

Suspect drug(s):
Dexamethasone
    Dosage: ni topical
    Administration route: Topical
    Indication: Angle Closure Glaucoma

Acetazolamide
    Dosage: ni intravenous (nos)
    Indication: Angle Closure Glaucoma

Apraclonidine
    Indication: Angle Closure Glaucoma

Pilocarpine
    Indication: Angle Closure Glaucoma