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Index of reports
> Cases resulting in other serious reactions (196)
> Cases with Blood Lactate Dehydrogenase Increased (20)
Below is the selection of adverse event reports related to Voltaren (Diclofenac) that includes cases resulting in other serious reactions where reactions include blood lactate dehydrogenase increased.
Adverse event in 75 year old female receiving Voltaren (Diclofenac)
Reported by a health professional (non-physician/pharmacist) from Japan on 2007-10-16
Patient: 75 year old female, weighing 49.0 kg (107.8 pounds)
Adverse reactions / side effects: Hypoventilation, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Anaphylactic Shock, Hypoaesthesia, Hypoxic Encephalopathy, Heart Rate Decreased, Gamma-Glutamyltransferase Increased, Blood Potassium Decreased, Aspartate Aminotransferase Increased, Nuclear Magnetic Resonance Imaging Abnormal, Blood Sodium Increased, Blood Pressure Immeasurable, Altered State of Consciousness
Adverse event resulted in: life threatening event
Suspect drug(s):
Voltaren (Diclofenac)
Adverse event in 23 year old female receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-07-20
Patient: 23 year old female, weighing 47.0 kg (103.4 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Blood Alkaline Phosphatase Increased, Hepatitis C Antibody Positive, Nausea, Hepatitis C, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Biopsy Liver Abnormal, Liver Disorder, Discomfort, Malaise, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Marzulene
Dosage: unk, unk
Administration route: Oral
Indication: Nausea
Start date: 2007-06-01
End date: 2007-06-01
Strocain
Dosage: unk, unk
Administration route: Oral
Indication: Flank Pain
Start date: 2007-06-01
End date: 2007-06-01
Voltaren
Dosage: 25 mg/day
Administration route: Oral
Indication: Flank Pain
Start date: 2007-05-31
End date: 2007-05-31
Adverse event in 23 year old female receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-07-20
Patient: 23 year old female, weighing 47.0 kg (103.4 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Blood Alkaline Phosphatase Increased, Hepatitis C Antibody Positive, Nausea, Hepatitis C, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Biopsy Liver Abnormal, Liver Disorder, Discomfort, Malaise, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Marzulene
Dosage: unk, unk
Administration route: Oral
Indication: Nausea
Start date: 2007-06-01
End date: 2007-06-01
Strocain
Dosage: unk, unk
Administration route: Oral
Indication: Flank Pain
Start date: 2007-06-01
End date: 2007-06-01
Voltaren
Dosage: 25 mg/day
Administration route: Oral
Indication: Flank Pain
Start date: 2007-05-31
End date: 2007-05-31
Adverse event in 61 year old female receiving Voltaren (Diclofenac)
Reported by a individual with unspecified qualification from Japan on 2007-07-16
Patient: 61 year old female, weighing 59.0 kg (129.8 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Drug Eruption, Thoracic Cavity Drainage, Disseminated Intravascular Coagulation, Pyrexia, Erythema, Laboratory Test Abnormal, Gamma-Glutamyltransferase Increased, C-Reactive Protein Increased, Pleural Effusion, Blood Creatinine Increased, Lymphocyte Count Decreased, Oxygen Saturation Decreased, White Blood Cell Count Increased, Blood Urea Increased, Dyspnoea, Neutrophil Count Increased, Monocyte Count Decreased, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Urine Output Decreased, Lymphocyte Stimulation Test Positive, Rash Macular, Haemoglobin Decreased, Renal Failure, Aspartate Aminotransferase Increased, Oliguria, Platelet Count Decreased, Lung Infiltration
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Dacarbazine
Dosage: 180 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-12
