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This is an index of reports of adverse events (side effects, adverse reactions, etc.) related to Depakene (Valproic Acid). Click on the relevant link below to view a selection of reports according to the event's seriousness level and/or the nature of the side effect / adverse reaction. Or scroll down to view a sample of recent reports further on this page.
Our database includes reports from Jan 2007 to Dec 2007. The information is not vetted and should not be cosidered as verified clinical evidence.
All cases (252)
Cases resulting in a serious event (249)
Cases resulting in death (22)
Cases resulting in life threatening events (36)
Cases resulting in hospitalization (163)
Cases resulting in disability (13)
Cases resulting in other serious reactions (96)
Below is a sample of reports where side effects / adverse reactions may be related to Depakene (Valproic Acid). For a complete list and/or a specific selection of reports, please use the links in the index above.
Adverse event in male receiving Depakene (Valproic Acid)
Reported by a pharmacist from France on 2007-10-30
Patient: male, weighing 72.0 kg (158.4 pounds)
Adverse reactions / side effects: Priapism
Adverse event resulted in: hospitalization
Suspect drug(s):
Zarontin
Administration route: Oral
Indication: Epilepsy
Depakene
Dosage: daily dose:2000mg
Administration route: Oral
Indication: Epilepsy
Other drugs received by patient: Combivir; Viramune
Adverse event in 20 year old male receiving Depakene (Valproic Acid)
Reported by a physician from France on 2007-10-30
Patient: 20 year old male, weighing 70.0 kg (154.0 pounds)
Adverse reactions / side effects: Respiratory Disorder, Blood Creatine Phosphokinase Increased, High Density Lipoprotein Increased, Lymphadenopathy, Urinary Incontinence, Visual Acuity Reduced, Ulcerative Keratitis, Pyrexia, Transaminases Increased, Obstructive Uropathy, C-Reactive Protein Increased, Acute Respiratory Distress Syndrome, Dermatitis Bullous, Mucous Membrane Disorder, Cough, Mechanical Ventilation, Back Pain, Dysphagia, Toxic Epidermal Necrolysis, Corneal Opacity, Prothrombin Time Ratio Decreased, Blood Creatine Phosphokinase MB Increased, Heart Rate Decreased, Rash Erythematous, Ureteral Catheterisation, Renal Colic, Skin Exfoliation, Eye Discharge, Corneal Neovascularisation, Symblepharon, Scab, Intubation, Nephrolithiasis, Corneal Transplant, Microlithiasis, Bone Marrow Failure, Thrombocytopenia, Renal Failure Acute, Catheter Related Complication, Depilation, Cataract, Iris Adhesions, Lacrimation Decreased, Alopecia, Lithotripsy, Asthenia, Leukopenia
Adverse event resulted in: life threatening event, hospitalization, disablity
Suspect drug(s):
Depakene
Dosage: 1.6 g daily
Indication: Partial Seizures
End date: 2004-11-22
Trileptal
Dosage: 600 mg, bid
Administration route: Oral
Indication: Partial Seizures
Start date: 2005-02-14
End date: 2005-02-21
Depakene
Dosage: 1 g daily
Administration route: Oral
Indication: Partial Seizures
Start date: 2004-11-23
End date: 2004-11-23
Depakene
Dosage: 1.5 g daily
Start date: 2004-11-24
End date: 2005-02-21
Aspegic 325
Indication: Influenza Like Illness
Start date: 2005-02-01
Other drugs received by patient: Rivotril
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a health professional (non-physician/pharmacist) from France on 2007-10-29
Patient: female
Adverse reactions / side effects: Face Oedema, Dyspnoea, Dysphonia, Salivary Gland Enlargement, Drug Interaction, Disorientation, Parotid Gland Enlargement
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakene (Valproic Acid)
Other drugs received by patient possibly interacting with the suspect drug:
Amlodipine Besylate
Administration route: Oral
Indication: Hypertension
Start date: 2007-08-04
End date: 2007-08-20
Adverse event in 35 year old male receiving Depakene (Valproic Acid)
Reported by a consumer/non-health professional from France on 2007-10-26
