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This is an index of reports of adverse events (side effects, adverse reactions, etc.) related to Methotrexate. Click on the relevant link below to view a selection of reports according to the event's seriousness level and/or the nature of the side effect / adverse reaction. Or scroll down to view a sample of recent reports further on this page.
Our database includes reports from Jan 2007 to Dec 2007. The information is not vetted and should not be cosidered as verified clinical evidence.
All cases (1150)
Cases resulting in a serious event (1131)
Cases resulting in death (281)
Cases resulting in life threatening events (91)
Cases resulting in hospitalization (547)
Cases resulting in disability (71)
Cases resulting in other serious reactions (514)
Below is a sample of reports where side effects / adverse reactions may be related to Methotrexate. For a complete list and/or a specific selection of reports, please use the links in the index above.
Adverse event in 7 year old female receiving Methotrexate
Reported by a consumer/non-health professional from Greece on 2007-10-31
Patient: 7 year old female, weighing 25.0 kg (55.0 pounds)
Adverse reactions / side effects: Erythema Infectiosum, Histiocytosis Haematophagic
Adverse event resulted in: death
Suspect drug(s):
Azathioprine
Indication: Diffuse Vasculitis
Start date: 2001-08-01
Cyclophosphamide
Indication: Diffuse Vasculitis
Start date: 2007-04-27
End date: 2007-04-27
Cyclosporine
Indication: Diffuse Vasculitis
Start date: 2007-05-02
End date: 2007-05-04
Etanercept
Indication: Diffuse Vasculitis
Start date: 2001-08-01
Kineret
Indication: Diffuse Vasculitis
Start date: 2006-03-22
End date: 2007-04-20
Methotrexate
Indication: Diffuse Vasculitis
Start date: 2001-08-01
Methylprednisolone
Indication: Diffuse Vasculitis
Start date: 2007-05-03
End date: 2007-05-05
Prednisolone
Administration route: Oral
Indication: Diffuse Vasculitis
Start date: 2001-06-20
End date: 2002-05-15
Other drugs received by patient: Corticosteroid
Adverse event in receiving Methotrexate
Reported by a physician from United Kingdom on 2007-10-31
Patient:
Adverse reactions / side effects: Intra-Abdominal Haemorrhage
Adverse event resulted in: death
Suspect drug(s):
Cisplatin
Dosage: (50 mg/m2, over 4h days 3 and 4)
Indication: Germ Cell Cancer
Dactinomycin
Dosage: (1 mg/m2)
Indication: Germ Cell Cancer
Etoposide
Dosage: (90 mg/m2, days 1-4 over 2h)
Indication: Germ Cell Cancer
Methotrexate
Indication: Germ Cell Cancer
Adverse event in female receiving Methotrexate
Reported by a physician from United States on 2007-10-31
Patient: female
Adverse reactions / side effects: Cellulitis, Anorexia, Dehydration, Renal Failure Acute
Adverse event resulted in: hospitalization
Suspect drug(s):
Enbrel
Indication: Rheumatoid Arthritis
Start date: 2003-04-22
Methotrexate
Administration route: Oral
Start date: 2005-03-09
Other drugs received by patient: Prednisone; Lipitor; Zestril; Folic Acid; Diltiazem; Aspirin; Advair Diskus 100 / 50; Prevacid
Adverse event in 52 year old male receiving Methotrexate
Reported by a individual with unspecified qualification from Israel on 2007-10-31
Patient: 52 year old male
Adverse reactions / side effects: Drug Toxicity, Leukaemia, Bone Marrow Transplant, Hepatotoxicity, NO Therapeutic Response, Chronic Graft Versus Host Disease, Jaundice Cholestatic
Suspect drug(s):
Asparaginase(asparaginase) (Asparaginase)
Indication: B Precursor Type Acute Leukaemia
Cytarabine
Indication: B Precursor Type Acute Leukaemia
