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Aceon (Perindopril Erbumine) - Indications and Dosage




ACEON is indicated for the treatment of patients with essential hypertension. ACEON may be used alone or given with other classes of antihypertensives, especially thiazide diuretics.

Stable Coronary Artery Disease

ACEON is indicated for treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction. ACEON can be used with conventional treatment for management of coronary artery disease, such as antiplatelet, antihypertensive or lipid-lowering therapy.



Use in Uncomplicated Hypertensive Patients:  In patients with essential hypertension, the recommended initial dose is 4 mg once a day. The dose may be titrated, as needed to a maximum of 16 mg per day. The usual maintenance dose range is 4 mg to 8 mg administered as a single daily dose or in two divided doses.

Use in Elderly Patients:  The recommended initial daily dosage of ACEON for the elderly is 4 mg daily, given in one or two divided doses. Experience with ACEON is limited in the elderly at doses exceeding 8 mg. Dosages above 8 mg should be administered with careful blood pressure monitoring and dose titration [see Use in Specific Populations ].

Use with Diuretics:  In patients who are currently being treated with a diuretic, symptomatic hypotension can occur following the initial dose of ACEON. Consider reducing the dose of diuretic prior to starting ACEON [see Drug Interactions].

Stable Coronary Artery Disease

In patients with stable coronary artery disease, ACEON should be given at an initial dose of 4 mg once daily for 2 weeks, and then increased as tolerated, to a maintenance dose of 8 mg once daily. In elderly patients (greater than 70 years), ACEON should be given as a 2 mg dose once daily in the first week, followed by 4 mg once daily in the second week and 8 mg once daily for maintenance dose if tolerated.

Dose Adjustment in Renal Impairment and Dialysis

Perindoprilat elimination is decreased in renally impaired patients. ACEON is not recommended in patients with creatinine clearance <30 mL/min. For patients with lesser degrees of impairment, the initial dosage should be 2 mg/day and dosage should not exceed 8 mg/day. During dialysis, perindopril is removed with the same clearance as in patients with normal renal function.


Tablets are oblong with a score on one side.

2 mg tablet is white and debossed on the unscored side with "ACN 2".

4 mg tablet is pink and debossed on the unscored side with "ACN 4".

8 mg tablet is salmon and debossed on the unscored side with "ACN 8".


Tablets are oblong with a score on one side.

Tablets Appearance NDC (Bottles of 100)
2 mg White, debossed "ACN 2" on unscored side NDC 76234-000-01
4 mg Pink, debossed "ACN 4" on unscored side NDC 76234-001-01
8 mg Salmon-colored, debossed "ACN 8" on unscored side NDC 76234-002-01

Keep out of the reach of children.

Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. Protect from moisture.

For further information, please call our medical communications department toll-free 1-800-718-9884.

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