Patient: 35 year old male
Adverse reactions / side effects: Drug Ineffective, DRY Mouth, Epilepsy, Muscle Spasms
Suspect drug(s):
Depakene
Administration route: Oral
Indication: Grand MAL Convulsion
Start date: 2007-09-01
End date: 2007-10-01
Depakene
Administration route: Oral
Start date: 1997-01-01
End date: 2007-09-01
Depakene
Administration route: Oral
Start date: 2007-10-01
Other drugs received by patient: Folic Acid; Fish OIL
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a physician from France on 2007-10-25
Patient: female
Adverse reactions / side effects: Hypersensitivity, Angioedema, Lymphadenopathy, Urticaria, Disseminated Intravascular Coagulation, Nuclear Magnetic Resonance Imaging Brain Abnormal, Pyrexia, Convulsion, Mucosal Inflammation, Oedema, Platelet Count Decreased, Prothrombin Level Decreased
Adverse event resulted in: hospitalization
Suspect drug(s):
Lamictal
Administration route: Oral
Indication: Epilepsy
Start date: 2007-09-12
End date: 2007-10-15
Depakene
Administration route: Oral
Indication: Epilepsy
Keppra
Administration route: Oral
Indication: Epilepsy
Start date: 2007-10-15
Adverse event in male receiving Depakene (Valproic Acid)
Reported by a health professional (non-physician/pharmacist) from France on 2007-10-24
Patient: male
Adverse reactions / side effects: Pancytopenia
Adverse event resulted in: hospitalization
Suspect drug(s):
Meronem
Indication: Meningitis
Start date: 2007-09-10
End date: 2007-09-27
Vancomycin
Indication: Meningitis
Start date: 2007-09-10
End date: 2007-10-01
Fosfomycine
Indication: Meningitis
Start date: 2007-09-16
End date: 2007-09-27
Depakene
Administration route: Oral
Indication: Epilepsy
Start date: 2007-09-11
End date: 2007-09-27
Lovenox
Start date: 2007-09-18
End date: 2007-09-27
Adverse event in 65 year old male receiving Depakene (Valproic Acid)
Reported by a individual with unspecified qualification on 2007-10-24
Patient: 65 year old male
Adverse reactions / side effects: Pancytopenia
Adverse event resulted in: hospitalization
Suspect drug(s):
Lovenox
Start date: 2007-09-18
End date: 2007-09-27
Meronem / 01250501 /
Indication: Meningitis
Start date: 2007-09-10
End date: 2007-09-27
Vancomycin
Indication: Meningitis
Start date: 2007-09-10
End date: 2007-10-01
Fosfomycine
Indication: Meningitis
Start date: 2007-09-16
End date: 2007-09-27
Depakene
Dosage: route: nasogastric
Indication: Epilepsy
Start date: 2007-09-11
End date: 2007-09-27
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a health professional (non-physician/pharmacist) from France on 2007-10-19
Patient: female
Adverse reactions / side effects: Dyspnoea, Macrogenia, Drug Interaction, Disorientation, Face Oedema, Dysphonia, Salivary Gland Enlargement, Parotid Gland Enlargement
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakene (Valproic Acid)
Other drugs received by patient possibly interacting with the suspect drug:
Amlodipine Besylate
Administration route: Oral
Indication: Hypertension
Start date: 2007-08-04
End date: 2007-08-20
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a health professional (non-physician/pharmacist) from France on 2007-10-18
Patient: female, weighing 2.7 kg (5.9 pounds)
Adverse reactions / side effects: Oral Intake Reduced, Dyspnoea, Corynebacterium Infection, Pyrexia, Nasal Congestion, Myoclonus, Malaise, Microcephaly, Feeding Disorder Neonatal, Eye Movement Disorder
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakene (Valproic Acid)
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a health professional (non-physician/pharmacist) from France on 2007-10-17
Patient: female
Adverse reactions / side effects: Drug Level Above Therapeutic, Encephalopathy, Disorientation, Somnolence, Hallucination
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakene
Administration route: Oral
Indication: Epilepsy
End date: 2007-01-01
Depakene
Administration route: Oral
Start date: 2007-01-01
Carbamazepine