Feron
Dosage: 3000000 iu/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-12
Loxonin
Dosage: 60 mg, tid
Administration route: Oral
Indication: Pyrexia
Start date: 2005-11-10
End date: 2005-11-13
Nidran
Dosage: 100 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-08
Oncovin
Dosage: 1 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-08
Voltaren
Dosage: 37.5 mg/day
Administration route: Oral
Indication: Pyrexia
Start date: 2005-11-09
End date: 2005-11-10
Other drugs received by patient: Norvasc; Towamin; Lipitor; Voglibose
Adverse event in 23 year old female receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-07-06
Patient: 23 year old female, weighing 47.0 kg (103.4 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Blood Alkaline Phosphatase Increased, Hepatitis C Antibody Positive, Nausea, Hepatitis C, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Biopsy Liver Abnormal, Liver Disorder, Discomfort, Malaise, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Marzulene
Dosage: unk, unk
Administration route: Oral
Indication: Nausea
Start date: 2007-06-01
End date: 2007-06-01
Strocain
Dosage: unk, unk
Administration route: Oral
Indication: Flank Pain
Start date: 2007-06-01
End date: 2007-06-01
Voltaren
Dosage: 25 mg/day
Administration route: Oral
Indication: Flank Pain
Start date: 2007-05-31
End date: 2007-05-31
Adverse event in 70 year old male receiving Voltaren (Diclofenac)
Reported by a individual with unspecified qualification from Japan on 2007-07-02
Patient: 70 year old male, weighing 60.0 kg (132.0 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Productive Cough, Pruritus, Erythema Annulare, Pyrexia, Dermatitis, C-Reactive Protein Increased, White Blood Cell Count Increased, Pleurisy, Blood Lactate Dehydrogenase Increased, LIP Ulceration, Staphylococcal Infection, Cerebral Infarction, Aspartate Aminotransferase Increased, Insomnia, Depressed Level of Consciousness, Platelet Count Decreased, Hemiplegia, Drug Eruption, Oculomucocutaneous Syndrome, Post Procedural Complication, Culture Urine Positive, Liver Disorder, Lung Neoplasm Malignant, Pleural Effusion, White Blood Cell Count Decreased, Intercostal Neuralgia, Alanine Aminotransferase Increased, Haemorrhoids, Muscular Weakness, Rash, LIP Pain, Haematochezia, Agranulocytosis, Sepsis, Sputum Retention, Cardiac Arrest, Shock, Infection
Adverse event resulted in: death
Suspect drug(s):
Tegretol
Dosage: 100 mg/day
Administration route: Oral
Indication: Wound Complication
Start date: 2006-09-22
End date: 2006-09-23
Voltaren
Dosage: 25 mg/day
Indication: Wound Complication
Start date: 2006-08-24
End date: 2006-08-24
Voltaren
Dosage: 25 mg/day
Start date: 2006-09-04
End date: 2006-09-23
Voltaren
Dosage: 50 mg/day
Start date: 2006-09-17
End date: 2006-09-17
Voltaren
Dosage: 50 mg/day
Start date: 2006-09-20
End date: 2006-09-20
Voltaren
Dosage: 50 mg/day
Start date: 2006-09-21
End date: 2006-09-21
Voltaren
Dosage: 50 mg/day
Start date: 2006-09-22
End date: 2006-09-22
Other drugs received by patient: Amoban; Zolpidem; Rohypnol; Ubretid; Spelear; Selbex; Sennoside; Takepron; Naproxen; Aspirin; Polaramine; Aminofluid; Omepral; Cataclot; Solu-Medrol; Soldem 3A; Multivitamin Additive; Heparin Sodium; Pacil; Pansporin; Finibax; Flumarin; Perdipine; Potacol-R; Radicut; NEO-Minophagen C; LOW Molecular Dextran L; Bisolvon; Magmitt Kenei; Cercine; Phenobarbital TAB; Mobic; Loxonin; Distilled Water; Ketoprofen; Laxoberon; Rinderon-VG; Wakobital; Serum Albumin Human; Humulin 70 / 30; Ropivacaine; Aminotripa 1; Aminotripa 2
Adverse event in 61 year old female receiving Voltaren (Diclofenac)
Reported by a individual with unspecified qualification from Japan on 2007-06-29
