8-MOP (Methoxsalen) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

D. DRUG INTERACTIONS

See Warnings Section.

VIII. OVERDOSAGE

In the event of methoxsalen overdosage, induce emesis and keep the patient in a darkened room for at least 24 hours.  Emesis is beneficial only within the first 2 to 3 hours after ingestion of methoxsalen, since maximum blood levels are reached by this time.

IV. CONTRAINDICATIONS

1. Patients exhibiting idiosyncratic reactions to psoralen compounds.

2. Patients possessing a specific history of light sensitive disease states should not initiate methoxsalen therapy.  Diseases associated with photosensitivity include lupus erythematosus, porphyria cutanea tarda, erythropoietic protoporphyria, variegate porphyria, xeroderma pigmentosum, and albinism.

3. Patients exhibiting melanoma or possessing a history of melanoma.

4. Patients exhibiting invasive squamous cell carcinomas.

5. Patients with aphakia, because of the significantly increased risk of retinal damage due to the absence of lenses.