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Index of reports
> Cases resulting in a serious event (433)
> Cases with Diarrhoea (55)
Below is the selection of adverse event reports related to Nexavar (Sorafenib) that includes cases resulting in a serious event where reactions include diarrhoea.
Reports 1 - 25 of 55 Next >>
Adverse event in 58 year old female receiving Nexavar (Sorafenib)
Reported by a individual with unspecified qualification from United States on 2007-10-31
Patient: 58 year old female, weighing 74.8 kg (164.7 pounds)
Adverse reactions / side effects: Stomatitis, Abdominal Abscess, Diarrhoea, Pneumoperitoneum, Rash, Diverticular Perforation
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Nexavar
Dosage: 400 mg, bid, oral, 200 mg, bid, oral
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2006-11-01
End date: 2007-01-01
Nexavar
Dosage: 400 mg, bid, oral, 200 mg, bid, oral
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2007-01-01
End date: 2007-07-06
Other drugs received by patient: Glipizide; Avandia; Klor-CON; Mavik; Allopurinol; Zyrtec; Dolobid; Lasix; Vytorin; Centrum Silver; Toprol-XL; Imodium
Adverse event in 76 year old female receiving Nexavar (Sorafenib)
Reported by a individual with unspecified qualification from United States on 2007-10-31
Patient: 76 year old female
Adverse reactions / side effects: Exophthalmos, Gastrointestinal Haemorrhage, Rash Generalised, Stomatitis, Eye Discharge, Gastrointestinal Ulcer, Cheilitis, Diarrhoea, Skin Lesion, Eye Swelling, DRY Eye, Asthenia, Gastrooesophageal Reflux Disease, Blister
Adverse event resulted in: hospitalization
Suspect drug(s):
Nexavar
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2007-07-30
End date: 2007-08-07
Nexavar
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2007-08-10
End date: 2007-08-24
Other drugs received by patient: Oxycodone HCL; Reglan; Darvocet; Phenergan; Primacor
Adverse event in receiving Nexavar (Sorafenib)
Reported by a physician from United States on 2007-10-31
Patient:
Adverse reactions / side effects: Diarrhoea
Adverse event resulted in: hospitalization
Suspect drug(s):
Nexavar (Sorafenib)
Adverse event in 77 year old male receiving Nexavar (Sorafenib)
Reported by a physician from United States on 2007-10-31
Patient: 77 year old male
Adverse reactions / side effects: Hypogeusia, Diarrhoea, Headache
Suspect drug(s):
Nexavar
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Metastases TO Lung
Start date: 2006-04-20
End date: 2006-05-01
Nexavar
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2006-04-20
End date: 2006-05-01
Nexavar
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Metastases TO Lung
Start date: 2006-05-22
End date: 2006-05-23
Nexavar
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2006-05-22
End date: 2006-05-23
Nexavar
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Metastases TO Lung
Start date: 2006-05-24
Nexavar
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2006-05-24
Other drugs received by patient: Lipitor; Bisoprolol Fumarate and Hydrochlorothiazide; Calcium; MVI (Vitamins Nos); Vicodin; Imdur; Fish OIL; Prilosec; Oxycodone HCL; Senna; Colace
Adverse event in 56 year old male receiving Nexavar (Sorafenib)
Reported by a physician from China on 2007-10-25
Patient: 56 year old male
Adverse reactions / side effects: Jaundice, Blood Bilirubin Increased, Diarrhoea, Coma Hepatic, Rash, Transaminases Increased, Hepatitis
Suspect drug(s):
Nexavar (Sorafenib)
Adverse event in 52 year old male receiving Nexavar (Sorafenib)
Reported by a physician from United States on 2007-10-16
Patient: 52 year old male
Adverse reactions / side effects: Hyperkeratosis, Skin Exfoliation, Skin Fissures, Diplopia, Oedema Peripheral, Epistaxis, Bone Lesion, Pain in Extremity, Vith Nerve Paralysis, Palmar-Plantar Erythrodysaesthesia Syndrome, DRY Skin, Hypoaesthesia, Rash, Paraesthesia, Gingival Pain, Oral Pain, Diarrhoea, Impaired Healing, Anorexia, Nervous System Disorder
Suspect drug(s):
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2007-08-23
End date: 2007-09-01
Nexavar
Dosage: total daily dose: 400 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-09-17
Adverse event in 75 year old male receiving Nexavar (Sorafenib)
Reported by a pharmacist from Canada on 2007-10-11
