ACCOLATE SUMMARY
Absorption
Zafirlukast is a synthetic, selective peptide leukotriene receptor antagonist (LTRA), with the chemical name 4-(5-cyclopentyloxy-carbonylamino-1-methyl-indol-3-ylmethyl)
-3-methoxy-N-o-tolylsulfonylbenzamide.
ACCOLATE is indicated for the prophylaxis and chronic treatment of asthma in adults and children 5 years of age and older.
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NEWS HIGHLIGHTSMedia Articles Related to Accolate (Zafirlukast)
Children's Asthma Risk Linked To Folic Acid Supplements During Late Pregnancy, Australian Study
Source: Health News from Medical News Today [2009.11.05]
Researchers in Australia have identified a link between allergic asthma in 3 to 5 year-old children and exposure to folic acid that their birth mothers took as supplements during late pregnancy. They said the timing of when folic acid is taken in pregnancy might be important.
ViraCor-IBT Laboratories To Present At The American College Of Allergy, Asthma And Immunology's Annual Meeting
Source: Pharma Industry / Biotech Industry News From Medical News Today [2009.11.05]
Scientists from ViraCor-IBT Laboratories have been selected to provide four oral presentations and one poster presentation at this year's American College of Allergy, Asthma and Immunology's Annual Scientific Meeting in Miami, Florida. Michelle Altrich, PhD, HCLD (ABB), and Michael Ling, PhD, will present data on a wide range of topics including Filaggrin, Pneumococcal Antibody Avidity, Chronic Urticaria, Drug Hypersensitivity Reactions and T-Cell Excision Circles.
New Asthma Research Presented At CHEST 2009
Source: Allergy News From Medical News Today [2009.11.04]
Zinc Deficiency May Contribute to Allergic Asthma (#8362) Zinc deficiency may play a role in the development of extrinsic or allergic asthma. Researchers from India evaluated serum zinc levels and absolute eosinophil count in 96 cases of asthma (61 patients had intrinsic asthma and 35 had extrinsic asthma). Patients who suffered from any comorbid illness were excluded from the study.
Asthma Plagues World Trade Center Responders
Source: Respiratory / Asthma News From Medical News Today [2009.11.04]
Responders to the 2001 World Trade Center (WTC) terrorist attacks, who were exposed to caustic dust and toxic pollutants following the 9/11 disaster, suffer from asthma at a rate more than twice that of the general US population, according to new research presented at CHEST 2009, the 75th annual international scientific assembly of the American College of Chest Physicians (ACCP).
Study Links Folic Acid Supplements To Asthma
Source: Respiratory / Asthma News From Medical News Today [2009.11.04]
A University of Adelaide study may have shed light on the rise in childhood asthma in developed countries like Australia in recent decades. Researchers from the University's Robinson Institute have identified a link between folic acid supplements taken in late pregnancy and allergic asthma in children aged between 3 and 5 years, suggesting that the timing of supplementation in pregnancy is important.
Published Studies Related to Accolate (Zafirlukast)
Effects of zafirlukast on capsular contracture: controlled study measuring the mammary compliance. [2007.07]
Capsular contracture is a highly distressing, difficult complication after breast augmentation for both the patient and the surgeon.The present study suggests that zafirlukast may be effective in reducing pain and breast capsule distortion in patients with longstanding contracture who are either not surgical candidates or who do not wish to undergo surgery.
[Nasal budesonide plus zafirlukast vs nasal budesonide plus loratadine-pseudoephedrine for controlling the symptoms of rhinitis and asthma] [2005.03]
OBJECTIVE: To compare the efficacy of nasal budesonide plus oral zafirlukast against nasal budesonide plus oral loratadine/pseudoephedrine combination in the control of symptoms of rhinitis and asthma... CONCLUSIONS: The association of a nasal steroid with a leukotriene modifier (zafirlukast) was more effective for controlling nasal symptoms and especially bronchial symptoms than the association of a nasal steroid with antihistamines (loratadine) with pseudoephedrine. Other inflammation indicators, such as eosinophilia and nasal eosinophilia, were diminished; the VEF1 increased significantly in both treatment groups. All the above may be due to the nasal steroid use associated to a leukotriene modifier.
Treatment of category III A prostatitis with zafirlukast: a randomized controlled feasibility study. [2005.03]
The cause of category III A prostatitis, chronic prostatitis/chronic male pelvic pain syndrome category A (CP/CPPS A), is uncertain... The problems of recruitment into this study (in spite of a large number of patients with prostatic type pain being seen in our unit) suggest that multicentre treatment trials using non-invasive diagnostic techniques such as the CPSI (rather than single GU medicine units diagnosing CP/CPPS A by uncomfortable direct prostatic testing) are likely to be the most effective and objective methods of undertaking treatment trials in the CP/ CPPS A field in the future.
Leukotriene E(4)-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma. [2005.02]
BACKGROUND: We have shown that inhalation of leukotriene (LT) E 4 contributes to specific recruitment of eosinophils to the airway mucosa in patients with asthma at the time of maximal decrease in airway-specific conductance. OBJECTIVE: We examined the ability of the cysteinyl LT 1 receptor antagonist, zafirlukast, to improve or prevent LT-mediated eosinophilia and airway obstruction in asthma... CONCLUSION: Persistent LTE 4 -induced airway eosinophilia may form the basis of an amplification mechanism for further eosinophil recruitment. Zafirlukast prevents LTE 4 -induced eosinophilic airway inflammation in mild asthma.
The effects of add-on zafirlukast treatment to budesonide on bronchial hyperresponsiveness and serum levels of eosinophilic cationic protein and total antioxidant capacity in asthmatic patients. [2004.12]
Mild persistent asthma is most effectively controlled with inhaled corticosteroids...
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Accolate has an overall score of 1. The effectiveness score is 2 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Accolate review by 44 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Capsuar Contracture of Breast Implant |
| Dosage & duration: | | 20mg taken twice daily for the period of 3 months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The benefits were not good, and this drug was very expensive and was not effective at all for the problem I was experiencing. At the time when I was experiencing complications from the implants, I truly believed that my Doctor did not prescribed the drug in time. The literature I read on this drug claims that it is more likely to work if used early in the treatment of Capsular Contracture. |
| Side effects: | | I tolerated the medication very well. I didn't experience any illness or side effects from Accolate. I felt a strong mental negativity towards the drug when it was prescribed based on the literature I read and my Doctor's statement about being treated early. I think I tried the treatment knowing in my mind that it was not going to work. |
| Comments: | | I was required to take Accolate for three months to promote softening of my Breast Implants. The 20mg tablets were to be taken twice daily along with continued daily massage of my breasts. My Doctor said that the treatment had more chances of being effective if used early in detecting the Capsular Contracture (My treatment was started 5 months after the breast implant surgery). If the treatment didn't work, he advised, I would need surgery. |
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Page last updated: 2009-11-05
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