Estrace (Estradiol Vaginal) - Adverse Event Reports - Serious Event - Malignant Breast Lump Removal

Adverse event in 57 year old female receiving Estrace (Estradiol Vaginal)

Reported by a individual with unspecified qualification from United States on 2007-07-05

Patient: 57 year old female, weighing 68.0 kg (149.7 pounds)

Adverse reactions / side effects: Tooth Extraction, Neck Injury, Skin Burning Sensation, Breast Cancer in Situ, Malignant Breast Lump Removal, Rash, Biopsy, Biopsy Site Unspecified Abnormal, Erythema, Skin Reaction, Hot Flush, Road Traffic Accident, Depression, Bone Density Decreased, Ligament Sprain

Suspect drug(s):
Combipatch
    Indication: Menopause
    Start date: 2002-11-14
    End date: 2002-12-31

Oral Contraceptive NOS
    Dosage: unk, unk
    Administration route: Oral
    Start date: 1965-01-01
    End date: 1972-01-01

Prempro
    Indication: Menopause
    Start date: 1996-01-01
    End date: 1999-01-01

Estratest

Provera
    Indication: Menopause
    Start date: 1999-06-01
    End date: 2005-03-01

Estrace

Other drugs received by patient: Tamoxifen Citrate; Arimidex

Adverse event in 62 year old female receiving Estrace (Estradiol Vaginal)

Reported by a individual with unspecified qualification from United States on 2007-07-02

Patient: 62 year old female, weighing 99.8 kg (219.5 pounds)

Adverse reactions / side effects: Polyp Colorectal, Mammogram Abnormal, Fibrocystic Breast Disease, Intervertebral Disc Disorder, Postmenopausal Haemorrhage, Breast Microcalcification, Blood Cholesterol Increased, Benign Breast Neoplasm, Breast Hyperplasia, Breast Cancer, Tonsillectomy, Abscess Drainage, Mastitis, Radiotherapy, Malignant Breast Lump Removal, Appendicitis, Anal Fissure, Haematochezia, Hysterectomy, Uterine Dilation and Curettage, Colonoscopy Abnormal

Adverse event resulted in: hospitalization

Suspect drug(s):
Estraderm
    Start date: 1989-01-01

Premarin
    Dosage: 0.625 unk, unk
    Administration route: Oral
    Start date: 1989-01-01

Prempro
    Indication: Menopause
    Start date: 1999-04-01
    End date: 2002-04-01

Provera
    Dosage: 10 mg, unk
    Start date: 1989-01-01

Estratest
    Start date: 1990-01-01
    End date: 1999-01-01

Cycrin
    Start date: 1999-01-01

Estrace
    Dosage: unk, qhs
    Start date: 1999-01-01

Other drugs received by patient: Steroids NOS; Oxygen Therapy; Lotrel; Cardizem

Adverse event in 53 year old female receiving Estrace (Estradiol Vaginal)

Reported by a individual with unspecified qualification from United States on 2007-06-26

Patient: 53 year old female, weighing 47.6 kg (104.8 pounds)

Adverse reactions / side effects: Breast Cancer, Chondropathy, Joint Manipulation, Neuropathy, Rectal Polyp, Radiotherapy, Malignant Breast Lump Removal, Periarthritis, Paraesthesia, Rectal Polypectomy, Anxiety, Breast Microcalcification, Depression, Neuralgia

Suspect drug(s):
Estraderm
    Indication: Menopause
    Start date: 1995-05-31
    End date: 1995-01-01

Provera
    Dosage: 10 mg, unk
    Administration route: Oral
    Indication: Menopause
    Start date: 1994-05-27
    End date: 1996-02-26

Ortho-EST
    Indication: Menopause
    Start date: 1994-05-27

Estrace
    Indication: Menopause
    Start date: 1994-06-24
    End date: 1996-02-26

Prempro
    Indication: Menopause
    Start date: 1996-04-05
    End date: 1996-10-11

Climara
    Indication: Menopause
    Start date: 1995-06-22
    End date: 1995-01-01

Adverse event in 56 year old female receiving Estrace (Estradiol Vaginal)

Reported by a physician from United States on 2007-06-05

Patient: 56 year old female, weighing 63.5 kg (139.7 pounds)

Adverse reactions / side effects: Hysteroscopy, Liver Disorder, Fibrocystic Breast Disease, Uterine Leiomyoma, Liver Function Test Abnormal, Oedema Peripheral, Breast Microcalcification, Depression, Breast Hyperplasia, Pain in Extremity, Radiotherapy, Malignant Breast Lump Removal, Osteopenia, Hepatic Steatosis, Breast Cancer Metastatic, Uterine Dilation and Curettage, Menometrorrhagia

Suspect drug(s):
Estraderm
    Dosage: 0.05mg
    Indication: Hormone Replacement Therapy
    Start date: 1990-12-01
    End date: 1992-01-01

Premphase 14 / 14
    Dosage: 0.625mg
    Indication: Hormone Replacement Therapy
    Start date: 1990-01-01
    End date: 1999-10-01