Patient: 61 year old female, weighing 59.0 kg (129.8 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Thoracic Cavity Drainage, Disseminated Intravascular Coagulation, Pyrexia, Erythema, Laboratory Test Abnormal, Gamma-Glutamyltransferase Increased, C-Reactive Protein Increased, Pleural Effusion, Blood Creatinine Increased, Lymphocyte Count Decreased, Oxygen Saturation Decreased, White Blood Cell Count Increased, Monocyte Count Decreased, Neutrophil Count Increased, Blood Urea Increased, Dyspnoea, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Urine Output Decreased, Lymphocyte Stimulation Test Positive, Rash Macular, Haemoglobin Decreased, Renal Failure, Aspartate Aminotransferase Increased, Oliguria, Platelet Count Decreased, Lung Infiltration
Adverse event resulted in: life threatening event
Suspect drug(s):
Dacarbazine
Dosage: 180 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-12
Feron
Dosage: 3000000 iu/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-12
Loxonin
Dosage: 60 mg, tid
Administration route: Oral
Indication: Pyrexia
Start date: 2005-11-10
End date: 2005-11-13
Nidran
Dosage: 100 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-08
Oncovin
Dosage: 1 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-08
Voltaren
Dosage: 37.5 mg/day
Administration route: Oral
Indication: Pyrexia
Start date: 2005-11-09
End date: 2005-11-10
Other drugs received by patient: Norvasc; Towamin; Lipitor; Voglibose
Adverse event in 61 year old female receiving Voltaren (Diclofenac)
Reported by a individual with unspecified qualification from Japan on 2007-06-19
Patient: 61 year old female, weighing 59.0 kg (129.8 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Thoracic Cavity Drainage, Disseminated Intravascular Coagulation, Pyrexia, Laboratory Test Abnormal, Gamma-Glutamyltransferase Increased, C-Reactive Protein Increased, Pleural Effusion, Blood Creatinine Increased, Oxygen Saturation Decreased, Lymphocyte Count Decreased, White Blood Cell Count Increased, Neutrophil Count Increased, Blood Urea Increased, Dyspnoea, Monocyte Count Decreased, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Urine Output Decreased, Lymphocyte Stimulation Test Positive, Rash Macular, Haemoglobin Decreased, Renal Failure, Aspartate Aminotransferase Increased, Oliguria, Platelet Count Decreased, Lung Infiltration
Adverse event resulted in: life threatening event
Suspect drug(s):
Dacarbazine
Dosage: 180 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-12
Feron
Dosage: 3000000 iu/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-12
Loxonin
Dosage: 60 mg, tid
Administration route: Oral
Indication: Pyrexia
Start date: 2005-11-10
End date: 2005-11-13
Nidran
Dosage: 100 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-08
Oncovin
Dosage: 1 mg/day
Indication: Malignant Melanoma
Start date: 2005-11-08
End date: 2005-11-08
Voltaren
Dosage: 37.5 mg/day
Administration route: Oral
Indication: Pyrexia
Start date: 2005-11-09
End date: 2005-11-10
Other drugs received by patient: Norvasc; Towamin; Lipitor; Voglibose
Adverse event in 51 year old female receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-05-29
Patient: 51 year old female, weighing 62.0 kg (136.4 pounds)
Adverse reactions / side effects: Blood Alkaline Phosphatase Increased, Blood Creatine Phosphokinase Increased, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Paralysis, Lymphocyte Stimulation Test Positive, Pallor, Tremor, Haemoglobin Decreased, Gamma-Glutamyltransferase Increased, Palpitations, C-Reactive Protein Increased, Aspartate Aminotransferase Increased
Suspect drug(s):
Voltaren (Diclofenac)
Other drugs received by patient: Allegra; Aspirin; Ferromia
Adverse event in 71 year old male receiving Voltaren (Diclofenac)
Reported by a pharmacist from Japan on 2007-05-23
Patient: 71 year old male, weighing 62.0 kg (136.4 pounds)
