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Acetaminophen with Codeine (Codeine Phosphate / Acetaminophen) - Summary



Acetaminophen and codeine is supplied in tablet form for oral administration. Acetaminophen, 4'-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. Codeine phosphate, 7,8-didehydro-4,5α-epoxy-3-methoxy-17methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate, a white crystalline powder, is a narcotic analgesic and antitussive.

Acetaminophen and codeine phosphate tablets are indicated for the relief of mild to moderately severe pain.

See all Acetaminophen with Codeine indications & dosage >>


Media Articles Related to Acetaminophen with Codeine (Codeine / Acetaminophen)

Hepatocyte Growth Factor Shows Benefit for Diabetic Pain
Source: Medscape NeurologyHeadlines [2015.10.09]
The nonviral gene therapy shows higher efficacy in pain relief among patients not taking pregabalin or gabapentin.
Medscape Medical News

Combined Stimulation Improves Pain, Not Outcome, in Migraine
Source: Medscape NeurologyHeadlines [2015.10.09]
Combined stimulation alleviated pain for patients with chronic migraine but did not improve long-term functional outcomes, a new study shows.
Medscape Medical News

Long-term opioid therapy relieves chronic pain in only 20% of women
Source: Pain / Anesthetics News From Medical News Today [2015.10.09]
Women, and especially younger women, are much less likely than men to have good relief of chronic, non-cancer pain with long-term opioid use, with only one in five women reporting low levels of...

CardioBrief: Test May Allow Early Discharge of Chest Pain Patients (CME/CE)
Source: MedPage Today Cardiovascular [2015.10.09]
(MedPage Today) -- High-sensitivity cardiac troponin has "excellent" performance in Scottish study

Medical News Today: Exercise before pregnancy reduces risk of pelvic girdle pain
Source: Featured Health News from Medical News Today [2015.10.08]
Pelvic girdle pain is a common problem during pregnancy; new research shows that exercise before pregnancy can reduce the incidence of this pain.

more news >>

Published Studies Related to Acetaminophen with Codeine (Codeine / Acetaminophen)

Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than

Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. [2014]
(DEA) Schedule III narcotics... CONCLUSIONS: Both medications decreased NRS pain scores by approximately 50%.

A randomized, double-blind, placebo-controlled study of oral oxycodone plus acetaminophen for the treatment of pain in photodynamic therapy on port wine stains. [2014]
efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ┬▒ 4.58 min in

Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. [2014]
control efforts efficacy and decrease the adverse effects of each medication... CONCLUSION: Intravenous acetaminophen plus oral oxycodone is as effective as

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

more studies >>

Clinical Trials Related to Acetaminophen with Codeine (Codeine / Acetaminophen)

Effect on Acetaminophen Metabolism by Liquid Formulations [Completed]
The purpose of this study is to determine whether excipients in the liquid formulation of acetaminophen prevent the formation of the toxic metabolites of acetaminophen.

Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing [Recruiting]
A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the toxic metabolites of acetaminophen.

Acetaminophen for Cancer Pain [Recruiting]
Many patients with cancer pain have pain not fully controlled on opioids (eg. morphine). The addition of acetaminophen (Tylenol) to opioids in a small study in cancer patients demonstrated better pain control without an increase in side effects. This study will determine if regular acetaminophen improves pain control when added to strong opioids in patients with cancer pain.

Equality Study of Ofirmev vs Oral Acetaminophen [Not yet recruiting]
Acetaminophen (Tylenol) is a drug that is used commonly for relief of mild to moderate pain. It is found in many pain medicines that people take after having surgery. Narcotics are other drugs also used for pain (examples of narcotics are morphine and related pain medications). Medical science knows for a fact that acetaminophen works well when taken with narcotics for moderate to severe pain. Recently, acetaminophen has become available in an intravenous (IV) form called Ofirmev«. The IV form means that acetaminophen can be given into a vein. The benefits of getting medicine from an IV include:

- making the medicine work quickly

- less medicine having to pass through the liver to be changed into a form that your body

can process The investigators know that acetaminophen is helpful for pain relief at the time of surgery and after surgery. Acetaminophen is a very popular drug in outpatient surgery for pain control when patients go home. The patient's surgeon uses it to control pain after surgery at home in the form of Lortab or Percocet (Lortab and Percocet also have a narcotic medicine that mixes with acetaminophen). Also, currently at Surgicare, some anesthesiologists give intravenous acetaminophen while the patient is waiting to go to surgery. The investigators currently do not give any patient acetaminophen by mouth BEFORE surgery. However, since the addition of the IV form to the drug market, there has been interest to see if the oral form is just as good or better in reducing pain after surgery. This is why we are asking patients to join our study. The goal of this study is to find out if the oral form (by mouth) or the IV form (given into a vein) of acetaminophen controls pain after surgery better.

A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults [Withdrawn]
This study is being done to determine the systemic absorption of nasally inhaled acetaminophen (Tylenol«) versus orally ingested acetaminophen by comparing the serum drug concentrations of the two groups obtained at various times after study drug administration.

more trials >>

Page last updated: 2015-10-09

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