Metformin (Metformin) - Adverse Event Reports - Hospitalization - Lactic Acidosis

Adverse event in 69 year old male receiving Metformin

Reported by a individual with unspecified qualification from Norway on 2007-10-16

Patient: 69 year old male

Adverse reactions / side effects: Abdominal Pain, Drug Interaction, Lactic Acidosis, Hyperventilation, Nephrolithiasis, Renal Failure, Catheter Placement, Diarrhoea, Visual Disturbance, Circulatory Collapse, Respiratory Arrest, Blood Creatinine Increased

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Losartan Potassium
    Dosage: 50 mg, unk
    Indication: Hypertension

Metformin
    Indication: Type 2 Diabetes Mellitus

Esidrix
    Dosage: 12.5 mg, unk
    Indication: Hypertension

Adverse event in 73 year old female receiving Metformin

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2007-07-10

Patient: 73 year old female, weighing 53.9 kg (118.6 pounds)

Adverse reactions / side effects: Lactic Acidosis, Renal Failure Acute

Adverse event resulted in: hospitalization

Suspect drug(s):
Glipizide
    Administration route: Oral

Perindopril Erbumine
    Administration route: Oral
    Indication: Blood Pressure Increased

Metformin
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus

Other drugs received by patient: Amlodipine; Aspirin; Omeprazole; Pravastatin

Adverse event in 57 year old male receiving Metformin

Reported by a physician from Canada on 2007-04-26

Patient: 57 year old male, weighing 82.0 kg (180.4 pounds)

Adverse reactions / side effects: Hyperkalaemia, Urine Output Decreased, Lactic Acidosis, Haemodialysis, Malaise, Diarrhoea, Dehydration, Renal Failure Acute

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Darunavir
    Dosage: 600mg twice per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2007-01-03
    End date: 2007-02-12

Ritonavir
    Dosage: 100mg twice per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2007-01-03
    End date: 2007-02-12

Tenofovir
    Dosage: 300mg per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2007-01-03
    End date: 2007-02-12

Metformin
    Indication: Diabetes Mellitus

Abacavir Sulfate
    Indication: HIV Infection

Other drugs received by patient: Enfuvirtide; Bactrim; Fenofibrate; Trazodone HCL; Zopiclone; Atorvastatin Calcium; Levothyroxin Sodium; Rosiglitazone Maleate; Quinine; Folic Acid

Adverse event in 72 year old female receiving Metformin

Reported by a health professional (non-physician/pharmacist) from Sweden on 2007-04-05

Patient: 72 year old female

Adverse reactions / side effects: Lactic Acidosis, Haemodialysis

Adverse event resulted in: hospitalization

Suspect drug(s):
Vasotec
    Administration route: Oral

Zocor
    Administration route: Oral

Metformin

Other drugs received by patient: Folic Acid; Bendroflumethiazide; Furosemide; Glyburide

Adverse event in 81 year old female receiving Metformin

Reported by a physician from Norway on 2007-03-30

Patient: 81 year old female

Adverse reactions / side effects: Abdominal Pain, Vomiting, Hyperthermia, Hypotension, Rectal Haemorrhage, Lactic Acidosis, Haematemesis, Hyperventilation, Malaise, Diarrhoea, Renal Failure Acute

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Prinivil
    Administration route: Oral
    Indication: Hypertension

Metformin
    Administration route: Oral
    Indication: Diabetes Mellitus non-Insulin-Dependent

Other drugs received by patient: Glimepiride; Hydrodiuril; [therapy Unspecified]

Adverse event in 73 year old female receiving Metformin

Reported by a physician from Germany on 2007-03-29

Patient: 73 year old female

Adverse reactions / side effects: Lactic Acidosis, Renal Tubular Necrosis, Renal Failure Acute, Shock

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Ultravist 300
    Dosage: 100 ml, 1 dose
    Start date: 2006-03-29
    End date: 2006-03-29

Metformin
    Dosage: 850 mg, 2x/day
    Indication: Diabetes Mellitus

Other drugs received by patient: Insulin; Coaprovel; Gabapentin; Gastrografin

Adverse event in receiving Metformin

Reported by a physician from United Kingdom on 2007-02-20

Patient:

Adverse reactions / side effects: Rhabdomyolysis, Sensory Loss, Lactic Acidosis, Pallor, Partial Seizures, Overdose, Cardio-Respiratory Arrest, Oedema Peripheral, Tachypnoea, Apnoea, Abdominal Pain Lower, Vomiting, Metabolic Acidosis, Pain in Extremity, Hypotension, Compartment Syndrome, Body Temperature Decreased, Blood Lactic Acid Increased, Renal Impairment, Diarrhoea, Dehydration, LEG Amputation

Adverse event resulted in: life threatening event, hospitalization, disablity

Suspect drug(s):
Altace
    Dosage: 35 mg, single

Metformin
    Dosage: 56 g, single

Alcohol / 00002101 /
    Dosage: 500 ml over 4 hours