Gleevec (Imatinib) - Adverse Event Reports - Serious Event - Pyrexia

Adverse event in 39 year old male receiving Gleevec (Imatinib)

Reported by a individual with unspecified qualification from Japan on 2007-10-26

Patient: 39 year old male

Adverse reactions / side effects: Mechanical Ventilation, Status Epilepticus, Pyrexia, Disorientation, Rash, Convulsion, Pruritus Generalised, Encephalitis Herpes, Human Herpes Virus 6 Serology Positive, Memory Impairment, Altered State of Consciousness

Adverse event resulted in: life threatening event, disablity

Suspect drug(s):
Alkeran
    Dosage: 135 g/d
    Start date: 2007-01-15
    End date: 2007-01-15

Fludara
    Dosage: 42 g/d
    Start date: 2007-01-10
    End date: 2007-01-14

Foscarnet

Gleevec
    Dosage: 800 mg/d
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    End date: 2007-01-15

Gleevec
    Dosage: 600/d
    Administration route: Oral
    Start date: 2007-05-01

Other drugs received by patient: Diflucan; Urso 250; Zovirax; Denosine; Methotrexate; Tacrolimus

Adverse event in 39 year old male receiving Gleevec (Imatinib)

Reported by a individual with unspecified qualification from Japan on 2007-10-22

Patient: 39 year old male

Adverse reactions / side effects: Mechanical Ventilation, Encephalitis Herpes, Human Herpes Virus 6 Serology Positive, Memory Impairment, Pyrexia, Status Epilepticus, Altered State of Consciousness

Adverse event resulted in: life threatening event, disablity

Suspect drug(s):
Alkeran
    Dosage: 135 g/d
    Start date: 2007-01-15
    End date: 2007-01-15

Fludara
    Dosage: 42 g/d
    Start date: 2007-01-10
    End date: 2007-01-14

Gleevec
    Dosage: 600 /d
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    End date: 2007-01-15

Gleevec
    Dosage: 600/d
    Administration route: Oral
    Start date: 2007-05-01

Other drugs received by patient: Diflucan; Urso 250; Zovirax; Denosine

Adverse event in 75 year old male receiving Gleevec (Imatinib)

Reported by a individual with unspecified qualification from Japan on 2007-10-19

Patient: 75 year old male

Adverse reactions / side effects: Blood Urea Increased, Malignant Neoplasm Progression, Anaemia, Urinary Tract Infection, Pyrexia, C-Reactive Protein Increased, Platelet Count Decreased, Blood Creatinine Increased, Renal Failure Acute, White Blood Cell Count Increased, Pyelonephritis

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Gleevec
    Dosage: 200 mg/d
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2006-06-07
    End date: 2006-06-14

Gleevec
    Dosage: 400 mg/d
    Administration route: Oral
    Start date: 2006-06-15
    End date: 2006-07-04

Gleevec
    Dosage: 300 mg/d
    Administration route: Oral
    Start date: 2006-07-21
    End date: 2006-09-14

Gleevec
    Dosage: 200 mg/d
    Administration route: Oral
    Start date: 2006-09-29
    End date: 2007-02-06

Gleevec
    Dosage: 300 mg/d
    Administration route: Oral
    Start date: 2007-02-07
    End date: 2007-04-23

Other drugs received by patient: Klaricid; Famotidine; Zyloric; Bladderon; Predonine; Magnesium Oxide

Adverse event in receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-10-15

Patient:

Adverse reactions / side effects: Peripheral Coldness, Disseminated Intravascular Coagulation, Pyrexia, Generalised Oedema, Malaise, Face Oedema, Bone Marrow Failure, Anuria, Oxygen Saturation Decreased, Hypotension, Febrile Neutropenia, Pancytopenia, Mucosal Inflammation, Diarrhoea, Bacteraemia, Heart Rate Increased, Sepsis, Neutrophil Count Decreased, Shock

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Gleevec (Imatinib)

Adverse event in 62 year old male receiving Gleevec (Imatinib)

Reported by a individual with unspecified qualification from Germany on 2007-10-08

Patient: 62 year old male, weighing 80.0 kg (176.0 pounds)

