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This is an index of adverse event reports related to Leucovorin. Click on the relevant link below to view a selection of reports according to the event's seriousness level and/or the nature of the adverse reaction. Or scroll down to view a sample of recent reports further on this page.
Our database includes reports from Jan 2007 to Dec 2007. The information is not vetted and should not be cosidered as verified clinical evidence.
All cases (37)
Cases resulting in a serious event (37)
Cases resulting in death (11)
Cases resulting in life threatening events (5)
Cases resulting in hospitalization (23)
Cases resulting in other serious reactions (8)
Below is a sample of adverse event reports reports related to Leucovorin. For a complete list and/or a specific selection of reports, please use the links in the index above.
Adverse event in female receiving Leucovorin
Reported by a consumer/non-health professional from United Kingdom on 2007-10-31
Patient: female, weighing 61.5 kg (135.3 pounds)
Adverse reactions / side effects: Vomiting, Diarrhoea, Hypokalaemia
Adverse event resulted in: hospitalization
Suspect drug(s):
Bevacizumab
Dosage: 326 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-04
Fluorouracil
Dosage: 650 mg, q2w
Start date: 2007-04-04
Leucovorin
Dosage: 320 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-04
Oxaliplatin
Dosage: 137 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-04
Other drugs received by patient: Rabeprazole Sodium; Zofran; Prochlorperazine; Aluminum Hydroxide Gel; Norvasc; Bisoprolol Fumarate; Ramipril
Adverse event in 77 year old male receiving Leucovorin
Reported by a physician from Germany on 2007-10-31
Patient: 77 year old male
Adverse reactions / side effects: Nephrotic Syndrome, Renal Failure Acute
Adverse event resulted in: hospitalization
Suspect drug(s):
Erbitux
Indication: Colon Cancer
Start date: 2006-08-10
End date: 2007-02-13
Fluorouracil
Dosage: no.of dosage=d1+d2
Indication: Colon Cancer
Start date: 2005-07-19
End date: 2007-02-13
Irinotecan HCL
Indication: Colon Cancer
Start date: 2005-07-19
End date: 2007-02-13
Leucovorin
Dosage: no.of dosage=d1+d2
Indication: Colon Cancer
Start date: 2005-07-19
End date: 2007-02-13
Other drugs received by patient: Penmix
Adverse event in female receiving Leucovorin
Reported by a physician from Egypt on 2007-10-30
Patient: female, weighing 65.0 kg (143.0 pounds)
Adverse reactions / side effects: Pneumonia, Pancytopenia
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Fluorouracil
Dosage: 400 mg/m2 bolus followed by 600 mg/m2 infusion
Start date: 2006-12-18
End date: 2006-12-19
Leucovorin
Start date: 2006-12-18
End date: 2006-12-19
Oxaliplatin
Indication: Colon Cancer
Start date: 2006-12-18
End date: 2006-12-18
Adverse event in male receiving Leucovorin
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-29
Patient: male, weighing 175.0 kg (385.0 pounds)
Adverse reactions / side effects: Hepatic Failure, Disease Progression
Adverse event resulted in: hospitalization
Suspect drug(s):
Aranesp
Dosage: 200 a?g, prn
Indication: Anaemia
Avastin
Dosage: 590 mg, unk
Indication: Metastatic Neoplasm
Start date: 2005-07-18
End date: 2005-08-02
Fluorouracil
Dosage: 1140 mg, unk
Indication: Metastatic Neoplasm
Start date: 2005-07-18
End date: 2005-07-20
Fluorouracil
Dosage: 760 mg, unk
Start date: 2005-08-02
End date: 2005-08-03
