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Aceon (Perindopril Erbumine) - Summary

 
 



PRINCIPAL DISPLAY PANEL - 8 mg Tablet

NDC 78234-002-01

100 Tablets

ACEON®
(perindopril erbumine) Tablets
8 mg

Rx only
Keep out of the reach of children

WARNING: FETAL TOXICITY

  • When pregnancy is detected, discontinue ACEON as soon as possible. (5.4)
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (5.4)
 

ACEON SUMMARY

ACEON® (perindopril erbumine) Tablets contain the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

Hypertension

ACEON is indicated for the treatment of patients with essential hypertension. ACEON may be used alone or given with other classes of antihypertensives, especially thiazide diuretics.

Stable Coronary Artery Disease

ACEON is indicated for treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction. ACEON can be used with conventional treatment for management of coronary artery disease, such as antiplatelet, antihypertensive or lipid-lowering therapy.


See all Aceon indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Aceon (Perindopril Erbumine)

Bioequivalence study of two perindopril erbumine tablet formulations in healthy volunteers. [2011]
The present study was performed to compare the bioavailability of two perindopril erbumine (CAS 107133-36-8) 4 mg tablet formulations (test formulation and reference formulation). This study was a randomized, single-blind, two-period, two-sequence cross-over study which included 20 healthy adult male and female subjects under fasting conditions...

Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease. [2010.12]
CONCLUSION: The treatment benefits of a routine administration of a fixed combination of perindopril-indapamide to patients with type 2 diabetes on cardiovascular and renal outcomes, and death, are consistent across all stages of CKD at baseline. Absolute risk reductions are larger in patients with CKD highlighting the importance of blood pressure-lowering in this population.

Cost-effectiveness of lowering blood pressure with a fixed combination of perindopril and indapamide in type 2 diabetes mellitus: an ADVANCE trial-based analysis. [2010.09.20]
OBJECTIVE: To determine the cost-effectiveness of routine administration, irrespective of blood pressure (BP), of a fixed-dose combination of perindopril and indapamide to patients with type 2 diabetes mellitus... CONCLUSION: The combination of perindopril and indapamide in patients with type 2 diabetes appears to be cost-effective. TRIAL REGISTRATION: United States National Library of Medicine NCT00145925.

The effect of treatment based on a diuretic (indapamide) +/- ACE inhibitor (perindopril) on fractures in the Hypertension in the Very Elderly Trial (HYVET). [2010.09]
BACKGROUND: fractures may have serious implications in an elderly individual, and fracture prevention may include a careful choice of medications. DESIGN: the Hypertension in the Very Elderly Trial (HYVET) was a double-blind placebo-controlled trial of a thiazide-like diuretic (indapamide 1.5 mg SR) with the optional addition of the angiotensin-converting enzyme (ACE) inhibitor (perindopril 2-4 mg). Fracture was a secondary end point of the trial. SETTING: HYVET recruited participants from Eastern and Western Europe, China, Australasia, and Tunisia. SUBJECTS: all participants were > or =80 years of age and hypertensive... CONCLUSIONS: despite the lowering of blood pressure, treatment with a thiazide-like diuretic and an ACE inhibitor does not increase and may decrease fracture rate.

The angiotensin-converting enzyme inhibitor perindopril treatment alters cardiovascular and subjective effects of methamphetamine in humans. [2010.08.30]
A variety of medications have been assessed for their potential efficacy for the treatment of methamphetamine dependence... There were significant perindoprilmethamphetamine interactions for diastolic blood pressure and for ratings of "Any Drug Effect", indicating inverted U dose-effect functions for these indices.

more studies >>

Clinical Trials Related to Aceon (Perindopril Erbumine)

Bioequivalence Study of Two Formulations of Perindopril 4 mg Tablet Under Fasting Condition [Completed]
The objective of this study was to find out whether the bioavailability of PT Dexa Medica's formulation of 4 mg perindopril tert-butylamine tablets was equivalent to that of the innovator's product (Prexum 4 mg, Servier).

Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease [Recruiting]
The aim of this current study was to assess the therapeutic effects of perindopril and telmisartan for hypertensive patients with NAFLD and make comparison between the therapeutic effects of these two kind of drugs. This study is a randomized parallel control clinical trial which would be carried out in Nanfang Hospital, Southern Medical University. About one hundred and eighty patients would be randomly assigned to perindopril,telmisartan and amlodipine three groups.

Efficacy of Perindopril to Prevent Recurrence of Atrial Fibrillation in Patients With Essential Hypertension [Active, not recruiting]
The purpose of this 7- to 13-month study is to determine the efficacy of 8 mg/day oral perindopril to prevent the recurrence of atrial fibrillation (AF) in patients with essential hypertension.

An ACE Inhibitor (Perindopril) or an Angiotensin Receptor Blocker (Candesartan) as a Treatment for Methamphetamine Dependence [Recruiting]
The primary objective is to determine the dose dependent effects of treatment with perindopril on methamphetamine (MA)-induced craving and on the reinforcing effects of MA indexed by MA self-administration. We will also determine the effects of treatment with candesartan on MA-induced craving and on the reinforcing effects of MA indexed by MA self-administration.

Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease [Not yet recruiting]
The purpose of this study is to compare the effect of valsartan and perindopril on HOMA-IR Index in patients with chronic kidney disease.

more trials >>

Reports of Suspected Aceon (Perindopril Erbumine) Side Effects

Drug Ineffective (17)Fatigue (13)Dizziness (13)Blood Pressure Increased (12)Nausea (11)Dyspnoea (10)Diarrhoea (10)Drug Interaction (9)Renal Failure Acute (9)Cough (8)more >>


Page last updated: 2011-12-09

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