Patient: 75 year old male, weighing 73.0 kg (160.6 pounds)
Adverse reactions / side effects: Weight Decreased, Death, Diarrhoea, Anorexia, Constipation, Abdominal Pain Upper
Adverse event resulted in: death
Suspect drug(s):
Nexavar (Sorafenib)
Other drugs received by patient: Lactulose; Lactulose
Adverse event in 52 year old male receiving Nexavar (Sorafenib)
Reported by a consumer/non-health professional from United States on 2007-10-09
Patient: 52 year old male
Adverse reactions / side effects: Pain in Extremity, Skin Exfoliation, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Hypoaesthesia, DRY Skin, Paraesthesia, Skin Fissures, Diplopia, Impaired Healing, Diarrhoea, Oral Pain, Anorexia, Oedema Peripheral, Nervous System Disorder, Epistaxis
Suspect drug(s):
Nexavar
Dosage: total daily dose: 400 mg unit dose: 200 mg
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2007-09-01
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-08-01
End date: 2007-09-01
Other drugs received by patient: Chemotherapy
Adverse event in 70 year old male receiving Nexavar (Sorafenib)
Reported by a individual with unspecified qualification from United States on 2007-10-08
Patient: 70 year old male
Adverse reactions / side effects: Abdominal Pain, Jaundice, Abasia, Abdominal Discomfort, Skin Ulcer, Oedema Peripheral, Abdominal Distension, Blood Glucose Increased, Vomiting, Dyspnoea, Nausea, Anaemia, Muscular Weakness, General Physical Health Deterioration, Blood Glucose Decreased, Diarrhoea, Anorexia, Asthenia
Suspect drug(s):
Nexavar
Dosage: unit dose: 200 mg
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2007-08-20
Nexavar
Dosage: unit dose: 200 mg
Administration route: Oral
Start date: 2007-08-06
Nexavar
Dosage: unit dose: 200 mg
Administration route: Oral
Start date: 2007-07-10
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-07-06
End date: 2007-07-09
Other drugs received by patient: Humalog; Humulin 70 / 30; Lasix; Lipitor; Coreg; Levothyroxine Sodium; Aspirin; Ascorbic Acid; Potassium Chloride; Stool Softener
Adverse event in 77 year old male receiving Nexavar (Sorafenib)
Reported by a individual with unspecified qualification from United States on 2007-10-05
Patient: 77 year old male
Adverse reactions / side effects: Weight Decreased, Flatulence, Urine Odour Abnormal, Constipation, Cardiac Disorder, Urine Output Increased, Myalgia, Fatigue, Dizziness, Hiccups, Decreased Appetite, Fluid Retention, Blood Pressure Increased, Stomatitis, Nausea, Anaemia, Therapeutic Embolisation, Diarrhoea
Adverse event resulted in: hospitalization
Suspect drug(s):
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2007-06-12
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-04-05
End date: 2007-04-26
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-02-22
End date: 2007-03-11
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-01-08
End date: 2007-01-22
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-10-02
End date: 2006-11-01
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-11-12
End date: 2006-12-15
Other drugs received by patient: Lasix; Inderal; Vitamin E; Ascorbic Acid; Lanoxin; Niacin; Altace; Atarax; Folbee; MAG-TAB; Aspirin
Adverse event in 81 year old male receiving Nexavar (Sorafenib)
Reported by a physician from United States on 2007-10-05
Patient: 81 year old male
Adverse reactions / side effects: Diarrhoea, Basal Cell Carcinoma, Rash Papular, Rash Pruritic
Suspect drug(s):
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2007-08-01
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-02-01
End date: 2006-01-01
Nexavar
Dosage: total daily dose: 400 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-01-01
End date: 2006-01-01
Other drugs received by patient: Tricor; Triamterene and Hydrochlorothiazide; Altace; Omeprazole; Plavix; Simvastatin; Nifedipine; Potchlor SR; Centrum; Cholinoid
Adverse event in 55 year old female receiving Nexavar (Sorafenib)
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-02
Patient: 55 year old female
Adverse reactions / side effects: Chills, Pyrexia, Eye Infection, Jugular Vein Thrombosis, Stevens-Johnson Syndrome, Blister, Cough, Vomiting, Rash Generalised, Stomatitis, Nausea, Anaemia, Hypotension, Staphylococcal Sepsis, Convulsion, Diarrhoea, Staphylococcal Infection
