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Index of reports
> Cases resulting in life threatening events (12)
> Cases with Toxic Epidermal Necrolysis (11)
Below is the selection of adverse event reports related to Ethyol (Amifostine) that includes cases resulting in life threatening events where reactions include toxic epidermal necrolysis.
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a individual with unspecified qualification from France on 2007-06-07
Patient: 68 year old male
Adverse reactions / side effects: Ischaemia, Serratia Infection, Corneal Perforation, Radiation Skin Injury, Pyrexia, Bronchial Obstruction, Erythema, Fall, Somnolence, Haemodynamic Instability, Multi-Organ Failure, Malaise, Poor Peripheral Circulation, Hypoxia, Pleural Effusion, Histiocytosis Haematophagic, Dysphagia, Hypothermia, Hypotension, Toxic Epidermal Necrolysis, Respiratory Distress, Mucosal Inflammation, Agranulocytosis, Renal Failure, Respiratory Failure, Staphylococcal Infection, Heart Rate Increased, Sepsis, Disturbance in Attention, Dermatitis Exfoliative, Leukopenia
Adverse event resulted in: life threatening event, hospitalization, disablity
Suspect drug(s):
Ethyol
Dosage: 340 mg, 3 in 1 wk, intravenous (not otherwise specified)
Indication: Prophylaxis
Start date: 2006-09-28
End date: 2006-11-06
Ethyol
Dosage: 340 mg, 3 in 1 wk, intravenous (not otherwise specified)
Indication: Radiotherapy
Start date: 2006-09-28
End date: 2006-11-06
Ciprofloxacin
Dosage: oral
Administration route: Oral
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Augmentin '125'
Dosage: intravenous (not otherwise specified)
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Fluconazole
Dosage: intravenous (not otherwise specified)
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Acetaminophen
Dosage: intravenous (not otherwise specified)
Start date: 2006-11-06
End date: 2006-11-07
Primperan TAB
Dosage: intravenous (not otherwise specified)
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
Primperan TAB
Dosage: intravenous (not otherwise specified)
Indication: Vomiting
Start date: 2006-11-06
End date: 2006-11-06
Other drugs received by patient: Citalopram Hydrobromide; Lorazepam; Zaldiar (Paracetamol, Tramadol Hydrochloride); Acetaminophen; Radiation Therapy
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a individual with unspecified qualification from France on 2007-05-14
Patient: 68 year old male
Adverse reactions / side effects: Serratia Infection, Ulcerative Keratitis, Bronchial Obstruction, Tympanic Membrane Perforation, Adhesion, Post Procedural Infection, Histiocytosis Haematophagic, Dysphagia, Hypotension, Toxic Epidermal Necrolysis, General Physical Health Deterioration, Respiratory Distress, Staphylococcal Infection, Depressed Level of Consciousness, Nervous System Disorder, Otitis Media, Dermatitis Exfoliative, Keratitis, Transplant, Ischaemia, Head Injury, Corneal Perforation, Symblepharon, Somnolence, Fall, Multi-Organ Failure, Eyelid Disorder, Pleural Effusion, Pathogen Resistance, Catheter Site Infection, Hernia, Mucosal Inflammation, Agranulocytosis, Renal Failure, Iris Disorder, Respiratory Failure, Heart Rate Increased, Sepsis, Peripheral Circulatory Failure, Leukopenia, Shock, Infusion Related Reaction
Adverse event resulted in: life threatening event, hospitalization, disablity
Suspect drug(s):
Ethyol
Dosage: 340 mg, 3 in 1 wk, intravenous
Indication: Prophylaxis
Start date: 2006-09-28
End date: 2006-11-06
Ethyol
Dosage: 340 mg, 3 in 1 wk, intravenous
Indication: Radiotherapy
Start date: 2006-09-28
End date: 2006-11-06
Ciprofloxacin
Dosage: oral
Administration route: Oral
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Augmentin '125'
Dosage: intravenous
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Fluconazole
Dosage: intravenous
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Perfalgan (Paracetamol)
Dosage: intravenous
Start date: 2006-11-06
End date: 2006-11-07
Primperan TAB
Dosage: intravenous
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
Primperan TAB
Dosage: intravenous
Indication: Vomiting
Start date: 2006-11-06
End date: 2006-11-06
Other drugs received by patient: Citalopram Hydrobromide; Lorazepam; Zaldiar (Paracetamol, Tramadol Hydrochloride); Acetaminophen; Radiation Therapy
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a physician from France on 2007-05-01
Patient: 68 year old male
Adverse reactions / side effects: Skin Exfoliation, Conjunctival Oedema, Symblepharon, Toxic Epidermal Necrolysis, Erythema, Eye Infection, Haemodynamic Instability, Multi-Organ Failure, Renal Failure, Agranulocytosis, Respiratory Failure, Nervous System Disorder, Eye Disorder, Keratitis
Adverse event resulted in: life threatening event, hospitalization, disablity
Suspect drug(s):
Ciprofloxacin HCL
Dosage: total daily dose: 1 g unit dose: 500 mg
Administration route: Oral
