Acetaminophen and codeine is supplied in tablet form for oral administration.
Acetaminophen, 4'-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic.
Codeine phosphate, 7,8-didehydro-4,5α-epoxy-3-methoxy-17methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate, a white crystalline powder, is a narcotic analgesic and antitussive.
Acetaminophen and codeine phosphate tablets are indicated for the relief of mild to moderately severe pain.
Media Articles Related to Acetaminophen with Codeine (Codeine / Acetaminophen)
New Bill to Put 7-Day Limit on Pain Med Prescriptions
Source: Medscape Anesthesiology Headlines [2017.04.19]
Following similar action by several states, two US senators have introduced bipartisan legislation that would limit initial opioid prescription for acute pain to 7 days.
Medscape Medical News
Structural Pathology Not Related to Knee Pain and Function
Source: Medscape Anesthesiology Headlines [2017.04.19]
A new study found that structural knee pathologies were not associated with patient-reported symptoms among those undergoing arthroscopic meniscal surgery.
British Journal of Sports Medicine
Study paints somber picture of US mental health status and access to care
Source: Psychology / Psychiatry News From Medical News Today [2017.04.19]
More Americans than ever before suffer from serious psychological distress, and the country's ability to meet the growing demand for mental health services is rapidly eroding.
CardioBrief: Single Blood Test May Rapidly Rule Out MI in Chest Pain for Some Patients
Source: MedPage Today Emergency Medicine [2017.04.17]
(MedPage Today) -- New high-sensitivity troponin tests may ease perpetual ED dilemma
Spinal manipulation treatment for low back pain associated with modest improvement in pain, function
Source: Bones / Orthopedics News From Medical News Today [2017.04.14]
Among patients with acute low back pain, spinal manipulation therapy was associated with modest improvements in pain and function at up to 6 weeks, with temporary minor musculoskeletal harms...
Published Studies Related to Acetaminophen with Codeine (Codeine / Acetaminophen)
Comparison of subjective effects of extended-release versus immediate-release
oxycodone/acetaminophen tablets in healthy nondependent recreational users of
prescription opioids: a randomized trial. 
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than
Randomized clinical trial of hydrocodone/acetaminophen versus
codeine/acetaminophen in the treatment of acute extremity pain after emergency
department discharge. 
(DEA) Schedule III narcotics... CONCLUSIONS: Both medications decreased NRS pain scores by approximately 50%.
A randomized, double-blind, placebo-controlled study of oral oxycodone plus
acetaminophen for the treatment of pain in photodynamic therapy on port wine
efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ┬▒ 4.58 min in
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate
in acute bone fracture pain control: a double-blind placebo-controlled randomized
clinical trial. 
control efforts efficacy and decrease the adverse effects of each medication... CONCLUSION: Intravenous acetaminophen plus oral oxycodone is as effective as
Comparison of the efficacy and safety of dual-opioid treatment with morphine plus
oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after
total knee arthroplasty. 
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose
Clinical Trials Related to Acetaminophen with Codeine (Codeine / Acetaminophen)
Effect on Acetaminophen Metabolism by Liquid Formulations [Completed]
The purpose of this study is to determine whether excipients in the liquid formulation of
acetaminophen prevent the formation of the toxic metabolites of acetaminophen.
Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing [Recruiting]
A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating
pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to
determine if it prevents the formation of the toxic metabolites of acetaminophen.
Acetaminophen for Cancer Pain [Recruiting]
Many patients with cancer pain have pain not fully controlled on opioids (eg. morphine).
The addition of acetaminophen (Tylenol) to opioids in a small study in cancer patients
demonstrated better pain control without an increase in side effects. This study will
determine if regular acetaminophen improves pain control when added to strong opioids in
patients with cancer pain.
Equality Study of Ofirmev vs Oral Acetaminophen [Not yet recruiting]
Acetaminophen (Tylenol) is a drug that is used commonly for relief of mild to moderate pain.
It is found in many pain medicines that people take after having surgery. Narcotics are
other drugs also used for pain (examples of narcotics are morphine and related pain
medications). Medical science knows for a fact that acetaminophen works well when taken
with narcotics for moderate to severe pain. Recently, acetaminophen has become available
in an intravenous (IV) form called Ofirmev«. The IV form means that acetaminophen can be
given into a vein. The benefits of getting medicine from an IV include:
- making the medicine work quickly
- less medicine having to pass through the liver to be changed into a form that your body
can process The investigators know that acetaminophen is helpful for pain relief at the
time of surgery and after surgery. Acetaminophen is a very popular drug in outpatient
surgery for pain control when patients go home. The patient's surgeon uses it to
control pain after surgery at home in the form of Lortab or Percocet (Lortab and
Percocet also have a narcotic medicine that mixes with acetaminophen). Also, currently
at Surgicare, some anesthesiologists give intravenous acetaminophen while the patient
is waiting to go to surgery. The investigators currently do not give any patient
acetaminophen by mouth BEFORE surgery. However, since the addition of the IV form to
the drug market, there has been interest to see if the oral form is just as good or
better in reducing pain after surgery. This is why we are asking patients to join our
study. The goal of this study is to find out if the oral form (by mouth) or the IV
form (given into a vein) of acetaminophen controls pain after surgery better.
A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults [Withdrawn]
This study is being done to determine the systemic absorption of nasally inhaled
acetaminophen (Tylenol«) versus orally ingested acetaminophen by comparing the serum drug
concentrations of the two groups obtained at various times after study drug administration.