ADVERSE REACTIONS
Fluid and Electrolyte Disturbances
Sodium retention, Fluid retention, Congestive
heart failure in susceptible patients, Potassium loss, Hypokalemic
alkalosis, Hypertension
Musculoskeletal
Muscle weakness,
Steroid myopathy, Loss of muscle mass, Osteoporosis, Vertebral compression
fractures, Aseptic necrosis of femoral and humeral heads, Pathologic
fracture of long bones
Gastrointestinal
Peptic ulcer with
possible perforation and hemorrhage, Pancreatitis, Abdominal distention,
Ulcerative esophagitis
Dermatologic
Impaired wound healing,
Thin fragile skin, Petechiae and ecchymoses, Facial erythema, Increased
sweating, May suppress reactions to skin tests
Neurological
Convulsions, Increased intracranial pressure with papilledema (pseudotumor
cerebri) usually after treatment, Vertigo, Headache
Endocrine
Menstrual irregularities, Development of Cushingoid state, Suppression
of growth in children, Secondary adrenocortical and pituitary unresponsiveness,
particularly in times of stress, as in trauma, surgery, or illness,
Decreased carbohydrate tolerance, Manifestations of latent diabetes
mellitus, Increased requirements of insulin or oral hypoglycemic agents
in diabetics
Ophthalmic
Posterior subcapsular cataracts, Increased
intraocular pressure, Glaucoma, Exophthalmos
Metabolic
Negative nitrogen balance due to protein catabolism
The following additional reactions are related to parenteral corticosteroid
therapy:
Allergic, anaphylactic or other hypersensitivity
reactions, Hyperpigmentation or hypopigmentation, Subcutaneous and
cutaneous atrophy, Sterile abscess
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