Adverse reactions / side effects: Cryptogenic Organising Pneumonia, Bronchoalveolar Lavage Abnormal, Dyspnoea, Gamma-Glutamyltransferase Increased, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Voltaren (Diclofenac)
Other drugs received by patient: Lipovas; Norvasc; Fluitran; Inhibace
Adverse event in 55 year old male receiving Voltaren (Diclofenac)
Reported by a individual with unspecified qualification from Japan on 2007-05-14
Patient: 55 year old male
Adverse reactions / side effects: Biopsy Lung Abnormal, Dyspnoea, Thoracic Cavity Drainage, Eosinophilic Pneumonia, Blood Lactate Dehydrogenase Increased, Pyrexia, Eosinophil Count Increased, Chest X-RAY Abnormal, Haemoglobin Decreased, Pneumothorax, Cough, Lymphocyte Count Decreased
Suspect drug(s):
Voltaren (Diclofenac)
Adverse event in 41 year old male receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-05-11
Patient: 41 year old male, weighing 60.0 kg (132.0 pounds)
Adverse reactions / side effects: Brain Death, Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Blood Calcium Increased, Pyrexia, C-Reactive Protein Increased, Brain Oedema, Blood Creatinine Increased, White Blood Cell Count Increased, Mydriasis, Brain Stem Haemorrhage, Blood Urea Increased, Dyspnoea, Urine Output Decreased, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Dependence ON Respirator, Haemodialysis, Brain Stem Syndrome, Dehydration, Aspartate Aminotransferase Increased, Platelet Count Decreased, Blood Pressure Decreased
Adverse event resulted in: death, life threatening event, hospitalization
Suspect drug(s):
Voltaren (Diclofenac)
Other drugs received by patient: Adona; Transamin; Primperan INJ; Gaster; Glyceol
Adverse event in 51 year old female receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-05-04
Patient: 51 year old female, weighing 62.0 kg (136.4 pounds)
Adverse reactions / side effects: Blood Alkaline Phosphatase Increased, Blood Creatine Phosphokinase Increased, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Paralysis, Pallor, Tremor, Haemoglobin Decreased, Gamma-Glutamyltransferase Increased, C-Reactive Protein Increased, Palpitations, Aspartate Aminotransferase Increased
Suspect drug(s):
Voltaren (Diclofenac)
Other drugs received by patient: Allegra; Aspirin; Ferromia
Adverse event in 41 year old male receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-04-06
Patient: 41 year old male, weighing 60.0 kg (132.0 pounds)
Adverse reactions / side effects: Brain Death, Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Blood Calcium Increased, Pyrexia, C-Reactive Protein Increased, Brain Oedema, Blood Creatinine Increased, White Blood Cell Count Increased, Mydriasis, Brain Stem Haemorrhage, Blood Urea Increased, Dyspnoea, Urine Output Decreased, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Dependence ON Respirator, Haemodialysis, Brain Stem Syndrome, Dehydration, Aspartate Aminotransferase Increased, Platelet Count Decreased, Blood Pressure Decreased
Adverse event resulted in: death, life threatening event, hospitalization
Suspect drug(s):
Voltaren (Diclofenac)
Other drugs received by patient: Adona; Transamin; Primperan INJ; Gaster; Glyceol
Adverse event in 56 year old male receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-04-04
Patient: 56 year old male, weighing 65.0 kg (143.0 pounds)
Adverse reactions / side effects: Abdominal Pain, Blood Alkaline Phosphatase Increased, Enterocolitis Haemorrhagic, Blood Creatine Phosphokinase Increased, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Colonoscopy, Drug Interaction, Liver Disorder, Glycosylated Haemoglobin Increased, Colonic Stenosis, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Pancreatitis, Melaena, White Blood Cell Count Increased
Adverse event resulted in: disablity