Daunorubicin HCL
Indication: B Precursor Type Acute Leukaemia
Dexamethasone
Indication: B Precursor Type Acute Leukaemia
Mercaptopurine
Indication: B Precursor Type Acute Leukaemia
Methotrexate
Dosage: intrathecal
Indication: B Precursor Type Acute Leukaemia
Methotrexate
Dosage: intrathecal
Indication: B Precursor Type Acute Leukaemia
Vincristine
Indication: B Precursor Type Acute Leukaemia
Other drugs received by patient: Cyclophosphamide; Cyclophosphamide; Lamivudine
Adverse event in 50 year old female receiving Methotrexate
Reported by a consumer/non-health professional from United States on 2007-10-31
Patient: 50 year old female
Adverse reactions / side effects: Lung Disorder, Overdose, Tumour Lysis Syndrome, Bone Marrow Failure, Septic Shock, Renal Failure Acute
Adverse event resulted in: death, life threatening event
Suspect drug(s):
Doxorubicin HCL
Indication: Burkitt's Lymphoma
Start date: 2007-09-18
End date: 2007-09-18
Endoxan
Indication: Burkitt's Lymphoma
Start date: 2007-09-19
End date: 2007-09-19
Methotrexate
Dosage: 5900mg intravenous therapy dates 17sep2007-17sep2007
Indication: Burkitt's Lymphoma
Start date: 2007-09-17
End date: 2007-09-18
Oncovin
Indication: Burkitt's Lymphoma
Start date: 2007-09-17
End date: 2007-09-17
Other drugs received by patient: Ranitidine HCL; Zelitrex; Imodium; Tazocilline
Adverse event in 34 year old female receiving Methotrexate
Reported by a individual with unspecified qualification on 2007-10-31
Patient: 34 year old female
Adverse reactions / side effects: Weight Decreased, Cryptococcal Cutaneous Infection, Drug Ineffective, Meningitis Cryptococcal, Headache
Suspect drug(s):
Alefacept
Indication: Pustular Psoriasis
Cyclosporine
Indication: Pustular Psoriasis
Cyclosporine
Start date: 2004-11-01
Efalizumab
Indication: Pustular Psoriasis
Start date: 2004-11-01
Hydroxycarbamide
Indication: Pustular Psoriasis
Methotrexate
Administration route: Oral
Indication: Pustular Psoriasis
Methotrexate
Start date: 2004-11-01
Mycophenolate Mofetil
Indication: Pustular Psoriasis
Other drugs received by patient: Amphotericin B Desoxycholate; Flucytosine; Fluconazole
Adverse event in male receiving Methotrexate
Reported by a individual with unspecified qualification from United Kingdom on 2007-10-31
Patient: male
Adverse reactions / side effects: Sepsis
Adverse event resulted in: death
Suspect drug(s):
Cisplatin
Dosage: 50 mg/m2, over 4th days 3 and 4
Indication: Germ Cell Cancer
Dactinomycin
Dosage: 1 mg/m2
Indication: Germ Cell Cancer
Etoposide
Dosage: 90 mg/m2, days 1-4 over 2h)
Indication: Germ Cell Cancer
Methotrexate
Indication: Germ Cell Cancer
Adverse event in 58 year old female receiving Methotrexate
Reported by a individual with unspecified qualification on 2007-10-31
Patient: 58 year old female
Adverse reactions / side effects: Cataract Nuclear, Drug Ineffective FOR Unapproved Indication, Uveitis
Suspect drug(s):
Dexamethasone 0.5mg TAB
Indication: Uveitis
Etanercept
Indication: Rheumatoid Arthritis
Methotrexate
Administration route: Oral
Indication: Rheumatoid Arthritis
Triamicinolone
Indication: Uveitis
Other drugs received by patient: Rifampin; Isoniazid; Pyrazinamide; Ethambutol HCL
Adverse event in female receiving Methotrexate
Reported by a physician from Japan on 2007-10-31
Patient: female
Adverse reactions / side effects: Pneumocystis Jiroveci Pneumonia
Adverse event resulted in: hospitalization
Suspect drug(s):
Methotrexate
Administration route: Oral
Indication: Rheumatoid Arthritis
Remicade
Remicade
Dosage: 2 infusions on unspecified dates.