Cycrin
    Dosage: 10mg unk
    Indication: Hormone Replacement Therapy
    Start date: 1990-01-01
    End date: 1992-01-01

Estratest
    Indication: Hormone Replacement Therapy
    Start date: 1990-01-01
    End date: 2002-01-01

Premarin
    Dosage: unk, unk
    Indication: Hormone Replacement Therapy
    Start date: 1993-07-01
    End date: 1993-01-01

Provera
    Dosage: unk, unk
    Indication: Hormone Replacement Therapy
    Start date: 1991-12-01
    End date: 1996-01-01

Ogen
    Indication: Hormone Replacement Therapy
    Start date: 1999-01-01
    End date: 2002-01-01

Estrace
    Dosage: unk, unk
    Indication: Hormone Replacement Therapy
    Start date: 1993-01-01
    End date: 1996-01-01

Prempro
    Indication: Menopause
    Start date: 2001-12-01
    End date: 2002-01-01

Other drugs received by patient: Paxil; Xanax; Pamelor

Adverse event in 56 year old female receiving Estrace (Estradiol Vaginal)

Reported by a individual with unspecified qualification from United States on 2007-04-16

Patient: 56 year old female, weighing 59.0 kg (129.7 pounds)

Adverse reactions / side effects: Tinnitus, Seroma, Hyperhidrosis, Depression Postoperative, Mammogram Abnormal, Hot Flush, Malaise, Breast Cyst, Uterine Leiomyoma, Bacterial Test Positive, Nervousness, Breast Cancer, Back Pain, Pain in Extremity, Breast Haematoma, Radiotherapy, Libido Decreased, Osteopenia, Bursitis, Dolichocolon, Pain, Breast Oedema, Radiation Skin Injury, Constipation, Gastritis, Abdominal Pain Upper, Weight Increased, Blepharoplasty, Fatigue, Body Dysmorphic Disorder, Nerve Root Lesion, Abdominal Distension, Depression, Oestrogen Receptor Assay Positive, Gastrooesophageal Reflux Disease, Intestinal Polyp, Scoliosis, Haemorrhoids, Deafness Neurosensory, Malignant Breast Lump Removal, Progesterone Receptor Assay Positive, Anxiety, Spinal Osteoarthritis, Asthenia, Hypertension

Suspect drug(s):
Premarin
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 1999-01-01

Provera
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 1999-01-01

Estraderm
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 1999-01-01

Medroxyprogesterone
    Dosage: 5 mg, unk
    Indication: Hormone Replacement Therapy
    Start date: 1998-07-29
    End date: 1999-10-01

Estrace
    Indication: Hormone Replacement Therapy

Other drugs received by patient: Inderal; Nexium

Adverse event in 65 year old female receiving Estrace (Estradiol Vaginal)

Reported by a physician from United States on 2007-04-03

Patient: 65 year old female, weighing 64.9 kg (142.7 pounds)

Adverse reactions / side effects: Diverticulitis, Breast Cellulitis, Exomphalos, Irritable Bowel Syndrome, Depression, Lymphadenectomy, Breast Cancer, Radiotherapy, Malignant Breast Lump Removal, Hernia Repair, Facet Joint Syndrome, Spondylitis, Anxiety, Cholelithiasis, Cholecystectomy, Spinal Osteoarthritis

Suspect drug(s):
Estraderm
    Indication: Hormone Replacement Therapy
    Start date: 1988-08-08
    End date: 1991-01-01

Estrace
    Administration route: Oral
    Indication: Hormone Replacement Therapy
    Start date: 1991-01-01
    End date: 1996-01-01

Prempro
    Administration route: Oral
    Indication: Hormone Replacement Therapy
    Start date: 1996-01-01
    End date: 2001-01-01

Premarin
    Indication: Hormone Replacement Therapy
    Start date: 1996-01-01
    End date: 2001-01-01

Adverse event in 61 year old female receiving Estrace (Estradiol Vaginal)

Reported by a individual with unspecified qualification from United States on 2007-03-28

Patient: 61 year old female, weighing 89.8 kg (197.5 pounds)

Adverse reactions / side effects: Breast Cancer, Biopsy Breast Abnormal, Breast Mass, Malignant Breast Lump Removal, Progesterone Receptor Assay Positive, Haemangioma of Liver, Limb Discomfort, Oedema Peripheral, Depression, Lymphadenectomy, Knee Arthroplasty, Oestrogen Receptor Assay Positive, Lung Infiltration

Adverse event resulted in: hospitalization

Suspect drug(s):
Vivelle
    Indication: Hormone Replacement Therapy

Vivelle-DOT
    Indication: Hormone Replacement Therapy

Estrace
    Indication: Night Sweats

Estratab
    Dosage: 0.625 mg, qd
    Indication: Night Sweats

Estropipate
    Dosage: 1 mg, unk
    Indication: Amnesia

Prempro
    Indication: Amnesia

Premarin
    Dosage: 0.625 mg, unk
    Indication: Affective Disorder

Provera
    Dosage: 2.5 mg, qd
    Indication: Hormone Replacement Therapy

Other drugs received by patient: Fish OIL; Alprazolam; Celebrex