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This is an index of reports of adverse events (side effects, adverse reactions, etc.) related to Depakote (Divalproex). Click on the relevant link below to view a selection of reports according to the event's seriousness level and/or the nature of the side effect / adverse reaction. Or scroll down to view a sample of recent reports further on this page.
Our database includes reports from Jan 2007 to Dec 2007. The information is not vetted and should not be cosidered as verified clinical evidence.
All cases (187)
Cases resulting in a serious event (178)
Cases resulting in death (19)
Cases resulting in life threatening events (15)
Cases resulting in hospitalization (104)
Cases resulting in disability (10)
Cases resulting in other serious reactions (80)
Below is a sample of reports where side effects / adverse reactions may be related to Depakote (Divalproex). For a complete list and/or a specific selection of reports, please use the links in the index above.
Adverse event in female receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from United States on 2007-10-30
Patient: female, weighing 84.9 kg (186.8 pounds)
Adverse reactions / side effects: Confusional State, Mania, Panic Attack, Insomnia, Dizziness, Headache, Somnolence, Tremor
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakote
Administration route: Oral
Indication: Bipolar Disorder
Start date: 2007-01-01
End date: 2007-01-01
Depakote
Administration route: Oral
Start date: 2007-01-01
Depakote
Administration route: Oral
Indication: Bipolar Disorder
Start date: 1997-01-01
End date: 2007-01-01
Cyclobenzaprine HCL
Indication: Fibromyalgia
End date: 2007-10-03
Other drugs received by patient: Escitalopram Oxalate; Escitalopram Oxalate; Levothyroxine Sodium; Propacet 100; Propacet 100; Lorastat Plus; Lorastat Plus; Zyetia; Simvastatin; Alprazolam; Alprazolam
Adverse event in 18 year old female receiving Depakote (Divalproex)
Reported by a individual with unspecified qualification from United States on 2007-10-30
Patient: 18 year old female, weighing 57.0 kg (125.4 pounds)
Adverse reactions / side effects: Pruritus, Streptococcal Bacteraemia, Tachycardia, Pyrexia, Fatigue, Multiple System Atrophy, Musculoskeletal Stiffness, Pneumothorax, Adrenal Insufficiency, Pleural Effusion, Coordination Abnormal, Splenomegaly, Pharyngeal Erythema, Pulmonary Artery Dilatation, Cardiac Failure Congestive, Lung Injury, Hypotension, Pancytopenia, Abnormal Behaviour, Encephalopathy, Rash, Cognitive Disorder, Convulsion, Myoclonus, Irritability, Agranulocytosis, Eye Rolling, Diarrhoea, Sepsis, Ear Pain
Adverse event resulted in: hospitalization
Suspect drug(s):
Tegretol
Indication: Epilepsy
Topiramate
Depakote
Tegretol
Start date: 1992-01-01
End date: 1999-01-01
Tegretol
Start date: 1999-01-01
Keppra
Dosage: 750 mg, bid
End date: 2006-06-01
Keppra
Dosage: 750 mg, bid
Felbamate
End date: 2006-06-08
Augmentin
Start date: 2006-05-01
Adverse event in 61 year old female receiving Depakote (Divalproex)
Reported by a health professional (non-physician/pharmacist) from France on 2007-10-26
Patient: 61 year old female
Adverse reactions / side effects: Hyponatraemia
Adverse event resulted in: hospitalization
Suspect drug(s):
Aprovel
Indication: Hypertension
Tegretol
Dosage: tegretol lp 200 mg
Indication: Epilepsy
End date: 2007-06-30
Athymil
Depakote
Indication: Epilepsy
Doliprane
Indication: Pain
Adverse event in 68 year old male receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from France on 2007-10-26
Patient: 68 year old male
Adverse reactions / side effects: Respiratory Rate Increased, Nightmare, Hypoventilation, Nonspecific Reaction, Drug Interaction, Disorientation, Memory Impairment, Hallucination, Feeling Abnormal
