NEWS HIGHLIGHTSMedia Articles Related to Accolate (Zafirlukast)
Exposure To Traffic Pollution And Indoor Allergens Multiplies Risk Of Asthma In High-Risk Kids
Source: Health News from Medical News Today [2009.11.23]
Children who are exposed to high levels of traffic-related pollution and high levels of indoor endotoxin early in life have six times the risk of developing persistent wheezing by age three than children exposed to low levels of traffic and indoor-related pollutants, according to new research from the University of Cincinnati College of Medicine.
Asthma Combo Seems Less Influenced by Genes (HealthDay)
Source: Y! Health Asthma News [2009.11.22]
HealthDay - THURSDAY, Nov. 19 (HealthDay News) -- People's genetic makeup has
been shown to affect how they respond to asthma medications, but a new
study finds that many people respond well to a particular combination
treatment regardless of their genes.
Mother's Depression A Risk Factor In Childhood Asthma Symptoms
Source: Respiratory / Asthma News From Medical News Today [2009.11.21]
Maternal depression can worsen asthma symptoms in their children, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology.
Sweet! Sugared Polymer A New Weapon Against Allergies And Asthma
Source: Allergy News From Medical News Today [2009.11.20]
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way. For more than a decade, a team led by Bruce S. Bochner, M.D.
Asthma A Significant Risk Factor For Complications In Children With H1N1
Source: Respiratory / Asthma News From Medical News Today [2009.11.20]
A new study on pediatric H1N1 influenza admissions has found that asthma is a significant risk factor for severe disease in children with pandemic H1N1 compared with the seasonal flu. The study (http://www.cmaj.ca/cgi/rapidpdf/cmaj.091724), led by researchers from The Hospital for Sick Children (SickKids) in Toronto, Ontario, is published online in CMAJ (Canadian Medical Association Journal).
Published Studies Related to Accolate (Zafirlukast)
Effects of zafirlukast on capsular contracture: controlled study measuring the mammary compliance. [2007.07]
Capsular contracture is a highly distressing, difficult complication after breast augmentation for both the patient and the surgeon.The present study suggests that zafirlukast may be effective in reducing pain and breast capsule distortion in patients with longstanding contracture who are either not surgical candidates or who do not wish to undergo surgery.
[Nasal budesonide plus zafirlukast vs nasal budesonide plus loratadine-pseudoephedrine for controlling the symptoms of rhinitis and asthma] [2005.03]
OBJECTIVE: To compare the efficacy of nasal budesonide plus oral zafirlukast against nasal budesonide plus oral loratadine/pseudoephedrine combination in the control of symptoms of rhinitis and asthma... CONCLUSIONS: The association of a nasal steroid with a leukotriene modifier (zafirlukast) was more effective for controlling nasal symptoms and especially bronchial symptoms than the association of a nasal steroid with antihistamines (loratadine) with pseudoephedrine. Other inflammation indicators, such as eosinophilia and nasal eosinophilia, were diminished; the VEF1 increased significantly in both treatment groups. All the above may be due to the nasal steroid use associated to a leukotriene modifier.
Treatment of category III A prostatitis with zafirlukast: a randomized controlled feasibility study. [2005.03]
The cause of category III A prostatitis, chronic prostatitis/chronic male pelvic pain syndrome category A (CP/CPPS A), is uncertain... The problems of recruitment into this study (in spite of a large number of patients with prostatic type pain being seen in our unit) suggest that multicentre treatment trials using non-invasive diagnostic techniques such as the CPSI (rather than single GU medicine units diagnosing CP/CPPS A by uncomfortable direct prostatic testing) are likely to be the most effective and objective methods of undertaking treatment trials in the CP/ CPPS A field in the future.
Leukotriene E(4)-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma. [2005.02]
BACKGROUND: We have shown that inhalation of leukotriene (LT) E 4 contributes to specific recruitment of eosinophils to the airway mucosa in patients with asthma at the time of maximal decrease in airway-specific conductance. OBJECTIVE: We examined the ability of the cysteinyl LT 1 receptor antagonist, zafirlukast, to improve or prevent LT-mediated eosinophilia and airway obstruction in asthma... CONCLUSION: Persistent LTE 4 -induced airway eosinophilia may form the basis of an amplification mechanism for further eosinophil recruitment. Zafirlukast prevents LTE 4 -induced eosinophilic airway inflammation in mild asthma.
The effects of add-on zafirlukast treatment to budesonide on bronchial hyperresponsiveness and serum levels of eosinophilic cationic protein and total antioxidant capacity in asthmatic patients. [2004.12]
Mild persistent asthma is most effectively controlled with inhaled corticosteroids...
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Accolate has an overall score of 1. The effectiveness score is 2 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Accolate review by 44 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Capsuar Contracture of Breast Implant |
| Dosage & duration: | | 20mg taken twice daily for the period of 3 months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The benefits were not good, and this drug was very expensive and was not effective at all for the problem I was experiencing. At the time when I was experiencing complications from the implants, I truly believed that my Doctor did not prescribed the drug in time. The literature I read on this drug claims that it is more likely to work if used early in the treatment of Capsular Contracture. |
| Side effects: | | I tolerated the medication very well. I didn't experience any illness or side effects from Accolate. I felt a strong mental negativity towards the drug when it was prescribed based on the literature I read and my Doctor's statement about being treated early. I think I tried the treatment knowing in my mind that it was not going to work. |
| Comments: | | I was required to take Accolate for three months to promote softening of my Breast Implants. The 20mg tablets were to be taken twice daily along with continued daily massage of my breasts. My Doctor said that the treatment had more chances of being effective if used early in detecting the Capsular Contracture (My treatment was started 5 months after the breast implant surgery). If the treatment didn't work, he advised, I would need surgery. |
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