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Acetazolamide (Acetazolamide) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

ACETAZOLAMIDE drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

No data are available regarding AcetaZOLAMIDE overdosage in humans as no cases of acute poisoning with this drug have been reported. Animal data suggest that AcetaZOLAMIDE is remarkably nontoxic. No specific antidote is known. Treatment should be symptomatic and supportive.

Electrolyte imbalance, development of an acidotic state, and central nervous effects might be expected to occur. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.

Supportive measures are required to restore electrolyte and pH balance. The acidotic state can usually be corrected by the administration of bicarbonate.

Despite its high intraerythrocytic distribution and plasma protein binding properties, AcetaZOLAMIDE may be dialyzable. This may be particularly important in the management of AcetaZOLAMIDE overdosage when complicated by the presence of renal failure.

CONTRAINDICATIONS

AcetaZOLAMIDE therapy is contraindicated in situations in which sodium and/or potassium blood serum levels are depressed, in cases of marked kidney and liver disease or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. It is contraindicated in patients with cirrhosis because of the risk of development of hepatic encephalopathy.

Long-term administration of AcetaZOLAMIDE is contraindicated in patients with chronic noncongestive angle-closure glaucoma since it may permit organic closure of the angle to occur while the worsening glaucoma is masked by lowered intraocular pressure.

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