Adverse reactions / side effects: Eyelid Oedema, Blood Bilirubin Increased, Pyrexia, Prothrombin Time Prolonged, Biopsy, Chloroma, Pericardial Effusion, Disease Progression, Abdominal Pain Upper, Chest Pain, Pleural Effusion, Oedema, Pancreatitis Chronic, Blood Creatinine Increased, Peritoneal Disorder, Antithrombin III Decreased, Enteritis, Cough, Pneumonia, Ultrasound Scan Abnormal, Colonoscopy, Coronary Artery Disease, Arteriogram Coronary Abnormal, Blood Fibrinogen Increased, Computerised Tomogram Abnormal, Chronic Myeloid Leukaemia, Blood Lactic Acid Increased, Cholelithiasis, Diarrhoea, Colitis, Echography Abnormal, Ultrasound Abdomen Abnormal

Adverse event resulted in: hospitalization

Suspect drug(s):
Gleevec
    Dosage: 400 mg/day
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2007-02-13
    End date: 2007-02-16

Gleevec
    Dosage: 800 mg/day
    Administration route: Oral
    Start date: 2007-02-25
    End date: 2007-06-23

Gleevec
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2007-08-16

Other drugs received by patient: Ramipril; Pantoprazole Sodium; Torsemide; Nebilet; Insulin; Protaphan; Novalgin; Voltaren Dispers ^novartis^; Perenterol

Adverse event in 72 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-07-31

Patient: 72 year old male

Adverse reactions / side effects: Eyelid Oedema, Drug Resistance, Abscess Drainage, Metastases TO Liver, Anaemia, Malignant Neoplasm Progression, Pyrexia, Pruritus Generalised, Anorexia, Sepsis, Liver Abscess, Septic Shock

Adverse event resulted in: death, life threatening event, hospitalization

Suspect drug(s):
Gleevec
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Gastrointestinal Stromal Tumour
    Start date: 2003-09-23
    End date: 2004-08-10

Gleevec
    Dosage: 200 mg, qd
    Administration route: Oral
    Start date: 2004-08-11
    End date: 2004-08-24

Adverse event in 75 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-07-25

Patient: 75 year old male

Adverse reactions / side effects: Blood Urea Increased, Malignant Neoplasm Progression, Anaemia, Urinary Tract Infection, Pyrexia, C-Reactive Protein Increased, Platelet Count Decreased, Drug Level Decreased, Blood Creatinine Increased, White Blood Cell Count Increased, Renal Failure Acute, Pyelonephritis

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Gleevec
    Dosage: 200 mg/d
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2006-06-07
    End date: 2006-06-14

Gleevec
    Dosage: 400 mg/d
    Administration route: Oral
    Start date: 2006-06-15
    End date: 2006-07-04

Gleevec
    Dosage: 300 mg/d
    Administration route: Oral
    Start date: 2006-07-21
    End date: 2006-09-14

Gleevec
    Dosage: 200 mg/d
    Administration route: Oral
    Start date: 2006-09-29
    End date: 2007-02-06

Gleevec
    Dosage: 300 mg/d
    Administration route: Oral
    Start date: 2007-02-07
    End date: 2007-04-23

Other drugs received by patient: Clarithromycin; Famotidine; Allopurinol; Bladderon; Predonine; Magnesium Oxide

Adverse event in 66 year old female receiving Gleevec (Imatinib)

Reported by a individual with unspecified qualification from Japan on 2007-07-23

Patient: 66 year old female, weighing 54.0 kg (118.8 pounds)

Adverse reactions / side effects: Drug Eruption, Blood Bilirubin Increased, Blood Creatine Phosphokinase Increased, Respiratory Disorder, Fibrin Degradation Products Increased, Disseminated Intravascular Coagulation, Intubation, Pyrexia, Erythema, Multi-Organ Failure, C-Reactive Protein Increased, Blood Creatinine Increased, Oral Mucosa Erosion, Blood Urea Increased, Alanine Aminotransferase Increased, Toxic Epidermal Necrolysis, General Physical Health Deterioration, Sepsis, Dehydration, Aspartate Aminotransferase Increased, Skin Erosion, Blood Pressure Decreased, Dermatitis Exfoliative, Infection

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Allopurinol
    Dosage: 300 mg/day
    Administration route: Oral
    Indication: Hyperuricaemia
    Start date: 2006-07-18
    End date: 2006-10-06

Cephadol
    Dosage: 3 df/day
    Administration route: Oral
    Indication: Dizziness
    Start date: 2006-07-25
    End date: 2006-10-06

