Media Articles Related to Ablavar (Gadofosveset)
Diagnostic pill that can be swallowed
Source: Cancer / Oncology News From Medical News Today [2013.12.06]
A tiny capsule that can carry out a chemical analysis of the contents of one's stomach could identify the presence of so-called "occult" blood at very low levels. The data is automatically broadcast to an external monitoring device for detection of early stage stomach cancer by one's physician.
Diagnostic Errors Cause Up To 160,000 Deaths Annually, USA
Source: Litigation / Medical Malpractice News From Medical News Today [2013.04.24]
Misdiagnosing patients or making diagnostic errors is one of the most costly and dangerous mistakes made by doctors in the U.S., resulting in up to 160,000 deaths per year. Johns Hopkins researchers have reviewed over 350,000 malpractice claim payouts in the U.S over the past 25 years.
Ultrasound, CT Comparable to Detect Appendicitis in Children
Source: Medscape Emergency Medicine Headlines [2013.12.05]
Using ultrasound as the first diagnostic imaging technique to detect appendicitis in children produces comparable outcomes to CT with less radiation and without increasing hospital length of stay.
Medscape Medical News
Initial study results demonstrate detection rate of 75% for colorectal cancer
Source: Clinical Trials / Drug Trials News From Medical News Today [2013.11.11]
VolitionRx Limited (OTC: VNRX), a life sciences company focused on developing blood-based diagnostic tests for different types of cancer, has announced the publication of preliminary data from an ongoing independent trial of one of its NuQ® assays. Priv.-Doz. Dr.
New membrane pores with DNA nanotechnology
Source: Biology / Biochemistry News From Medical News Today [2013.11.07]
A new way to build membrane-crossing pores, using Lego-like DNA building blocks, has been developed by scientists at UCL, in collaboration with colleagues at the University of Cambridge and the University of Southampton.The approach provides a simple and low cost tool for synthetic biology and the technique has potential applications in diagnostic devices and drug discovery.
Published Studies Related to Ablavar (Gadofosveset)
Contrast-enhanced whole-heart MR coronary angiography at 3.0 T using the intravascular contrast agent gadofosveset. [2009.07]
OBJECTIVES: The purpose of this study was to compare contrast-enhanced (CE) whole-heart coronary magnetic resonance angiography (MRA) at 3.0 T using gadofosveset to noncontrast-enhanced steady-state free precession (SSFP) coronary MRA at 1.5 T... CONCLUSIONS: CE whole-heart coronary MRA at 3.0 T demonstrated higher overall CNR between coronary blood and myocardium and an improved image quality of the distal coronary segments compared with noncontrast-enhanced SSFP coronary MRA at 1.5 T.
Safety and efficacy of gadofosveset-enhanced MR angiography for evaluation of pedal arterial disease: multicenter comparative phase 3 study. [2008.01]
CONCLUSION: Because of markedly better efficacy than no contrast agent and a minimal and transient side-effect profile, 0.03 mmol/kg of gadofosveset was found safe and effective for MR angiography of patients with pedal arterial disease.
Contrast-enhanced MRA of the renal and aorto-iliac-femoral arteries: comparison of gadobenate dimeglumine and gadofosveset trisodium. [2011.02]
RATIONALE AND OBJECTIVES: Dedicated contrast agents are now available for contrast-enhanced magnetic resonance angiography (CE-MRA). This study retrospectively compares the safety and diagnostic performance data from Phase III regulatory trials performed to evaluate gadobenate dimeglumine (MultiHance((R))) and gadofosveset trisodium (Vasovist(R))) for renal and peripheral CE-MRA... CONCLUSION: The diagnostic performance of CE-MRA for the detection of significant steno-occlusive disease is similar with gadofosveset and gadobenate dimeglumine although the rate of adverse events appears higher with gadofosveset. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
CMR assessment of endothelial damage and angiogenesis in porcine coronary arteries using gadofosveset. [2011.01.26]
CONCLUSION: Contrast enhanced coronary CMR with gadofosveset can detect experimentally induced endothelial damage and angiogenesis in the porcine coronary artery wall.
Diffusion magnetic resonance imaging with gadofosveset trisodium as a negative contrast agent for lymph node metastases assessment. [2011.01]
PURPOSE: The aim of this study was to assess the feasibility of using intravenously administered gadofosveset trisodium as a negative contrast agent for lymph node (LN) assessment with diffusion-weighted imaging (DWI) using a VX2 tumor model in rabbits... CONCLUSION: The SI of metastatic LNs at DWI is less suppressed than that of nonmetastatic LNs after the intravenous administration of gadofosveset trisodium. Therefore, intravenously administered gadofosveset trisodium shows promise for use as a negative contrast agent for discriminating metastatic from nonmetastatic LNs at DWI.
Clinical Trials Related to Ablavar (Gadofosveset)
LMI - Ablavar - 401 - Study of Incidence of Nephrogenic Systemic Fibrosis(NSF) in Kidney Disease Patients Undergoing MRI With Ablavar [Not yet recruiting]
In this phase 4 study, all patients will receive 1 dose of Ablavar as part of an MRI
examination in their routine clinical management.
A standardized NSF questionnaire will be administered to the patient at various time points
post-dose. At 1 year and 2 years (+1 or - 1 month) patients will return to the clinic for a
limited examination for skin abnormalities and formal review of signs and symptoms
suggestive of NSF.
Dose-varied Evaluation of Ablavar-enhanced MR Angiography of the Central Veins of the Chest in Healthy Participants [Recruiting]
The purpose of this study is to assess the image quality of Ablavar-enhanced MR angiography
of the central veins of the chest, and to determine whether dose reduction can be performed
while maintaining image quality. This will be a prospective randomized study, in which
healthy volunteers will be recruited to undergo a central veins magnetic resonance angiogram
(MRA). They will receive either the FDA-approved dose or a lower dose of Ablavar.
Quantitative and qualitative analysis will be performed on the images.
Detection of Liver Fibrosis With Magnetic Resonance Imaging (MRI) [Recruiting]
Patients with chronic liver disease are at high risk of developing liver scarring
(fibrosis), with ultimate risks of cirrhosis and liver cancer that may require liver
transplant. The investigators would like to develop non invasive advanced Magnetic Resonance
Imaging (MRI) techniques (MR diffusion, perfusion and elastography) to assess the degree of
liver damage in patients with chronic liver disease. These techniques combined could reach
high diagnostic performance for detection of liver fibrosis; and could decrease the number
of liver biopsies, which have risks and sample only a small portion of the liver.
Nodal Staging in Breast Cancer With MRL [Recruiting]
The aim of this study is to examine the diagnostic performance of gadofosveset enhanced
magnetic resonance imaging lymphography (MRL).
The diagnostic performance of MRL will be determined on the basis of a node-to-node matching
of imaged nodes to the definitive histopathology. The pathologic examination of the sentinel
lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) will be regarded as the
golden standard for nodal involvement.
Diagnostic Value of Novel MR Imaging Techniques for the Primary Staging and Restaging of Rectal Cancer [Recruiting]