Fluorouracil
Dosage: 1140 mg, unk
Start date: 2005-08-02
End date: 2005-08-04
Leucovorin
Dosage: 380 mg, unk
Indication: Metastatic Neoplasm
Start date: 2005-07-18
End date: 2005-08-03
Oxaliplatin
Dosage: 160 mg, unk
Indication: Metastatic Neoplasm
Start date: 2005-07-18
End date: 2005-08-02
Adverse event in female receiving Leucovorin
Reported by a physician from United Kingdom on 2007-10-25
Patient: female, weighing 137.8 kg (303.2 pounds)
Adverse reactions / side effects: Abdominal Pain, Vomiting, Pyrexia
Adverse event resulted in: hospitalization
Suspect drug(s):
Bevacizumab
Dosage: 312.5 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-23
Fluorouracil
Dosage: 660 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-23
Leucovorin
Dosage: 660 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-23
Oxaliplatin
Dosage: 140 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-23
Other drugs received by patient: Neupogen; Modulon; Iron Supplement
Adverse event in 65 year old female receiving Leucovorin
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-25
Patient: 65 year old female
Adverse reactions / side effects: Sudden Death
Adverse event resulted in: death
Suspect drug(s):
Eloxatin
Dosage: unk
Indication: Colon Cancer Metastatic
Start date: 2007-10-10
End date: 2007-10-10
Fluorouracil
Dosage: unk
Indication: Colon Cancer Metastatic
Leucovorin
Dosage: unk
Indication: Colon Cancer Metastatic
Start date: 2007-10-10
End date: 2007-10-10
Other drugs received by patient: Anzemet; Decadron
Adverse event in female receiving Leucovorin
Reported by a physician from United States on 2007-10-24
Patient: female
Adverse reactions / side effects: Asthenia
Adverse event resulted in: hospitalization
Suspect drug(s):
Fluorouracil
Irinotecan HCL
Leucovorin
Panitumumab
Indication: Colorectal Cancer
Start date: 2007-07-26
Panitumumab
Start date: 2007-08-14
End date: 2007-08-14
Other drugs received by patient: Synthroid; Wellbutrin
Adverse event in male receiving Leucovorin
Reported by a individual with unspecified qualification from United States on 2007-10-24
Patient: male, weighing 27.9 kg (61.4 pounds)
Adverse reactions / side effects: Cholecystitis Acute, Enterobacter Sepsis
Adverse event resulted in: hospitalization
Suspect drug(s):
Fluorouracil
Indication: Metastatic Neoplasm
Start date: 2007-08-07
End date: 2007-08-19
Fluorouracil
Irinotecan HCL
Indication: Metastatic Neoplasm
Leucovorin
Indication: Metastatic Neoplasm
Sutent
Dosage: daily dose:25mg-freq:1 daily
Administration route: Oral
Indication: Metastatic Neoplasm
Start date: 2007-08-08
End date: 2007-08-20
Adverse event in female receiving Leucovorin
Reported by a physician from Italy on 2007-10-23
Patient: female
Adverse reactions / side effects: White Blood Cell Count Decreased, Fatigue, Anaemia, Lymphocytic Leukaemia, Pyrexia, Hyperhidrosis, Cerebral Haemorrhage
Adverse event resulted in: death, life threatening event
Suspect drug(s):
Eloxatin
Indication: Colon Cancer
Start date: 2005-11-01
End date: 2006-05-01
Eloxatin
Indication: Sigmoidectomy
Start date: 2005-11-01
End date: 2006-05-01
Fluorouracil
Dosage: unk
Indication: Colon Cancer
Start date: 2005-11-01
End date: 2006-05-01
Leucovorin
Dosage: unk
Indication: Colon Cancer
Start date: 2005-11-01
End date: 2006-05-01
Adverse event in male receiving Leucovorin
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-23
Patient: male, weighing 175.0 kg (385.0 pounds)
