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Index of reports
> Cases resulting in life threatening events (51)
> Cases with Alanine Aminotransferase Increased (12)
Below is the selection of adverse event reports related to Diovan (Valsartan) that includes cases resulting in life threatening events where reactions include alanine aminotransferase increased.
Adverse event in 77 year old female receiving Diovan (Valsartan)
Reported by a individual with unspecified qualification from United States on 2007-10-18
Patient: 77 year old female, weighing 67.6 kg (148.7 pounds)
Adverse reactions / side effects: Weight Decreased, Abdominal Pain, Gastrointestinal Haemorrhage, Autoimmune Hepatitis, Blood Albumin Decreased, Bloody Airway Discharge, Oedema Peripheral, Paracentesis, Blood Test Abnormal, Hepatic Cirrhosis, Iron Binding Capacity Total Decreased, Blood Alkaline Phosphatase Increased, Biliary Fibrosis, Bursitis, Tremor, Aspartate Aminotransferase Increased, Cholecystectomy, Portal Hypertension, Jaundice, Acid Fast Stain Positive, Dyslipidaemia, General Physical Condition Abnormal, Brain Natriuretic Peptide Decreased, Blood Thyroid Stimulating Hormone Abnormal, Disease Progression, Hepatitis B Antibody Abnormal, International Normalised Ratio Decreased, Blood Bilirubin Abnormal, Pleural Effusion, Oedema, Abdominal Distension, Gastrooesophageal Reflux Disease, Decreased Appetite, Dyspnoea, Cataract, Vomiting, Alanine Aminotransferase Increased, Biopsy Liver Abnormal, Ascites, Hepatic Enzyme Increased, Hypertension
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan (Valsartan)
Other drugs received by patient: Ranitidine HCL; Allegra; Fosamax; Calcium; Atarax; Ambien; Lasix; Librium; Imuran; Prednisone; Aldactone; Aldactone; Lactulose; Esomeprazole; Stool Softener
Adverse event in 78 year old male receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-07-26
Patient: 78 year old male, weighing 52.0 kg (114.4 pounds)
Adverse reactions / side effects: Jaundice, Eosinophil Count Decreased, Blood Bilirubin Increased, Nasopharyngitis, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Liver Disorder, Weight Increased, Haemoglobin Decreased, Haematocrit Decreased, Malaise, Gamma-Glutamyltransferase Increased, RED Blood Cell Count Decreased, Aspartate Aminotransferase Increased, Peritoneal Effusion
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan
Dosage: 40 mg/day
Administration route: Oral
Indication: Hypertension
Start date: 2006-11-01
Flomox
Dosage: 300 mg/day
Administration route: Oral
Indication: Upper Respiratory Tract Inflammation
Start date: 2007-05-21
End date: 2007-05-25
Kakkon-TO
Dosage: 7.5 g/day
Administration route: Oral
Indication: Upper Respiratory Tract Inflammation
Start date: 2007-05-21
End date: 2007-05-25
Adverse event in 84 year old female receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-07-25
Patient: 84 year old female, weighing 38.0 kg (83.6 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Blood Alkaline Phosphatase Increased, Hepatic Function Abnormal, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Purpura, Eosinophilia, Cholelithiasis, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Platelet Count Decreased, Thrombocytopenia, Bilirubin Conjugated Increased
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan (Valsartan)
Other drugs received by patient: Spiriva; Frandol
Adverse event in 78 year old male receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-07-24
Patient: 78 year old male, weighing 52.0 kg (114.4 pounds)
Adverse reactions / side effects: Jaundice, Eosinophil Count Decreased, Blood Bilirubin Increased, Nasopharyngitis, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Liver Disorder, Weight Increased, Haemoglobin Decreased, Haematocrit Decreased, Malaise, Gamma-Glutamyltransferase Increased, RED Blood Cell Count Decreased, Aspartate Aminotransferase Increased, Peritoneal Effusion
