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Ablavar (Gadofosveset Trisodium) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

Following injection, Ablavar binds to blood albumin and has the potential to alter the binding of other drugs that also bind to albumin. No drug interaction reactions were observed in clinical trials. Consider the possibility of Ablavar interaction with concomitantly administered medications that bind to albumin. An interaction may enhance or decrease the activity of the concomitant medication [ see Clinical Pharmacology (12.3) ].

Warfarin

In a clinical trial of 10 patients receiving a stable dose of warfarin, a single dose of Ablavar (0.05 mmol/kg) did not alter the anticoagulant activity of warfarin as measured by the International Normalized Ratio (INR).

OVERDOSAGE

Ablavar Injection has been administered to humans up to a dose of 0.15 mmol/kg (5 times the clinical dose). No Ablavar overdoses were reported in clinical trials. In the event of an overdose, direct treatment toward the support of all vital functions and prompt institution of symptomatic therapy. Gadofosveset has been shown to be removed by hemodialysis using a high flux dialysis procedure [ see Clinical Pharmacology (12.3) ].

CONTRAINDICATIONS

History of a prior allergic reaction to a gadolinium-based contrast agent.

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