Suspect drug(s):
Depakote (Divalproex)
Other drugs received by patient possibly interacting with the suspect drug:
Nicotine
Indication: EX-Smoker
Start date: 2007-09-24
End date: 2007-09-25
Ziprasidone HCL
Indication: Drug USE FOR Unknown Indication
Adverse event in male receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from France on 2007-10-25
Patient: male
Adverse reactions / side effects: Adenoma Benign, Thrombocytopenia
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakote (Divalproex)
Adverse event in 31 year old female receiving Depakote (Divalproex)
Reported by a individual with unspecified qualification from United States on 2007-10-24
Patient: 31 year old female
Adverse reactions / side effects: Ultrasound Scan Abnormal, Abortion Spontaneous
Suspect drug(s):
Depakote (Divalproex)
Adverse event in 30 year old female receiving Depakote (Divalproex)
Reported by a individual with unspecified qualification from United States on 2007-10-24
Patient: 30 year old female
Adverse reactions / side effects: Ectopic Pregnancy
Suspect drug(s):
Depakote
Indication: Epilepsy
Start date: 1998-12-01
Phenytoin
Indication: Epilepsy
Start date: 1998-12-01
Other drugs received by patient: Folic Acid
Adverse event in 6 year old male receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from United States on 2007-10-24
Patient: 6 year old male
Adverse reactions / side effects: Convulsion
Suspect drug(s):
Depakote
Indication: Drug USE FOR Unknown Indication
Lamotrigine
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Adverse event in 3 year old male receiving Depakote (Divalproex)
Reported by a individual with unspecified qualification from United States on 2007-10-23
Patient: 3 year old male, weighing 21.8 kg (47.9 pounds)
Adverse reactions / side effects: Pancreatitis, Hallucination, Convulsion
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Depakote (Divalproex)
Adverse event in female receiving Depakote (Divalproex)
Reported by a individual with unspecified qualification from United States on 2007-10-22
Patient: female, weighing 3.2 kg (7.0 pounds)
Adverse reactions / side effects: Microcephaly, Clonus, Hyperreflexia, Neonatal Disorder, Hypoxic Encephalopathy, Hypertonia Neonatal
Suspect drug(s):
Norvir
Indication: Drug Exposure During Pregnancy
Depakote
Indication: Drug Exposure During Pregnancy
Abacavir Sulfate
Indication: Drug Exposure During Pregnancy
Atazanavir Sulfate
Indication: Drug Exposure During Pregnancy
Adverse event in 21 year old female receiving Depakote (Divalproex)
Reported by a physician from United States on 2007-10-22
Patient: 21 year old female
Adverse reactions / side effects: Liver Injury, Hepatitis C Antibody Positive, Hepatitis C, Prothrombin Time Prolonged, Appendicitis
Suspect drug(s):
Depakote (Divalproex)
Adverse event in male receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from United States on 2007-10-19
Patient: male, weighing 88.5 kg (194.7 pounds)
Adverse reactions / side effects: Osteoporosis, Therapeutic Agent Toxicity, Osteopenia, Erythema, Convulsion, Weight Increased, Body Height Decreased, Oedema Peripheral, Pharmaceutical Product Complaint
Adverse event resulted in: hospitalization, disablity
Suspect drug(s):
Dilantin
Administration route: Oral
Indication: Convulsion
Depakote
Dosage: freq:unknown
Indication: Convulsion
Phenytoin
Dosage: freq:unknown
Indication: Convulsion
Adverse event in 73 year old female receiving Depakote (Divalproex)
Reported by a physician from France on 2007-10-19
Patient: 73 year old female
Adverse reactions / side effects: Arthralgia, Hyperthermia, Chills, Pallor, Anaemia Macrocytic
