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This is an index of reports of adverse events (side effects, adverse reactions, etc.) related to Sevoflurane. Click on the relevant link below to view a selection of reports according to the event's seriousness level and/or the nature of the side effect / adverse reaction. Or scroll down to view a sample of recent reports further on this page.
Our database includes reports from Jan 2007 to Dec 2007. The information is not vetted and should not be cosidered as verified clinical evidence.
All cases (82)
Cases resulting in a serious event (79)
Cases resulting in death (6)
Cases resulting in life threatening events (17)
Cases resulting in hospitalization (28)
Cases resulting in disability (3)
Cases resulting in other serious reactions (47)
Below is a sample of reports where side effects / adverse reactions may be related to Sevoflurane. For a complete list and/or a specific selection of reports, please use the links in the index above.
Adverse event in 8 month old male receiving Sevoflurane
Reported by a consumer/non-health professional from United States on 2007-10-30
Patient: 8 month old male
Adverse reactions / side effects: Renal Tubular Disorder, Rhabdomyolysis, Coagulopathy, Tachycardia, Muscular Dystrophy, Hypokalaemia, Partial Seizures, Hypomagnesaemia, Hypocalcaemia, Procedural Complication, Postoperative Fever, Metabolic Acidosis, Hypotension, General Physical Health Deterioration, Sepsis, NO Therapeutic Response, END-Tidal CO2 Increased, Bradycardia
Adverse event resulted in: death
Suspect drug(s):
Fentanyl
Indication: General Anaesthesia
Propofol
Dosage: intravenous drip
Indication: General Anaesthesia
Rocuronium Bromide
Sevoflurane
Adverse event in male receiving Sevoflurane
Reported by a individual with unspecified qualification from Italy on 2007-10-30
Patient: male
Adverse reactions / side effects: Renal Failure, Hepatic Necrosis, Cardiac Failure, Respiratory Failure, Coagulopathy, Coma, Shock
Adverse event resulted in: death
Suspect drug(s):
Sevoflurane
Other drugs received by patient: Thiopental Sodium; Succinylcholine Chloride
Adverse event in 61 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-30
Patient: 61 year old male
Adverse reactions / side effects: Hyperkalaemia, Ventricular Fibrillation, Arteriospasm Coronary, Cardiac Arrest
Suspect drug(s):
Sevoflurane
Other drugs received by patient: Propofol; Vecuronium Bromide; Remifentanil Hydrochloride; Calcium Channel Blockers
Adverse event in 30 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification from United States on 2007-10-29
Patient: 30 year old male
Adverse reactions / side effects: Mental Impairment, Bradycardia, Hypoxic Encephalopathy, Shock
Adverse event resulted in: disablity
Suspect drug(s):
Brevibloc
Dosage: dose unit:unknown
Indication: Drug USE FOR Unknown Indication
Start date: 2004-04-01
End date: 2004-04-01
Sevoflurane
Dosage: dose unit:unknown
Indication: Drug USE FOR Unknown Indication
Start date: 2004-04-01
Adverse event in 30 year old male receiving Sevoflurane
Reported by a health professional (non-physician/pharmacist) from Japan on 2007-10-26
Patient: 30 year old male
Adverse reactions / side effects: Bradycardia, Hypoxic Encephalopathy, Shock
Adverse event resulted in: disablity
Suspect drug(s):
Brevibloc
Start date: 2004-04-01
End date: 2004-04-01
Sevoflurane
Start date: 2004-04-01
End date: 2004-04-01
Adverse event in 61 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-24
Patient: 61 year old male
Adverse reactions / side effects: Hyperkalaemia, Ventricular Fibrillation, Arteriospasm Coronary, Cardiac Arrest
Suspect drug(s):
Sevoflurane
Other drugs received by patient: Propofol; Vecuronium Bromide; Remifentanil Hydrochloride; Calcium Channel Blockers
Adverse event in 43 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-23
Patient: 43 year old male
Adverse reactions / side effects: Renal Failure, Respiratory Failure