Administration route: Oral
Indication: Epilepsy
Other drugs received by patient: Levothyroxine Sodium
Adverse event in male receiving Depakene (Valproic Acid)
Reported by a physician from Switzerland on 2007-10-16
Patient: male
Adverse reactions / side effects: Drug Interaction, Respiratory Depression, Sopor
Adverse event resulted in: hospitalization
Suspect drug(s):
Lorazepam
Dosage: (2.5 mg 1x oral)
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-02
End date: 2007-04-02
Clopixol Acutard (Clopixol Acutard Zuclopenthixol Acetate) (Not Specif
Dosage: (75 mg 1x intramuscular)
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-01
End date: 2007-04-01
Diazepam
Dosage: (10 mg 1x intramuscular)
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-01
End date: 2007-04-01
Depakene
Dosage: (800 mg qd oral), (1600 mg qd oral), (1000 mg qd oral)
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-02
End date: 2007-04-02
Depakene
Dosage: (800 mg qd oral), (1600 mg qd oral), (1000 mg qd oral)
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-03
End date: 2007-04-04
Depakene
Dosage: (800 mg qd oral), (1600 mg qd oral), (1000 mg qd oral)
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-05
Zyprexa
Dosage: (10 mg qd oral), (15 mg qd oral)
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-02
End date: 2007-04-02
Zyprexa
Dosage: (10 mg qd oral), (15 mg qd oral)
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Start date: 2007-04-04
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a pharmacist from France on 2007-10-15
Patient: female
Adverse reactions / side effects: Confusional State, Hypersensitivity, Depersonalisation, Multiple Myeloma, Pyrexia, Hepatitis, Loss of Consciousness, Hypokinesia, Spinal Compression Fracture, Skin Lesion, Inappropriate Antidiuretic Hormone Secretion, Humerus Fracture, Back Pain, Phlebitis, Pain in Extremity, Musculoskeletal Pain, Hyponatraemia, Amnesia, Epilepsy, Spondylitis, Renal Failure, Respiratory Failure, Staphylococcal Infection, Sepsis, Blood Pressure Decreased
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Depakene
Administration route: Oral
Indication: Facial Neuralgia
Start date: 2004-10-18
End date: 2004-11-01
Hydrochlorothiazide
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Start date: 1999-01-01
End date: 2004-11-01
Other drugs received by patient: Amlodipine; Irbesartan; Omeprazole; Domperidone; Nitrofurantoin; Nifedipine
Adverse event in 84 year old female receiving Depakene (Valproic Acid)
Reported by a individual with unspecified qualification from France on 2007-10-15
Patient: 84 year old female
Adverse reactions / side effects: Anticonvulsant Drug Level Above Therapeutic, Encephalopathy, Disorientation, Hallucination, Somnolence
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakene
Administration route: Oral
Indication: Epilepsy
Tegretol
Administration route: Oral
Indication: Epilepsy
Other drugs received by patient: Levothyrox
Adverse event in male receiving Depakene (Valproic Acid)
Reported by a consumer/non-health professional from France on 2007-10-12
Patient: male
Adverse reactions / side effects: Drug Exposure During Pregnancy, Congenital Central Nervous System Anomaly, Talipes
Adverse event resulted in: hospitalization
Suspect drug(s):
Lamictal
Dosage: 100mg twice per day
Indication: Epilepsy
Depakene
Indication: Epilepsy
Gardan TAB
Dosage: 50mg twice per day
Indication: Epilepsy
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a pharmacist from France on 2007-10-12
Patient: female
Adverse reactions / side effects: Confusional State, Hypersensitivity, Depersonalisation, Multiple Myeloma, Pyrexia, Hepatitis, Loss of Consciousness, Hypokinesia, Spinal Compression Fracture, Skin Lesion, Inappropriate Antidiuretic Hormone Secretion, Humerus Fracture, Back Pain, Phlebitis, Pain in Extremity, Musculoskeletal Pain, Hyponatraemia, Amnesia, Epilepsy, Spondylitis, Renal Failure, Respiratory Failure, Staphylococcal Infection, Sepsis, Blood Pressure Decreased