Adverse reactions / side effects: Abdominal Pain, Jaundice, Metastatic Neoplasm, Bile Duct Obstruction, Malignant Neoplasm Progression, Hepatic Failure, Oedema Peripheral, Abdominal Distension, Decreased Appetite, Lethargy
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Aranesp
Indication: Anaemia
Avastin
Indication: Metastatic Neoplasm
Start date: 2005-08-02
End date: 2005-08-02
Avastin
Dosage: unk
Fluorouracil
Indication: Metastatic Neoplasm
Start date: 2005-08-02
End date: 2005-08-04
Leucovorin
Indication: Metastatic Neoplasm
Start date: 2005-08-02
End date: 2005-08-03
Oxaliplatin
Indication: Metastatic Neoplasm
Start date: 2005-08-02
End date: 2005-08-02
Adverse event in female receiving Leucovorin
Reported by a physician from United States on 2007-10-23
Patient: female
Adverse reactions / side effects: Acute Myocardial Infarction
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Fluorouracil
Irinotecan HCL
Leucovorin
Panitumumab
Indication: Colorectal Cancer
Start date: 2007-09-13
Adverse event in male receiving Leucovorin
Reported by a physician from United States on 2007-10-23
Patient: male
Adverse reactions / side effects: Dehydration, Sepsis, Paraneoplastic Syndrome
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Bevacizumab
Indication: Colorectal Cancer Metastatic
Start date: 2007-07-09
End date: 2007-07-09
Eloxatin
Dosage: 65 mg/m2 (131.3 mg) every 2 weeks
Indication: Colorectal Cancer Metastatic
Start date: 2007-07-09
End date: 2007-07-09
Fluorouracil
Dosage: 606 mg bolus (300 mg/m2); 3636 mg (1800 mg/m2) every 2 weeks
Indication: Colorectal Cancer Metastatic
Start date: 2007-07-11
End date: 2007-07-11
Leucovorin
Dosage: 800 mg (400 mg/m2) every 2 weeks
Indication: Colorectal Cancer Metastatic
Start date: 2007-07-09
End date: 2007-07-09
Other drugs received by patient: Multi-Vitamin; Lipitor; Digitek; Pepcid; Cardizem; Cozaar; Coumadin; Megace; Nystatin
Adverse event in female receiving Leucovorin
Reported by a physician from United States on 2007-10-22
Patient: female, weighing 66.8 kg (147.0 pounds)
Adverse reactions / side effects: Transient Ischaemic Attack
Suspect drug(s):
Bevacizumab
Start date: 2006-05-15
End date: 2006-05-15
CA / MG OR Placebo
Start date: 2006-05-15
End date: 2006-05-15
Fluorouracil
Dosage: 2400 mg/m2 iv on day 1 and day 2, q2w
Start date: 2006-05-15
End date: 2006-05-16
Leucovorin
Start date: 2006-05-15
End date: 2006-05-15
Oxaliplatin
Indication: Colorectal Cancer Metastatic
Start date: 2006-05-15
End date: 2006-05-15
Adverse event in female receiving Leucovorin
Reported by a consumer/non-health professional from United Kingdom on 2007-10-19
Patient: female, weighing 61.5 kg (135.3 pounds)
Adverse reactions / side effects: Vomiting, Blood Potassium Decreased, Diarrhoea
Adverse event resulted in: hospitalization
Suspect drug(s):
Bevacizumab
Dosage: 326 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-04
Fluorouracil
Dosage: 650 mg, q2w
Start date: 2007-04-04
Leucovorin
Dosage: 320 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-04
Oxaliplatin
Dosage: 137 mg, q2w
Indication: Colon Cancer
Start date: 2007-04-04
Other drugs received by patient: Rabeprazole Sodium; Zofran; Prochlorperazine; Aluminum Hydroxide Gel; Norvasc; Bisoprolol Fumarate; Ramipril
Adverse event in 74 year old male receiving Leucovorin
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-19
Patient: 74 year old male