Adverse event resulted in: hospitalization
Suspect drug(s):
Abraxane
Indication: Malignant Melanoma
Carboplatin
Indication: Malignant Melanoma
Nexavar
Dosage: total daily dose: 400 mg unit dose: 200 mg
Administration route: Oral
Indication: Metastatic Malignant Melanoma
Start date: 2006-09-01
End date: 2006-11-07
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-08-14
End date: 2006-09-01
Pyridoxine (Vitamin B6)
Indication: Drug USE FOR Unknown Indication
Vancomycin
Indication: Staphylococcal Infection
Other drugs received by patient: Coumadin; Atenolol; Hydroxizine
Adverse event in 69 year old male receiving Nexavar (Sorafenib)
Reported by a physician from United States on 2007-10-01
Patient: 69 year old male, weighing 73.0 kg (160.6 pounds)
Adverse reactions / side effects: Retching, DRY Skin, Malaise, Dyspnoea Exertional, Fatigue, Throat Irritation, Dysphonia, Diarrhoea, Anorexia, Choking, DRY Throat, Renal Cell Carcinoma Stage Unspecified, Gastrooesophageal Reflux Disease, Asthenia, Cough
Suspect drug(s):
Nexavar (Sorafenib)
Other drugs received by patient: Glucosamine / Contritim; Glipizide; Actos; Ecotrin; Lipitor; Cardizem; Lanoxin; Zetia; Lisinopril; Avapro; Toprol-XL; Lantus; Lomotil
Adverse event in male receiving Nexavar (Sorafenib)
Reported by a consumer/non-health professional from United States on 2007-07-27
Patient: male
Adverse reactions / side effects: Death, Diarrhoea, Ammonia Increased
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Nexavar (Sorafenib)
Adverse event in female receiving Nexavar (Sorafenib)
Reported by a health professional (non-physician/pharmacist) from China on 2007-07-20
Patient: female
Adverse reactions / side effects: Blood Pressure Increased, Diarrhoea, Pain in Extremity, Palmar-Plantar Erythrodysaesthesia Syndrome, Venous Stasis, Rash
Adverse event resulted in: hospitalization
Suspect drug(s):
Nexavar
Dosage: total daily dose: 800 mg
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2007-07-03
End date: 2007-07-17
Nexavar
Dosage: total daily dose: 400 mg
Administration route: Oral
Start date: 2007-07-17
End date: 2007-07-17
Other drugs received by patient: Dexamethasone 0.5mg TAB; Claritin
Adverse event in male receiving Nexavar (Sorafenib)
Reported by a consumer/non-health professional from United States on 2007-07-20
Patient: male
Adverse reactions / side effects: Diarrhoea, Ammonia Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Nexavar (Sorafenib)
Adverse event in 76 year old male receiving Nexavar (Sorafenib)
Reported by a consumer/non-health professional from United States on 2007-07-19
Patient: 76 year old male
Adverse reactions / side effects: Weight Decreased, Blood Calcium Decreased, Diarrhoea, Metastatic Renal Cell Carcinoma, Decreased Appetite
Suspect drug(s):
Nexavar (Sorafenib)
Other drugs received by patient: Caltrate; Vitamin D; Magnesium Sulfate; Maxzide; Nexium; Claritin; Folic Acid; Atenolol; Cardura; Plendil; Zocor; Ecotrin; Allopurinol; Centrum Silver; Vitamin E
Adverse event in 64 year old male receiving Nexavar (Sorafenib)
Reported by a pharmacist from United States on 2007-07-16
Patient: 64 year old male
Adverse reactions / side effects: Dyspnoea, Pneumonia, Haemoptysis, Therapeutic Agent Toxicity, Hypotension, Diarrhoea, Dehydration, Ejection Fraction Decreased
Adverse event resulted in: hospitalization
Suspect drug(s):
Nexavar (Sorafenib)
Other drugs received by patient: Zocor; Isosorbide Dinitrate; Lasix; Lisinopril; Digoxin; Atenolol; Lovenox
Adverse event in 77 year old male receiving Nexavar (Sorafenib)
Reported by a individual with unspecified qualification from United States on 2007-07-13
Patient: 77 year old male
Adverse reactions / side effects: Weight Decreased, Flatulence, Urine Odour Abnormal, Constipation, Cardiac Disorder, Urine Output Increased, Myalgia, Fatigue, Dizziness, Hiccups, Decreased Appetite, Fluid Retention, Blood Pressure Increased, Stomatitis, Nausea, Anaemia, Therapeutic Embolisation, Diarrhoea
Adverse event resulted in: hospitalization
Suspect drug(s):
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2007-06-12
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-04-05
End date: 2007-04-26
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-02-22
End date: 2007-03-11