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Augmentin '125'
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Triflucan
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Ethyol
Indication: Unevaluable Event
Start date: 2006-09-28
End date: 2006-11-06
Perfalgan
Indication: Unevaluable Event
Start date: 2006-11-06
End date: 2006-11-07
Primperan INJ
Dosage: total daily dose: 60 mg unit dose: 10 mg
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
Other drugs received by patient: Seropram; Temesta; Acetaminophen and Tramadol HCL; Acetaminophen
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a individual with unspecified qualification from France on 2007-05-01
Patient: 68 year old male
Adverse reactions / side effects: Serratia Infection, Radiation Injury, Ulcerative Keratitis, Corneal Disorder, Haemodynamic Instability, Tympanic Membrane Perforation, Adhesion, Dysphagia, Histiocytosis Haematophagic, Hypothermia, Conjunctival Oedema, Hypotension, Toxic Epidermal Necrolysis, Respiratory Distress, Staphylococcal Infection, Dysphonia, Disturbance in Attention, Dermatitis Exfoliative, Keratitis, Ischaemia, Head Injury, Corneal Perforation, Symblepharon, Fall, Somnolence, Multi-Organ Failure, Pleural Effusion, Ear Infection, Hernia, Blood Culture, Mucosal Inflammation, Renal Failure, Agranulocytosis, Respiratory Failure, Eyelid Function Disorder, Sepsis, Leukopenia
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Ethyol (Amifostine)
Other drugs received by patient: Citalopram Hydrobromide; Lorazepam; (Paracetamol, Tramadol Hydrochloride); Acetaminophen; Radiation Therapy
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a health professional (non-physician/pharmacist) from France on 2007-04-30
Patient: 68 year old male
Adverse reactions / side effects: Multi-Organ Failure, Agranulocytosis, Toxic Epidermal Necrolysis, Eye Disorder
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Triflucan
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Ciprofloxacin
Dosage: text:1 g
Administration route: Oral
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Augmentin '125'
Dosage: text:3 g
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Ethyol
Dosage: daily dose:340mg
Start date: 2006-09-28
End date: 2006-11-06
Paracetamol
Dosage: daily dose:1gram
Start date: 2006-11-06
End date: 2006-11-07
Metoclopramide
Dosage: daily dose:60mg
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
Metoclopramide
Indication: Vomiting
Other drugs received by patient: Seropram; Temesta; ALL Other Therapeutic Products
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a health professional (non-physician/pharmacist) from France on 2007-04-26
Patient: 68 year old male
Adverse reactions / side effects: Vomiting, Nausea, Symblepharon, Post Procedural Complication, Conjunctival Oedema, Pseudomonas Infection, General Physical Health Deterioration, Toxic Epidermal Necrolysis, Multi-Organ Failure, Agranulocytosis, Serratia Sepsis, Staphylococcal Infection, Eye Disorder, Keratitis
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Triflucan
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Ciprofloxacin
Dosage: text:1 g
Administration route: Oral
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Augmentin '125'
Dosage: text:3 g
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Ethyol
Dosage: daily dose:340mg
Start date: 2006-09-28
End date: 2006-11-06
Paracetamol
Dosage: daily dose:1gram
Start date: 2006-11-06
End date: 2006-11-07
Metoclopramide
Dosage: daily dose:60mg
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
Metoclopramide
Indication: Vomiting
Other drugs received by patient: Seropram; Temesta; ALL Other Therapeutic Products; Acetaminophen
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a individual with unspecified qualification from France on 2007-04-23
Patient: 68 year old male
Adverse reactions / side effects: Serratia Infection, Ulcerative Keratitis, Corneal Disorder, Bronchial Obstruction, Wound Secretion, Malaise, Catheter Related Infection, Blood Culture Positive, Hypoxia, Adhesion, Tympanic Membrane Perforation, Skin Inflammation, Dysphagia, Histiocytosis Haematophagic, Hypothermia, Pseudomonas Infection, Conjunctival Oedema, General Physical Health Deterioration, Toxic Epidermal Necrolysis, Respiratory Distress, Staphylococcal Infection, NO Therapeutic Response, Disturbance in Attention, Otitis Media, Dermatitis Exfoliative, Keratitis, Ischaemia, Symblepharon, Radiation Skin Injury, Multi-Organ Failure, Corneal Transplant, Eyelid Disorder, Pleural Effusion, Pathogen Resistance, Ear Infection, Bronchial Injury, Mucosal Inflammation, Haemoglobin Decreased, Agranulocytosis, Renal Failure, Cardiac Failure, Respiratory Failure, Oliguria, Sepsis, Leukopenia, Shock, Inflammation of Lacrimal Passage
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Ethyol
Dosage: 340 mg, 3 in 1 wk, intravenous
Indication: Prophylaxis
Start date: 2006-09-28