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Depakene
Administration route: Oral
Indication: Facial Neuralgia
Start date: 2004-10-18
End date: 2004-11-01
Hydrochlorothiazide
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Start date: 1999-01-01
End date: 2004-11-01
Other drugs received by patient: Amlodipine; Irbesartan; Omeprazole; Domperidone; Nitrofurantoin; Nifedipine
Adverse event in 79 year old female receiving Depakene (Valproic Acid)
Reported by a physician from Japan on 2007-10-09
Patient: 79 year old female, weighing 48.0 kg (105.6 pounds)
Adverse reactions / side effects: White Blood Cell Count Decreased, Glioblastoma Multiforme, Hepatic Function Abnormal, Malignant Neoplasm Progression, Neutrophil Count Decreased
Adverse event resulted in: hospitalization
Suspect drug(s):
Temodal
Dosage: 75 mg/m2; qd; po; 150 mg/m2;qd;po; 150 mg/m2;qd;po; 150 mg/m2;qd;po 150 mg/m2;qd;po 150 mg/m2;qd;po
Administration route: Oral
Indication: Glioblastoma Multiforme
Start date: 2007-03-30
End date: 2007-04-12
Temodal
Dosage: 75 mg/m2; qd; po; 150 mg/m2;qd;po; 150 mg/m2;qd;po; 150 mg/m2;qd;po 150 mg/m2;qd;po 150 mg/m2;qd;po
Administration route: Oral
Indication: Glioblastoma Multiforme
Start date: 2007-06-20
End date: 2007-06-20
Temodal
Dosage: 75 mg/m2; qd; po; 150 mg/m2;qd;po; 150 mg/m2;qd;po; 150 mg/m2;qd;po 150 mg/m2;qd;po 150 mg/m2;qd;po
Administration route: Oral
Indication: Glioblastoma Multiforme
Start date: 2007-06-27
End date: 2007-06-27
Temodal
Dosage: 75 mg/m2; qd; po; 150 mg/m2;qd;po; 150 mg/m2;qd;po; 150 mg/m2;qd;po 150 mg/m2;qd;po 150 mg/m2;qd;po
Administration route: Oral
Indication: Glioblastoma Multiforme
Start date: 2007-06-29
End date: 2007-06-29
Temodal
Dosage: 75 mg/m2; qd; po; 150 mg/m2;qd;po; 150 mg/m2;qd;po; 150 mg/m2;qd;po 150 mg/m2;qd;po 150 mg/m2;qd;po
Administration route: Oral
Indication: Glioblastoma Multiforme
Start date: 2007-07-02
End date: 2007-07-02
Temodal
Dosage: 75 mg/m2; qd; po; 150 mg/m2;qd;po; 150 mg/m2;qd;po; 150 mg/m2;qd;po 150 mg/m2;qd;po 150 mg/m2;qd;po
Administration route: Oral
Indication: Glioblastoma Multiforme
Start date: 2007-08-01
End date: 2007-08-05
Depakene
Dosage: po
Administration route: Oral
Indication: Convulsion
End date: 2007-04-13
Other drugs received by patient: Seroquel (Con.); Navoban (Con.); Primperan (Con.); Magnesium Oxide (Con.); Pursennid (Con.)
Adverse event in 23 year old female receiving Depakene (Valproic Acid)
Reported by a pharmacist from Japan on 2007-10-08
Patient: 23 year old female
Adverse reactions / side effects: Abortion Spontaneous
Suspect drug(s):
Halcion
Dosage: text:tdd:0.25mg
Indication: Insomnia
Cercine
Depakene
Administration route: Oral
Seroquel
Administration route: Oral
Lexotan
Administration route: Oral
Omepral
Administration route: Oral
Buscopan
Other drugs received by patient: LAC B
Adverse event in 42 year old female receiving Depakene (Valproic Acid)
Reported by a physician from France on 2007-10-04
Patient: 42 year old female
Adverse reactions / side effects: Medication Error, Hypotonia, Miosis, Depressed Level of Consciousness, Accidental Overdose
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakene
Administration route: Oral
Indication: Convulsion Prophylaxis
Start date: 2007-01-31
End date: 2007-02-01
Depakene
Other drugs received by patient: Paracetamol; Levothyroxine Sodium; Methylprednisolone Sodium Succinate; Heparin-Fraction, Sodium Salt
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a health professional (non-physician/pharmacist) from France on 2007-10-04
Patient: female
Adverse reactions / side effects: Neonatal Respiratory Distress Syndrome, Premature Baby, Pneumothorax
Adverse event resulted in: life threatening event
Suspect drug(s):
Depakene
Indication: Drug Exposure During Pregnancy
Folic Acid
Indication: Drug Exposure During Pregnancy