Adverse reactions / side effects: Myelodysplastic Syndrome, Rash Pruritic
Suspect drug(s):
Epirubicin
Indication: Oesophageal Adenocarcinoma
Etoposide
Indication: Oesophageal Adenocarcinoma
Fluorouracil
Indication: Oesophageal Adenocarcinoma
Leucovorin
Indication: Oesophageal Adenocarcinoma
Methotrexate
Indication: Oesophageal Adenocarcinoma
Mitomycin
Indication: Oesophageal Adenocarcinoma
Proleukin
Indication: Oesophageal Adenocarcinoma
Radiotherapy
Indication: Oesophageal Adenocarcinoma
Adverse event in female receiving Leucovorin
Reported by a physician from United States on 2007-10-19
Patient: female, weighing 130.2 kg (286.4 pounds)
Adverse reactions / side effects: Abdominal Pain, Vomiting, Nausea, Heart Rate Increased, Pancytopenia, Neutropenia, Pyrexia, Blood Pressure Decreased
Suspect drug(s):
Eloxatin
Indication: Colon Cancer Stage III
Start date: 2007-01-01
End date: 2007-01-01
Fluorouracil
Indication: Colon Cancer Stage III
Start date: 2006-07-30
End date: 2006-07-30
Leucovorin
Indication: Colon Cancer Stage III
Start date: 2006-07-30
End date: 2006-07-30
Other drugs received by patient: Aranesp; Neupogen; Restoril; Ambien; Lunesta; Lantus; Avandia; Zestril; Glucotrol; Glucophage; Zocor; Dexamethasone 0.5mg TAB; Zofran
Adverse event in female receiving Leucovorin
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-19
Patient: female, weighing 57.6 kg (126.7 pounds)
Adverse reactions / side effects: Abdominal Pain, Empty Sella Syndrome, Diarrhoea, Septic Shock, Cerebrovascular Accident
Adverse event resulted in: hospitalization
Suspect drug(s):
Fluorouracil
Indication: Colorectal Cancer
Leucovorin
Indication: Colorectal Cancer
Oxaliplatin
Indication: Colorectal Cancer
Start date: 2007-07-25
End date: 2007-07-25
Other drugs received by patient: Lipitor; Hydrochlorothiazide; Xanax
Adverse event in female receiving Leucovorin
Reported by a physician from United Kingdom on 2007-10-16
Patient: female
Adverse reactions / side effects: Renal Failure, Reversible Posterior Leukoencephalopathy Syndrome, Headache, Hypertension
Adverse event resulted in: hospitalization
Suspect drug(s):
Bevacizumab
Dosage: 5 mg/kg, q2w
Indication: Rectal Cancer
Start date: 2007-06-25
Eloxatin
Dosage: 85 mg/m2, q2w
Indication: Rectal Cancer
Start date: 2007-06-25
Fluorouracil
Dosage: 400 mg/m2, q2w/x3
Indication: Rectal Cancer
Start date: 2007-06-25
Lasix
Dosage: 20 mg, qd
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Leucovorin
Dosage: 400 mg/m2, q2w
Indication: Rectal Cancer
Start date: 2007-06-25
Lisinopril
Dosage: 7.5 mg, qd
Indication: Drug USE FOR Unknown Indication
Adverse event in male receiving Leucovorin
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-15
Patient: male, weighing 77.1 kg (169.6 pounds)
Adverse reactions / side effects: Anal Fistula, Gastrointestinal Anastomotic Leak, Lower Gastrointestinal Haemorrhage, Rectal Abscess
Adverse event resulted in: death
Suspect drug(s):
Bevacizumab
Start date: 2007-07-11
End date: 2007-07-11
Fluorouracil
Dosage: 400 mg/m2 iv bolus on d1 then 2.4 g/m2 as continuous infusion over 46 h
Start date: 2007-07-12
End date: 2007-07-13
Leucovorin
Start date: 2007-07-11
End date: 2007-07-11
Oxaliplatin
Indication: Rectal Cancer
Start date: 2007-07-11
End date: 2007-07-11
Other drugs received by patient: Reglan; Zofran; Ativan; Procrit; Vicodin; Radiation
Adverse event in receiving Leucovorin