Gleevec
    Dosage: 400 mg/day
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2006-07-25
    End date: 2006-10-06

Merislon
    Dosage: 18 mg/day
    Administration route: Oral
    Indication: Dizziness
    Start date: 2006-07-25
    End date: 2006-10-06

Novamin
    Dosage: 15 mg/day
    Administration route: Oral
    Indication: Nausea
    Start date: 2006-07-25
    End date: 2006-10-06

Ticlopidine HCL
    Dosage: 200 mg/day
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2006-07-25
    End date: 2006-10-06

Uralyt
    Dosage: 6 df/day
    Administration route: Oral
    Indication: Hyperuricaemia
    Start date: 2006-07-18
    End date: 2006-10-06

Adverse event in 75 year old female receiving Gleevec (Imatinib)

Reported by a physician from Germany on 2007-07-17

Patient: 75 year old female, weighing 69.0 kg (151.8 pounds)

Adverse reactions / side effects: Dysphagia, Pneumonia, Chills, Pyrexia, Multi-Organ Failure, Mucosal Inflammation, Sepsis, Granulocytopenia, Neutropenia, Thrombocytopenia, Leukopenia

Adverse event resulted in: death, life threatening event, hospitalization

Suspect drug(s):
Fluorouracil
    Dosage: 3500mg/day
    Indication: Pancreatic Carcinoma
    Start date: 2005-02-01
    End date: 2005-02-02

Gleevec
    Dosage: 500 mg, qd
    Administration route: Oral
    Indication: Pancreatic Carcinoma
    Start date: 2005-01-28
    End date: 2005-02-04

Other drugs received by patient: Leucovorin Calcium

Adverse event in 55 year old male receiving Gleevec (Imatinib)

Reported by a physician from Germany on 2007-07-06

Patient: 55 year old male, weighing 91.0 kg (200.2 pounds)

Adverse reactions / side effects: Agitation, Confusional State, Lumbar Puncture, Coma, Pyrexia, Extensor Plantar Response, Somnolence, Nuclear Magnetic Resonance Imaging Abnormal, Intracranial Pressure Increased, Meningitis, Hydrocephalus, CSF Shunt Operation

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Gleevec
    Dosage: 600 mg/day
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-06-08
    End date: 2007-06-01

Pegaspargase
    Dosage: 4000 iu, once/single
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-06-24
    End date: 2007-06-24

Adverse event in 79 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-07-06

Patient: 79 year old male, weighing 35.0 kg (77.0 pounds)

Adverse reactions / side effects: Hypercapnia, Pyrexia, Somnolence, Multi-Organ Failure, Cardio-Respiratory Arrest, Dyspnoea Exertional, Interstitial Lung Disease, Lung Neoplasm Malignant, Hypoxia, Carbon Dioxide Increased, Gastrectomy, Fluid Retention, Oxygen Saturation Decreased, Pneumonia, Respiratory Failure, Cardiac Failure, Activities of Daily Living Impaired, Anorexia, Asthenia, Blood Pressure Decreased

Adverse event resulted in: death, life threatening event

Suspect drug(s):
Gleevec
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2003-01-15
    End date: 2003-01-31

Gleevec
    Dosage: 300 mg/d
    Administration route: Oral
    Start date: 2003-02-26
    End date: 2003-07-10

Gleevec
    Dosage: 300 mg, qd
    Administration route: Oral
    Start date: 2005-07-11
    End date: 2005-12-18

Gleevec
    Dosage: 200 mg, qd
    Administration route: Oral
    Start date: 2005-12-19
    End date: 2006-01-10

Other drugs received by patient: Aldactone; Lasix; Warfarin Sodium; Sunrythm; Gaster; Neuer; Selbex; Berizym; Allopurinol; Actonel; Aspirin; Hydrea; Sulperazon; Stomilase

Adverse event in 41 year old female receiving Gleevec (Imatinib)

Reported by a physician from Belgium on 2007-07-06

Patient: 41 year old female

Adverse reactions / side effects: Breast Pain, Galactorrhoea, Blood Prolactin Increased, Pyrexia

Adverse event resulted in: hospitalization

Suspect drug(s):
Gleevec
    Dosage: 600 mg/d
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-05-01
    End date: 2007-05-29

