Media Articles Related to Acetaminophen with Codeine (Codeine / Acetaminophen)
Structure of key pain-related protein unveiled
Source: Pain / Anesthetics News From Medical News Today [2013.12.06]
In a technical tour de force, UC San Francisco (UCSF) scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.
Vitamin D 'reduces pain and depression' in type 2 diabetic women
Source: Depression News From Medical News Today [2013.12.05]
Type 2 diabetes has long been linked to higher risk of depression in women, and previous research has associated both of these conditions with pain. But a new study suggests that vitamin D supplementation can reduce both depression and pain in women with type 2 diabetes.
Factors that influence the choice of abused pain drugs
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2013.12.04]
Prescription opioid abuse has reached epidemic levels in the past 15 years. Scientists investigating why people favor one drug over another have found that oxycodone and hydrocodone are the drugs of choice for 75% of opioid-dependent individuals.
The daily struggle of living with chronic pain creates a 'new self'
Source: Bones / Orthopedics News From Medical News Today [2013.12.04]
People who suffer with chronic musculoskeletal pain face a daily struggle with their sense of self and find it difficult to prove the legitimacy of their condition.
Pain affects quality of life of half of older Americans
Source: Pain / Anesthetics News From Medical News Today [2013.12.04]
More than half of older adults in the United States - an estimated 18.7 million people - have experienced bothersome pain in the previous month, impairing their physical function and underscoring the need for public health action on pain. Many of those interviewed by investigators for a study published in the current issue of PAIN® reported pain in multiple areas.
Published Studies Related to Acetaminophen with Codeine (Codeine / Acetaminophen)
A randomized controlled trial comparing acetaminophen, acetaminophen and ibuprofen, and acetaminophen and codeine for postoperative pain relief after Mohs surgery and cutaneous reconstruction. [2011.07]
BACKGROUND: There are no population-based data comparing analgesics after Mohs micrographic surgery (MMS) and reconstruction. OBJECTIVE To compare the efficacy in pain management of three analgesic combinations... CONCLUSIONS: The combination of Ac+Ib is superior to Ac alone or Ac+Co in controlling postoperative pain after MMS and cutaneous reconstruction. (c) 2011 by the American Society for Dermatologic Surgery, Inc.
Analgesia with paracetamol/tramadol vs. paracetamol/codeine in one day-surgery: a randomized open study. [2011.02]
OBJECTIVES: The analgesic efficacy of two fixed combinations of tramadol/paracetamol (TP 37.5/325 mg) and codeine/paracetamol (CP 30/500 mg) was compared in 122 patients undergoing one-day surgical procedures (hallux valgus, haemorrhoidectomy, varicectomy and inguinal hernia repair), randomly treated with TP 37.5/325 mg or CP 30/500 mg one tablet after surgery ended, followed by one tablet four times daily for 48 hours... CONCLUSIONS: We conclude that a fixed association of tramadol/paracetamol is a valuable and safe tool for pain management in day hospital surgery, especially whenever any effort is done to reduce the time for hospitalization.
The influence of ondansetron on the analgesic effect of acetaminophen after laparoscopic hysterectomy. [2010.06]
The 5-HT(3) antagonists tropisetron and granisetron have been shown to block the analgesic effect of acetaminophen in healthy volunteers. To study the interaction between ondansetron and acetaminophen in women undergoing laparoscopic hysterectomy, we randomized 134 patients into three groups to receive acetaminophen-placebo (AP), acetaminophen-ondansetron (AO), or placebo-placebo (PP)...
A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. [2010.02]
OBJECTIVES: To determine the effectiveness of around-the-clock (ATC) analgesic administration, with or without nurse coaching, compared with standard care with as needed (PRN) dosing in children undergoing outpatient tonsillectomy. METHODS: Children 6 to 15 years of age were randomized to receive acetaminophen and hydrocodone (167 mg/2.5 mg/5 mL) for 3 days after surgery: Group A (N=39)-every 4 hours PRN, with standard postoperative instructions; Group B (N=34)-every 4 hours ATC, with standard postoperative instructions, without nurse coaching; and Group C (N=40)-every 4 hours ATC, with standard postoperative instructions, with coaching...
Oxycodone/acetaminophen at low dosage: an alternative pain treatment for patients with rheumatoid arthritis. [2010.01]
OBJECTIVES: To assess efficacy and safety of the association oxycodone/acetaminophen (oxycodone/acetaminophen) for pain treatment and disability improvement in patients with rheumatoid arthritis (RA)... CONCLUSION: Oxycodone/acetaminophen at low dosages for the treatment of chronic pain in RA patients can be a good alternative to non-steroidal antiinflammatory drugs (NSAIDs), allowing the reduction of their consumption, while keeping RA therapy stable.
Clinical Trials Related to Acetaminophen with Codeine (Codeine / Acetaminophen)
Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days [Completed]
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by
processing it in the liver. During the processing, some of the acetaminophen may bind to
proteins in the liver. The protein-acetaminophen product is called an "adduct". After a large
acetaminophen overdose, the liver has to process a lot of acetaminophen, so large amounts of
adducts are formed. However, we have found that lower levels may be formed even when people
take recommended doses. The purpose of this study is to measure the amount of adducts formed
when healthy people who do not drink alcohol take normal doses of acetaminophen for 10 days.
A Study of the Efficacy and Safety of Tramadol HCl/Acetaminophen, Hydrocodone Bitartrate/Acetaminophen and Placebo in Patients With Pain From an Ankle Sprain With a Partial Torn Ligament [Completed]
The purpose of this study is to explore the pain-relieving effects and safety of two
analgesic treatment regimens as compared to placebo in patients experiencing acute
musculoskeletal pain. Patients who are experiencing at least moderate acute musculoskeletal
pain from an ankle sprain severe enough to require prescription pain relief medication will
be randomized to receive either tramadol HCl/acetaminophen, hydrocodone
bitartrate/acetaminophen or placebo.
Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-Menopausal Women With Low Bone Mass [Completed]
This study will evaluate the efficacy of acetaminophen or fluvastatin in reducing the rate of
occurrence and the severity of post dose symptoms that may occur during the 3 day period
following a zoledronic acid infusion in post menopausal women with low bone mass.
The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [Completed]
Aspirin is a medication commonly used to relieve minor pains. Aspirin has also been used to
prevent heart attacks and strokes. Aspirin, however, can also cause damage to the stomach
and/or intestinal lining leading to the development of erosions ("small sores") and/or ulcers
("large sores"). Erosions may cause bleeding ("bleeding ulcers") and/or perforations ("holes
in the stomach"). Acetaminophen, often referred by the brand name, Tylenol, is also used to
treat minor pains but is not commonly recognized to cause damage to the stomach lining.
Many patients often take both of these medications together. While the effects on the
stomach lining of each medication, when used alone, are known, the effects of both
medications, when used together, are not.
The purpose of this study is to show whether or not the collective effects of both aspirin
and acetaminophen, when used together, increase the damage on the stomach lining when
compared to either medication alone.
Acetaminophen-Protein Adduct Resolution [Recruiting]
The purpose of this study is to better understand the pharmacokinetics of acetaminophen and
further clinical interpretations of laboratory results that confirm the presence of
acetaminophen-cys adducts. This study will determine how long adducts persist in serum after
a therapeutic course of acetaminophen as taken in a previous study (COMIRB 06-1265).
Subjects will be asked to complete three study visits, each three days apart, following
termination of COMIRB 06-1265. Each study visit will include collection of blood samples for
batch testing of aminotransferase, serum acetaminophen and protein adducts. No interventions