Indication: Rheumatoid Arthritis
Adverse event in receiving Methotrexate
Reported by a individual with unspecified qualification from United Kingdom on 2007-10-31
Patient:
Adverse reactions / side effects: Drug Toxicity, Intra-Abdominal Haemorrhage, Sepsis, Febrile Neutropenia
Adverse event resulted in: death
Suspect drug(s):
Cisplatin
Dosage: 50 mg/m2, over 4h days 3 and 4
Indication: Germ Cell Cancer
Dactinomycin
Dosage: 1 mg/m2
Indication: Germ Cell Cancer
Etoposide
Dosage: 90 mg/m2, days 1-4 over 2h
Indication: Germ Cell Cancer
Methotrexate
Indication: Germ Cell Cancer
Adverse event in 7 year old female receiving Methotrexate
Reported by a physician from Greece on 2007-10-30
Patient: 7 year old female, weighing 25.0 kg (55.0 pounds)
Adverse reactions / side effects: Parvovirus Infection, Histiocytosis Haematophagic, Drug Interaction, Immunosuppression
Adverse event resulted in: death
Suspect drug(s):
Azathioprine
Indication: Drug USE FOR Unknown Indication
Cyclophosphamide
Dosage: 800 mg iv
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-27
End date: 2007-04-27
Cyclosporine
Indication: Drug USE FOR Unknown Indication
Start date: 2007-05-02
End date: 2007-05-04
Entanercept
Indication: Drug USE FOR Unknown Indication
Kineret
Dosage: 25 mg/kg once sc
Indication: Vasculitis
Start date: 2006-03-22
End date: 2007-04-20
Methotrexate
Indication: Drug USE FOR Unknown Indication
Methylprednisolone
Dosage: 300 mg/kg iv
Indication: Drug USE FOR Unknown Indication
Start date: 2007-05-03
End date: 2007-05-05
Prednisolone
Indication: Drug USE FOR Unknown Indication
Start date: 2001-06-21
End date: 2002-05-15
Adverse event in female receiving Methotrexate
Reported by a consumer/non-health professional from United States on 2007-10-30
Patient: female
Adverse reactions / side effects: Nausea, Dizziness, Paralysis, Loss of Consciousness
Suspect drug(s):
Chantix
Etanercept
Lipitor
Methotrexate
Adverse event in receiving Methotrexate
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2007-10-30
Patient:
Adverse reactions / side effects: Sepsis
Adverse event resulted in: death
Suspect drug(s):
Cisplatin
Dosage: 50mg/m2 over 4 h days 3 and 4.
Indication: Germ Cell Cancer
Dactinomycin
Dosage: 1(mg/m2)day
Indication: Germ Cell Cancer
Etoposide
Dosage: 90mg/m2days 1-4 over2h:methotrexate loading dose over 30min followed by 12hinfusion
Indication: Germ Cell Cancer
Methotrexate
Indication: Germ Cell Cancer
Other drugs received by patient: Carboplatin; Neupogen; Leucovorin
Adverse event in 28 year old female receiving Methotrexate
Reported by a consumer/non-health professional from United States on 2007-10-30
Patient: 28 year old female
Adverse reactions / side effects: Grand MAL Convulsion, Bone Marrow Failure, Leukoencephalopathy, Respiratory Distress, Convulsion, Cough, Oxygen Saturation Decreased
Adverse event resulted in: hospitalization
Suspect drug(s):
Cytarabine
Indication: Burkitt's Lymphoma
Start date: 2007-08-28
End date: 2007-08-28
Endoxan
Indication: Burkitt's Lymphoma
Start date: 2007-08-23
End date: 2007-08-23
Methotrexate
Indication: Burkitt's Lymphoma
Start date: 2007-08-28
End date: 2007-08-28
Vincristine Sulfate
Indication: Burkitt's Lymphoma
Start date: 2007-08-23
End date: 2007-08-23
Other drugs received by patient: Rituxan; Doxorubicin HCL; Combivir; Sustiva; Inipomp; Cortancyl; Prednisone
Adverse event in 54 year old male receiving Methotrexate
Reported by a consumer/non-health professional from Norway on 2007-10-29
Patient: 54 year old male
Adverse reactions / side effects: Tongue Neoplasm Malignant Stage Unspecified
Adverse event resulted in: hospitalization
Suspect drug(s):
Adalimumab
Dosage: 40 mg, q2w
Indication: Psoriatic Arthropathy
Start date: 2005-01-01