Suspect drug(s):
Sevoflurane
Other drugs received by patient: Oxygen; Remifentanil Hydrochloride; Vecuronium Bromide
Adverse event in male receiving Sevoflurane
Reported by a health professional (non-physician/pharmacist) from Japan on 2007-10-23
Patient: male, weighing 66.0 kg (145.2 pounds)
Adverse reactions / side effects: Multi-Organ Failure, Haemolytic Uraemic Syndrome
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Ceftazidime
Indication: Drug USE FOR Unknown Indication
Etilefrine Hydrochloride
Indication: Drug USE FOR Unknown Indication
Nitrous Oxide
Indication: Drug USE FOR Unknown Indication
Sevoflurane
Indication: General Anaesthesia
Start date: 2007-03-14
End date: 2007-03-14
Other drugs received by patient: Thiamylal Sodium; Suxamethonium Chloride; Pancuronium Bromide; Lidocaine 1%; 2 % Lidocaine; Atropine Sulfate; Atropine Sulfate; Pethidine Hydrochloride; Isepamicin Sulfate; Neostigmine Methysulfate
Adverse event in female receiving Sevoflurane
Reported by a health professional (non-physician/pharmacist) from Australia on 2007-10-23
Patient: female
Adverse reactions / side effects: Myoclonus, Fatigue, Asthenia
Adverse event resulted in: hospitalization
Suspect drug(s):
Fentanyl
Indication: Drug USE FOR Unknown Indication
Rocuronium Bromide
Indication: Drug USE FOR Unknown Indication
Sevoflurane
Indication: Drug USE FOR Unknown Indication
Tramadol HCL
Indication: Drug USE FOR Unknown Indication
Other drugs received by patient: Propofol; Dexamethasone
Adverse event in 15 year old female receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-18
Patient: 15 year old female, weighing 20.0 kg (44.0 pounds)
Adverse reactions / side effects: Musculoskeletal Stiffness, Carbon Dioxide Increased
Suspect drug(s):
Sevoflurane
Other drugs received by patient: Fentanyl; Fentanyl; Midazolam; Vecuronium Bromide; Alprostadil
Adverse event in receiving Sevoflurane
Reported by a individual with unspecified qualification from United States on 2007-10-18
Patient:
Adverse reactions / side effects: Convulsion
Suspect drug(s):
Sevoflurane
Adverse event in 43 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-18
Patient: 43 year old male
Adverse reactions / side effects: Renal Failure, Respiratory Failure
Suspect drug(s):
Sevoflurane
Other drugs received by patient: Oxygen; Remifentanil Hydrochloride; Vecuronium Bromide
Adverse event in male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-18
Patient: male, weighing 2.7 kg (5.9 pounds)
Adverse reactions / side effects: Blood Pressure Systolic Decreased, Pulmonary Congestion
Suspect drug(s):
Albumin (Human)
Dosage: volume loading, total 60 ml of 5%
Indication: Hypotension
Sevoflurane
Indication: Maintenance of Anaesthesia
Other drugs received by patient: Fentanyl; Pancuronium; Oxygen; Oxygen; Oxygen; Fluids; Fluids
Adverse event in receiving Sevoflurane
Reported by a individual with unspecified qualification from United States on 2007-10-17
Patient:
Adverse reactions / side effects: Convulsion
Suspect drug(s):
Sevoflurane
Adverse event in 15 year old female receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-16
Patient: 15 year old female, weighing 20.0 kg (44.0 pounds)
Adverse reactions / side effects: Musculoskeletal Stiffness, Carbon Dioxide Increased
Suspect drug(s):
Sevoflurane
Other drugs received by patient: Fentanyl; Fentanyl; Midazolam HCL; Vecuronium Bromide; Alprostadil
Adverse event in 69 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-12
Patient: 69 year old male
Adverse reactions / side effects: Ventricular Tachycardia, Cardiac Arrest
Adverse event resulted in: life threatening event
Suspect drug(s):
Sevoflurane
Indication: Maintenance of Anaesthesia
Sevoflurane
Dosage: not reported
Other drugs received by patient: Propofol; Propofol; Fentanyl; Vecuronium Bromide; Remifentanil Hydrochloride; Remifentanil Hydrochloride; Nicorandil; Nicorandil; Diltiazem Hydrochloride; Diltiazem Hydrochloride; Oxygen