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a consumer/non-health professional from Brazil on 2007-10-03
Patient: female, weighing 75.0 kg (165.0 pounds)
Adverse reactions / side effects: Abdominal Pain, Pruritus, Flatulence, Muscle Rigidity, Oral Discomfort, Abdominal Discomfort, Malaise, Hair Texture Abnormal, Dyspepsia, Sedation, Oedema Peripheral, DRY Mouth, DRY Throat, Poisoning, Nail Disorder, Nervousness, Restlessness, Pain in Extremity, Drug Withdrawal Syndrome, Micturition Urgency, Tremor, Eating Disorder, Insomnia, Suicide Attempt, Vision Blurred, Drug Ineffective, Pain, Disorientation, Somnolence, Constipation, Gastritis, Abdominal Pain Upper, Weight Increased, Diplopia, Hypokinesia, Skin Lesion, Abdominal Distension, Formication, Onychoclasis, Depression, Sinusitis, Nightmare, Musculoskeletal Pain, Anxiety, Dysgeusia, Arthralgia, Impaired Healing, Diarrhoea, Dysuria, Alopecia, Spinal Disorder, Asthenia
Adverse event resulted in: hospitalization
Suspect drug(s):
Frontal
Administration route: Oral
Indication: Depression
Start date: 2005-01-01
End date: 2007-09-01
Frontal
Administration route: Oral
Indication: Anxiety
Frontal XR
Start date: 2005-01-01
End date: 2005-01-01
Valproate Sodium
Omeprazole
Administration route: Oral
Indication: Gastritis
Fluoxetine
Administration route: Oral
Depakene
Administration route: Oral
Other drugs received by patient: Dimeticone; ALL Other Therapeutic Products; Levonorgestrel; Paroxetine HCL; Levonorgestrel and Ethinyl Estradiol; Ethinyl Estradiol TAB; Luftal
Adverse event in male receiving Depakene (Valproic Acid)
Reported by a consumer/non-health professional from Brazil on 2007-10-01
Patient: male, weighing 66.0 kg (145.2 pounds)
Adverse reactions / side effects: Abdominal Neoplasm, Pulmonary Oedema, Neck Mass
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakene (Valproic Acid)
Adverse event in male receiving Depakene (Valproic Acid)
Reported by a health professional (non-physician/pharmacist) from France on 2007-07-30
Patient: male
Adverse reactions / side effects: Hypersensitivity, Skin Exfoliation, Rash, Pyrexia, Erythema, Ascites, Nephritis Interstitial, Colonic Polyp, Myalgia, Renal Impairment, Arthralgia, Aspiration Bone Marrow, Lymphadenopathy Mediastinal, Pleural Effusion, Hypothyroidism, Oedema, Normochromic Normocytic Anaemia
Adverse event resulted in: hospitalization
Suspect drug(s):
Depakene (Valproic Acid)
Adverse event in male receiving Depakene (Valproic Acid)
Reported by a health professional (non-physician/pharmacist) from France on 2007-07-27
Patient: male, weighing 1.9 kg (4.3 pounds)
Adverse reactions / side effects: Asperger's Disorder, Stereotypy, Dysmorphism, Congenital Hair Disorder, Abnormal Behaviour, Ear Malformation, Intelligence Test Abnormal, Disturbance in Attention
Suspect drug(s):
Depakene (Valproic Acid)
Adverse event in female receiving Depakene (Valproic Acid)
Reported by a physician from Japan on 2007-07-24
Patient: female, weighing 54.0 kg (118.8 pounds)
Adverse reactions / side effects: Decreased Activity, Hyponatraemia, Somnolence, Asthenia
Adverse event resulted in: disablity
Suspect drug(s):
Genotropin
Indication: Hypopituitarism
Start date: 2006-12-07
End date: 2007-02-04
Depakene
Dosage: daily dose:800mg
Administration route: Oral
Indication: Epilepsy
Start date: 2006-09-30
End date: 2007-02-21
Depakene
Dosage: daily dose:400mg
Administration route: Oral
Other drugs received by patient: Cortril; Thyradin S; Desmopressin; Aspara-CA
Adverse event in 20 month old female receiving Depakene (Valproic Acid)
Reported by a physician from France on 2007-07-20
Patient: 20 month old female
Adverse reactions / side effects: Dysphagia, Nausea, Cytolytic Hepatitis, Tonsillitis, Hepatic Failure, Fall, Electroencephalogram Abnormal, Hepatitis Cholestatic, Anorexia, Salivary Hypersecretion, Asthenia, Decreased Appetite
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Depakene (Valproic Acid)
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