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Index of reports
> Cases resulting in life threatening events (6)
> Cases with Lactic Acidosis (5)
Below is the selection of adverse event reports related to Metformin that includes cases resulting in life threatening events where reactions include lactic acidosis.
Adverse event in 69 year old male receiving Metformin
Reported by a individual with unspecified qualification from Norway on 2007-10-16
Patient: 69 year old male
Adverse reactions / side effects: Abdominal Pain, Drug Interaction, Lactic Acidosis, Hyperventilation, Nephrolithiasis, Renal Failure, Catheter Placement, Diarrhoea, Visual Disturbance, Circulatory Collapse, Respiratory Arrest, Blood Creatinine Increased
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Esidrix
Dosage: 12.5 mg, unk
Indication: Hypertension
Losartan Potassium
Dosage: 50 mg, unk
Indication: Hypertension
Metformin
Indication: Type 2 Diabetes Mellitus
Adverse event in 49 year old female receiving Metformin
Reported by a health professional (non-physician/pharmacist) from Norway on 2007-10-15
Patient: 49 year old female
Adverse reactions / side effects: Metabolic Acidosis, Hypothermia, Hypoglycaemia, Drug Interaction, Lactic Acidosis, Accidental Overdose, Haemodialysis, Blood Lactic Acid Increased, Loss of Consciousness, Hyperventilation, Drug Toxicity, Respiratory Failure, Circulatory Collapse, Gastroenteritis, Renal Failure Acute
Adverse event resulted in: life threatening event
Suspect drug(s):
Esidrix
Dosage: 12.5 mg, unk
Indication: Hypertension
Losartan Potassium
Dosage: 50 mg, unk
Indication: Hypertension
Metformin
Dosage: 6 g/day
Administration route: Oral
Other drugs received by patient: Glibenklamid
Adverse event in 57 year old male receiving Metformin
Reported by a physician from Canada on 2007-04-26
Patient: 57 year old male, weighing 82.0 kg (180.4 pounds)
Adverse reactions / side effects: Hyperkalaemia, Urine Output Decreased, Lactic Acidosis, Haemodialysis, Malaise, Diarrhoea, Dehydration, Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Abacavir Sulfate
Indication: HIV Infection
Darunavir
Dosage: 600mg twice per day
Administration route: Oral
Indication: HIV Infection
Start date: 2007-01-03
End date: 2007-02-12
Metformin
Indication: Diabetes Mellitus
Ritonavir
Dosage: 100mg twice per day
Administration route: Oral
Indication: HIV Infection
Start date: 2007-01-03
End date: 2007-02-12
Tenofovir
Dosage: 300mg per day
Administration route: Oral
Indication: HIV Infection
Start date: 2007-01-03
End date: 2007-02-12
Other drugs received by patient: Enfuvirtide; Bactrim; Fenofibrate; Trazodone HCL; Zopiclone; Atorvastatin Calcium; Levothyroxin Sodium; Rosiglitazone Maleate; Quinine; Folic Acid
Adverse event in 81 year old female receiving Metformin
Reported by a physician from Norway on 2007-03-30
Patient: 81 year old female
Adverse reactions / side effects: Abdominal Pain, Vomiting, Hyperthermia, Hypotension, Rectal Haemorrhage, Lactic Acidosis, Haematemesis, Hyperventilation, Malaise, Diarrhoea, Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Metformin
Administration route: Oral
Indication: Diabetes Mellitus non-Insulin-Dependent
Prinivil
Administration route: Oral
Indication: Hypertension
Other drugs received by patient: Glimepiride; Hydrodiuril; [therapy Unspecified]
Adverse event in receiving Metformin
Reported by a physician from United Kingdom on 2007-02-20
Patient:
Adverse reactions / side effects: Rhabdomyolysis, Sensory Loss, Lactic Acidosis, Pallor, Partial Seizures, Overdose, Cardio-Respiratory Arrest, Oedema Peripheral, Tachypnoea, Apnoea, Abdominal Pain Lower, Vomiting, Metabolic Acidosis, Pain in Extremity, Hypotension, Compartment Syndrome, Body Temperature Decreased, Blood Lactic Acid Increased, Renal Impairment, Diarrhoea, Dehydration, LEG Amputation
Adverse event resulted in: life threatening event, hospitalization, disablity
Suspect drug(s):
Alcohol / 00002101 /
Dosage: 500 ml over 4 hours
Altace
Dosage: 35 mg, single
Metformin
Dosage: 56 g, single
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