Gleevec
    Dosage: 400 mg/d
    Administration route: Oral
    Start date: 2007-05-30
    End date: 2007-06-13

Gleevec
    Dosage: unk, unk
    Administration route: Oral
    Start date: 2007-06-22

Gleevec
    Dosage: 400 mg/d
    Administration route: Oral
    Start date: 2007-05-01
    End date: 2007-05-01

Other drugs received by patient: Chemotherapeutics,other; Litican; Kytril

Adverse event in 69 year old female receiving Gleevec (Imatinib)

Reported by a individual with unspecified qualification from Italy on 2007-06-27

Patient: 69 year old female

Adverse reactions / side effects: Acute Lymphocytic Leukaemia, Pyrexia

Adverse event resulted in: hospitalization

Suspect drug(s):
Gleevec (Imatinib)

Adverse event in receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-06-20

Patient:

Adverse reactions / side effects: Peripheral Coldness, Disseminated Intravascular Coagulation, Pyrexia, Generalised Oedema, Malaise, Face Oedema, Bone Marrow Failure, Anuria, Oxygen Saturation Decreased, Febrile Neutropenia, Pancytopenia, Mucosal Inflammation, Diarrhoea, Bacteraemia, Sepsis, Heart Rate Increased, Neutrophil Count Decreased, Blood Pressure Decreased, Shock

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Gleevec (Imatinib)

Adverse event in 75 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-06-19

Patient: 75 year old male

Adverse reactions / side effects: Blood Urea Increased, Anaemia, Urinary Tract Infection, Pyrexia, C-Reactive Protein Increased, Platelet Count Decreased, Blood Creatinine Increased, Drug Level Decreased, White Blood Cell Count Increased, Renal Failure Acute, Pyelonephritis

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Gleevec
    Dosage: 200 mg/d
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2006-06-07
    End date: 2006-06-14

Gleevec
    Dosage: 400 mg/d
    Administration route: Oral
    Start date: 2006-06-15
    End date: 2006-07-04

Gleevec
    Dosage: 300 mg/d
    Administration route: Oral
    Start date: 2006-07-21
    End date: 2006-09-14

Gleevec
    Dosage: 200 mg/d
    Administration route: Oral
    Start date: 2006-09-29
    End date: 2007-02-06

Gleevec
    Dosage: 300 mg/d
    Administration route: Oral
    Start date: 2007-02-07
    End date: 2007-03-06

Other drugs received by patient: Clarithromycin; Gaster D; Allopurinol; Bladderon; Predonine; Magnesium Oxide

Adverse event in 53 year old male receiving Gleevec (Imatinib)

Reported by a physician from United States on 2007-06-18

Patient: 53 year old male, weighing 69.0 kg (151.8 pounds)

Adverse reactions / side effects: Mucosal Inflammation, Arthralgia, Haemorrhage, Pyrexia, Neutrophil Count Decreased, Thrombocytopenia

Adverse event resulted in: hospitalization

Suspect drug(s):
Gleevec
    Dosage: 400 mg, qd, oral; 600 mg, qd, oral
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2006-03-21
    End date: 2006-06-16

Gleevec
    Dosage: 400 mg, qd, oral; 600 mg, qd, oral
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2006-06-16
    End date: 2007-01-08

Adverse event in 49 year old male receiving Gleevec (Imatinib)

Reported by a health professional (non-physician/pharmacist) from United States on 2007-06-14

Patient: 49 year old male

Adverse reactions / side effects: Kidney Enlargement, Haematuria, Blood PH Decreased, Blood Albumin Decreased, Pyrexia, Renal Atrophy, Hypokalaemia, Oedema Peripheral, Renal Arteriosclerosis, Proteinuria, Hypomagnesaemia, Urinary Retention, Renal Tubular Necrosis, Blood Creatinine Increased, Renal Failure Acute

Adverse event resulted in: hospitalization

Suspect drug(s):
Doxorubicin HCL
    Dosage: 20 mg/m2 on day 1-3

Gleevec
    Indication: Gastrointestinal Stromal Tumour

Ifosfamide
    Dosage: 2500 mg/m2 on days 1-3
    Indication: Gastrointestinal Stromal Tumour

Mesna
    Dosage: 600 mg/m2 on day 1-3

Pamidronate Disodium
    Dosage: 90 mg, once/single
    Indication: Hypercalcaemia of Malignancy