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakote
Administration route: Oral
Indication: Depression
Start date: 2007-06-01
Depakote
Indication: Bipolar Disorder
Other drugs received by patient: Cyamemazine; Mianserin Hydrochloride; Hydrocortisone; Hydrocortisone; Hydrocortisone
Adverse event in 44 year old female receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from United States on 2007-10-16
Patient: 44 year old female
Adverse reactions / side effects: Gallbladder Pain, Dyspnoea, Post Procedural Swelling, Abdominal Pain Upper, Incision Site Pain, Weight Increased, Alopecia, Pancreatitis, Procedural Nausea
Adverse event resulted in: hospitalization
Suspect drug(s):
Alli
Administration route: Oral
Indication: Weight Loss Diet
Start date: 2007-06-01
End date: 2007-09-26
Depakote
Dosage: 1000mg unknown
Administration route: Oral
Indication: Migraine
Start date: 2007-08-01
Other drugs received by patient: Topamax; Effexor; Lithium
Adverse event in 66 year old female receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from United States on 2007-10-16
Patient: 66 year old female, weighing 88.6 kg (194.9 pounds)
Adverse reactions / side effects: Overdose, Abasia
Adverse event resulted in: hospitalization
Suspect drug(s):
Seroquel
Administration route: Oral
Depakote
Adverse event in 4 year old female receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from United States on 2007-10-12
Patient: 4 year old female
Adverse reactions / side effects: Multiple Drug Overdose
Adverse event resulted in: death
Suspect drug(s):
Tylenol (Caplet)
Indication: Nasopharyngitis
Seroquel
Indication: Affective Disorder
Depakote
Indication: Affective Disorder
Clonidine
Indication: Affective Disorder
Adverse event in 56 year old male receiving Depakote (Divalproex)
Reported by a physician from France on 2007-10-12
Patient: 56 year old male
Adverse reactions / side effects: Confusional State, Vomiting, Drug Level Increased, Encephalopathy, Drug Interaction, Disorientation, Muscle Rigidity, Tremor, Anxiety, Speech Disorder, Asterixis, Psychomotor Skills Impaired, Extrapyramidal Disorder
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakote (Divalproex)
Other drugs received by patient possibly interacting with the suspect drug:
Tianeptine
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Other drugs received by patient: Lithium Carbonate; Levothyroxine Sodium; Amisulpride; Trihexyphenidyl Hydrochloride
Adverse event in male receiving Depakote (Divalproex)
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-12
Patient: male, weighing 16.8 kg (37.0 pounds)
Adverse reactions / side effects: Drug Interaction, Blood Calcium Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakote (Divalproex)
Other drugs received by patient possibly interacting with the suspect drug:
Diflucan
Indication: Skin Infection
Other drugs received by patient: Risperidone; Clonazepam; Levocarnitine; ALL Other Therapeutic Products; Metoclopramide; Pulmicort
Adverse event in 41 year old female receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from United States on 2007-10-10
Patient: 41 year old female
Adverse reactions / side effects: Overdose, Vomiting, Bipolar Disorder, Diarrhoea
Suspect drug(s):
Betaseron
Dosage: 8 miu, every 2d
Indication: Multiple Sclerosis
Start date: 2002-06-24
Depakote
Administration route: Oral
Indication: Bipolar Disorder
End date: 2006-09-01
Adverse event in female receiving Depakote (Divalproex)
Reported by a physician from Italy on 2007-10-08
Patient: female
Adverse reactions / side effects: Conjunctival Haemorrhage, Amaurosis, Gingival Bleeding, Subarachnoid Haemorrhage, Hyperpyrexia, Retinal Haemorrhage, Ecchymosis, Pancytopenia
