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Index of reports
> Cases resulting in hospitalization (22)
> Cases with Acute Hepatic Failure (5)
Below is the selection of adverse event reports related to Noxafil (Posaconazole) that includes cases resulting in hospitalization where reactions include acute hepatic failure.
Adverse event in 68 year old female receiving Noxafil (Posaconazole)
Reported by a physician from Germany on 2007-07-06
Patient: 68 year old female
Adverse reactions / side effects: Hypovolaemic Shock, Haemoptysis, Coagulopathy, Disseminated Intravascular Coagulation, Pulmonary Embolism, Hepatocellular Damage, Haemodialysis, Multi-Organ Failure, Capillary Leak Syndrome, Hepatotoxicity, Acute Hepatic Failure, Diffuse Alveolar Damage
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Noxafil (Posaconazole)
Other drugs received by patient: Levofloxacin; Tegretol; Liskantin; Magno Sanol; Kalinor RET; Carmustine; Cytarabine; Etoposide; Melphalan; Palifermin; Ambisome; Cancidas; Diflucan; Vfend; Acyclovir; Clexane
Adverse event in female receiving Noxafil (Posaconazole)
Reported by a health professional (non-physician/pharmacist) from Germany on 2007-06-19
Patient: female, weighing 48.1 kg (105.8 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Hypovolaemic Shock, Pruritus, Disseminated Intravascular Coagulation, Prothrombin Time Prolonged, Pyrexia, B-Cell Lymphoma Stage III, Metabolic Disorder, Lung Injury, Bronchopulmonary Aspergillosis, Pneumonia, Blood Lactate Dehydrogenase Increased, General Physical Health Deterioration, Haemolysis, Fungal Infection, Aspartate Aminotransferase Increased, Disturbance in Attention, Colon Polypectomy, Hypersensitivity, Endometriosis, Osteoporosis, Chills, Salpingo-Oophorectomy, Somnolence, Polyneuropathy, Chest X-RAY Abnormal, Stem Cell Transplant, Capillary Leak Syndrome, Fatigue, Gamma-Glutamyltransferase Increased, Thyroidectomy, Liver Function Test Abnormal, Pleural Effusion, Antithrombin III Decreased, Thrombocytopenia, Haptoglobin Decreased, Haemoptysis, Laparoscopic Sterilisation, Rash, Varicose Vein, T-Cell Lymphoma Stage III, Osteoarthritis, Renal Failure, Diarrhoea, Cardiac Failure, Sepsis, Acute Hepatic Failure, Asthenia, Venous Stent Insertion, Infection
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Tegretol
Dosage: 200 mg/day
Administration route: Oral
Noxafil
Dosage: unk, unk
Start date: 2006-12-15
End date: 2006-12-20
Other drugs received by patient: Cytarabine; Cytarabine; Rituximab; Cisplatin; Dexamethasone 0.5mg TAB; Carmustine; Etoposide; Melphalan; Liskantin; Kalinor Retard; Ambisome; Ambisome; Ambisome; Ambisome; Cancidas; Cancidas; Cancidas; Diflucan; Vfend; Acyclovir; Clexane; Palifermin; Palifermin; Tavanic
Adverse event in female receiving Noxafil (Posaconazole)
Reported by a physician from Germany on 2007-05-15
Patient: female, weighing 48.1 kg (105.8 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Pruritus, Disseminated Intravascular Coagulation, Prothrombin Time Prolonged, Pyrexia, Chemotherapy, B-Cell Lymphoma Stage III, Metabolic Disorder, Bronchopulmonary Aspergillosis, Pneumonia, Blood Lactate Dehydrogenase Increased, General Physical Health Deterioration, Haemolysis, Fungal Infection, Aspartate Aminotransferase Increased, Disturbance in Attention, Colon Polypectomy, Hypersensitivity, Osteoporosis, Endometriosis, Chills, Salpingo-Oophorectomy, Somnolence, Chest X-RAY Abnormal, Polyneuropathy, Stem Cell Transplant, Fatigue, Gamma-Glutamyltransferase Increased, Thyroidectomy, Liver Function Test Abnormal, Pleural Effusion, Thrombocytopenia, Antithrombin III Decreased, Haptoglobin Decreased, Haemoptysis, Laparoscopic Sterilisation, Rash, Varicose Vein, T-Cell Lymphoma Stage III, Osteoarthritis, Diarrhoea, Sepsis, Acute Hepatic Failure, Asthenia, Venous Stent Insertion, Infection
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Tegretol
Dosage: 200 mg/day
Administration route: Oral
Noxafil
Dosage: unk, unk
Start date: 2006-12-15
End date: 2006-12-20
Other drugs received by patient: Arac; Arac; Rituximab; Cisplatin; Dexamethasone 0.5mg TAB; Carmustine; Etoposide; Melphalan; Liskantin; Kalinor Retard; Ambisome; Ambisome; Ambisome; Ambisome; Cancidas; Cancidas; Cancidas; Diflucan; Vfend; Acyclovir; Clexane; Palifermin; Palifermin; Tavanic
Adverse event in 68 year old female receiving Noxafil (Posaconazole)
Reported by a physician from Germany on 2007-03-12
Patient: 68 year old female
Adverse reactions / side effects: Drug Toxicity, Haemoptysis, Disseminated Intravascular Coagulation, Acute Hepatic Failure, Hepatocellular Damage, Haemolysis, Haemodialysis
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Noxafil (Posaconazole)
Other drugs received by patient: Tavanic; Tegretol; Liskantin; Magno Sanol; Kalinor RET; Carmustine; Arac; Etoposide; Melphalan; Palifermin; Ambisome; Diflucan; Vfend; Acyclovir; Clexane
Adverse event in 68 year old female receiving Noxafil (Posaconazole)
Reported by a physician from Germany on 2007-02-23
Patient: 68 year old female
Adverse reactions / side effects: Acute Hepatic Failure, Haemodialysis
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Noxafil
Dosage: 800 mg;qd;po
Administration route: Oral
Indication: Aspergillosis
Start date: 2006-12-15
End date: 2006-12-22
Noxafil
Dosage: 800 mg;qd;po
Administration route: Oral
Indication: Prophylaxis
Start date: 2006-12-15
End date: 2006-12-22
Other drugs received by patient: Tavanic; Tegretol; Liskantin; Magno Sanol; Kalinor RET; Carmustine; Arac; Etoposide; Melphalan; Paliformin; Ambisome; Cancidas; Diflucan; Vfend; Acyclovir; Clexane
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