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2007-01-08
End date: 2007-01-22
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-10-02
End date: 2006-11-01
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-11-12
End date: 2006-12-15
Other drugs received by patient: Lasix; Inderal; Vitamin E; Ascorbic Acid; Lanoxin; Niacin; Altace; Atarax; Folbee; MAG-TAB; Aspirin
Adverse event in 72 year old female receiving Nexavar (Sorafenib)
Reported by a physician from Sweden on 2007-07-13
Patient: 72 year old female
Adverse reactions / side effects: Back Pain, Diarrhoea, Skin Discolouration, Palmar-Plantar Erythrodysaesthesia Syndrome, Visual Acuity Reduced, Skin Atrophy
Suspect drug(s):
Nexavar
Dosage: as used: 200 mg
Administration route: Oral
Indication: Neoplasm Malignant
Start date: 2007-04-15
End date: 2007-05-01
Nexavar
Dosage: as used: 200 mg
Administration route: Oral
Start date: 2007-05-01
Adverse event in 56 year old male receiving Nexavar (Sorafenib)
Reported by a individual with unspecified qualification from United States on 2007-07-11
Patient: 56 year old male
Adverse reactions / side effects: Total Cholesterol / HDL Ratio Increased, Blood Pressure Increased, Diarrhoea, Blood Triglycerides Increased, Blood Cholesterol Increased, Lipids Increased, Rash
Suspect drug(s):
Nexavar (Sorafenib)
Other drugs received by patient: Gemfibrozil
Adverse event in 71 year old male receiving Nexavar (Sorafenib)
Reported by a individual with unspecified qualification from United States on 2007-07-10
Patient: 71 year old male, weighing 108.0 kg (237.6 pounds)
Adverse reactions / side effects: Bone Pain, Headache, Hypoaesthesia Oral, Fatigue, Proteinuria, Dizziness, Muscle Spasms, Epistaxis, Blister, Blood Alkaline Phosphatase Increased, Pain in Extremity, Palmar-Plantar Erythrodysaesthesia Syndrome, Hypoaesthesia, Nephrotic Syndrome, Diarrhoea, Gait Disturbance, Hypertension
Suspect drug(s):
Nexavar
Dosage: total daily dose: 400 mg unit dose: 200 mg
Administration route: Oral
Indication: Renal Cell Carcinoma Stage Unspecified
Start date: 2006-01-01
Nexavar
Administration route: Oral
Start date: 2006-05-01
Nexavar
Dosage: total daily dose: 400 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-03-01
End date: 2006-05-01
Nexavar
Dosage: as used: 200/400 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-01-01
End date: 2006-01-01
Nexavar
Dosage: total daily dose: 800 mg unit dose: 200 mg
Administration route: Oral
Start date: 2006-02-02
End date: 2006-01-01
Other drugs received by patient: Aceon; Metformin Hydrochloride; Zocor; Lisinopril
Adverse event in 62 year old female receiving Nexavar (Sorafenib)
Reported by a individual with unspecified qualification from United States on 2007-07-06
Patient: 62 year old female, weighing 68.0 kg (149.6 pounds)
Adverse reactions / side effects: Pruritus, Disorientation, Blood Magnesium Decreased, DRY Skin, Headache, Paraesthesia, Haemoglobin Decreased, Diarrhoea, Dehydration, Platelet Count Decreased
Adverse event resulted in: hospitalization
Suspect drug(s):
Nexavar (Sorafenib)
Other drugs received by patient: Tarceva; Cisplatin; Hycamtin
Adverse event in 55 year old male receiving Nexavar (Sorafenib)
Reported by a consumer/non-health professional from China on 2007-07-06
Patient: 55 year old male
Adverse reactions / side effects: Diarrhoea, Anorexia, Bone Pain, Malignant Neoplasm Progression, Rash
Adverse event resulted in: death
Suspect drug(s):
Nexavar
Dosage: total daily dose: 800 mg
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2007-04-01
End date: 2007-05-01
Nexavar
Dosage: total daily dose: 1200 mg
Administration route: Oral
Start date: 2007-05-01
End date: 2007-06-19
Adverse event in 55 year old male receiving Nexavar (Sorafenib)
Reported by a consumer/non-health professional from China on 2007-07-05
Patient: 55 year old male
Adverse reactions / side effects: Diarrhoea, Anorexia, Bone Pain, Malignant Neoplasm Progression, Rash
Adverse event resulted in: death
Suspect drug(s):
Nexavar
Dosage: total daily dose: 800 mg
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2007-04-01
End date: 2007-05-01
Nexavar
Dosage: total daily dose: 1200 mg
Administration route: Oral
Start date: 2007-05-01
End date: 2007-06-19
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