Adverse event resulted in: life threatening event
Suspect drug(s):
Risperdal
Administration route: Oral
Indication: Bipolar I Disorder
Depakote
Administration route: Oral
Indication: Bipolar I Disorder
Other drugs received by patient: Omerprazole; Calcium D3; Eutirox; Fosavance
Adverse event in 4 year old female receiving Depakote (Divalproex)
Reported by a individual with unspecified qualification on 2007-10-08
Patient: 4 year old female
Adverse reactions / side effects: Overdose
Adverse event resulted in: death
Suspect drug(s):
Clonidine
Indication: Attention Deficit / Hyperactivity Disorder
Depakote
Seroquel
Other drugs received by patient: Children's Tylenol Plus Cough + Runny Nose
Adverse event in female receiving Depakote (Divalproex)
Reported by a consumer/non-health professional from United States on 2007-10-06
Patient: female, weighing 86.2 kg (189.6 pounds)
Adverse reactions / side effects: Drug Screen Positive, Abasia, Fall, Pancreatic Disorder, Drug Toxicity, Body Height Decreased, Road Traffic Accident, Arthropathy, Balance Disorder, Dizziness, Bone Disorder, Carpal Tunnel Syndrome, Type 1 Diabetes Mellitus, Scoliosis, Intervertebral Disc Protrusion, Clavicle Fracture, Patellofemoral Pain Syndrome, Dysarthria, Grand MAL Convulsion, Thyroid Disorder, Gait Disturbance, Feeling Drunk
Adverse event resulted in: hospitalization
Suspect drug(s):
Dilantin
Indication: Epilepsy
Phenytoin
Depakote
Other drugs received by patient: Synthroid; Glipizide; Effexor XR; Effexor XR; Zonisamide; Avandia; Lipitor; Mobic; Klonopin; Remeron
Adverse event in male receiving Depakote (Divalproex)
Reported by a individual with unspecified qualification from United States on 2007-10-05
Patient: male
Adverse reactions / side effects: Confusional State, Movement Disorder, Adverse Drug Reaction, Mental Status Changes, Weight Increased, Drug Toxicity, Fatigue, Oedema, Pleural Effusion, Aneurysm, Cardiac Failure Congestive, Pneumonia, Dyspnoea, Hypotension, Coronary Artery Disease, Dysarthria, Radial Nerve Palsy, Nervous System Disorder, Complex Partial Seizures, Metabolic Encephalopathy, Meningioma
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakote
Indication: Convulsion
Start date: 2006-02-01
End date: 2006-02-04
Depakote
Start date: 2006-04-03
End date: 2006-04-07
Bivalirudin
Indication: Drug USE FOR Unknown Indication
Start date: 2005-11-05
End date: 2005-11-05
Bivalirudin
Start date: 2005-11-05
End date: 2005-11-05
Other drugs received by patient: Atorvastatin Calcium; Furosemide; Spironolactone; Digoxin; Warfarin Sodium; Aspirin; Simvastatin; Potassium Chloride; Lisinopril; Escitalopram Oxalate; Tolterodine Tartrate; Lorazepam; Iron; Oxcarbazepine; Oxcarbazepine; Ramipril; Carvedilol
Adverse event in female receiving Depakote (Divalproex)
Reported by a health professional (non-physician/pharmacist) from United States on 2007-10-05
Patient: female
Adverse reactions / side effects: Cholelithiasis, Cardio-Respiratory Arrest, Pancreatic Pseudocyst, Tachycardia, Pancreatitis, Septic Shock
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Depakote
Administration route: Oral
Indication: Convulsion
Start date: 2006-02-01
Depakote
Indication: Bipolar Disorder
Other drugs received by patient: Oyster Shell Calcium with Vitamin D; Lactulose; Quetiapine Fumarate; Atorvastatin Calcium; Metformin Hydrochloride; Unknown Medications
Adverse event in 44 year old male receiving Depakote (Divalproex)
Reported by a physician from France on 2007-10-05
Patient: 44 year old male
Adverse reactions / side effects: Visual Acuity Reduced, Optic Neuritis
Suspect drug(s):
Depakote (Divalproex)
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