End date: 2006-11-06
Ethyol
Dosage: 340 mg, 3 in 1 wk, intravenous
Indication: Radiotherapy
Start date: 2006-09-28
End date: 2006-11-06
Other drugs received by patient: Citalopram Hydrobromide; Lorazepam; Zaldiar (Paracetamol, Tramadol Hydrochloride); Acetaminophen
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a consumer/non-health professional from France on 2007-04-23
Patient: 68 year old male
Adverse reactions / side effects: Serratia Infection, Ulcerative Keratitis, Pyrexia, Bronchial Obstruction, Haemodynamic Instability, Poor Peripheral Circulation, Hypoxia, Dysphagia, Histiocytosis Haematophagic, Hypothermia, Eye Infection Bacterial, Hypotension, Conjunctival Oedema, Toxic Epidermal Necrolysis, Staphylococcal Sepsis, Respiratory Distress, Conjunctival Disorder, Disturbance in Attention, Ear Pain, Otitis Media, Septic Shock, Keratitis, Skin Exfoliation, Corneal Perforation, Head Injury, Symblepharon, Eye Operation, Somnolence, Fall, Glasgow Coma Scale Abnormal, Ventricular Hypertrophy, Lacrimal Disorder, Skin Discolouration, Skin Lesion, Pleural Effusion, Rash Pustular, Skin Disorder, Iris Adhesions, Rash Macular, Mucosal Inflammation, Renal Failure, Iris Disorder, Oliguria, Leukopenia
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Augmentin '125'
Dosage: 3g per day
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Triflucan
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Triflucan
Indication: Infection Parasitic
Start date: 2006-11-06
End date: 2006-11-09
Ethyol
Dosage: 340mg three times per week
Start date: 2006-09-28
End date: 2006-11-06
Ciprofloxacin HCL
Dosage: 500mg twice per day
Administration route: Oral
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Ciprofloxacin HCL
Dosage: 500mg twice per day
Administration route: Oral
Indication: Infection Parasitic
Start date: 2006-11-06
End date: 2006-11-09
Perfalgan
Dosage: 1g per day
Start date: 2006-11-06
End date: 2006-11-07
Primperan INJ
Dosage: 60mg per day
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
Other drugs received by patient: Seropram; Temesta; Acetaminophen and Tramadol HCL; Acetaminophen; Radiotherapy; Morphine; Tranxene; Kytril; Rehydration
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a physician from France on 2007-04-18
Patient: 68 year old male
Adverse reactions / side effects: Skin Exfoliation, Conjunctival Oedema, Symblepharon, Toxic Epidermal Necrolysis, Erythema, Eye Infection, Haemodynamic Instability, Multi-Organ Failure, Renal Failure, Agranulocytosis, Respiratory Failure, Nervous System Disorder, Eye Disorder, Keratitis
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Ciprofloxacin HCL
Dosage: total daily dose: 1 g unit dose: 500 mg
Administration route: Oral
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Augmentin '125'
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Triflucan
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Ethyol
Indication: Unevaluable Event
Start date: 2006-09-28
End date: 2006-11-06
Perfalgan
Indication: Unevaluable Event
Start date: 2006-11-06
End date: 2006-11-07
Primperan INJ
Dosage: total daily dose: 60 mg unit dose: 10 mg
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
Other drugs received by patient: Seropram; Temesta; Acetaminophen and Tramadol HCL; Acetaminophen
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a consumer/non-health professional from France on 2007-01-29
Patient: 68 year old male
Adverse reactions / side effects: Toxic Epidermal Necrolysis
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Augmentin '125'
Dosage: 3g per day
Start date: 2006-11-06
End date: 2006-11-09
Triflucan
Start date: 2006-11-06
End date: 2006-11-09
Ethyol
Dosage: 340mg three times per week
Start date: 2006-09-28
End date: 2006-11-06
Ciprofloxacin
Dosage: 500mg twice per day
Administration route: Oral
Start date: 2006-11-06
End date: 2006-11-09
Perfalgan
Dosage: 1g per day
Start date: 2006-11-06
End date: 2006-11-07
Primperan
Dosage: 60mg per day
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
Adverse event in 68 year old male receiving Ethyol (Amifostine)
Reported by a physician from France on 2007-01-19
Patient: 68 year old male
Adverse reactions / side effects: Toxic Epidermal Necrolysis
Adverse event resulted in: life threatening event
Suspect drug(s):
Ciprofloxacin
Dosage: total daily dose: 1 g unit dose: 500 mg
Administration route: Oral
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Augmentin '125'
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Triflucan
Indication: Infection
Start date: 2006-11-06
End date: 2006-11-09
Ethyol
Indication: Unevaluable Event
Start date: 2006-09-28
End date: 2006-11-06
Perfalgan
Indication: Unevaluable Event
Start date: 2006-11-06
End date: 2006-11-07
Primperan
Dosage: total daily dose: 60 mg unit dose: 10 mg
Indication: Nausea
Start date: 2006-11-06
End date: 2006-11-06
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