End date: 2005-07-01
Etanercept
Dosage: 50 mg, 1/week
Indication: Psoriatic Arthropathy
Start date: 2006-06-01
End date: 2007-08-01
Mabthera
Dosage: 2 g, q2w
Indication: Psoriatic Arthropathy
Start date: 2006-10-01
End date: 2007-06-01
Methotrexate
Dosage: 12.5 mg, 1/week
Indication: Psoriatic Arthropathy
End date: 2007-08-01
Remicade
Dosage: 25 mg, 2/week
Indication: Psoriatic Arthropathy
Start date: 1999-09-01
End date: 2007-06-01
Other drugs received by patient: Prednisolone
Adverse event in 66 year old female receiving Methotrexate
Reported by a physician from Portugal on 2007-10-29
Patient: 66 year old female, weighing 45.0 kg (99.0 pounds)
Adverse reactions / side effects: Bone Marrow Failure, Pancytopenia
Adverse event resulted in: life threatening event, hospitalization, disablity
Suspect drug(s):
Methotrexate
Dosage: 15 mg, 1/week
Indication: Rheumatoid Arthritis
Rituxan
Indication: Drug USE FOR Unknown Indication
Other drugs received by patient: Folic Acid; Methylprednisolone; Furosemide; Warfarin Sodium
Adverse event in male receiving Methotrexate
Reported by a individual with unspecified qualification from United States on 2007-10-29
Patient: male, weighing 62.9 kg (138.4 pounds)
Adverse reactions / side effects: Gastrointestinal Necrosis, Pyrexia, Constipation, Faecaloma, Gastritis, Oesophageal Candidiasis, Inappropriate Antidiuretic Hormone Secretion, Colitis, Neutropenia
Adverse event resulted in: hospitalization
Suspect drug(s):
Cytarabine
Dosage: 70 mg
Daunorubicin HCL
Dosage: 172 mg
Methotrexate
Dosage: 30 mg
PEG-L-Asparaginase (K-H)
Dosage: 4300 iu
Prednisone TAB
Dosage: 2800 mg
Vincristine Sulfate
Dosage: 8 mg
Adverse event in female receiving Methotrexate
Reported by a individual with unspecified qualification from United States on 2007-10-29
Patient: female, weighing 104.0 kg (228.8 pounds)
Adverse reactions / side effects: Fluid Overload, Pancytopenia, Lobar Pneumonia, Pericardial Effusion
Adverse event resulted in: hospitalization
Suspect drug(s):
Leucovorin Calcium
Dosage: 350 mg
End date: 2007-10-19
Mercaptopurine
Dosage: 775 mg
End date: 2007-10-14
Methotrexate
Dosage: 4435 mg
End date: 2007-10-13
Vincristine Sulfate
Dosage: 4 mg
End date: 2007-10-12
Adverse event in 43 year old male receiving Methotrexate
Reported by a individual with unspecified qualification from United Kingdom on 2007-10-26
Patient: 43 year old male
Adverse reactions / side effects: Osteonecrosis, Spinal Fracture, Osteoporosis
Adverse event resulted in: hospitalization
Suspect drug(s):
Cyclophosphamide
Dosage: text:6df
Indication: Burkitt's Lymphoma
Start date: 1998-01-01
End date: 1998-09-01
Cytarabine
Indication: Burkitt's Lymphoma
Doxorubicin Hydrochloride
Dosage: text:6df
Indication: Burkitt's Lymphoma
Start date: 1998-04-01
End date: 1998-09-01
Hydrocortisone Acetate
Administration route: Oral
Indication: Burkitt's Lymphoma
Start date: 1998-04-01
End date: 1998-09-01
Methotrexate
Indication: Burkitt's Lymphoma
Start date: 1998-01-01
End date: 1998-09-01
Prednisolone
Administration route: Oral
Indication: Burkitt's Lymphoma
Start date: 1998-04-01
End date: 1998-09-01
Ritonavir
Dosage: daily dose:800mg
Administration route: Oral
Indication: Acquired Immunodeficiency Syndrome
Saquinavir
Dosage: daily dose:800mg
Administration route: Oral
Indication: Acquired Immunodeficiency Syndrome
Start date: 1998-04-01
Sulfamethoxazole
Trimethoprim
Administration route: Oral
Indication: Pneumocystis Jiroveci Infection
Vincristine
Dosage: text:6df-freq:1 cyclical
Indication: Burkitt's Lymphoma
Start date: 1998-04-01
End date: 1998-09-01
Other drugs received by patient: CO-Trimoxazole
Adverse event in 7 year old female receiving Methotrexate