Adverse event in 2 year old female receiving Sevoflurane
Reported by a individual with unspecified qualification on 2007-10-11
Patient: 2 year old female, weighing 14.6 kg (32.1 pounds)
Adverse reactions / side effects: Respiratory Arrest, Apnoea, Delayed Recovery From Anaesthesia
Suspect drug(s):
Lidocaine
Indication: Local Anaesthesia
Morphine
Indication: General Anaesthesia
Propofol
Indication: Induction of Anaesthesia
Sevoflurane
Indication: Maintenance of Anaesthesia
Other drugs received by patient: Dexamethasone 0.5mg TAB; Ondansetron
Adverse event in male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-08
Patient: male, weighing 2.7 kg (5.9 pounds)
Adverse reactions / side effects: Blood Pressure Systolic Decreased, Pulmonary Congestion
Suspect drug(s):
Albumin (Human)
Dosage: volume loading, total 60 ml of 5%
Indication: Hypotension
Sevoflurane
Indication: Maintenance of Anaesthesia
Other drugs received by patient: Fentanyl; Pancuronium; Oxygen; Oxygen; Oxygen; Fluids; Fluids
Adverse event in male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-08
Patient: male, weighing 2.7 kg (5.9 pounds)
Adverse reactions / side effects: Blood Pressure Systolic Decreased, Pulmonary Congestion
Suspect drug(s):
Albumin (Human)
Dosage: volume loading, total 60 ml of 5%
Indication: Hypotension
Sevoflurane
Indication: Maintenance of Anaesthesia
Other drugs received by patient: Fentanyl; Pancuronium; Oxygen; Oxygen; Oxygen; Fluids; Fluids
Adverse event in 67 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-10-05
Patient: 67 year old male
Adverse reactions / side effects: Venous Haemorrhage, Pulmonary Oedema, Operative Haemorrhage, Tumour Haemorrhage, Shock
Adverse event resulted in: life threatening event
Suspect drug(s):
Sevoflurane
Other drugs received by patient: Nitrous Oxide; Oxygen
Adverse event in 55 year old female receiving Sevoflurane
Reported by a physician from United Kingdom on 2007-10-01
Patient: 55 year old female, weighing 60.0 kg (132.0 pounds)
Adverse reactions / side effects: Myoclonus, Movement Disorder, Dystonia, Drug Interaction, Myotonia, Sinus Tachycardia
Adverse event resulted in: hospitalization
Suspect drug(s):
Alfentanil Hydrochloride
Indication: Anaesthesia
Start date: 2005-07-01
End date: 2006-12-01
Decadron
Indication: Anaesthesia
Start date: 2006-12-01
End date: 2006-12-01
Decadron
Start date: 2005-07-01
End date: 2005-07-01
Fentanyl
Indication: Anaesthesia
Start date: 2006-06-01
End date: 2006-06-01
Fentanyl
Start date: 2005-07-01
End date: 2005-07-01
Gabapentin
Administration route: Oral
Indication: Musculoskeletal Pain
Start date: 2005-05-01
End date: 2006-01-01
Isoflurane
Indication: General Anaesthesia
Start date: 2006-06-01
End date: 2006-06-01
Propofol
Indication: Anaesthesia
Start date: 2006-06-01
End date: 2006-06-01
Sevoflurane
Indication: General Anaesthesia
Start date: 2006-12-01
End date: 2006-12-01
Other drugs received by patient: Acetaminophen; Acetaminophen; Codeine Phosphate; Alfentanil Hydrochloride; Oxygen; Propofol
Adverse event in 15 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification on 2007-07-27
Patient: 15 year old male, weighing 69.0 kg (151.8 pounds)
Adverse reactions / side effects: Dizziness, Sensory Loss, Vision Blurred, Hemiplegia, Migraine With Aura
Adverse event resulted in: hospitalization
Suspect drug(s):
Fentanyl
Dosage: 100 mcg x 1 dose
Indication: Anaesthesia
Midazolam HCL
Dosage: 2.5 mg x 1 dose
Indication: Anaesthesia
Morphine
Dosage: 20 mg in divided doses
Indication: Analgesia
Nitrous Oxide
Indication: Anaesthesia
Paracetamol
Dosage: 1 gm x 1 dose
Indication: Analgesia
Parecoxib Sodium
Dosage: 40 mg x 1 dose
Indication: Analgesia
Propofol
Dosage: 150 mg x 1 dose
Indication: Anaesthesia
Sevoflurane
Indication: Anaesthesia
Other drugs received by patient: Seratide; Salbutamol