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan
Dosage: 40 mg/day
Administration route: Oral
Indication: Hypertension
Start date: 2006-11-01
Flomox
Dosage: 300 mg/day
Administration route: Oral
Indication: Upper Respiratory Tract Inflammation
Start date: 2007-05-21
End date: 2007-05-25
Kakkon-TO
Dosage: 7.5 g/day
Administration route: Oral
Indication: Upper Respiratory Tract Inflammation
Start date: 2007-05-21
End date: 2007-05-25
Adverse event in 87 year old female receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-07-23
Patient: 87 year old female, weighing 35.0 kg (77.0 pounds)
Adverse reactions / side effects: Blood Bilirubin Increased, Coagulopathy, Cholestasis, Coma, Hepatic Failure, Gastrointestinal Tube Insertion, Liver Disorder, Hepatic Encephalopathy, Subdural Haematoma, Malaise, Gamma-Glutamyltransferase Increased, Cholecystitis, Gallbladder Disorder, Prothrombin Time Ratio Increased, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Tremor, Cholelithiasis, Anorexia, Aspartate Aminotransferase Increased, Gallbladder Polyp
Adverse event resulted in: death, life threatening event, hospitalization
Suspect drug(s):
Amaryl
Dosage: 1 mg/day
Administration route: Oral
Indication: Diabetes Mellitus
Start date: 2007-04-01
End date: 2007-05-17
Aspirin
Dosage: 100 mg/day
Administration route: Oral
Indication: Angina Pectoris
Start date: 2007-04-01
End date: 2007-05-26
Diovan
Dosage: 40 mg/day
Administration route: Oral
Indication: Hypertension
Start date: 2006-06-14
End date: 2007-05-23
Norvasc
Dosage: 2.5 mg/day
Administration route: Oral
Indication: Hypertension
Start date: 1999-05-01
End date: 2007-05-25
Other drugs received by patient: Roxatidine Acetate HCL; Nateglinide; Triazolam; Lisinopril; Lisinopril
Adverse event in 79 year old male receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-07-09
Patient: 79 year old male
Adverse reactions / side effects: Blood Bilirubin Increased, Pyrexia, Liver Disorder, Malaise, Haematocrit Decreased, RED Blood Cell Count Decreased, Gamma-Glutamyltransferase Increased, White Blood Cell Count Increased, Blood Glucose Increased, Lymphocyte Count Decreased, Blood Alkaline Phosphatase Increased, Blood Urea Increased, Pneumonia, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Urine Output Decreased, Haemoglobin Decreased, Aspartate Aminotransferase Increased, Platelet Count Decreased
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan (Valsartan)
Other drugs received by patient: Lendormin; Pariet; Norvasc; Rinderon; Aspirin; Clarithromycin; Rizaben
Adverse event in 51 year old male receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-06-27
Patient: 51 year old male
Adverse reactions / side effects: Drug Eruption, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Toxic Epidermal Necrolysis, Cerebral Haemorrhage, Hypoalbuminaemia, Stevens-Johnson Syndrome, Infection
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan
Dosage: 1 dosage forms, 1 in 1 d, oral
Administration route: Oral
Indication: Hypertension
Start date: 2006-12-31
End date: 2007-03-17
Zonisamide
Dosage: 200 mg, 2 in 1 d, oral
Administration route: Oral
Indication: Cerebral Haemorrhage
Start date: 2007-01-04
End date: 2007-02-07
Other drugs received by patient: Takepron (Lansoprazole) (Lansoprazole); NI (Magnesium Oxide) (Magnesium Oxide); Pursennid (Sennoside) (Senna Leaf)
Adverse event in 51 year old male receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-06-19
Patient: 51 year old male
Adverse reactions / side effects: Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Toxic Epidermal Necrolysis, Varicella, Mycoplasma Infection, Staphylococcal Infection, NO Therapeutic Response, Hypoalbuminaemia, Dermatitis Exfoliative, White Blood Cell Count Increased, Infection
