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Aceon (Perindopril Erbumine) - Summary

 

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USE IN PREGNANCY

When used in pregnancy, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, ACEON® Tablets should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.

 

ACEON SUMMARY

ACEON®
(perindopril erbumine) Tablets

ACEON® (perindopril erbumine) Tablets is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

ACEON® (perindopril erbumine) Tablets is indicated for the treatment of patients with essential hypertension. ACEON® Tablets may be used alone or given with other classes of antihypertensives, especially thiazide diuretics.

When using ACEON® Tablets, consideration should be given to the fact that another angiotensin converting enzyme inhibitor (captopril) has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease. Available data are insufficient to determine whether ACEON® Tablets has a similar potential. (See WARNINGS.)

In considering use of ACEON® Tablets, it should be noted that in controlled trials ACE inhibitors have an effect on blood pressure that is less in black patients than in nonblacks. In addition, it should be noted that black patients receiving ACE inhibitor monotherapy have been reported to have a higher incidence of angioedema compared to nonblacks. (See WARNINGS: Head and Neck Angioedema .)

ACEON NEWS HIGHLIGHTS

Published Studies Related to Aceon (Perindopril Erbumine)

Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. [2007.10.09]

Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial. [2007.10.03]

Effect of perindopril on coronary remodelling: insights from a multicentre, randomized study. [2007.10]

Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. [2007.09.08]

Perindopril preventive treatment on mortality in Duchenne muscular dystrophy: 10 years' follow-up. [2007.09]

more>>

Clinical Trials Related to Aceon (Perindopril Erbumine)

Study to Determine the Efficacy of Perindopril to Prevent the Recurrence of Atrial Fibrillation in Patients With Essential Hypertension [Not yet recruiting]

Cardiovascular Response and Adverse Events Associated With Perindopril in Treating Methamphetamine Dependent Individuals - 1 [Recruiting]

Angiotensin Converting Enzyme Inhibitors in Marfan Syndrome [Completed]

S90652 in Paediatric Hypertension [Recruiting]

S90652 in Paediatric Hypertension [Recruiting]

more>>

Page last updated: 2007-10-18

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