Reported by a health professional (non-physician/pharmacist) from Greece on 2007-10-26
Patient: 7 year old female, weighing 25.0 kg (55.0 pounds)
Adverse reactions / side effects: Parvovirus Infection, Histiocytosis Haematophagic, Immunosuppression, Infection in AN Immunocompromised Host
Adverse event resulted in: death
Suspect drug(s):
Azathioprine
Cyclophosphamide
Dosage: 800 mg; 1x ; iv
Start date: 2007-04-27
End date: 2007-04-27
Cyclosporine
Dosage: 1 1x
Start date: 2007-05-02
End date: 2007-05-04
Etanercept (Etanercept)
Kineret
Dosage: 2.5 mg/kg; qd; sc
Indication: Vasculitis
Start date: 2007-04-14
End date: 2007-04-20
Methotrexate
Methylprednisolone
Dosage: 300 mg; iv
Start date: 2007-05-03
End date: 2007-05-05
Prednisone
Dosage: po
Administration route: Oral
Start date: 2001-06-20
End date: 2002-05-15
Adverse event in 66 year old female receiving Methotrexate
Reported by a physician from Portugal on 2007-10-26
Patient: 66 year old female, weighing 45.0 kg (99.0 pounds)
Adverse reactions / side effects: Liver Function Test Abnormal, Hypovolaemia
Suspect drug(s):
Methotrexate
Dosage: 15 mg, 1/week
Administration route: Oral
Indication: Rheumatoid Arthritis
Rituxan
Indication: Drug USE FOR Unknown Indication
Other drugs received by patient: Folic Acid; Medrol; Furosemide
Adverse event in 50 year old female receiving Methotrexate
Reported by a individual with unspecified qualification from Brazil on 2007-10-26
Patient: 50 year old female, weighing 65.0 kg (143.0 pounds)
Adverse reactions / side effects: Back Pain, Chest Discomfort, Pain, Rhinitis, Lobar Pneumonia, Cardiac Failure, Diarrhoea, Respiratory Failure, Pleural Effusion
Adverse event resulted in: death
Suspect drug(s):
Humira
Indication: Rheumatoid Arthritis
Start date: 2007-04-01
End date: 2007-10-08
Methotrexate
Indication: Rheumatoid Arthritis
Start date: 2006-01-01
End date: 2007-10-04
Methotrexate
End date: 2001-01-01
Other drugs received by patient: Leflunomide; Prednisone; Unknown Diuretic; Captopril; Metformin
Adverse event in 73 year old female receiving Methotrexate
Reported by a health professional (non-physician/pharmacist) from Canada on 2007-10-26
Patient: 73 year old female, weighing 59.0 kg (129.8 pounds)
Adverse reactions / side effects: Respiratory Disorder, Troponin Increased, non-Hodgkin's Lymphoma Unspecified Histology Aggressive, Cardiac Failure Congestive, Fluid Retention, Tracheal Deviation
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Humira
Indication: Rheumatoid Arthritis
Start date: 2004-10-13
End date: 2007-10-09
Methotrexate
Administration route: Oral
Indication: Rheumatoid Arthritis
Other drugs received by patient: Folic Acid; Alendronate Sodium; Levothyroxine Sodium
Adverse event in 66 year old female receiving Methotrexate
Reported by a physician from Portugal on 2007-10-26
Patient: 66 year old female, weighing 45.0 kg (99.0 pounds)
Adverse reactions / side effects: Ischaemia, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Bone Marrow Failure, Pancytopenia, Blood Creatinine Increased, Hypovolaemia
Adverse event resulted in: life threatening event, hospitalization, disablity
Suspect drug(s):
Methotrexate
Dosage: 15 mg, 1/week
Administration route: Oral
Indication: Rheumatoid Arthritis
Rituxan
Indication: Drug USE FOR Unknown Indication
Other drugs received by patient: Folic Acid; Medrol; Furosemide
Adverse event in male receiving Methotrexate
Reported by a consumer/non-health professional from Sweden on 2007-10-25
Patient: male
Adverse reactions / side effects: Pneumonia
Adverse event resulted in: hospitalization
Suspect drug(s):
Enbrel
Dosage: dose strength and frequency unknown
Indication: Rheumatoid Arthritis
Start date: 2006-06-01
Methotrexate
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