Suspect drug(s):
Rocephin
Dosage: 2 g/day
Indication: Pyrexia
Start date: 2007-02-07
End date: 2007-02-13
Voltaren
Dosage: 100 mg/day
Indication: Pyrexia
Start date: 2007-02-06
End date: 2007-02-13
Other drugs received by patient: Futhan
Adverse event in 56 year old male receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-03-28
Patient: 56 year old male, weighing 65.0 kg (143.0 pounds)
Adverse reactions / side effects: Abdominal Pain, Blood Alkaline Phosphatase Increased, Enterocolitis Haemorrhagic, Blood Creatine Phosphokinase Increased, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Colonoscopy, Drug Interaction, Glycosylated Haemoglobin Increased, Colonic Stenosis, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Pancreatitis, Melaena, White Blood Cell Count Increased
Adverse event resulted in: disablity
Suspect drug(s):
Rocephin
Dosage: 2 g/day
Indication: Pyrexia
Start date: 2007-02-07
End date: 2007-02-13
Voltaren
Dosage: 100 mg/day
Indication: Pyrexia
Start date: 2007-02-06
End date: 2007-02-13
Other drugs received by patient: Futhan
Adverse event in 41 year old male receiving Voltaren (Diclofenac)
Reported by a physician from Japan on 2007-03-16
Patient: 41 year old male, weighing 60.0 kg (132.0 pounds)
Adverse reactions / side effects: Brain Death, Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Blood Calcium Increased, Pyrexia, C-Reactive Protein Increased, Brain Oedema, Blood Creatinine Increased, White Blood Cell Count Increased, Mydriasis, Brain Stem Haemorrhage, Blood Urea Increased, Dyspnoea, Urine Output Decreased, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Dependence ON Respirator, Haemodialysis, Brain Stem Syndrome, Dehydration, Aspartate Aminotransferase Increased, Platelet Count Decreased, Blood Pressure Decreased
Adverse event resulted in: death, life threatening event, hospitalization
Suspect drug(s):
Voltaren (Diclofenac)
Other drugs received by patient: Adona; Transamin; Primperan INJ; Gaster; Glyceol
Adverse event in receiving Voltaren (Diclofenac)
Reported by a physician from China on 2007-02-22
Patient:
Adverse reactions / side effects: Abdominal Pain, Renal Impairment, Dysuria, Blood Lactate Dehydrogenase Increased, Albumin Urine Present, Beta 2 Microglobulin Increased, RED Blood Cell Sedimentation Rate Increased
Suspect drug(s):
Voltaren (Diclofenac)
Other drugs received by patient: Chlorzoxazone; Gutai
Adverse event in 75 year old female receiving Voltaren (Diclofenac)
Reported by a pharmacist from Japan on 2007-01-17
Patient: 75 year old female, weighing 49.0 kg (107.8 pounds)
Adverse reactions / side effects: Hypoventilation, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Anaphylactic Shock, Hypoaesthesia, Hypoxic Encephalopathy, Heart Rate Decreased, Blood Potassium Decreased, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Nuclear Magnetic Resonance Imaging Abnormal, Blood Sodium Increased, Depressed Level of Consciousness, Blood Pressure Immeasurable
Adverse event resulted in: life threatening event
Suspect drug(s):
Voltaren (Diclofenac)
Adverse event in 75 year old female receiving Voltaren (Diclofenac)
Reported by a pharmacist from Japan on 2007-01-16
Patient: 75 year old female, weighing 49.0 kg (107.8 pounds)
Adverse reactions / side effects: Hypoventilation, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Anaphylactic Shock, Hypoaesthesia, Hypoxic Encephalopathy, Heart Rate Decreased, Blood Potassium Decreased, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Nuclear Magnetic Resonance Imaging Abnormal, Blood Sodium Increased, Depressed Level of Consciousness, Blood Pressure Immeasurable
Adverse event resulted in: life threatening event
Suspect drug(s):
Voltaren (Diclofenac)
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