No data are available regarding AcetaZOLAMIDE overdosage in humans as no cases of acute poisoning with this drug have been reported. Animal data suggest that AcetaZOLAMIDE is remarkably nontoxic. No specific antidote is known. Treatment should be symptomatic and supportive.
Electrolyte imbalance, development of an acidotic state, and central nervous effects might be expected to occur. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.
Supportive measures are required to restore electrolyte and pH balance. The acidotic state can usually be corrected by the administration of bicarbonate.
Despite its high intraerythrocytic distribution and plasma protein binding properties, AcetaZOLAMIDE may be dialyzable. This may be particularly important in the management of AcetaZOLAMIDE overdosage when complicated by the presence of renal failure.