Other drugs received by patient: Loratadine; Darbepoetin Alfa; Methylphenidate HCL

Adverse event in 58 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-06-11

Patient: 58 year old male, weighing 57.0 kg (125.4 pounds)

Adverse reactions / side effects: Pyrexia, Liver Disorder, Urticaria Generalised, Malaise, Generalised Erythema, Hepatotoxicity, Gamma-Glutamyltransferase Increased, Bone Marrow Failure, Acute Respiratory Failure, Blood Creatinine Increased, Blister, Iatrogenic Infection, White Blood Cell Count Decreased, Renal Disorder, Pneumonia, Blood Urea Increased, Vomiting, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Methicillin-Resistant Staphylococcal Aureus Test Positive, Rash, Acute Lymphocytic Leukaemia, Aspartate Aminotransferase Increased, Oliguria, Sepsis, Blood Pressure Decreased, Shock

Adverse event resulted in: death, life threatening event

Suspect drug(s):
Funguard
    Dosage: 150 mg/day
    Indication: White Blood Cell Count Decreased
    Start date: 2007-04-23

Gleevec
    Dosage: 600 mg/d
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-05-01
    End date: 2007-05-03

Loxonin
    Dosage: 60 mg/day
    Administration route: Oral
    Indication: Pyrexia
    Start date: 2007-05-03
    End date: 2007-05-03

Meropen
    Dosage: 2 g/day
    Indication: Sepsis
    Start date: 2007-05-03
    End date: 2007-05-04

Other drugs received by patient: Norvasc; Cylocide; Idarubicin HCL; Vancomycin HCL; Prednisolone

Adverse event in 50 year old male receiving Gleevec (Imatinib)

Reported by a individual with unspecified qualification from France on 2007-06-08

Patient: 50 year old male

Adverse reactions / side effects: Blood Creatine Phosphokinase Increased, Disseminated Intravascular Coagulation, Intubation, Pyrexia, Multi-Organ Failure, Cardio-Respiratory Arrest, Cardiac Massage, C-Reactive Protein Increased, Bacterial Sepsis, Bone Marrow Failure, Blood Creatinine Increased, Oxygen Saturation Decreased, White Blood Cell Count Decreased, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Life Support, Protein Total Decreased, Respiratory Distress, Haemoglobin Decreased, Renal Failure, Blood Potassium Decreased, Aspartate Aminotransferase Increased, Platelet Count Decreased, Septic Shock, Prothrombin Level Decreased

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Gleevec
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Purinethol
    Dosage: 50 mg, bid
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Vepesid
    Dosage: 150 mg daily
    Indication: Acute Lymphocytic Leukaemia

Other drugs received by patient: Dexamethasone 0.5mg TAB

Adverse event in 48 year old female receiving Gleevec (Imatinib)

Reported by a physician from Spain on 2007-06-08

Patient: 48 year old female

Adverse reactions / side effects: Dyspnoea, Pyrexia, Lung Infiltration, Alveolitis Allergic

Adverse event resulted in: hospitalization

Suspect drug(s):
Gleevec (Imatinib)

Adverse event in 58 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-06-05

Patient: 58 year old male, weighing 57.0 kg (125.4 pounds)

Adverse reactions / side effects: Pyrexia, Liver Disorder, Urticaria Generalised, Malaise, Generalised Erythema, Hepatotoxicity, Gamma-Glutamyltransferase Increased, Bone Marrow Failure, Blood Creatinine Increased, Acute Respiratory Failure, Blister, White Blood Cell Count Decreased, Vomiting, Renal Disorder, Pneumonia, Blood Urea Increased, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Methicillin-Resistant Staphylococcal Aureus Test Positive, Rash, Oliguria, Aspartate Aminotransferase Increased, Sepsis, Blood Pressure Decreased, Shock

Adverse event resulted in: death, life threatening event

Suspect drug(s):
Funguard
    Dosage: 150 mg/day
    Indication: White Blood Cell Count Decreased
    Start date: 2007-04-23

Gleevec
    Dosage: 600 mg/d
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-05-01
    End date: 2007-05-03

Loxonin
    Dosage: 60 mg/day
    Administration route: Oral
    Indication: Pyrexia
    Start date: 2007-05-03
    End date: 2007-05-03

