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Accutane (Isotretinoin) - Published Studies


Accutane Related Published Studies

Well-designed clinical trials related to Accutane (Isotretinoin)

Isotretinoin 5 mg daily for low-grade adult acne vulgaris--a placebo-controlled, randomized double-blind study. [2014]

A single blind randomized clinical study: the efficacy of isotretinoin plus narrow band ultraviolet B in the treatment of psoriasis vulgaris. [2011.06]

A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma. [2010.11]

Mortality in the randomized, controlled lung intergroup trial of isotretinoin. [2010.06]

A randomized and controlled trial about the use of oral isotretinoin for photoaging. [2010.02]

Dose response of retinol and isotretinoin in the prevention of nonmelanoma skin cancer recurrence. [2010]

A randomized and controlled trial about the use of oral isotretinoin for photoaging. [2010]

Comparison of dose-related ocular side effects during systemic isotretinoin administration. [2009.03]

Oral isotretinoin in photoaging: clinical and histopathological evidence of efficacy of an off-label indication. [2009.02]

Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne. [2008.03]

Beneficial effect of a moisturizing cream as adjunctive treatment to oral isotretinoin or topical tretinoin in the management of acne. [2006.11]

Randomized phase III trial of low-dose isotretinoin for prevention of second primary tumors in stage I and II head and neck cancer patients. [2006.04.05]

Evaluation of the clinical and histological effectiveness of isotretinoin in the therapy of oral leukoplakia: ten years of experience: is management still up to date and effective? [2006.03]

Effects of isotretinoin on the metabolism of triglyceride-rich lipoproteins and on the lipid profile in patients with acne. [2006.03]

Prospective, randomized, multicenter, double-blind placebo-controlled trial comparing adjuvant interferon alfa and isotretinoin with interferon alfa alone in stage IIA and IIB melanoma: European Cooperative Adjuvant Melanoma Treatment Study group. [2005.12.01]

Treatment of photoaged skin with a cream containing 0.05% isotretinoin and sunscreens. [2005.04]

Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris. [2005.03]

Oral isotretinoin in the treatment of recalcitrant condylomata acuminata of the cervix: a randomised placebo controlled trial. [2004.06]

Comparative bioequivalence study of two isotretinoin soft gel capsule formulations in healthy male volunteers. [2003.07]

Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial. [2002.09]

Isotretinoin for low-grade cervical dysplasia in human immunodeficiency virus-infected women. [2002.05]

Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne. [2001.11]

Safety of a new micronized formulation of isotretinoin in patients with severe recalcitrant nodular acne: A randomized trial comparing micronized isotretinoin with standard isotretinoin. [2001.08]

Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer. [2001.04.18]

Comparison of the cumulative irritation potential of adapalene gel and cream with that of erythromycin/tretinoin solution and gel and erythromycin/isotretinoin gel. [2001.02]

A double-blind investigation of the potential systemic absorption of isotretinoin, when combined with chemical sunscreens, following topical application to patients with widespread acne of the face and trunk. [2001.01]

Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial. [2000.11]

Oral isotretinoin as part of the treatment of cutaneous aging. [2000.07]

Melanoma-associated retinopathy versus abnormal retinal function due to interferon-alpha/Isotretinoin therapy in cutaneous malignant melanoma. [2000]

Topical isotretinoin for melasma in Thai patients: a vehicle-controlled clinical trial. [1999.09]

bcl-2 expression and apoptotic bodies in 13-cis-retinoic acid (isotretinoin)-topically treated oral leukoplakia: a pilot study. [1999.05]

Hemodialysis-related nodulocystic acne treated with isotretinoin. [1999.02]

A placebo-controlled clinical trial to compare a gel containing a combination of isotretinoin (0.05%) and erythromycin (2%) with gels containing isotretinoin (0.05%) or erythromycin (2%) alone in the topical treatment of acne vulgaris. [1999]

Topical isotretinoin vs. topical retinoic acid in the treatment of acne vulgaris. [1998.01]

Trial of retinol and isotretinoin in skin cancer prevention: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. [1997.11]

Comparative study of systemic interferon alfa-2a with oral isotretinoin and oral isotretinoin alone in the treatment of recurrent condylomata accuminata. [1996]

Comparative study of systemic interferon alfa-2a plus isotretinoin versus isotretinoin in the treatment of recurrent condyloma acuminatum in men. [1995.05]

Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia. [1994.05]

A comparison of the efficacy of topical tretinoin and low-dose oral isotretinoin in rosacea. [1994.03]

A prospective study of the effect of isotretinoin on the follicular reservoir and sustainable sebum excretion rate in patients with acne. [1994.03]

Clinical evaluation of topical isotretinoin in the treatment of actinic keratoses. [1994.03]

Effect of isotretinoin on endogenous tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in humans. [1993.12.20]

Clinical and laboratory adverse effects associated with long-term, low-dose isotretinoin: incidence and risk factors. The Isotretinoin-Basal Cell Carcinomas Study Group. [1993.07]

Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis. [1993.01.07]

Topical isotretinoin for photodamaged skin. [1992.12]

Skeletal hyperostosis in patients receiving chronic, very-low-dose isotretinoin. [1992.07]

A double-blind evaluation of topical isotretinoin 0.05%, benzoyl peroxide gel 5% and placebo in patients with acne. [1992.05]

Staphylococcus aureus and intra-nasal mupirocin in patients receiving isotretinoin for acne. [1992.04]

Clinical panel assessment of photodamaged skin treated with isotretinoin using photographs. [1992.03]

Isotretinoin-basal cell carcinoma prevention trial. Design, recruitment results, and baseline characteristics of the trial participants. The ISO-BCC Study Group. [1990.12]

Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. [1990.09.20]

Comparative study of systemic interferon alfa-nl and isotretinoin in the treatment of resistant condylomata acuminata. [1989.06]

Treatment of advanced squamous cell carcinoma of the head and neck with isotretinoin: a phase II randomized trial. [1988.04]

Well-designed clinical trials possibly related to Accutane (Isotretinoin)

Lack of irritative potential of nadifloxacin 1% when combined with other topical anti-acne agents. [2012]

What's new in acne? An analysis of systematic reviews and clinically significant trials published in 2010-11. [2011.12]

Gene expression profiling predicts the development of oral cancer. [2011.02]

Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients. [2011.02]

A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899. [2010.02.24]

Effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle-controlled, double-blind study of adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel with doxycycline hyclate 100 mg. [2010.02]

DeltaNp63 overexpression, alone and in combination with other biomarkers, predicts the development of oral cancer in patients with leukoplakia. [2009.10.01]

Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma. [2009.08.10]

A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer. [2009.05]

A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer. [2009.05]

Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. [2009.03.01]

Randomized trial of 13-cis retinoic acid compared with retinyl palmitate with or without beta-carotene in oral premalignancy. [2009.02.01]

Outcome of high-risk stage 3 neuroblastoma with myeloablative therapy and 13-cis-retinoic acid: a report from the Children's Oncology Group. [2009.01]

Cyclin D1 and cancer development in laryngeal premalignancy patients. [2009.01]

Cyclin D1 and cancer development in laryngeal premalignancy patients. [2009.01]

[Randomized control study on the treatment of 26 cases of acne conglobata with encircling acupuncture combined with venesection and cupping] [2008.12]

Effect of oral 13-cis-retinoic acid treatment on postoperative clinical outcome of eyes with proliferative vitreoretinopathy. [2008.09]

Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients. [2008.01]

Tamoxifen vs Tamoxifen plus 13-cis-retinoic acid vs Tamoxifen plus Interferon alpha-2a as first-line endocrine treatments in advanced breast cancer: updated results of a phase II, prospective, randomised multicentre trial. [2007.12]

Proliferative changes in the bronchial epithelium of former smokers treated with retinoids. [2007.11.07]

Retinoids for preventing the progression of cervical intra-epithelial neoplasia. [2007.10.17]

Randomized trial of adjuvant 13-cis-retinoic acid and interferon alfa for patients with aggressive skin squamous cell carcinoma. [2007.05.20]

Feasibility of retinoids for the treatment of emphysema study. [2006.11]

Interleukin-2/interferon-alpha2a/13-retinoic acid-based chemoimmunotherapy in advanced renal cell carcinoma: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN). [2006.08.21]

Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer. [2006.06.15]

Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. [2006.01]

Phase II randomized study of interleukin-2 with or without 13-cis retinoic acid as maintenance therapy in patients with advanced cancer responsive to chemotherapy. [2005.07]

Randomized phase II/III trial of interferon Alfa-2a with and without 13-cis-retinoic acid in patients with progressive metastatic renal cell Carcinoma: the European Organisation for Research and Treatment of Cancer Genito-Urinary Tract Cancer Group (EORTC 30951). [2005.06.20]

Adapalene vs. metronidazole gel for the treatment of rosacea. [2005.03]

Chemoprevention of head and neck cancer with retinoids: a negative result. [2005.03]

Interferon-alpha-2a with or without 13-cis retinoic acid in patients with progressive, measurable metastatic renal cell carcinoma. [2004.08.01]

13-cis retinoic acid in head and neck cancer chemoprevention: results of a randomized trial from the Italian Head and Neck Chemoprevention Study Group. [2004.06]

Interleukin-2- and interferon alfa-2a-based immunochemotherapy in advanced renal cell carcinoma: a Prospectively Randomized Trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN). [2004.04.01]

The risk of second primary tumors after resection of stage I nonsmall cell lung cancer. [2003.10]

Impact of radiotherapy for high-risk neuroblastoma: a Children's Cancer Group study. [2003.05.01]

Second primary tumors in patients with upper aerodigestive tract cancers: joint effects of smoking and alcohol (United States). [2003.03]

Clinical evaluation of Double Strength Isotrexin versus Benzamycin in the topical treatment of mild to moderate acne vulgaris. [2002.09]

13-cis retinoic acid and complete androgen blockade in advanced hormone-naive prostate cancer patients: report of a phase II randomized study. [2002.01.15]

The impact of smoking status, disease stage, and index tumor site on second primary tumor incidence and tumor recurrence in the head and neck retinoid chemoprevention trial. [2001.08]

Modulation of proliferating cell nuclear antigen in the bronchial epithelium of smokers. [2001.04]

Quantitative tumor cell content of bone marrow and blood as a predictor of outcome in stage IV neuroblastoma: a Children's Cancer Group Study. [2000.12.15]

A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy. [2000.11]

Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma. [2000.08]

Interferon-alpha and 13-cis-retinoic acid as maintenance therapy after high-dose combination chemotherapy with growth factor support for small cell lung cancer--a feasibility study. [2000.02]

Placebo-controlled trial of 13-cis-retinoic acid activity on retinoic acid receptor-beta expression in a population at high risk: implications for chemoprevention of lung cancer. [1999.11]

Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. [1999.10.14]

Nuclear retinoid acid receptor beta in bronchial epithelium of smokers before and during chemoprevention. [1999.08.04]

Carboplatin, vindesine, 5-fluorouracil-leucovorin and 13-cis retinoic acid in the treatment of advanced non-small cell lung cancer. A phase II study. [1999.07]

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