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Index of reports
> Cases resulting in a serious event (31)
> Cases with Lactic Acidosis (10)
Below is the selection of adverse event reports related to Metformin that includes cases resulting in a serious event where reactions include lactic acidosis.
Adverse event in 69 year old male receiving Metformin
Reported by a individual with unspecified qualification from Norway on 2007-10-16
Patient: 69 year old male
Adverse reactions / side effects: Abdominal Pain, Drug Interaction, Lactic Acidosis, Hyperventilation, Nephrolithiasis, Renal Failure, Catheter Placement, Diarrhoea, Visual Disturbance, Circulatory Collapse, Respiratory Arrest, Blood Creatinine Increased
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Losartan Potassium
Dosage: 50 mg, unk
Indication: Hypertension
Metformin
Indication: Type 2 Diabetes Mellitus
Esidrix
Dosage: 12.5 mg, unk
Indication: Hypertension
Adverse event in 49 year old female receiving Metformin
Reported by a health professional (non-physician/pharmacist) from Norway on 2007-10-15
Patient: 49 year old female
Adverse reactions / side effects: Metabolic Acidosis, Hypothermia, Hypoglycaemia, Drug Interaction, Lactic Acidosis, Accidental Overdose, Haemodialysis, Blood Lactic Acid Increased, Loss of Consciousness, Hyperventilation, Drug Toxicity, Respiratory Failure, Circulatory Collapse, Gastroenteritis, Renal Failure Acute
Adverse event resulted in: life threatening event
Suspect drug(s):
Losartan Potassium
Dosage: 50 mg, unk
Indication: Hypertension
Metformin
Dosage: 6 g/day
Administration route: Oral
Esidrix
Dosage: 12.5 mg, unk
Indication: Hypertension
Other drugs received by patient: Glibenklamid
Adverse event in 73 year old female receiving Metformin
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2007-07-10
Patient: 73 year old female, weighing 53.9 kg (118.6 pounds)
Adverse reactions / side effects: Lactic Acidosis, Renal Failure Acute
Adverse event resulted in: hospitalization
Suspect drug(s):
Glipizide
Administration route: Oral
Perindopril Erbumine
Administration route: Oral
Indication: Blood Pressure Increased
Metformin
Administration route: Oral
Indication: Type 2 Diabetes Mellitus
Other drugs received by patient: Amlodipine; Aspirin; Omeprazole; Pravastatin
Adverse event in 57 year old male receiving Metformin
Reported by a physician from Canada on 2007-04-26
Patient: 57 year old male, weighing 82.0 kg (180.4 pounds)
Adverse reactions / side effects: Hyperkalaemia, Urine Output Decreased, Lactic Acidosis, Haemodialysis, Malaise, Diarrhoea, Dehydration, Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Darunavir
Dosage: 600mg twice per day
Administration route: Oral
Indication: HIV Infection
Start date: 2007-01-03
End date: 2007-02-12
Ritonavir
Dosage: 100mg twice per day
Administration route: Oral
Indication: HIV Infection
Start date: 2007-01-03
End date: 2007-02-12
Tenofovir
Dosage: 300mg per day
Administration route: Oral
Indication: HIV Infection
Start date: 2007-01-03
End date: 2007-02-12
Metformin
Indication: Diabetes Mellitus
Abacavir Sulfate
Indication: HIV Infection
Other drugs received by patient: Enfuvirtide; Bactrim; Fenofibrate; Trazodone HCL; Zopiclone; Atorvastatin Calcium; Levothyroxin Sodium; Rosiglitazone Maleate; Quinine; Folic Acid
Adverse event in 72 year old female receiving Metformin
Reported by a health professional (non-physician/pharmacist) from Sweden on 2007-04-05
Patient: 72 year old female
Adverse reactions / side effects: Lactic Acidosis, Haemodialysis
Adverse event resulted in: hospitalization
Suspect drug(s):
Vasotec
Administration route: Oral
Zocor
Administration route: Oral
Metformin
Other drugs received by patient: Folic Acid; Bendroflumethiazide; Furosemide; Glyburide
Adverse event in 81 year old female receiving Metformin
Reported by a physician from Norway on 2007-03-30
Patient: 81 year old female
Adverse reactions / side effects: Abdominal Pain, Vomiting, Hyperthermia, Hypotension, Rectal Haemorrhage, Lactic Acidosis, Haematemesis, Hyperventilation, Malaise, Diarrhoea, Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Prinivil
Administration route: Oral
Indication: Hypertension
Metformin
Administration route: Oral
Indication: Diabetes Mellitus non-Insulin-Dependent
Other drugs received by patient: Glimepiride; Hydrodiuril; [therapy Unspecified]
Adverse event in 73 year old female receiving Metformin
Reported by a physician from Germany on 2007-03-29
Patient: 73 year old female
Adverse reactions / side effects: Lactic Acidosis, Renal Tubular Necrosis, Renal Failure Acute, Shock
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Ultravist 300
Dosage: 100 ml, 1 dose
Start date: 2006-03-29
End date: 2006-03-29
Metformin
Dosage: 850 mg, 2x/day
Indication: Diabetes Mellitus
Other drugs received by patient: Insulin; Coaprovel; Gabapentin; Gastrografin
Adverse event in 81 year old female receiving Metformin
Reported by a individual with unspecified qualification from Norway on 2007-03-05
Patient: 81 year old female
Adverse reactions / side effects: Lactic Acidosis, Renal Failure Acute
Suspect drug(s):
Glimepiride
Administration route: Oral
Calcium Channel Blockers
Dosage: dose: unk
Hydrochlorothiazide
Dosage: dose: unk
Lisinopril
Metformin
Adverse event in 69 year old female receiving Metformin
Reported by a individual with unspecified qualification from Norway on 2007-03-05
Patient: 69 year old female
Adverse reactions / side effects: Diarrhoea, Nausea, Lactic Acidosis, Renal Failure Acute
Suspect drug(s):
Glimepiride
Dosage: dose: unk
Hydrochlorothiazide
Indication: Hypertension
Losartan Potassium
Metformin
Adverse event in receiving Metformin
Reported by a physician from United Kingdom on 2007-02-20
Patient:
Adverse reactions / side effects: Rhabdomyolysis, Sensory Loss, Lactic Acidosis, Pallor, Partial Seizures, Overdose, Cardio-Respiratory Arrest, Oedema Peripheral, Tachypnoea, Apnoea, Abdominal Pain Lower, Vomiting, Metabolic Acidosis, Pain in Extremity, Hypotension, Compartment Syndrome, Body Temperature Decreased, Blood Lactic Acid Increased, Renal Impairment, Diarrhoea, Dehydration, LEG Amputation
Adverse event resulted in: life threatening event, hospitalization, disablity
Suspect drug(s):
Altace
Dosage: 35 mg, single
Metformin
Dosage: 56 g, single
Alcohol / 00002101 /
Dosage: 500 ml over 4 hours
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