Reported by a consumer/non-health professional from United Kingdom on 2007-10-12
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Avastin
Dosage: 5 mg/kg, qow
Indication: Colorectal Cancer Metastatic
Fluorouracil
Dosage: 500 mg/m2, 1/week
Indication: Colorectal Cancer Metastatic
Leucovorin
Dosage: 500 mg/m2, q8w
Indication: Colorectal Cancer Metastatic
Adverse event in male receiving Leucovorin
Reported by a physician from United Kingdom on 2007-10-11
Patient: male
Adverse reactions / side effects: Pulmonary Hypertension, Pulmonary Embolism, Tumour Embolism, Alveolitis Allergic, Disease Progression, Cardio-Respiratory Arrest, Cardiac Failure, Arterial Spasm, Shock
Suspect drug(s):
Bevacizumab
Dosage: 100 unit, unk
Indication: Colon Cancer
Start date: 2007-09-03
End date: 2007-09-08
Fluorouracil
Indication: Colon Cancer
Start date: 2007-09-03
Leucovorin
Indication: Colon Cancer
Start date: 2007-09-03
Oxaliplatin
Indication: Colon Cancer
Start date: 2007-09-03
Adverse event in female receiving Leucovorin
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-10
Patient: female, weighing 65.3 kg (143.7 pounds)
Adverse reactions / side effects: Gastric Cancer
Suspect drug(s):
Bevacizumab
Dosage: 350 mg, q2w
Indication: Colorectal Cancer Metastatic
Start date: 2007-02-23
Cetuximab
Dosage: 470 mg, 1/week
Indication: Colorectal Cancer Metastatic
Start date: 2007-02-23
Fluorouracil
Dosage: 712 mg, q2w
Indication: Colorectal Cancer Metastatic
Start date: 2007-02-23
Fluorouracil
Dosage: 4072 mg, q2w
Leucovorin
Dosage: 712 mg, q2w
Indication: Colorectal Cancer Metastatic
Start date: 2007-02-23
Other drugs received by patient: Coumadin; Benadryl; Tylenol (Caplet); Decadron
Adverse event in receiving Leucovorin
Reported by a physician from United States on 2007-10-10
Patient:
Adverse reactions / side effects: Diaphragmatic Paralysis
Suspect drug(s):
Eloxatin
Dosage: unk
Indication: Drug USE FOR Unknown Indication
Fluorouracil
Dosage: unk
Indication: Drug USE FOR Unknown Indication
Leucovorin
Dosage: unk
Indication: Drug USE FOR Unknown Indication
Adverse event in 53 year old male receiving Leucovorin
Reported by a physician from United States on 2007-10-09
Patient: 53 year old male
Adverse reactions / side effects: Myocardial Infarction
Adverse event resulted in: hospitalization
Suspect drug(s):
Avastin
Indication: Rectal Cancer
Start date: 2007-09-17
End date: 2007-09-17
Eloxatin
Indication: Rectal Cancer
Start date: 2007-09-17
End date: 2007-09-17
Fluorouracil
Indication: Rectal Cancer
Start date: 2007-09-17
End date: 2007-09-17
Leucovorin
Indication: Rectal Cancer
Start date: 2007-09-17
End date: 2007-09-17
Adverse event in male receiving Leucovorin
Reported by a consumer/non-health professional from United Kingdom on 2007-10-08
Patient: male, weighing 92.0 kg (202.4 pounds)
Adverse reactions / side effects: Oesophagitis, Gastritis
Adverse event resulted in: hospitalization
Suspect drug(s):
Bevacizumab
Dosage: 460 mg, q2w
Indication: Colon Cancer
Start date: 2005-12-13
End date: 2006-03-21
Fluorouracil
Dosage: 840 mg, 2/week/q2w
Indication: Colon Cancer
Start date: 2005-12-13
Fluorouracil
Dosage: 1260 mg, 2/week/q2w
Start date: 2005-12-13
Leucovorin
Dosage: 420 mg, q2w
Indication: Colon Cancer
Start date: 2005-12-13
Oxaliplatin
Dosage: 178 mg, q2w
Indication: Colon Cancer
Start date: 2005-12-13
Other drugs received by patient: Epoetin Beta
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