Meropen
    Dosage: 2 g/day
    Indication: Sepsis
    Start date: 2007-05-03
    End date: 2007-05-04

Other drugs received by patient: Norvasc; Cylocide; Idarubicin HCL; Vancomycin HCL; Prednisolone

Adverse event in 68 year old female receiving Gleevec (Imatinib)

Reported by a consumer/non-health professional from Taiwan, Province of China on 2007-05-25

Patient: 68 year old female

Adverse reactions / side effects: Surgery, Cyst, Pyrexia

Adverse event resulted in: hospitalization

Suspect drug(s):
Gleevec (Imatinib)

Adverse event in 87 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-05-24

Patient: 87 year old male

Adverse reactions / side effects: White Blood Cell Count Decreased, Drug Eruption, Haemoglobin Decreased, Dyspnoea, Haematocrit Decreased, RED Blood Cell Count Decreased, Platelet Count Decreased, Pyrexia, Bronchiolitis

Adverse event resulted in: hospitalization

Suspect drug(s):
Gleevec
    Dosage: 400 mg/d
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2005-06-27
    End date: 2005-07-25

Gleevec
    Dosage: 100 mg/d
    Administration route: Oral
    Start date: 2005-12-26
    End date: 2006-06-11

Gleevec
    Dosage: 200 mg/d
    Administration route: Oral
    Start date: 2006-06-12

Other drugs received by patient: Famotidine; Mucosta; Aspirin; Lasix; Cleanal; Uralyt

Adverse event in 58 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-05-22

Patient: 58 year old male, weighing 57.0 kg (125.4 pounds)

Adverse reactions / side effects: Hepatic Function Abnormal, Pyrexia, Urticaria Generalised, Malaise, Generalised Erythema, Hepatotoxicity, Gamma-Glutamyltransferase Increased, Bone Marrow Failure, Blood Creatinine Increased, Acute Respiratory Failure, Blister, White Blood Cell Count Decreased, Vomiting, Renal Disorder, Pneumonia, Blood Urea Increased, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Methicillin-Resistant Staphylococcal Aureus Test Positive, Rash, Oliguria, Aspartate Aminotransferase Increased, Sepsis, Blood Pressure Decreased, Shock

Adverse event resulted in: death, life threatening event

Suspect drug(s):
Funguard
    Dosage: 150 mg/day
    Indication: White Blood Cell Count Decreased
    Start date: 2007-04-23

Gleevec
    Dosage: 600 mg/d
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-05-01
    End date: 2007-05-03

Loxonin
    Dosage: 60 mg/day
    Administration route: Oral
    Indication: Pyrexia
    Start date: 2007-05-03
    End date: 2007-05-03

Meropen
    Dosage: 1 g/day
    Indication: Sepsis
    Start date: 2007-05-03
    End date: 2007-05-04

Other drugs received by patient: Norvasc; Cylocide; Idarubicin HCL; Vancomycin; Prednisolone

Adverse event in 79 year old male receiving Gleevec (Imatinib)

Reported by a physician from Japan on 2007-05-14

Patient: 79 year old male, weighing 35.0 kg (77.0 pounds)

Adverse reactions / side effects: Hypercapnia, Pyrexia, Somnolence, Cardio-Respiratory Arrest, Dyspnoea Exertional, Interstitial Lung Disease, Lung Neoplasm Malignant, Hypoxia, Carbon Dioxide Increased, Fluid Retention, Oxygen Saturation Decreased, Pneumonia, Cardiac Failure, Activities of Daily Living Impaired, Respiratory Failure, Anorexia, Blood Pressure Decreased

Adverse event resulted in: death, life threatening event

Suspect drug(s):
Gleevec
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2003-01-15
    End date: 2003-01-31

Gleevec
    Dosage: 300 mg/d
    Administration route: Oral
    Start date: 2003-02-26
    End date: 2003-07-10

Gleevec
    Dosage: 300 mg, qd
    Administration route: Oral
    Start date: 2005-07-11
    End date: 2005-12-18

Gleevec
    Dosage: 200 mg, qd
    Administration route: Oral
    Start date: 2005-12-19
    End date: 2006-01-10

Other drugs received by patient: Aldactone; Lasix; Warfarin; Sunrythm; Gaster; Neuer; Selbex; Berizym; Allopurinol; Actonel; Aspirin; Hydrea; Sulperazon; Stomilase