Adverse event in 63 year old male receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-07-27
Patient: 63 year old male
Adverse reactions / side effects: Autonomic Nervous System Imbalance, Coronary Artery Stenosis, Blood Pressure Immeasurable, Arteriospasm Coronary, Sinus Tachycardia, Electromechanical Dissociation, Shock
Adverse event resulted in: life threatening event
Suspect drug(s):
Fentanyl Citrate
Dosage: intravenous (nos)
Indication: Induction of Anaesthesia
Start date: 2006-08-18
End date: 2006-08-18
Ketamine Hydrochloride
Dosage: intravenous (nos)
Indication: Induction of Anaesthesia
Start date: 2006-09-04
End date: 2006-09-04
Midazolam Hydrochloride
Dosage: intravenous (nos)
Indication: Induction of Anaesthesia
Start date: 2006-09-04
End date: 2006-09-04
Propofol
Dosage: intravenous (nos)
Indication: Induction of Anaesthesia
Start date: 2006-08-18
End date: 2006-08-18
Propofol
Dosage: intravenous (nos)
Indication: Sedation
Start date: 2006-08-18
End date: 2006-08-18
Propofol
Dosage: intravenous (nos)
Indication: Induction of Anaesthesia
Start date: 2006-09-05
End date: 2006-09-05
Propofol
Dosage: intravenous (nos)
Indication: Sedation
Start date: 2006-09-05
End date: 2006-09-05
Propofol
Dosage: intravenous (nos)
Indication: Induction of Anaesthesia
Start date: 2006-09-04
End date: 2006-09-05
Propofol
Dosage: intravenous (nos)
Indication: Sedation
Start date: 2006-09-04
End date: 2006-09-05
Sevoflurane
Dosage: respiratory (inhalation)
Indication: Maintenance of Anaesthesia
Start date: 2006-09-05
End date: 2006-09-05
Vecuronium Bromide
Dosage: ni; intravenous (nos)
Indication: Muscle Relaxant Therapy
Start date: 2006-08-18
End date: 2006-08-18
Vecuronium Bromide
Dosage: ni; intravenous (nos)
Indication: Muscle Relaxant Therapy
Start date: 2006-09-04
End date: 2006-09-04
Vecuronium Bromide
Dosage: ni; intravenous (nos)
Indication: Muscle Relaxant Therapy
Start date: 2006-09-05
End date: 2006-09-05
Other drugs received by patient: Diazepam; Roxatidine Acetate HCL; Isosorbide Dinitrate; Nicorandil; Diltiazem Hydrochloride; Dopamine HCL; Norepinephrine
Adverse event in 50 year old female receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-07-27
Patient: 50 year old female
Adverse reactions / side effects: Torsade DE Pointes, Procedural Complication
Adverse event resulted in: life threatening event
Suspect drug(s):
Fentanyl Transdermal System
Indication: Anaesthesia
Start date: 2006-09-27
End date: 2006-09-27
Fentanyl Transdermal System
Indication: Maintenance of Anaesthesia
Start date: 2006-09-27
End date: 2006-09-27
Fentanyl Transdermal System
Indication: Analgesic Therapy
Sevoflurane
Dosage: 1-5%
Indication: Anaesthesia
Start date: 2006-09-27
End date: 2006-09-28
Sevoflurane
Indication: Maintenance of Anaesthesia
Other drugs received by patient: Nitrous Oxide; Thiamylal Sodium; Atropine Sulfate; Atropine Sulfate; Suxamethonium Chloride; Diltiazem HCL; Diltiazem HCL; Ephedrine Hydrochloride; Vecuronium Bromide; Vecuronium Bromide; Vecuronium Bromide; Neostigmine Metilsulfate
Adverse event in 62 year old female receiving Sevoflurane
Reported by a individual with unspecified qualification from Japan on 2007-07-27
Patient: 62 year old female
Adverse reactions / side effects: Torsade DE Pointes
Adverse event resulted in: life threatening event
Suspect drug(s):
Disopyramide Phosphate
Indication: Arrhythmia
Start date: 2006-09-24
End date: 2006-09-24
Sevoflurane
Dosage: 1-5%
Indication: Anaesthesia
Start date: 2006-09-24
End date: 2006-09-24
Sevoflurane
Indication: Maintenance of Anaesthesia
Other drugs received by patient: Fentanyl Transdermal System; Nitrous Oxide; Thiamylal Sodium; Atropine Sulfate; Atropine Sulfate; Suxamethonium Chloride; Diltiazem HCL; Diltiazem HCL; Nicardipine Hydrochloride; Lidocaine; Verapamil Hydrochloride; Epinephrine; Vecuronium Bromide; Vecuronium Bromide; Vecuronium Bromide; Neostigmine Methylsulfate
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