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan
Dosage: 1 dosage forms, 1 in 1 d, oral
Administration route: Oral
Indication: Hypertension
Start date: 2006-12-31
End date: 2007-03-17
Zonisamide
Dosage: 200 mg, 2 in 1 d, oral
Administration route: Oral
Indication: Cerebral Haemorrhage
Start date: 2007-01-04
End date: 2007-02-07
Other drugs received by patient: Lansoprazole; NI (Magnesium Oxide); Pursennid (Sennoside) (Senna Leaf)
Adverse event in 87 year old female receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-06-11
Patient: 87 year old female
Adverse reactions / side effects: Blood Bilirubin Increased, Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Hepatic Failure, Tremor
Adverse event resulted in: life threatening event
Suspect drug(s):
Amaryl
Dosage: 1 mg/day
Administration route: Oral
Aspirin
Dosage: 100 mg/day
Administration route: Oral
Diovan
Dosage: 40 mg/day
Administration route: Oral
Indication: Hypertension
End date: 2007-05-23
Norvasc
Dosage: 2.5 mg/day
Administration route: Oral
Other drugs received by patient: Urso 250
Adverse event in 51 year old male receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-05-29
Patient: 51 year old male
Adverse reactions / side effects: Drug Eruption, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, NO Therapeutic Response, Toxic Epidermal Necrolysis
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan
Dosage: 1 in 1 d; oral
Administration route: Oral
Indication: Hypertension
Start date: 2006-12-31
End date: 2007-03-17
Diovan
Dosage: 1 in 1 d; oral
Administration route: Oral
Indication: Hypertension
Start date: 2006-12-31
End date: 2007-03-17
Zonisamide
Dosage: 200 mg, 2 in 1 d; oral
Administration route: Oral
Indication: Cerebral Haemorrhage
Start date: 2007-01-04
End date: 2007-02-07
Zonisamide
Dosage: 200 mg, 2 in 1 d; oral
Administration route: Oral
Indication: Cerebral Haemorrhage
Start date: 2007-01-04
End date: 2007-02-07
Other drugs received by patient: Takepron (Lansoprazole) (Lansoprazole); NI (Magnesium Oxide ) (Magnesium Oxide); Pursennid (Sennoside) (Senna Leaf); Takepron (Lansoprazole) (Lansoprazole); NI (Magnesium Oxide ) (Magnesium Oxide); Pursennid (Sennoside) (Senna Leaf)
Adverse event in 51 year old male receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-05-22
Patient: 51 year old male
Adverse reactions / side effects: Drug Eruption, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Toxic Epidermal Necrolysis, Pyrexia, Dermatitis Exfoliative, Stevens-Johnson Syndrome
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan
Dosage: 1 in 1 d, oral
Administration route: Oral
Indication: Hypertension
Start date: 2006-12-31
End date: 2007-03-17
Zonisamide
Dosage: 200 mg, 2 in 1 d, oral
Administration route: Oral
Indication: Cerebral Haemorrhage
Start date: 2007-01-04
End date: 2007-02-07
Other drugs received by patient: Takepron (Lansoprazole) (Lansoprazole); NI (Magnesium Oxide) (Magnesium Oxide); Pursennid (Sennoside) (Senna Leaf)
Adverse event in 51 year old male receiving Diovan (Valsartan)
Reported by a physician from Japan on 2007-05-14
Patient: 51 year old male
Adverse reactions / side effects: Drug Eruption, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Toxic Epidermal Necrolysis, Pyrexia, White Blood Cell Count Increased
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Diovan
Dosage: 1 in 1 d, oral
Administration route: Oral
Indication: Hypertension
Start date: 2006-12-31
End date: 2007-03-17
Zonisamide
Dosage: 200 mg, 2 in 1 d, oral
Administration route: Oral
Indication: Cerebral Haemorrhage
Start date: 2007-01-04
End date: 2007-02-07
Other drugs received by patient: Lansoprazole; (Magnesium Oxide) (Magnesium Oxide); Pursennid (Sennoside) (Senna Leaf)
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